Designing hydrogel particles for controlled or targeted release of lipophilic bioactive agents in the gastrointestinal tract

European Polymer Journal

Volumn 72, Issue , 2015, Pages 698-716

  Zhang, Zipei ^a,b   Zhang, Ruojie ^a,b   Chen, Long ^a   Tong, Qunyi ^a   McClements, David Julian ^b,c  

^a JIANGNAN UNIVERSITY   (China)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Emulsions; Gastrointestinal tract; Hydrogel particles; Lipophilic bioactive agents; Targeted release

Indexed keywords

BIOCHEMISTRY; BIOPOLYMERS; EMULSIONS; HYDROGELS; THERMAL PROCESSING (FOODS);

ANTI-SOLVENT PRECIPITATIONS; BIOACTIVE AGENTS; GASTROINTESTINAL TRACT; HYDROGEL PARTICLES; ORAL BIOAVAILABILITIES; PHARMACEUTICAL INDUSTRY; PROCESSING OPERATIONS; TARGETED RELEASE;

PRECIPITATION (CHEMICAL);

EID: 84945468575     PISSN: 00143057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpolymj.2015.01.013     Document Type: Article

References (184)

1. D.J. McClements, and Y. Li Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components Adv Colloid Interface Sci 159 2 2010 213 228
2. S. Gouin Microencapsulation: industrial appraisal of existing technologies and trends Trends Food Sci Technol 15 7 2004 330 347
3. D.J. McClements, E.A. Decker, and J. Weiss Emulsion-based delivery systems for lipophilic bioactive components J Food Sci 72 8 2007 R109 R124
4. T.R. Hoare, and D.S. Kohane Hydrogels in drug delivery: progress and challenges Polymer 49 8 2008 1993 2007
5. D.J. McClements Emulsion design to improve the delivery of functional lipophilic components Ann Rev Food Sci Technol 1 2010 241 269
6. A. Matalanis, E.A. Decker, and D.J. McClements Inhibition of lipid oxidation by encapsulation of emulsion droplets within hydrogel microspheres Food Chem 132 2 2012 766 772
7. Z. Zhang, E.A. Decker, and D.J. McClements Encapsulation, protection, and release of polyunsaturated lipids using biopolymer-based hydrogel particles Food Res Int 64 2014 520 526
8. Y. Li, M. Hu, Y. Du, H. Xiao, and D.J. McClements Control of lipase digestibility of emulsified lipids by encapsulation within calcium alginate beads Food Hydrocolloids 25 1 2011 122 130
9. Y. Li, J. Kim, Y. Park, and D.J. McClements Modulation of lipid digestibility using structured emulsion-based delivery systems: comparison of in vivo and in vitro measurements Food Funct 3 5 2012 528 536
10. J.Y. Jung, R.D. Arnold, and L. Wicker Pectin and charge modified pectin hydrogel beads as a colon-targeted drug delivery carrier Colloids Surf B-Biointerfaces 104 2013 116 121
11. Z. Zhang, R. Zhang, E.A. Decker, and D.J. McClements Development of food-grade filled hydrogels for oral delivery of lipophilic active ingredients: pH-triggered release Food Hydrocolloids 2014
12. S. Ray, S. Banerjee, S. Maiti, B. Laha, S. Barik, B. Sa, and et al. Novel interpenetrating network microspheres of xanthan gum-poly(vinyl alcohol) for the delivery of diclofenac sodium to the intestine-in vitro and in vivo evaluation Drug Delivery 17 7 2010 508 519
13. G. Di Colo, A. Baggiani, Y. Zambito, G. Mollica, M. Geppi, and M.F. Serafini A new hydrogel for the extended and complete prednisolone release in the GI tract Int J Pharm 310 1-2 2006 154 161
14. H. Richards, C.P. Thomas, J.L. Bowen, and C.M. Heard In-vitro transcutaneous delivery of ketoprofen and polyunsaturated fatty acids from a pluronic lecithin organogel vehicle containing fish oil J Pharm Pharmacol 58 7 2006 903 908
15. S.L. Kosaraju, R. Weerakkody, and M.A. Augustin In-vitro evaluation of hydrocolloid-based encapsulated fish oil Food Hydrocolloids 23 5 2009 1413 1419
16. Josephson DB, Soper JC, Yang X. Method of encapsulating flavors and fragrances by controlled water transport into microcapsules. Google Patents; 2000.
17. Soper JC, Thomas MT. Enzymatically protein-encapsulating oil particles by complex coacervation. Google Patents; 2001.
18. M.E. Monge, D. Bulone, D. Giacomazza, R.M. Negri, and D.L. Bernik Electronic nose screening of limonene release from multicomponent essential oils encapsulated in pectin gels Comb Chem High Throughput Screening 7 4 2004 337 344
19. H. Yu, and Q. Huang Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch Food Chem 119 2 2010 669 674
20. S. Bisht, G. Feldmann, S. Soni, R. Ravi, C. Karikar, A. Maitra, and et al. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy J Nanobiotechnol 5 3 2007 1 18
21. F. Cao, B. Ding, M. Sun, C. Guo, L. Zhang, and G. Zhai Lung-targeted delivery system of curcumin loaded gelatin microspheres Drug Delivery 18 8 2011 545 554
22. S. Das, and K.-Y. Ng Colon-specific delivery of resveratrol: optimization of multi-particulate calcium-pectinate carrier Int J Pharm 385 1 2010 20 28
23. M.A. Augustin, L. Sanguansri, and T. Lockett Nano-and micro-encapsulated systems for enhancing the delivery of resveratrol Ann N Y Acad Sci 1290 1 2013 107 112
24. G.M. Fujiwara, R. Campos, C.K. Costa, J.d.F.G. Dias, O.G. Miguel, M.D. Miguel, and et al. Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique Braz J Pharm Sci 49 3 2013 537 547
25. Q. Chen, D. McGillivray, J. Wen, F. Zhong, and S.Y. Quek Co-encapsulation of fish oil with phytosterol esters and limonene by milk proteins J Food Eng 117 4 2013 505 512
26. A.J. Ribeiro, R.J. Neufeld, P. Arnaud, and J.C. Chaumeil Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres Int J Pharm 187 1 1999 115 123
27. H. Jizomoto, E. Kanaoka, K. Sugita, and K. Hirano Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract Pharm Res 10 8 1993 1115 1122
28. S. Mourtas, S. Fotopoulou, S. Duraj, V. Sfika, C. Tsakiroglou, and S.G. Antimisiaris Liposomal drugs dispersed in hydrogels: effect of liposome, drug and gel properties on drug release kinetics Colloids Surf, B: Biointerfaces 55 2 2007 212 221
29. W. Somchue, W. Sermsri, J. Shiowatana, and A. Siripinyanond Encapsulation of α-tocopherol in protein-based delivery particles Food Res Int 42 8 2009 909 914
30. L. Liang, V. Leung Sok Line, G.E. Remondetto, and M. Subirade In vitro release of α-tocopherol from emulsion-loaded β-lactoglobulin gels Int Dairy J 20 3 2010 176 181
31. I.I. Muhamad, L.S. Fen, N.H. Hui, and N.A. Mustapha Genipin-cross-linked kappa-carrageenan/carboxymethyl cellulose beads and effects on beta-carotene release Carbohydr Polym 83 3 2011 1207 1212
32. A.B. Hernández-Espinoza, M.I. Piñón-Muñiz, A. Rascón-Chu, V.M. Santana-Rodríguez, and E. Carvajal-Millan Lycopene/arabinoxylan gels: rheological and controlled release characteristics Molecules 17 3 2012 2428 2436
33. D.F. Silva, C.S. Favaro-Trindade, G.A. Rocha, and M. Thomazini Microencapsulation of lycopene by gelatin-pectin complex coacervation J Food Process Preserv 36 2 2012 185 190
34. X.-Y. Qv, Z.-P. Zeng, and J.-G. Jiang Preparation of lutein microencapsulation by complex coacervation method and its physicochemical properties and stability Food Hydrocolloids 25 6 2011 1596 1603
35. R. Arunkumar, K.V. Harish Prashanth, and V. Baskaran Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: characterization and bioavailability of lutein in vitro and in vivo Food Chem 141 1 2013 327 337
36. T. Coviello, P. Matricardi, C. Marianecci, and F. Alhaique Polysaccharide hydrogels for modified release formulations J Control Release 119 1 2007 5 24
37. D. Saha, and S. Bhattacharya Hydrocolloids as thickening and gelling agents in food: a critical review J Food Sci Technol 47 6 2010 587 597
38. J.H. Hamman Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems Marine Drugs 8 4 2010 1305 1322
39. S. Sungthongjeen, P. Sriamornsak, T. Pitaksuteepong, A. Somsiri, and S. Puttipipatkhachorn Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets Aaps Pharmscitech 5 1 2004 50 57
40. M.K. Chourasia, and S.K. Jain Pharmaceutical approaches to colon targeted drug delivery systems J Pharm Pharm Sci 6 1 2003 33 66
41. A.T.-B. Nguyen, P. Winckler, P. Loison, Y. Wache, and O. Chambin Physico-chemical state influences in vitro release profile of curcumin from pectin beads Colloids Surf, B: Biointerfaces 121 2014 290 298
42. E.I. DÍaz-Rojas, R. Pacheco-Aguilar, J. Lizardi, W. Argüelles-Monal, M.A. Valdez, M. Rinaudo, and et al. Linseed pectin: gelling properties and performance as an encapsulation matrix for shark liver oil Food Hydrocolloids 18 2 2004 293 304
43. J.S. Kim, J.-S. Lee, P.-S. Chang, and H.G. Lee Optimization in vitro release and bioavailability of γ-oryzanol-loaded calcium pectinate microparticles reinforced with chitosan New Biotechnol 27 4 2010 368 373
44. G. Dongowski Influence of pectin structure on the interaction with bile acids under in vitro conditions Z Lebensm-Unters For 201 4 1995 390 398
45. M. Hu, Y. Li, E.A. Decker, and D.J. McClements Role of calcium and calcium-binding agents on the lipase digestibility of emulsified lipids using an in vitro digestion model Food Hydrocolloids 24 8 2010 719 725
46. T.A.J. Verrijssen, L.G. Balduyck, S. Christiaens, A.M. Van Loey, S. Van Buggenhout, and M.E. Hendrickx The effect of pectin concentration and degree of methyl-esterification on the in vitro bioaccessibility of β-carotene-enriched emulsions Food Res Int 57 2014 71 78
47. D. Sun-Waterhouse, W. Wang, and G.I.N. Waterhouse Canola oil encapsulated by alginate and its combinations with starches of low and high amylose content: effect of quercetin on oil stability Food Bioprocess Technol 2013 1 19
48. E.-S. Chan Preparation of Ca-alginate beads containing high oil content: influence of process variables on encapsulation efficiency and bead properties Carbohydr Polym 84 4 2011 1267 1275
49. P. Burey, B.R. Bhandari, T. Howes, and M.J. Gidley Hydrocolloid gel particles: formation, characterization, and application Crit Rev Food Sci Nutr 48 5 2008 361 377
50. P. Lertsutthiwong, K. Noomun, N. Jongaroonngamsang, P. Rojsitthisak, and U. Nimmannit Preparation of alginate nanocapsules containing turmeric oil Carbohydr Polym 74 2 2008 209 214
51. M. George, and T.E. Abraham Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan - a review J Control Release 114 1 2006 1 14
52. P.R. Hari, T. Chandy, and C.P. Sharma Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin J Microencapsul 13 3 1996 319 329
53. B. Amsden, and N. Turner Diffusion characteristics of calcium alginate gels Biotechnol Bioeng 65 5 1999 605 610
54. Sato AC, Perrechil F, Michelon M, Cunha R. Biopolymeric microbeads for incorporation of lipophilic and hydrophilic compounds. Book of abstracts of the 1st congress on food structure design. p. 52.
55. A.I. Usov Structural analysis of red seaweed galactans of agar and carrageenan groups Food Hydrocolloids 12 3 1998 301 308
56. A.P. Imeson, G.O. Phillips, and P.A. Williams Carrageenan Handbook Hydrocolloids 2000 87 102
57. H. Hezaveh, and I.I. Muhamad The effect of nanoparticles on gastrointestinal release from modified κ-carrageenan nanocomposite hydrogels Carbohydr Polym 89 1 2012 138 145
58. L. Piazza, and S. Benedetti Investigation on the rheological properties of agar gels and their role on aroma release in agar/limonene solid emulsions Food Res Int 43 1 2010 269 276
59. M. Lahaye, and C. Rochas Chemical structure and physico-chemical properties of agar International workshop on gelidium 1991 Springer 137 148
60. I.J. Joye, and D.J. McClements Biopolymer-based nanoparticles and microparticles: fabrication, characterization, and application Curr Opin Colloid Interface Sci 2014
61. R. Meena, J.P. Chaudhary, P.K. Agarwal, P. Maiti, S. Chatterjee, H.D. Raval, and et al. Surfactant-induced coagulation of agarose from aqueous extract of Gracilaria dura seaweed as an energy-efficient alternative to the conventional freeze-thaw process RSC Adv 4 53 2014 28093 28098
62. A. Shalviri, Q. Liu, M.J. Abdekhodaie, and X.Y. Wu Novel modified starch-xanthan gum hydrogels for controlled drug delivery: synthesis and characterization Carbohydr Polym 79 4 2010 898 907
63. M.E. Malone, and I.A.M. Appelqvist Gelled emulsion particles for the controlled release of lipophilic volatiles during eating J Control Release 90 2 2003 227 241
64. S. Mun, Y.-R. Kim, and D.J. McClements Control of β-carotene bioaccessibility using starch-based filled hydrogels Food Chem 173 2015 454 461
65. H. Firoozmand, and D. Rousseau Microstructure and elastic modulus of phase-separated gelatin-starch hydrogels containing dispersed oil droplets Food Hydrocolloids 30 1 2013 333 342
66. L.-M. Zhang, C. Yang, and L. Yan Perspectives on: strategies to fabricate starch-based hydrogels with potential biomedical applications J Bioact Compat Polym 20 3 2005 297 314
67. E.I. Paramera, S.J. Konteles, and V.T. Karathanos Stability and release properties of curcumin encapsulated in Saccharomyces cerevisiae, β-cyclodextrin and modified starch Food Chem 125 3 2011 913 922
68. R. Hejazi, and M. Amiji Chitosan-based gastrointestinal delivery systems J Control Release 89 2 2003 151 165
69. Y. Luo, B. Zhang, M. Whent, L.L. Yu, and Q. Wang Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study Colloids Surf, B: Biointerfaces 85 2 2011 145 152
70. F.O.M.S. Abreu, E.F. Oliveira, H.C.B. Paula, and R. de Paula Chitosan/cashew gum nanogels for essential oil encapsulation Carbohydr Polym 89 4 2012 1277 1282
71. K. Nakagawa, N. Sowasod, W. Tanthapanichakoon, and T. Charinpanitkul Hydrogel based oil encapsulation for controlled release of curcumin by using a ternary system of chitosan, kappa carrageenan, and carboxymethylcellulose sodium salt LWT-Food Sci Technol 54 2 2013 600 605
72. J. Berger, M. Reist, J.M. Mayer, O. Felt, N.A. Peppas, and R. Gurny Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications Eur J Pharm Biopharm 57 1 2004 19 34
73. S. Dhawan, A.K. Singla, and V.R. Sinha Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods Aaps Pharmscitech 5 4 2004 122 128
74. S.K. Dhayal, H. Gruppen, R. de Vries, and P.A. Wierenga Controlled formation of protein nanoparticles by enzymatic cross-linking of α-lactalbumin with horseradish peroxidase Food Hydrocolloids 36 0 2014 53 59
75. Y.H. Cho, H.K. Shim, and J. Park Encapsulation of fish oil by an enzymatic gelation process using transglutaminase cross-linked proteins J Food Sci 68 9 2003 2717 2723
76. C.-Y. Gan, L.-H. Cheng, and A.M. Easa Evaluation of microbial transglutaminase and ribose cross-linked soy protein isolate-based microcapsules containing fish oil Innovat Food Sci Emerg Technol 9 4 2008 563 569
77. P. Montero, M.D. Fernández-DIaz, and M.C. Gómez-Guillén Characterization of gelatin gels induced by high pressure Food Hydrocolloids 16 3 2002 197 205
78. T. Chen, H.D. Embree, E.M. Brown, M.M. Taylor, and G.F. Payne Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications Biomaterials 24 17 2003 2831 2841
79. M. Borkova, and J. Snaselova Possibilities of different animal milk detection in milk and dairy products - a review Czech J Food Sci 23 2 2005 41 50
80. L. Beaulieu, L. Savoie, P. Paquin, and M. Subirade Elaboration and characterization of whey protein beads by an emulsification/cold gelation process: application for the protection of retinol Biomacromolecules 3 2 2002 239 248
81. T. Egan, J.-C. Jacquier, Y. Rosenberg, and M. Rosenberg Cold-set whey protein microgels for the stable immobilization of lipids Food Hydrocolloids 31 2 2013 317 324
82. A.C.A. Veloso, N. Teixeira, and I.M. Ferreira Separation and quantification of the major casein fractions by reverse-phase high-performance liquid chromatography and urea-polyacrylamide gel electrophoresis: detection of milk adulterations J Chromatogr A 967 2 2002 209 218
83. A. Benzaria, M. Maresca, N. Taieb, and E. Dumay Interaction of curcumin with phosphocasein micelles processed or not by dynamic high-pressure Food Chem 138 4 2013 2327 2337
84. M.J. Saiz-Abajo, C. Gonzalez-Ferrero, A. Moreno-Ruiz, A. Romo-Hualde, and C.J. Gonzalez-Navarro Thermal protection of beta-carotene in re-assembled casein micelles during different processing technologies applied in food industry Food Chem 138 2-3 2013 1581 1587
85. D. Chevalier-Lucia, C. Blayo, A. Gracia-Julia, L. Picart-Palmade, and E. Dumay Processing of phosphocasein dispersions by dynamic high pressure: effects on the dispersion physico-chemical characteristics and the binding of alpha-tocopherol acetate to casein micelles Innovat Food Sci Emerg Technol 12 4 2011 416 425
86. K. Pan, Q. Zhong, and S.J. Baek Enhanced dispersibility and bioactivity of curcumin by encapsulation in casein nanocapsules J Agric Food Chem 61 25 2013 6036 6043
87. E. Dickinson Flocculation of protein-stabilized oil-in-water emulsions Colloids Surf, B-Biointerfaces 81 1 2010 130 140
88. L.Y. Chen, G.E. Remondetto, and M. Subirade Food protein-based materials as nutraceutical delivery systems Trends Food Sci Technol 17 5 2006 272 283
89. Y. Luo, and Q. Wang Zein-based micro- and nano-particles for drug and nutrient delivery: a review J Appl Polym Sci 131 16 2014
90. I.J. Joye, V.A. Nelis, and D.J. McClements Gliadin-based nanoparticles: fabrication and stability of food-grade colloidal delivery systems Food Hydrocolloids 44 2015 86 93
91. I.J. Joye, and D.J. McClements Production of nanoparticles by anti-solvent precipitation for use in food systems Trends Food Sci Technol 34 2 2013 109 123
92. N.A. Peppas, P. Bures, W. Leobandung, and H. Ichikawa Hydrogels in pharmaceutical formulations Eur J Pharm Biopharm 50 1 2000 27 46
93. I.J. Joye, G. Davidov-Pardo, and D.J. McClements Nanotechnology for increased micronutrient bioavailability Trends Food Sci Technol 2014
94. D.J. McClements Comments on viscosity enhancement and depletion flocculation by polysaccharides Food Hydrocolloids 14 2 2000 173 177
95. M.N. Mason, A.T. Metters, C.N. Bowman, and K.S. Anseth Predicting controlled-release behavior of degradable PLA-b-PEG-b-PLA hydrogels Macromolecules 34 13 2001 4630 4635
96. G.M. Cruise, D.S. Scharp, and J.A. Hubbell Characterization of permeability and network structure of interfacially photopolymerized poly (ethylene glycol) diacrylate hydrogels Biomaterials 19 14 1998 1287 1294
97. Y. Li, and D.J. McClements Controlling lipid digestion by encapsulation of protein-stabilized lipid droplets within alginate-chitosan complex coacervates Food Hydrocolloids 25 5 2011 1025 1033
98. Y. Tamai, H. Tanaka, and K. Nakanishi Molecular dynamics study of polymer-water interaction in hydrogels. 1. Hydrogen-bond structure Macromolecules 29 21 1996 6750 6760
99. D.C. Tuncaboylu, M. Sari, W. Oppermann, and O. Okay Tough and self-healing hydrogels formed via hydrophobic interactions Macromolecules 44 12 2011 4997 5005
100. A. Bigi, S. Panzavolta, and K. Rubini Relationship between triple-helix content and mechanical properties of gelatin films Biomaterials 25 25 2004 5675 5680
101. B. Jeong, S.W. Kim, and Y.H. Bae Thermosensitive sol-gel reversible hydrogels Adv Drug Deliv Rev 54 1 2002 37 51
102. C.M. Bryant, and D.J. McClements Molecular basis of protein functionality with special consideration of cold-set gels derived from heat-denatured whey Trends Food Sci Technol 9 4 1998 143 151
103. V. Raikos, L. Campbell, and S.R. Euston Rheology and texture of hen's egg protein heat-set gels as affected by pH and the addition of sugar and/or salt Food Hydrocolloids 21 2 2007 237 244
104. A.M. Hermansson Soy protein gelation J Am Oil Chem Soc 63 5 1986 658 666
105. J.A. Gerrard Protein-protein crosslinking in food: methods, consequences, applications Trends Food Sci Technol 13 12 2002 391 399
106. R.A.A. Muzzarelli Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids Carbohydr Polym 77 1 2009 1 9
107. B. Zeeb, L. Fischer, and J. Weiss Stabilization of food dispersions by enzymes Food Funct 5 2 2014 198 213
108. O.G. Jones, and D.J. McClements Functional biopolymer particles: design, fabrication, and applications Compr Rev Food Sci Food Safety 9 4 2010 374 397
109. A.S. Hoffman Hydrogels for biomedical applications Adv Drug Deliv Rev 54 1 2002 3 12
110. A.S. Prata, M.H.A. Zanin, M.I. Ré, and C.R.F. Grosso Release properties of chemical and enzymatic crosslinked gelatin-gum Arabic microparticles containing a fluorescent probe plus vetiver essential oil Colloids Surf, B: Biointerfaces 67 2 2008 171 178
111. F. Weinbreck, M. Minor, and C.G. De Kruif Microencapsulation of oils using whey protein/gum arabic coacervates J Microencapsul 21 6 2004 667 679
112. J. Berger, M. Reist, J.M. Mayer, O. Felt, and R. Gurny Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications Eur J Pharm Biopharm 57 1 2004 35 52
113. T. Takahashi, K. Takayama, Y. Machida, and T. Nagai Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate Int J Pharm 61 1 1990 35 41
114. V. Chavasit, C. Kienzle-Sterzer, and J.A. Torres Formation and characterization of an insoluble polyelectrolyte complex: chitosan-polyacrylic acid Polym Bull 19 3 1988 223 230
115. W. Argüelles-Monal, O.L. Hechavarria, L. Rodriguez, and C. Peniche Swelling of membranes from the polyelectrolyte complex between chitosan and carboxymethyl cellulose Polym Bull 31 4 1993 471 478
116. K.Y. Lee, W.H. Park, and W.S. Ha Polyelectrolyte complexes of sodium alginate with chitosan or its derivatives for microcapsules J Appl Polym Sci 63 4 1997 425 432
117. L. Donato, C. Schmitt, L. Bovetto, and M. Rouvet Mechanism of formation of stable heat-induced β-lactoglobulin microgels Int Dairy J 19 5 2009 295 306
118. C.-Y. Yu, B.-C. Yin, W. Zhang, S.-X. Cheng, X.-Z. Zhang, and R.-X. Zhuo Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property Colloids Surf, B: Biointerfaces 68 2 2009 245 249
119. B. Mohanty, V.K. Aswal, P.S. Goyal, and H.B. Bohidar Small-angle neutron and dynamic light scattering study of gelatin coacervates Pramana 63 2 2004 271 276
120. A. Matalanis, U. Lesmes, E.A. Decker, and D.J. McClements Fabrication and characterization of filled hydrogel particles based on sequential segregative and aggregative biopolymer phase separation Food Hydrocolloids 24 8 2010 689 701
121. B.-C. Wu, B. Degner, and D.J. McClements Soft matter strategies for controlling food texture: formation of hydrogel particles by biopolymer complex coacervation J Phys: Condens Matter 26 46 2014 464104
122. E.H. Bromley, M.R. Krebs, and A.M. Donald Mechanisms of structure formation in particulate gels of beta-lactoglobulin formed near the isoelectric point Eur Phys J E, Soft Matter 21 2 2006 145 152
123. O.G. Jones, and D.J. McClements Biopolymer nanoparticles from heat-treated electrostatic protein-polysaccharide complexes: factors affecting particle characteristics J Food Sci 75 2 2010 N36 N43
124. A. Matalanis, O.G. Jones, and D.J. McClements Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds Food Hydrocolloids 25 8 2011 1865 1880
125. C. Schmitt, C. Bovay, M. Rouvet, S. Shojaei-Rami, and E. Kolodziejczyk Whey protein soluble aggregates from heating with NaCl: physicochemical, interfacial, and foaming properties Langmuir 23 8 2007 4155 4166
126. M.R.H. Krebs, G.L. Devlin, and A.M. Donald Protein particulates: another generic form of protein aggregation? Biophys J 92 4 2007 1336 1342
127. O.G. Jones, E.A. Decker, and D.J. McClements Formation of biopolymer particles by thermal treatment of β-lactoglobulin-pectin complexes Food Hydrocolloids 23 5 2009 1312 1321
128. C.-Y. Yu, L.-H. Jia, S.-X. Cheng, X.-Z. Zhang, and R.-X. Zhuo Fabrication of microparticle protein delivery systems based on calcium alginate J Microencapsul 27 2 2010 171 177
129. M. Albarghouthi, D.A. Fara, M. Saleem, T. El-Thaher, K. Matalka, and A. Badwan Immobilization of antibodies on alginate-chitosan beads Int J Pharm 206 1 2000 23 34
130. M.L. González-RodrIguez, M.A. Holgado, C. Sanchez-Lafuente, A.M. Rabasco, and A. Fini Alginate/chitosan particulate systems for sodium diclofenac release Int J Pharm 232 1 2002 225 234
131. C. Peniche, I. Howland, O. Carrillo, C. Zaldívar, and W. Argüelles-Monal Formation and stability of shark liver oil loaded chitosan/calcium alginate capsules Food Hydrocolloids 18 5 2004 865 871
132. G. Pasparakis, and N. Bouropoulos Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads Int J Pharm 323 1 2006 34 42
133. S. Wittaya-areekul, J. Kruenate, and C. Prahsarn Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone Int J Pharm 312 1 2006 113 118
134. I.F. Farres, R.J.A. Moakes, and I.T. Norton Designing biopolymer fluid gels: a microstructural approach Food Hydrocolloids 42 2014 362 372
135. I.F. Farres, and I.T. Norton Formation kinetics and rheology of alginate fluid gels produced by in-situ calcium release Food Hydrocolloids 40 2014 76 84
136. B. Wolf, W.J. Frith, S. Singleton, M. Tassieri, and I.T. Norton Shear behaviour of biopolymer suspensions with spheroidal and cylindrical particles Rheol Acta 40 3 2001 238 247
137. I. Fernández Farrés, and I.T. Norton Formation kinetics and rheology of alginate fluid gels produced by in-situ calcium release Food Hydrocolloids 40 2014 76 84
138. A. Gabriele, F. Spyropoulos, and I.T. Norton Kinetic study of fluid gel formation and viscoelastic response with kappa-carrageenan Food Hydrocolloids 23 8 2009 2054 2061
139. M.H. Mahdi, B.R. Conway, and A.M. Smith Evaluation of gellan gum fluid gels as modified release oral liquids Int J Pharm 475 1 2014 335 343
140. J.D. Oxley Spray cooling and spray chilling for food ingredient and nutraceutical encapsulation N. Garti, D.J. McClements, Encapsulation technologies and delivery systems for food ingredients and nutraceuticals 2012 Woodhead Publishing Oxford, U.K. 110 130
141. S. Drusch, Y. Serfert, M. Scampicchio, B. Schmidt-Hansberg, and K. Schwarz Impact of physicochemical characteristics on the oxidative stability of fish oil microencapsulated by spray-drying J Agric Food Chem 55 26 2007 11044 11051
142. C.-C. Lin, and A.T. Metters Hydrogels in controlled release formulations: network design and mathematical modeling Adv Drug Deliv Rev 58 12 2006 1379 1408
143. D.Y. Arifin, L.Y. Lee, and C.-H. Wang Mathematical modeling and simulation of drug release from microspheres: implications to drug delivery systems Adv Drug Deliv Rev 58 12 2006 1274 1325
144. B. Amsden Solute diffusion within hydrogels. Mechanisms and models Macromolecules 31 23 1998 8382 8395
145. L. Masaro, and X.X. Zhu Physical models of diffusion for polymer solutions, gels and solids Prog Polym Sci 24 5 1999 731 775
146. G.P. Lian, M.E. Malone, J.E. Homan, and I.T. Norton A mathematical model of volatile release in mouth from the dispersion of gelled emulsion particles J Control Release 98 1 2004 139 155
147. K.D. Yao, T. Peng, H.B. Feng, and Y.Y. He Swelling kinetics and release characteristic of crosslinked chitosan: polyether polymer network (semi-IPN) hydrogels J Polym Sci, Part A: Polym Chem 32 7 1994 1213 1223
148. N.A. Peppas, and A.R. Khare Preparation, structure and diffusional behavior of hydrogels in controlled release Adv Drug Deliv Rev 11 1 1993 1 35
149. M. Singh, J.A. Lumpkin, and J. Rosenblatt Mathematical modeling of drug release from hydrogel matrices via a diffusion coupled with desorption mechanism J Control Release 32 1 1994 17 25
150. N.A. Peppas, Y. Huang, M. Torres-Lugo, J.H. Ward, and J. Zhang Physicochemical foundations and structural design of hydrogels in medicine and biology Annu Rev Biomed Eng 2 1 2000 9 29
151. C.S. Brazel, and N.A. Peppas Dimensionless analysis of swelling of hydrophilic glassy polymers with subsequent drug release from relaxing structures Biomaterials 20 8 1999 721 732
152. R. Langer Modeling monomer release from bioerodible polymers J Control Release 33 1 1995 55 69
153. C.G. De Kruif, F. Weinbreck, and R. de Vries Complex coacervation of proteins and anionic polysaccharides Curr Opin Colloid Interface Sci 9 5 2004 340 349
154. Y.-H. Lin, H.-F. Liang, C.-K. Chung, M.-C. Chen, and H.-W. Sung Physically crosslinked alginate/N, O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs Biomaterials 26 14 2005 2105 2113
155. C.A. Butts, J.A. Monro, and P.J. Moughan In vitro determination of dietary protein and amino acid digestibility for humans Br J Nutr 108 2012 S282 S287
156. H. Babin, and E. Dickinson Influence of transglutaminase treatment on the thermoreversible gelation of gelatin Food Hydrocolloids 15 3 2001 271 276
157. A. Gunaratne, and R. Hoover Effect of heat-moisture treatment on the structure and physicochemical properties of tuber and root starches Carbohydr Polym 49 4 2002 425 437
158. S.T. Lim, J.A. Han, H.S. Lim, and J.N. BeMiller Modification of starch by dry heating with ionic gums Cereal Chem 79 5 2002 601 606
159. C.G. Oates, and D.A. Ledward Studies on the effect of heat on alginates Food Hydrocolloids 4 3 1990 215 220
160. A.S. Michel, M.M. Mestdagh, and M.A.V. Axelos Physico-chemical properties of carrageenan gels in presence of various cations Int J Biol Macromol 21 1 1997 195 200
161. L. Li Thermal gelation of methylcellulose in water: scaling and thermoreversibility Macromolecules 35 15 2002 5990 5998
162. M. Hamidi, A. Azadi, and P. Rafiei Hydrogel nanoparticles in drug delivery Adv Drug Deliv Rev 60 15 2008 1638 1649
163. C. Salles, A. Tarrega, P. Mielle, J. Maratray, P. Gorria, J. Liaboeuf, and et al. Development of a chewing simulator for food breakdown and the analysis of in vitro flavor compound release in a mouth environment J Food Eng 82 2 2007 189 198
164. K.B. de Roos Effect of texture and microstructure on flavour retention and release Int Dairy J 13 8 2003 593 605
165. A. Hansson, P. Giannouli, and S. van Ruth The influence of gel strength on aroma release from pectin gels in a model mouth and in vivo, monitored with proton-transfer-reaction mass spectrometry J Agric Food Chem 51 16 2003 4732 4740
166. T. Mills, F. Spyropoulos, I.T. Norton, and S. Bakalis Development of an in-vitro mouth model to quantify salt release from gels Food Hydrocolloids 25 1 2011 107 113
167. G. Lian, M.E. Malone, J.E. Homan, and I.T. Norton A mathematical model of volatile release in mouth from the dispersion of gelled emulsion particles J Control Release 98 1 2004 139 155
168. M.E. Malone, I.A.M. Appelqvist, and I.T. Norton Oral behaviour of food hydrocolloids and emulsions. Part 2. Taste and aroma release Food Hydrocolloids 17 6 2003 775 784
169. F. Kong, and R.P. Singh A model stomach system to investigate disintegration kinetics of solid foods during gastric digestion J Food Sci 73 5 2008 E202 E210
170. A. Guerra, L. Etienne-Mesmin, V. Livrelli, S. Denis, S. Blanquet-Diot, and M. Alric Relevance and challenges in modeling human gastric and small intestinal digestion Trends Biotechnol 30 11 2012 591 600
171. D.J. McClements Edible lipid nanoparticles: digestion, absorption, and potential toxicity Prog Lipid Res 52 4 2013 409 423
172. D.J. McClements, E.A. Decker, Y. Park, and J. Weiss Designing food structure to control stability, digestion, release and absorption of lipophilic food components Food Biophys 3 2 2008 219 228
173. Y. Murata, N. Sasaki, E. Miyamoto, and S. Kawashima Use of floating alginate gel beads for stomach-specific drug delivery Eur J Pharm Biopharm 50 2 2000 221 226
174. P. Sriamornsak, N. Thirawong, and S. Puttipipatkhachorn Morphology and buoyancy of oil-entrapped calcium pectinate gel beads AAPS J 6 3 2004 65 71
175. A. Matalanis, and D.J. McClements Impact of encapsulation within hydrogel microspheres on lipid digestion: an in vitro study Food Biophys 7 2 2012 145 154
176. L. Chen, G. Hebrard, E. Beyssac, S. Denis, and M. Subirade In vitro study of the release properties of soy-zein protein microspheres with a dynamic artificial digestive system J Agric Food Chem 58 17 2010 9861 9867
177. D.J. McClements Understanding and controlling the microstructure of complex foods 2007 Elsevier
178. S. Mun, Y.-R. Kim, and D.J. McClements Control of β-carotene bioaccessibility using starch-based filled hydrogels Food Chem 2014
179. J.M.W. Wong, R. de Souza, C.W.C. Kendall, A. Emam, and D.J.A. Jenkins Colonic health: fermentation and short chain fatty acids J Clin Gastroenterol 40 3 2006 235 243
180. Y. Yin, Y. Yang, and H. Xu Swelling behavior of hydrogels for colon-site drug delivery J Appl Polym Sci 83 13 2002 2835 2842
181. L. Xing, C. Dawei, X. Liping, and Z. Rongqing Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome J Control Release 93 3 2003 293 300
182. L. Hovgaard, and H. Brøndsted Dextran hydrogels for colon-specific drug delivery J Control Release 36 1 1995 159 166
183. E.J. Elias, S. Anil, S. Ahmad, and A. Daud Colon targeted curcumin delivery using guar gum Nat Prod Commun 5 6 2010 915 918
184. N. Bhattarai, J. Gunn, and M. Zhang Chitosan-based hydrogels for controlled, localized drug delivery Adv Drug Deliv Rev 62 1 2010 83 99