Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres

International Journal of Pharmaceutics

Volumn 187, Issue 1, 1999, Pages 115-123

  Ribeiro, Antonio J ^a,b   Neufeld, Ronald J ^a,b   Arnaud, Philippe ^c   Chaumeil, Jean C ^b  

^a MCGILL UNIVERSITY   (Canada)

^b Faculte de Pharmacie   (France)

^c Fac Med Pharm Pl S J   (France)

Author keywords

Alginate; Chitosan; Drug release; Encapsulation; Lipophilic drugs

Indexed keywords

ALGINIC ACID; CALCIUM CARBONATE; CHITOSAN; MICROSPHERE; SOYBEAN OIL;

ARTICLE; CONTROLLED RELEASE FORMULATION; DISPERSION; DRUG RELEASE; EMULSION; MICROENCAPSULATION; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ALGINATES; BIOCOMPATIBLE MATERIALS; CHITIN; CHITOSAN; COATED MATERIALS, BIOCOMPATIBLE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EMULSIONS; GLUCURONIC ACID; HEXURONIC ACIDS; MICROSPHERES; PARTICLE SIZE; SOYBEAN OIL;

EID: 0032857897     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00173-8     Document Type: Article

References (26)

1. Alex R., Bodmeier R. Encapsulation of water-soluble drugs by modified solvent evaporation method. Effect of process and formulation variables on drug entrapment. J. Microencapsulation. 7:1990;347-355.
2. Chandy T., Sharma C.P. Chitosan as a biomaterial. Biomater. Artif. Cells Artif. Organs. 18:1990;1-24.
3. Davis S.S., Hadgraft J., Palin K.J. Medical and pharmaceutical applications of emulsions. Becher P. Encyclopedia of Emulsion Technology. 1985;Marcel Dekker, New York.
4. Deasy P.B. Evaluation of drug-containing microcapsules. J. Microencapsulation. 11:1994;487-505.
5. Green F.J. The Sigma-Aldrich Handbook of Stains, Dyes and Indicators. 1991;Aldrich, Milwaukee, WI.
6. Harano S., Tobetto K., Hasegawa M., Matsuda N. Permeability properties of gels and membranes derived from chitosan. J. Biomater. Res. 14:1980;477-485.
7. Huguet M.L., Groboillot A., Neufeld R.J., Poncelet D., Dellacherie E. Hemoglobin encapsulation in chitosan/calcium alginate beads. J. Appl. Polym. Sci. 51:1994;1427-1432.
8. Kawashima Y., Handa T., Kasai A., Takenaka H., Lin S.Y., Ando Y. Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan. J. Pharm. Sci. 74:1985;264-268.
9. Kim C.K., Lee E.J. The controlled release of blue dextran from alginate beads. Int. J. Pharm. 79:1992;11-19.
10. Kristmundsdottir T., Ingvarsdottir K., Saemundsdottir G. Chitosan matrix tablets: the influence of excipients on drug release. Drug Dev. Ind. Pharm. 21:1995;1591-1598.
11. Lee B.-J., Min G.-H. Oral controlled release of melatonin using polymer-reinforced and coated alginate beads. Int. J. Pharm. 144:1996;37-46.
12. Robinson V.H.K., Lee J.R. Controlled Drug Delivery, Fundamentals and Applications. 1987;3-61 Marcel Dekker, New York.
13. Lin S.-Y., Perng R.-I. Adsorption and desorption of indomethacin on cellulose-like biopolymers: chitin and chitosan. Chem. Pharm. Bull. 40:1992;1058-1060.
14. Nagai T., Sawayanagi Y., Nambu N. Chitin, Chitosan, and Related Enzymes. 1984;21-39 Academic Press, Orlando, FL.
15. Neckers, D.C., Doyle, M.P., 1977. Organic Chemistry. Wiley, New York.
16. Nogueira Prista, L., Correia Aalves, A., Morgado, R., 1995. Tecnologia Farmaceutica, Fundacao Calouste Gulbenkian, Lisboa.
17. Okhamafe A.O., Amsden B., Chu W., Goosen M.F. Modulation of protein release from chitosan-alginate microcapsules using the pH-sensitive polymer hydroxypropyl methylcellulose acetate succinate. J. Microencapsulation. 13:1996;497-508.
18. Okhamafe A.O., Goosen M.F. Control of membrane permeability in microcapsules. Goosen M.F. Fundamentals of Animal Cell Encapsulation and Immobilization. 1993;CRC Press, Boca Raton, FL.
19. Overgaard S., Scharer J.M., Moo-Young M., Bols N.C. Immobilization of Hybridoma Cells in Chitosan Alginate Beads. Can. J. Chem. Eng. 69:1991;439-443.
20. Polk A., Amsden B., De Yao K., Peng T., Goosen M.F. Controlled release of albumin from chitosan-alginate microcapsules. J. Pharm. Sci. 83:1994;178-185.
21. Poncelet D., Lencki R., Beaulieu C., Halle J.P., Neufeld R.J., Fournier A. Production of alginate beads by emulsification/internal gelation. I. Methodology. Appl. Microbiol. Biotechnol. 38:1992;39-45.
22. Poncelet D., Poncelet De Smet B., Beaulieu C., Huguet M.L., Fournier A., Neufeld R.J. Production of alginate beads by emulsification/internal gelation. II. Physicochemistry. Appl. Microbiol. Biotechnol. 43:1995;644-650.
23. Quong D., Neufeld R.J., Skjåk-Bræk G., Poncelet D. External versus internal source of calcium during the gelation of alginate beads for DNA encapsulation. Biotechnol. Bioeng. 57:1998;438-446.
24. Stockwell A.F., Davis S.S. In vitro evaluation of alginate gel systems as sustained released drug delivery systems. J. Control. Rel. 3:1986;167-175.
25. Uchida T., Yoshida K., Goto S. Preparation and characterization of polylactic acid microspheres containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method. J. Microencapsulation. 13:1996;219-228.
26. Walstra P. Formation of Emulsions. Becher P. Encyclopedia of Emulsion Technology. 1983;Marcel Dekker, New York.