Colon-specific delivery of resveratrol: Optimization of multi-particulate calcium-pectinate carrier

International Journal of Pharmaceutics

Volumn 385, Issue 1-2, 2010, Pages 20-28

  Das, Surajit ^a   Ng, Ka Yun ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Beads; Calcium pectinate; Colon specific; Hardening agent; Polyethyleneimine; Resveratrol

Indexed keywords

CALCIUM PECTINATE; PECTIN; POLYETHYLENEIMINE; POLYSACCHARIDE; RESVERATROL; UNCLASSIFIED DRUG;

ARTICLE; COLON; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; PARTICULATE MATTER; PRIORITY JOURNAL; UPPER GASTROINTESTINAL TRACT;

CALCIUM CHLORIDE; CHEMISTRY, PHARMACEUTICAL; COLON; CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; GASTRIC JUICE; HARDNESS; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; KINETICS; PARTICLE SIZE; PECTINS; POLYETHYLENEIMINE; SOLUBILITY; STILBENES; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 72149114076     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.10.016     Document Type: Article

References (30)

1. Ahmed I.S. Effect of simulated gastrointestinal conditions on drug release from pectin/ethylcellulose as film coating for drug delivery to the colon. Drug Dev. Ind. Pharm. 31 (2005) 465-470
2. Atyabi F., Majzoob S., Iman M., Salehi M., and Dorkoosh F. In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon. Carbohydr. Polym. 61 (2005) 39-51
3. Basit A.W. Advances in colonic drug delivery. Drugs 65 (2005) 1991-2007
4. Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5 (2006) 493-506
5. Bourgeois S., Gernet M., Pradeau D., Andremont A., and Fattal E. Evaluation of critical formulation parameters influencing the bioactivity of beta-lactamases entrapped in pectin beads. Int. J. Pharm. 324 (2006) 2-9
6. Bourgeois S., Laham A., Besnard M., Andremont A., and Fattal E. In vitro and in vivo evaluation of pectin beads for the colon delivery of beta-lactamases. J. Drug. Target. 13 (2005) 277-284
7. Bourgeois S., Tsapis N., Honnas H., Andremont A., Shakweh M., Besnard M., and Fattal E. Colonic delivery of beta-lactamases does not affect amoxicillin pharmacokinetics in rats. J. Pharm. Sci. 97 (2008) 1853-1863
8. Das S., Lin H.S., Ho P.C., and Ng K.Y. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm. Res. 25 (2008) 2593-2600
9. Das, S., Ng, K.Y. Resveratrol-loaded calcium-pectinate beads: effects of formulation parameters on drug release and bead characteristics. J. Pharm. Sci., in press. doi:10.1002/jps.21880.
10. Delmas D., Lancon A., Colin D., Jannin B., and Latruffe N. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr. Drug Targets 7 (2006) 423-442
11. Friend D.R. New oral delivery systems for treatment of inflammatory bowel disease. Adv. Drug Deliv. Rev. 57 (2005) 247-265
12. Gescher A.J., and Steward W.P. Relationship between mechanisms, bioavailability, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol. Biomarkers Prev. 12 (2003) 953-957
13. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., Fong H.H., Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., and Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 (1997) 218-220
14. Kaldas M.I., Walle U.K., and Walle T. Resveratrol transport and metabolism by human intestinal Caco-2 cells. J. Pharm. Pharmacol. 55 (2003) 307-312
15. Liu L., Fishman M.L., Kost J., and Hicks K.B. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 24 (2003) 3333-3343
16. Maestrelli F., Cirri M., Corti G., Mennini N., and Mura P. Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery. Eur. J. Pharm. Biopharm. 69 (2008) 508-518
17. Maestrelli F., Zerrouk N., Cirri M., Mennini N., and Mura P. Microspheres for colonic delivery of ketoprofen-hydroxypropyl-beta-cyclodextrin complex. Eur. J. Pharm. Sci. 34 (2008) 1-11
18. Maier-Salamon A., Hagenauer B., Wirth M., Gabor F., Szekeres T., and Jager W. Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites. Pharm. Res. 23 (2006) 2107-2115
19. Marier J.F., Vachon P., Gritsas A., Zhang J., Moreau J.P., and Ducharme M.P. Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 302 (2002) 369-373
20. Martin A.R., Villegas I., La Casa C., and de la Lastra C.A. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem. Pharmacol. 67 (2004) 1399-1410
21. Martin A.R., Villegas I., Sanchez-Hidalgo M., and de la Lastra C.A. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br. J. Pharmacol. 147 (2006) 873-885
22. Rodriguez M., Vila-Jato J.L., and Torres D. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J. Control. Rel. 55 (1998) 67-77
23. Schneider Y., Duranton B., Gosse F., Schleiffer R., Seiler N., and Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr. Cancer 39 (2001) 102-107
24. Sriamornsak P. Investigation of pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads. Int. J. Pharm. 169 (1998) 213-220
25. Sriamornsak P. Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads. Eur. J. Pharm. Sci. 8 (1999) 221-227
26. Sriamornsak P., and Nunthanid J. Calcium pectinate gel beads for controlled release drug delivery: I. Preparation and in vitro release studies. Int. J. Pharm. 160 (1998) 207-212
27. Sriamornsak P., and Nunthanid J. Calcium pectinate gel beads for controlled release drug delivery: II. Effect of formulation and processing variables on drug release. J. Microencapsul. 16 (1999) 303-313
28. Tessitore L., Davit A., Sarotto I., and Caderni G. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis 21 (2000) 1619-1622
29. Thakur B.R., Singh R.K., and Handa A.K. Chemistry and uses of pectin-a review. Crit. Rev. Food Sci. 37 (1997) 47-73
30. Wong T.W., and Nurjaya S. Drug release property of chitosan-pectinate beads and its changes under the influence of microwave. Eur. J. Pharm. Biopharm. 69 (2008) 176-188