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Volumn 30, Issue 11, 2012, Pages 591-600

Relevance and challenges in modeling human gastric and small intestinal digestion

Author keywords

Human digestion; In vitro models; Stomach and small intestine

Indexed keywords

BIOLOGICAL SIGNIFICANCE; DIGESTION TECHNOLOGY; GROWING DEMAND; HUMAN DIGESTION; IN-VITRO; IN-VIVO; SMALL INTESTINE; SMALL-INTESTINAL DIGESTION; TECHNOLOGICAL COMPLEXITY; TECHNOLOGICAL INNOVATION;

EID: 84867698101     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2012.08.001     Document Type: Review
Times cited : (438)

References (91)
  • 1
    • 34249735929 scopus 로고    scopus 로고
    • Approaches to assess the oral bioaccessibility of persistent organic pollutants: a critical review
    • Dean J.R., Ma R. Approaches to assess the oral bioaccessibility of persistent organic pollutants: a critical review. Chemosphere 2007, 68:1399-1407.
    • (2007) Chemosphere , vol.68 , pp. 1399-1407
    • Dean, J.R.1    Ma, R.2
  • 2
    • 33847784843 scopus 로고    scopus 로고
    • Food microstructure affects the bioavailability of several nutrients
    • Parada J., Aguilera J.M. Food microstructure affects the bioavailability of several nutrients. J. Food Sci. 2007, 72:R21-R32.
    • (2007) J. Food Sci. , vol.72
    • Parada, J.1    Aguilera, J.M.2
  • 3
    • 77957742677 scopus 로고    scopus 로고
    • Dynamic dissolution: a step closer to predictive dissolution testing?
    • McAllister M. Dynamic dissolution: a step closer to predictive dissolution testing?. Mol. Pharm. 2010, 7:1374-1387.
    • (2010) Mol. Pharm. , vol.7 , pp. 1374-1387
    • McAllister, M.1
  • 4
    • 77957875901 scopus 로고    scopus 로고
    • In vitro human digestion models for food applications
    • Hur S.J., et al. In vitro human digestion models for food applications. Food Chem. 2011, 125:1-12.
    • (2011) Food Chem. , vol.125 , pp. 1-12
    • Hur, S.J.1
  • 5
    • 0000304902 scopus 로고
    • In vitro simulation of gastric digestion of milk proteins: comparison between in vitro and in vivo data
    • Yvon M., et al. In vitro simulation of gastric digestion of milk proteins: comparison between in vitro and in vivo data. J. Agric. Food Chem. 1992, 40:239-244.
    • (1992) J. Agric. Food Chem. , vol.40 , pp. 239-244
    • Yvon, M.1
  • 6
    • 0032217316 scopus 로고    scopus 로고
    • Interests of the 'artificial stomach' techniques to study antacid formulations: comparison with in vivo evaluation
    • Vatier J., et al. Interests of the 'artificial stomach' techniques to study antacid formulations: comparison with in vivo evaluation. Fundam. Clin. Pharmacol. 1998, 12:573-583.
    • (1998) Fundam. Clin. Pharmacol. , vol.12 , pp. 573-583
    • Vatier, J.1
  • 7
    • 16244420758 scopus 로고    scopus 로고
    • A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics
    • Mainville I., et al. A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics. Int. J. Food Microbiol. 2005, 99:287-296.
    • (2005) Int. J. Food Microbiol. , vol.99 , pp. 287-296
    • Mainville, I.1
  • 8
    • 0001151974 scopus 로고
    • A multicompartmental dynamic computer-controlled model simulating the stomach and small intestine
    • Minekus M., et al. A multicompartmental dynamic computer-controlled model simulating the stomach and small intestine. ATLA 1995, 23:197-209.
    • (1995) ATLA , vol.23 , pp. 197-209
    • Minekus, M.1
  • 9
    • 33746621992 scopus 로고    scopus 로고
    • Development of the BITE Master II and its application to the study of cheese hardness
    • Meullenet J.F., Gandhapuneni R.K. Development of the BITE Master II and its application to the study of cheese hardness. Physiol. Behav. 2006, 89:39-43.
    • (2006) Physiol. Behav. , vol.89 , pp. 39-43
    • Meullenet, J.F.1    Gandhapuneni, R.K.2
  • 10
    • 34147212393 scopus 로고    scopus 로고
    • Development of a chewing simulator for food breakdown and the analysis of in vitro flavor compound release in a mouth environment
    • Salles C., et al. Development of a chewing simulator for food breakdown and the analysis of in vitro flavor compound release in a mouth environment. J. Food Eng. 2007, 82:189-198.
    • (2007) J. Food Eng. , vol.82 , pp. 189-198
    • Salles, C.1
  • 11
    • 34247159880 scopus 로고    scopus 로고
    • Models for intestinal fermentation: association between food components, delivery systems, bioavailability and functional interactions in the gut
    • Macfarlane G.T., Macfarlane S. Models for intestinal fermentation: association between food components, delivery systems, bioavailability and functional interactions in the gut. Curr. Opin. Biotechnol. 2007, 18:156-162.
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 156-162
    • Macfarlane, G.T.1    Macfarlane, S.2
  • 12
    • 84355163054 scopus 로고    scopus 로고
    • Advances and perspectives in in vitro human gut fermentation modeling
    • Payne A.N., et al. Advances and perspectives in in vitro human gut fermentation modeling. Trends Biotechnol. 2012, 30:17-25.
    • (2012) Trends Biotechnol. , vol.30 , pp. 17-25
    • Payne, A.N.1
  • 13
    • 77953545678 scopus 로고    scopus 로고
    • Development and validation of a mastication simulator
    • Woda A., et al. Development and validation of a mastication simulator. J. Biomech. 2010, 43:1667-1673.
    • (2010) J. Biomech. , vol.43 , pp. 1667-1673
    • Woda, A.1
  • 15
    • 44949255007 scopus 로고    scopus 로고
    • Disintegration of solid foods in human stomach
    • Kong F., Singh R.P. Disintegration of solid foods in human stomach. J. Food Sci. 2008, 73:R67-R80.
    • (2008) J. Food Sci. , vol.73
    • Kong, F.1    Singh, R.P.2
  • 16
    • 75849147141 scopus 로고    scopus 로고
    • The influence of emulsion structure and stability on lipid digestion
    • Golding M., Wooster T.J. The influence of emulsion structure and stability on lipid digestion. Curr. Opin. Colloid Interface Sci. 2010, 15:90-101.
    • (2010) Curr. Opin. Colloid Interface Sci. , vol.15 , pp. 90-101
    • Golding, M.1    Wooster, T.J.2
  • 17
    • 84879552793 scopus 로고    scopus 로고
    • Evaluation of gastric processing and duodenal digestion of starch in six cereal meals on the associated glycaemic response using an adult fasted dynamic gastric model
    • Ballance S., et al. Evaluation of gastric processing and duodenal digestion of starch in six cereal meals on the associated glycaemic response using an adult fasted dynamic gastric model. Eur. J. Nutr. 2012, 10.1007/s00394-012-0386-5.
    • (2012) Eur. J. Nutr.
    • Ballance, S.1
  • 18
    • 77956648022 scopus 로고    scopus 로고
    • High temporal and inter-individual variation detected in the human ileal microbiota
    • Booijink C.C., et al. High temporal and inter-individual variation detected in the human ileal microbiota. Environ. Microbiol. 2010, 12:3213-3227.
    • (2010) Environ. Microbiol. , vol.12 , pp. 3213-3227
    • Booijink, C.C.1
  • 19
    • 79953204638 scopus 로고    scopus 로고
    • Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples
    • van den Bogert B., et al. Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples. Appl. Environ. Microbiol. 2011, 77:2071-2080.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 2071-2080
    • Van den Bogert, B.1
  • 20
    • 60749105533 scopus 로고    scopus 로고
    • Hormonal regulation of gastric acid secretion
    • Schubert M.L. Hormonal regulation of gastric acid secretion. Curr. Gastroenterol. Rep. 2008, 10:523-527.
    • (2008) Curr. Gastroenterol. Rep. , vol.10 , pp. 523-527
    • Schubert, M.L.1
  • 21
    • 79960645242 scopus 로고    scopus 로고
    • Gut feelings: the emerging biology of gut-brain communication
    • Mayer E.A. Gut feelings: the emerging biology of gut-brain communication. Nat. Rev. Neurosci. 2011, 12:453-466.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 453-466
    • Mayer, E.A.1
  • 22
    • 58149168626 scopus 로고    scopus 로고
    • Overview of gut immunology
    • Mason K.L., et al. Overview of gut immunology. Adv. Exp. Med. Biol. 2008, 635:1-14.
    • (2008) Adv. Exp. Med. Biol. , vol.635 , pp. 1-14
    • Mason, K.L.1
  • 23
    • 84986766134 scopus 로고
    • An in vitro method for prediction of the digestible crude protein content in pig feeds
    • Babinszky L., et al. An in vitro method for prediction of the digestible crude protein content in pig feeds. J. Sci. Food Agric. 1990, 50:173-178.
    • (1990) J. Sci. Food Agric. , vol.50 , pp. 173-178
    • Babinszky, L.1
  • 24
    • 0030049458 scopus 로고    scopus 로고
    • Measurement of resistant starch in vitro and in vivo
    • Englyst H.N., et al. Measurement of resistant starch in vitro and in vivo. Br. J. Nutr. 1996, 75:749-755.
    • (1996) Br. J. Nutr. , vol.75 , pp. 749-755
    • Englyst, H.N.1
  • 25
    • 0033213505 scopus 로고    scopus 로고
    • Development of an in vitro digestion method to assess carotenoid bioavailability from meals
    • Garrett D.A., et al. Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J. Agric. Food Chem. 1999, 47:4301-4309.
    • (1999) J. Agric. Food Chem. , vol.47 , pp. 4301-4309
    • Garrett, D.A.1
  • 26
    • 0037400331 scopus 로고    scopus 로고
    • Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants
    • Oomen A.G., et al. Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants. Arch. Environ. Contam. Toxicol. 2003, 44:281-287.
    • (2003) Arch. Environ. Contam. Toxicol. , vol.44 , pp. 281-287
    • Oomen, A.G.1
  • 27
    • 79954465293 scopus 로고    scopus 로고
    • Development of a simple model device for in vitro gastric digestion investigation
    • Chen J., et al. Development of a simple model device for in vitro gastric digestion investigation. Food Funct. 2011, 2:174-182.
    • (2011) Food Funct. , vol.2 , pp. 174-182
    • Chen, J.1
  • 28
    • 0019812105 scopus 로고
    • An in vitro method for estimation of iron availability from meals
    • Miller D.D., et al. An in vitro method for estimation of iron availability from meals. Am. J. Clin. Nutr. 1981, 34:2248-2256.
    • (1981) Am. J. Clin. Nutr. , vol.34 , pp. 2248-2256
    • Miller, D.D.1
  • 29
    • 0036750916 scopus 로고    scopus 로고
    • Development of an in vitro system simulating bucco-gastric digestion to assess the physical and chemical changes of food
    • Hoebler C., et al. Development of an in vitro system simulating bucco-gastric digestion to assess the physical and chemical changes of food. Int. J. Food Sci. Nutr. 2002, 53:389-402.
    • (2002) Int. J. Food Sci. Nutr. , vol.53 , pp. 389-402
    • Hoebler, C.1
  • 30
    • 79959904472 scopus 로고    scopus 로고
    • The effect of composition and gastric conditions on the self-emulsification process of ibuprofen-loaded self-emulsifying drug delivery systems: a microscopic and dynamic gastric model study
    • Mercuri A., et al. The effect of composition and gastric conditions on the self-emulsification process of ibuprofen-loaded self-emulsifying drug delivery systems: a microscopic and dynamic gastric model study. Pharm. Res. 2011, 28:1540-1551.
    • (2011) Pharm. Res. , vol.28 , pp. 1540-1551
    • Mercuri, A.1
  • 31
    • 84861145662 scopus 로고    scopus 로고
    • Achieving antral grinding forces in biorelevant in vitro models: comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with human in vivo data
    • Vardakou M., et al. Achieving antral grinding forces in biorelevant in vitro models: comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with human in vivo data. AAPS Pharm. Sci. Tech. 2011, 12:620-626.
    • (2011) AAPS Pharm. Sci. Tech. , vol.12 , pp. 620-626
    • Vardakou, M.1
  • 32
    • 78149380589 scopus 로고    scopus 로고
    • A human gastric simulator (HGS) to study food digestion in human stomach
    • Kong F., Singh R.P. A human gastric simulator (HGS) to study food digestion in human stomach. J. Food Sci. 2010, 75:E627-E635.
    • (2010) J. Food Sci. , vol.75
    • Kong, F.1    Singh, R.P.2
  • 33
    • 79961108736 scopus 로고    scopus 로고
    • Physical changes in white and brown rice during simulated gastric digestion
    • Kong F., et al. Physical changes in white and brown rice during simulated gastric digestion. J. Food Sci. 2011, 76:E450-E457.
    • (2011) J. Food Sci. , vol.76
    • Kong, F.1
  • 34
    • 0032893979 scopus 로고    scopus 로고
    • Drug interactions with diosmectite: a study using the artificial stomach-duodenum model
    • Castela-Papin N., et al. Drug interactions with diosmectite: a study using the artificial stomach-duodenum model. Int. J. Pharm. 1999, 182:111-119.
    • (1999) Int. J. Pharm. , vol.182 , pp. 111-119
    • Castela-Papin, N.1
  • 35
    • 84858607316 scopus 로고    scopus 로고
    • The impact of meals on a probiotic during transit through a model of the human upper gastrointestinal tract
    • Tompkins T.A., et al. The impact of meals on a probiotic during transit through a model of the human upper gastrointestinal tract. Benef. Microbes 2011, 2:295-303.
    • (2011) Benef. Microbes , vol.2 , pp. 295-303
    • Tompkins, T.A.1
  • 36
    • 65349181348 scopus 로고    scopus 로고
    • Digestive stability of xanthophylls exceeds that of carotenes as studied in a dynamic in vitro gastrointestinal system
    • Blanquet-Diot S., et al. Digestive stability of xanthophylls exceeds that of carotenes as studied in a dynamic in vitro gastrointestinal system. J. Nutr. 2009, 139:876-883.
    • (2009) J. Nutr. , vol.139 , pp. 876-883
    • Blanquet-Diot, S.1
  • 37
    • 84861228782 scopus 로고    scopus 로고
    • Enhancing the in vitro Fe(2+) bio-accessibility using ascorbate and cold-set whey protein gel particles
    • Martin A.H., de Jong G.A. Enhancing the in vitro Fe(2+) bio-accessibility using ascorbate and cold-set whey protein gel particles. Dairy Sci. Technol. 2012, 92:133-149.
    • (2012) Dairy Sci. Technol. , vol.92 , pp. 133-149
    • Martin, A.H.1    de Jong, G.A.2
  • 38
    • 0242411012 scopus 로고    scopus 로고
    • Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions
    • Krul C.A., et al. Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions. Food Chem. Toxicol. 2004, 42:51-63.
    • (2004) Food Chem. Toxicol. , vol.42 , pp. 51-63
    • Krul, C.A.1
  • 39
    • 78649851460 scopus 로고    scopus 로고
    • Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2)
    • Torres-Escribano S., et al. Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2). Sci. Total Environ. 2011, 409:604-611.
    • (2011) Sci. Total Environ. , vol.409 , pp. 604-611
    • Torres-Escribano, S.1
  • 40
    • 79551535215 scopus 로고    scopus 로고
    • Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system
    • Brouwers J., et al. Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system. Eur. J. Pharm. Biopharm. 2011, 77:313-319.
    • (2011) Eur. J. Pharm. Biopharm. , vol.77 , pp. 313-319
    • Brouwers, J.1
  • 41
    • 84860738206 scopus 로고    scopus 로고
    • An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs
    • Dickinson P.A., et al. An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs. AAPS J. 2012, 14:196-205.
    • (2012) AAPS J. , vol.14 , pp. 196-205
    • Dickinson, P.A.1
  • 42
    • 77953602162 scopus 로고    scopus 로고
    • Study of the physicochemical and biological stability of pediocin PA-1 in the upper gastrointestinal tract conditions using a dynamic in vitro model
    • Kheadr E., et al. Study of the physicochemical and biological stability of pediocin PA-1 in the upper gastrointestinal tract conditions using a dynamic in vitro model. J. Appl. Microbiol. 2010, 109:54-64.
    • (2010) J. Appl. Microbiol. , vol.109 , pp. 54-64
    • Kheadr, E.1
  • 43
    • 84862643560 scopus 로고    scopus 로고
    • Use of artificial digestive systems to investigate the biopharmaceutical factors influencing the survival of probiotic yeast during gastrointestinal transit in humans
    • Blanquet-Diot S., et al. Use of artificial digestive systems to investigate the biopharmaceutical factors influencing the survival of probiotic yeast during gastrointestinal transit in humans. Pharm. Res. 2012, 29:1444-1453.
    • (2012) Pharm. Res. , vol.29 , pp. 1444-1453
    • Blanquet-Diot, S.1
  • 44
    • 67650257151 scopus 로고    scopus 로고
    • Bioaccessibility of fatty acids from conjugated linoleic acid-enriched milk and milk emulsions studied in a dynamic in vitro gastrointestinal model
    • Gervais R., et al. Bioaccessibility of fatty acids from conjugated linoleic acid-enriched milk and milk emulsions studied in a dynamic in vitro gastrointestinal model. Int. Dairy J. 2009, 19:574-581.
    • (2009) Int. Dairy J. , vol.19 , pp. 574-581
    • Gervais, R.1
  • 45
    • 84858237139 scopus 로고    scopus 로고
    • Validation of an in vitro digestive system for studying macronutrient decomposition in humans
    • Kopf-Bolanz K.A., et al. Validation of an in vitro digestive system for studying macronutrient decomposition in humans. J. Nutr. 2012, 142:245-250.
    • (2012) J. Nutr. , vol.142 , pp. 245-250
    • Kopf-Bolanz, K.A.1
  • 46
    • 67650902376 scopus 로고    scopus 로고
    • Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds
    • Anson N.M., et al. Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds. J. Agric. Food Chem. 2009, 57:6148-6155.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 6148-6155
    • Anson, N.M.1
  • 47
    • 40449100163 scopus 로고    scopus 로고
    • In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene
    • Failla M.L., et al. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. J. Nutr. 2008, 138:482-486.
    • (2008) J. Nutr. , vol.138 , pp. 482-486
    • Failla, M.L.1
  • 48
    • 77956252154 scopus 로고    scopus 로고
    • Effect of carrot (Daucus carota) microstructure on carotene bioaccessibility in the upper gastrointestinal tract. 1. In vitro simulations of carrot digestion
    • Tydeman E.A., et al. Effect of carrot (Daucus carota) microstructure on carotene bioaccessibility in the upper gastrointestinal tract. 1. In vitro simulations of carrot digestion. J. Agric. Food Chem. 2010, 58:9847-9854.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 9847-9854
    • Tydeman, E.A.1
  • 49
    • 20444475028 scopus 로고    scopus 로고
    • The effect of folate-binding proteins on bioavailability of folate from milk products
    • Verwei M., et al. The effect of folate-binding proteins on bioavailability of folate from milk products. Trends Food Sci. Technol. 2005, 16:307-310.
    • (2005) Trends Food Sci. Technol. , vol.16 , pp. 307-310
    • Verwei, M.1
  • 50
    • 79961171984 scopus 로고    scopus 로고
    • Controlling lipid digestibility: response of lipid droplets coated by β-lactoglobulin-dextran Maillard conjugates to simulated gastrointestinal conditions
    • Lesmes U., McClements D.J. Controlling lipid digestibility: response of lipid droplets coated by β-lactoglobulin-dextran Maillard conjugates to simulated gastrointestinal conditions. Food Hydrocolloids 2012, 26:221-230.
    • (2012) Food Hydrocolloids , vol.26 , pp. 221-230
    • Lesmes, U.1    McClements, D.J.2
  • 51
    • 78649467538 scopus 로고    scopus 로고
    • In vitro approaches to estimate the effect of food processing on carotenoid bioavailability need thorough understanding of process induced microstructural changes
    • Van Buggenhout S., et al. In vitro approaches to estimate the effect of food processing on carotenoid bioavailability need thorough understanding of process induced microstructural changes. Trends Food Sci. Technol. 2010, 21:607-618.
    • (2010) Trends Food Sci. Technol. , vol.21 , pp. 607-618
    • Van Buggenhout, S.1
  • 52
    • 0043062766 scopus 로고    scopus 로고
    • Prolonged transit time through the stomach and small intestine improves iron dialyzability and uptake in vitro
    • Salovaara S., et al. Prolonged transit time through the stomach and small intestine improves iron dialyzability and uptake in vitro. J. Agric. Food Chem. 2003, 51:5131-5136.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 5131-5136
    • Salovaara, S.1
  • 53
    • 65349126450 scopus 로고    scopus 로고
    • Nutriomic analysis of fresh and processed fruit products. 1. During in vitro digestions
    • Epriliati I., et al. Nutriomic analysis of fresh and processed fruit products. 1. During in vitro digestions. J. Agric. Food Chem. 2009, 57:3363-3376.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 3363-3376
    • Epriliati, I.1
  • 54
    • 33846567968 scopus 로고    scopus 로고
    • Gastrointestinal digestion of food allergens: effect on their allergenicity
    • Moreno F.J. Gastrointestinal digestion of food allergens: effect on their allergenicity. Biomed. Pharmacother. 2007, 61:50-60.
    • (2007) Biomed. Pharmacother. , vol.61 , pp. 50-60
    • Moreno, F.J.1
  • 55
    • 80053920649 scopus 로고    scopus 로고
    • Bioaccessibility of trace elements as affected by soil parameters in smelter-contaminated agricultural soils: a statistical modeling approach
    • Pelfrene A., et al. Bioaccessibility of trace elements as affected by soil parameters in smelter-contaminated agricultural soils: a statistical modeling approach. Environ. Pollut. 2012, 160:130-138.
    • (2012) Environ. Pollut. , vol.160 , pp. 130-138
    • Pelfrene, A.1
  • 56
    • 79960069396 scopus 로고    scopus 로고
    • Factors affecting the bioaccessibility of methylmercury in several marine fish species
    • He M., Wang W.X. Factors affecting the bioaccessibility of methylmercury in several marine fish species. J. Agric. Food Chem. 2011, 59:7155-7162.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 7155-7162
    • He, M.1    Wang, W.X.2
  • 57
    • 1042289694 scopus 로고    scopus 로고
    • Effect of bile type on the bioaccessibility of soil contaminants in an in vitro digestion model
    • Oomen A.G., et al. Effect of bile type on the bioaccessibility of soil contaminants in an in vitro digestion model. Arch. Environ. Contam. Toxicol. 2004, 46:183-188.
    • (2004) Arch. Environ. Contam. Toxicol. , vol.46 , pp. 183-188
    • Oomen, A.G.1
  • 58
    • 80053448300 scopus 로고    scopus 로고
    • In vitro digestion and DGT techniques for estimating cadmium and lead bioavailability in contaminated soils: influence of gastric juice pH
    • Pelfrene A., et al. In vitro digestion and DGT techniques for estimating cadmium and lead bioavailability in contaminated soils: influence of gastric juice pH. Sci. Total Environ. 2011, 409:5076-5085.
    • (2011) Sci. Total Environ. , vol.409 , pp. 5076-5085
    • Pelfrene, A.1
  • 59
    • 69149106437 scopus 로고    scopus 로고
    • In vitro digestion methods for assessing the effect of food structure on allergen breakdown
    • Wickham M., et al. In vitro digestion methods for assessing the effect of food structure on allergen breakdown. Mol. Nutr. Food Res. 2009, 53:952-958.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 952-958
    • Wickham, M.1
  • 60
    • 44849119117 scopus 로고    scopus 로고
    • The role of protein digestibility and antacids on food allergy outcomes
    • Untersmayr E., Jensen-Jarolim E. The role of protein digestibility and antacids on food allergy outcomes. J. Allergy Clin. Immunol. 2008, 121:1301-1310.
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1301-1310
    • Untersmayr, E.1    Jensen-Jarolim, E.2
  • 61
    • 29744451337 scopus 로고    scopus 로고
    • Phospholipid interactions protect the milk allergen alpha-lactalbumin from proteolysis during in vitro digestion
    • Moreno F.J., et al. Phospholipid interactions protect the milk allergen alpha-lactalbumin from proteolysis during in vitro digestion. J. Agric. Food Chem. 2005, 53:9810-9816.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 9810-9816
    • Moreno, F.J.1
  • 62
    • 38349083815 scopus 로고    scopus 로고
    • Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease
    • Mitea C., et al. Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease. Gut 2008, 57:25-32.
    • (2008) Gut , vol.57 , pp. 25-32
    • Mitea, C.1
  • 63
    • 68949190912 scopus 로고    scopus 로고
    • Comparison of dissolution profiles obtained from nifedipine extended release once a day products using different dissolution test apparatuses
    • Garbacz G., et al. Comparison of dissolution profiles obtained from nifedipine extended release once a day products using different dissolution test apparatuses. Eur. J. Pharm. Sci. 2009, 38:147-155.
    • (2009) Eur. J. Pharm. Sci. , vol.38 , pp. 147-155
    • Garbacz, G.1
  • 64
    • 12244312516 scopus 로고    scopus 로고
    • Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility
    • Gu C.H., et al. Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility. J. Pharm. Sci. 2005, 94:199-208.
    • (2005) J. Pharm. Sci. , vol.94 , pp. 199-208
    • Gu, C.H.1
  • 65
    • 80053576484 scopus 로고    scopus 로고
    • Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model
    • Vardakou M., et al. Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model. Int. J. Pharm. 2011, 419:192-199.
    • (2011) Int. J. Pharm. , vol.419 , pp. 192-199
    • Vardakou, M.1
  • 66
    • 38449090138 scopus 로고    scopus 로고
    • Release of 5-aminosalicylate from an MMX mesalamine tablet during transit through a simulated gastrointestinal tract system
    • Tenjarla S., et al. Release of 5-aminosalicylate from an MMX mesalamine tablet during transit through a simulated gastrointestinal tract system. Adv. Ther. 2007, 24:826-840.
    • (2007) Adv. Ther. , vol.24 , pp. 826-840
    • Tenjarla, S.1
  • 67
    • 28444435904 scopus 로고    scopus 로고
    • A level A in vitro/in vivo correlation in fasted and fed states using different methods: applied to solid immediate release oral dosage form
    • Souliman S., et al. A level A in vitro/in vivo correlation in fasted and fed states using different methods: applied to solid immediate release oral dosage form. Eur. J. Pharm. Sci. 2006, 27:72-79.
    • (2006) Eur. J. Pharm. Sci. , vol.27 , pp. 72-79
    • Souliman, S.1
  • 68
    • 0035478927 scopus 로고    scopus 로고
    • The 'biodrug' concept: an innovative approach to therapy
    • Blanquet S., et al. The 'biodrug' concept: an innovative approach to therapy. Trends Biotechnol. 2001, 19:393-400.
    • (2001) Trends Biotechnol. , vol.19 , pp. 393-400
    • Blanquet, S.1
  • 69
    • 66149111002 scopus 로고    scopus 로고
    • Evaluation of the passage of Lactobacillus gasseri K7 and bifidobacteria from the stomach to intestines using a single reactor model
    • Ritter P., et al. Evaluation of the passage of Lactobacillus gasseri K7 and bifidobacteria from the stomach to intestines using a single reactor model. BMC Microbiol. 2009, 9:87.
    • (2009) BMC Microbiol. , vol.9 , pp. 87
    • Ritter, P.1
  • 70
    • 80051473239 scopus 로고    scopus 로고
    • Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion
    • Lo Curto A., et al. Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion. Food Microbiol. 2011, 28:1359-1366.
    • (2011) Food Microbiol. , vol.28 , pp. 1359-1366
    • Lo Curto, A.1
  • 71
    • 33846326880 scopus 로고    scopus 로고
    • Variation in acid resistance among enterohaemorrhagic Escherichia coli in a simulated gastric environment
    • Bergholz T.M., Whittam T.S. Variation in acid resistance among enterohaemorrhagic Escherichia coli in a simulated gastric environment. J. Appl. Microbiol. 2007, 102:352-362.
    • (2007) J. Appl. Microbiol. , vol.102 , pp. 352-362
    • Bergholz, T.M.1    Whittam, T.S.2
  • 72
    • 0031158713 scopus 로고    scopus 로고
    • Survival of lactic acid bacteria in a dynamic model of the stomach and small intestine: validation and the effects of bile
    • Marteau P., et al. Survival of lactic acid bacteria in a dynamic model of the stomach and small intestine: validation and the effects of bile. J. Dairy Sci. 1997, 80:1031-1037.
    • (1997) J. Dairy Sci. , vol.80 , pp. 1031-1037
    • Marteau, P.1
  • 73
    • 79551496197 scopus 로고    scopus 로고
    • Effect of a new probiotic Saccharomyces cerevisiae strain on survival of Escherichia coli O157:H7 in a dynamic gastrointestinal model
    • Etienne-Mesmin L., et al. Effect of a new probiotic Saccharomyces cerevisiae strain on survival of Escherichia coli O157:H7 in a dynamic gastrointestinal model. Appl. Environ. Microbiol. 2011, 77:1127-1131.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 1127-1131
    • Etienne-Mesmin, L.1
  • 74
    • 72449136262 scopus 로고    scopus 로고
    • Combining the dynamic TNO-gastrointestinal tract system with a Caco-2 cell culture model: application to the assessment of lycopene and alpha-tocopherol bioavailability from a whole food
    • Deat E., et al. Combining the dynamic TNO-gastrointestinal tract system with a Caco-2 cell culture model: application to the assessment of lycopene and alpha-tocopherol bioavailability from a whole food. J. Agric. Food Chem. 2009, 57:11314-11320.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 11314-11320
    • Deat, E.1
  • 75
    • 65349094614 scopus 로고    scopus 로고
    • Nutriomic analysis of fresh and processed fruit products. 2. During in vitro simultaneous molecular passages using Caco-2 cell monolayers
    • Epriliati I., et al. Nutriomic analysis of fresh and processed fruit products. 2. During in vitro simultaneous molecular passages using Caco-2 cell monolayers. J. Agric. Food Chem. 2009, 57:3377-3388.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 3377-3388
    • Epriliati, I.1
  • 76
    • 34247516835 scopus 로고    scopus 로고
    • Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell
    • Motz S.A., et al. Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell. Eur. J. Pharm. Biopharm. 2007, 66:286-295.
    • (2007) Eur. J. Pharm. Biopharm. , vol.66 , pp. 286-295
    • Motz, S.A.1
  • 77
    • 79957792697 scopus 로고    scopus 로고
    • In vitro estimates of bioaccessible nickel in field-contaminated soils, and comparison with in vivo measurement of bioavailability and identification of mineralogy
    • Vasiluk L., et al. In vitro estimates of bioaccessible nickel in field-contaminated soils, and comparison with in vivo measurement of bioavailability and identification of mineralogy. Sci. Total Environ. 2011, 409:2700-2706.
    • (2011) Sci. Total Environ. , vol.409 , pp. 2700-2706
    • Vasiluk, L.1
  • 78
    • 82155196433 scopus 로고    scopus 로고
    • Evaluation of antioxidant activity and antiproliferative effect of fruit juices enriched with Pycnogenol(R) in colon carcinoma cells. The effect of in vitro gastrointestinal digestion
    • Frontela-Saseta C., et al. Evaluation of antioxidant activity and antiproliferative effect of fruit juices enriched with Pycnogenol(R) in colon carcinoma cells. The effect of in vitro gastrointestinal digestion. Phytother. Res. 2011, 25:1870-1875.
    • (2011) Phytother. Res. , vol.25 , pp. 1870-1875
    • Frontela-Saseta, C.1
  • 79
    • 77749340870 scopus 로고    scopus 로고
    • Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion
    • Laparra J.M., Sanz Y. Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion. J. Cell. Biochem. 2010, 109:801-807.
    • (2010) J. Cell. Biochem. , vol.109 , pp. 801-807
    • Laparra, J.M.1    Sanz, Y.2
  • 80
    • 0023833804 scopus 로고
    • Biphasic nature of gastric emptying
    • Siegel J.A., et al. Biphasic nature of gastric emptying. Gut 1988, 29:85-89.
    • (1988) Gut , vol.29 , pp. 85-89
    • Siegel, J.A.1
  • 81
    • 0027251567 scopus 로고
    • Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem
    • Molly K., et al. Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Appl. Microbiol. Biotechnol. 1993, 39:254-258.
    • (1993) Appl. Microbiol. Biotechnol. , vol.39 , pp. 254-258
    • Molly, K.1
  • 82
    • 77952237175 scopus 로고    scopus 로고
    • In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements
    • Marzorati M., et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int. J. Food Microbiol. 2010, 139:168-176.
    • (2010) Int. J. Food Microbiol. , vol.139 , pp. 168-176
    • Marzorati, M.1
  • 83
    • 33845960065 scopus 로고    scopus 로고
    • In vitro fermentability of differently digested resistant starch preparations
    • Fassler C., et al. In vitro fermentability of differently digested resistant starch preparations. Mol. Nutr. Food Res. 2006, 50:1220-1228.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 1220-1228
    • Fassler, C.1
  • 84
    • 84863544278 scopus 로고    scopus 로고
    • Galacto-oligosaccharides have prebiotic activity in a dynamic in vitro colon model using a C-labeling technique
    • Maathuis A.J., et al. Galacto-oligosaccharides have prebiotic activity in a dynamic in vitro colon model using a C-labeling technique. J. Nutr. 2012, 142:1205-1212.
    • (2012) J. Nutr. , vol.142 , pp. 1205-1212
    • Maathuis, A.J.1
  • 85
    • 84865114981 scopus 로고    scopus 로고
    • In vitro fermentation of potential prebiotic flours from natural sources: Impact on the human colonic microbiota and metabolome
    • Maccaferri S., et al. In vitro fermentation of potential prebiotic flours from natural sources: Impact on the human colonic microbiota and metabolome. Mol. Nutr. Food Res. 2012, 56:1342-1352.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 1342-1352
    • Maccaferri, S.1
  • 86
    • 84860655294 scopus 로고    scopus 로고
    • The composition and metabolic activity of child gut microbiota demonstrate differential adaptation to varied nutrient loads in an in vitro model of colonic fermentation
    • Payne A.N., et al. The composition and metabolic activity of child gut microbiota demonstrate differential adaptation to varied nutrient loads in an in vitro model of colonic fermentation. FEMS Microbiol. Ecol. 2012, 80:608-623.
    • (2012) FEMS Microbiol. Ecol. , vol.80 , pp. 608-623
    • Payne, A.N.1
  • 87
    • 1842450785 scopus 로고    scopus 로고
    • A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions
    • Blanquet S., et al. A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Pharm. Res. 2004, 21:585-591.
    • (2004) Pharm. Res. , vol.21 , pp. 585-591
    • Blanquet, S.1
  • 88
    • 77953967817 scopus 로고    scopus 로고
    • Comparative resistance of food proteins to adult and infant in vitro digestion models
    • Dupont D., et al. Comparative resistance of food proteins to adult and infant in vitro digestion models. Mol. Nutr. Food Res. 2010, 54:767-780.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 767-780
    • Dupont, D.1
  • 89
    • 46749147662 scopus 로고    scopus 로고
    • Drug development for children: how is pharma tackling an unmet need?
    • Hawcutt D.B., Smyth R.L. Drug development for children: how is pharma tackling an unmet need?. IDrugs 2008, 11:502-507.
    • (2008) IDrugs , vol.11 , pp. 502-507
    • Hawcutt, D.B.1    Smyth, R.L.2
  • 90
    • 84856025771 scopus 로고    scopus 로고
    • Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment
    • Vermeiren J., et al. Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment. FEMS Microbiol. Ecol. 2012, 79:685-696.
    • (2012) FEMS Microbiol. Ecol. , vol.79 , pp. 685-696
    • Vermeiren, J.1
  • 91
    • 34547210353 scopus 로고    scopus 로고
    • Comparison of five in vitro digestion models to in vivo experimental results: lead bioaccessibility in the human gastrointestinal tract
    • Van de Wiele T.R., et al. Comparison of five in vitro digestion models to in vivo experimental results: lead bioaccessibility in the human gastrointestinal tract. J. Environ. Sci. Health. A: Tox. Hazard. Subst. Environ. Eng. 2007, 42:1203-1211.
    • (2007) J. Environ. Sci. Health. A: Tox. Hazard. Subst. Environ. Eng. , vol.42 , pp. 1203-1211
    • Van de Wiele, T.R.1


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