-
1
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-97
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway, C.A.3
-
2
-
-
0032170215
-
Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region
-
Poltorak A, Smirnova I, He X, Liu MY, Van Huffel C, et al. 1998. Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis. 24:340-55
-
(1998)
Blood Cells Mol. Dis.
, vol.24
, pp. 340-355
-
-
Poltorak, A.1
Smirnova, I.2
He, X.3
Liu, M.Y.4
Van Huffel, C.5
-
3
-
-
0024955886
-
Approaching the asymptote? Evolution and revolution in immunology
-
Janeway CA Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54(Part 1):1-13
-
(1989)
Cold Spring Harb. Symp. Quant. Biol.
, vol.54
, pp. 1-13
-
-
Janeway, C.A.1
-
4
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill LA, Bowie AG. 2007. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7:353-64
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 353-364
-
-
O'neill, L.A.1
Bowie, A.G.2
-
5
-
-
55149105005
-
The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
-
O'Neill LA. 2008. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol. Rev. 226:10-18
-
(2008)
Immunol. Rev.
, vol.226
, pp. 10-18
-
-
O'neill, L.A.1
-
6
-
-
84867427919
-
Sensing of microbial molecular patterns by Toll-like receptors
-
Song DH, Lee JO. 2012. Sensing of microbial molecular patterns by Toll-like receptors. Immunol. Rev. 250:216-29
-
(2012)
Immunol. Rev.
, vol.250
, pp. 216-229
-
-
Song, D.H.1
Lee, J.O.2
-
7
-
-
75549091673
-
The IL-1 family: Regulators of immunity
-
Sims JE, Smith DE. 2010. The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10:89-102
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 89-102
-
-
Sims, J.E.1
Smith, D.E.2
-
8
-
-
0032534729
-
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: A novel mechanism of regulation of IL-1 responsiveness
-
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, et al. 1998. The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. J. Immunol. 161:6871-77
-
(1998)
J. Immunol.
, vol.161
, pp. 6871-6877
-
-
Lang, D.1
Knop, J.2
Wesche, H.3
Raffetseder, U.4
Kurrle, R.5
-
9
-
-
84862777437
-
Helical assembly in the death domain (DD) superfamily
-
Ferrao R,Wu H. 2012. Helical assembly in the death domain (DD) superfamily. Curr. Opin. Struct. Biol. 22:241-47
-
(2012)
Curr. Opin. Struct. Biol.
, vol.22
, pp. 241-247
-
-
Ferrao, R.1
Wu, H.2
-
10
-
-
84877757564
-
Molecular basis of NF-κB signaling
-
Napetschnig J,Wu H. 2013. Molecular basis of NF-κB signaling. Annu. Rev. Biophys. 42:443-68
-
(2013)
Annu. Rev. Biophys.
, vol.42
, pp. 443-468
-
-
Napetschnig, J.1
Wu, H.2
-
11
-
-
84861732291
-
Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily
-
Ferrao R, Li J, Bergamin E, Wu H. 2012. Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci. Signal. 5:re3
-
(2012)
Sci. Signal.
, vol.5
, pp. re3
-
-
Ferrao, R.1
Li, J.2
Bergamin, E.3
Wu, H.4
-
12
-
-
0035692811
-
The leucine-rich repeat as a protein recognition motif
-
Kobe B, Kajava AV. 2001. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11:725-32
-
(2001)
Curr. Opin. Struct. Biol.
, vol.11
, pp. 725-732
-
-
Kobe, B.1
Kajava, A.V.2
-
13
-
-
34047161103
-
The molecular structure of the TLR3 extracellular domain
-
Bell JK, Botos I, Hall PR, Askins J, Shiloach J, et al. 2006. The molecular structure of the TLR3 extracellular domain. J. Endotoxin Res. 12:375-78
-
(2006)
J. Endotoxin Res.
, vol.12
, pp. 375-378
-
-
Bell, J.K.1
Botos, I.2
Hall, P.R.3
Askins, J.4
Shiloach, J.5
-
14
-
-
23044445303
-
Crystal structure of human Toll-like receptor 3 (TLR3) ectodomain
-
Choe J, Kelker MS, Wilson IA. 2005. Crystal structure of human Toll-like receptor 3 (TLR3) ectodomain. Science 309:581-85
-
(2005)
Science
, vol.309
, pp. 581-585
-
-
Choe, J.1
Kelker, M.S.2
Wilson, I.A.3
-
15
-
-
34548608447
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
-
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, et al. 2007. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071-82
-
(2007)
Cell
, vol.130
, pp. 1071-1082
-
-
Jin, M.S.1
Kim, S.E.2
Heo, J.Y.3
Lee, M.E.4
Kim, H.M.5
-
16
-
-
34548222514
-
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
-
Kim HM, Park BS, Kim JI, Kim SE, Lee J, et al. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130:906-17
-
(2007)
Cell
, vol.130
, pp. 906-917
-
-
Kim, H.M.1
Park, B.S.2
Kim, J.I.3
Kim, S.E.4
Lee, J.5
-
17
-
-
42349090335
-
Structural basis of Toll-like receptor 3 signaling with double-stranded RNA
-
Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, et al. 2008. Structural basis of Toll-like receptor 3 signaling with double-stranded RNA. Science 320:379-81
-
(2008)
Science
, vol.320
, pp. 379-381
-
-
Liu, L.1
Botos, I.2
Wang, Y.3
Leonard, J.N.4
Shiloach, J.5
-
18
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park BS, Song DH, KimHM, Choi BS, Lee H, Lee JO. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458:1191-95
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
Choi, B.S.4
Lee, H.5
Lee, J.O.6
-
19
-
-
84857335818
-
Structural basis of TLR5-flagellin recognition and signaling
-
Yoon SI, KurnasovO,Natarajan V, Hong M, Gudkov AV, et al. 2012. Structural basis of TLR5-flagellin recognition and signaling. Science 335:859-64
-
(2012)
Science
, vol.335
, pp. 859-864
-
-
Yoon, S.I.1
Kurnasov, O.2
Natarajan, V.3
Hong, M.4
Gudkov, A.V.5
-
20
-
-
84875425019
-
Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
-
Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T. 2013. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science 339:1426-29
-
(2013)
Science
, vol.339
, pp. 1426-1429
-
-
Tanji, H.1
Ohto, U.2
Shibata, T.3
Miyake, K.4
Shimizu, T.5
-
21
-
-
48549083746
-
Structures of TLR-ligand complexes
-
Jin MS, Lee JO. 2008. Structures of TLR-ligand complexes. Curr. Opin. Immunol. 20:414-19
-
(2008)
Curr. Opin. Immunol.
, vol.20
, pp. 414-419
-
-
Jin, M.S.1
Lee, J.O.2
-
22
-
-
48749128643
-
Structures of the Toll-like receptor family and its ligand complexes
-
Jin MS, Lee JO. 2008. Structures of the Toll-like receptor family and its ligand complexes. Immunity 29:182-91
-
(2008)
Immunity
, vol.29
, pp. 182-191
-
-
Jin, M.S.1
Lee, J.O.2
-
23
-
-
79959447465
-
Structural biology of theToll-like receptor family
-
Kang JY, Lee JO. 2011. Structural biology of theToll-like receptor family. Annu. Rev. Biochem. 80:917-41
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 917-941
-
-
Kang, J.Y.1
Lee, J.O.2
-
25
-
-
18544366127
-
Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)
-
Mulero JJ, Boyle BJ, Bradley S, Bright JM, Nelken ST, et al. 2002. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). Immunogenetics 54:293-300
-
(2002)
Immunogenetics
, vol.54
, pp. 293-300
-
-
Mulero, J.J.1
Boyle, B.J.2
Bradley, S.3
Bright, J.M.4
Nelken, S.T.5
-
26
-
-
0028924539
-
Lipopolysaccharide binding proteinmediated complexation of lipopolysaccharide with soluble CD14
-
Tobias PS, Soldau K, Gegner JA, Mintz D, Ulevitch RJ. 1995. Lipopolysaccharide binding proteinmediated complexation of lipopolysaccharide with soluble CD14. J. Biol. Chem. 270:10482-88
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 10482-10488
-
-
Tobias, P.S.1
Soldau, K.2
Gegner, J.A.3
Mintz, D.4
Ulevitch, R.J.5
-
27
-
-
84885865202
-
The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity
-
Eckert JK, Kim YJ, Kim JI, Gurtler K, Oh DY, et al. 2013. The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. Immunity 39:647-60
-
(2013)
Immunity
, vol.39
, pp. 647-660
-
-
Eckert, J.K.1
Kim, Y.J.2
Kim, J.I.3
Gurtler, K.4
Oh, D.Y.5
-
28
-
-
15744396047
-
Crystal structure of CD14 and its implications for lipopolysaccharide signaling
-
Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, et al. 2005. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J. Biol. Chem. 280:11347-51
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11347-11351
-
-
Kim, J.I.1
Lee, C.J.2
Jin, M.S.3
Lee, C.H.4
Paik, S.G.5
-
30
-
-
0027253760
-
The chemical structure of bacterial endotoxin in relation to bioactivity
-
Rietschel ET, Kirikae T, Schade FU, Ulmer AJ, HolstO, et al. 1993. The chemical structure of bacterial endotoxin in relation to bioactivity. Immunobiology 187:169-90
-
(1993)
Immunobiology
, vol.187
, pp. 169-190
-
-
Rietschel, E.T.1
Kirikae, T.2
Schade, F.U.3
Ulmer, A.J.4
Holst, O.5
-
31
-
-
1842588296
-
The bacterial flagellar motor: Structure and function of a complex molecular machine
-
Kojima S, Blair DF. 2004. The bacterial flagellar motor: structure and function of a complex molecular machine. Int. Rev. Cytol. 233:93-134
-
(2004)
Int. Rev. Cytol.
, vol.233
, pp. 93-134
-
-
Kojima, S.1
Blair, D.F.2
-
32
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor
-
Hayashi F, Smith KD,Ozinsky A,HawnTR, Yi EC, et al. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor. Nature 410:1099-103
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
Hawn, T.R.4
Yi, E.C.5
-
33
-
-
0034457684
-
Cloning and characterization of a sub-family of human Toll-like receptors: HTLR7, hTLR8 and hTLR9
-
Chuang TH, Ulevitch RJ. 2000. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11:372-78
-
(2000)
Eur. Cytokine Netw.
, vol.11
, pp. 372-378
-
-
Chuang, T.H.1
Ulevitch, R.J.2
-
34
-
-
22144452520
-
The evolution of vertebrate Toll-like receptors
-
Roach JC, Glusman G, Rowen L, Kaur A, PurcellMK, et al. 2005. The evolution of vertebrate Toll-like receptors. PNAS 102:9577-82
-
(2005)
PNAS
, vol.102
, pp. 9577-9582
-
-
Roach, J.C.1
Glusman, G.2
Rowen, L.3
Kaur, A.4
Purcell, M.K.5
-
35
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-31
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis Sousa, E.C.5
-
36
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 9
-
Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, et al. 2004. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 9. Science 303:1526-29
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
-
37
-
-
38849127573
-
Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis
-
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, et al. 2008. Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis. Science 319:624-27
-
(2008)
Science
, vol.319
, pp. 624-627
-
-
Asagiri, M.1
Hirai, T.2
Kunigami, T.3
Kamano, S.4
Gober, H.J.5
-
38
-
-
70449477746
-
Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells
-
Sepulveda FE, Maschalidi S, Colisson R, Heslop L, Ghirelli C, et al. 2009. Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity 31:737-48
-
(2009)
Immunity
, vol.31
, pp. 737-748
-
-
Sepulveda, F.E.1
Maschalidi, S.2
Colisson, R.3
Heslop, L.4
Ghirelli, C.5
-
39
-
-
0034597766
-
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
-
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, et al. 2000. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408:111-15
-
(2000)
Nature
, vol.408
, pp. 111-115
-
-
Xu, Y.1
Tao, X.2
Shen, B.3
Horng, T.4
Medzhitov, R.5
-
40
-
-
77956950823
-
Structural insights into the assembly and activation of IL-1βwith its receptors
-
Wang D, Zhang S,LiL,Liu X, MeiK,WangX. 2010. Structural insights into the assembly and activation of IL-1βwith its receptors. Nat. Immunol. 11:905-11
-
(2010)
Nat. Immunol.
, vol.11
, pp. 905-911
-
-
Wang, D.1
Zhang, S.2
Li, L.3
Liu, X.4
Mei, K.5
Wang, X.6
-
41
-
-
84861307007
-
Structure of the activating IL-1 receptor signaling complex
-
Thomas C, Bazan JF, Garcia KC. 2012. Structure of the activating IL-1 receptor signaling complex. Nat. Struct. Mol. Biol. 19:455-57
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 455-457
-
-
Thomas, C.1
Bazan, J.F.2
Garcia, K.C.3
-
42
-
-
84923278457
-
The structural basis for receptor recognition of human interleukin-18
-
Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, et al. 2014 . The structural basis for receptor recognition of human interleukin-18. Nat. Commun. 5:5340
-
(2014)
Nat. Commun.
, vol.5
, pp. 5340
-
-
Tsutsumi, N.1
Kimura, T.2
Arita, K.3
Ariyoshi, M.4
Ohnishi, H.5
-
43
-
-
84883815093
-
Structural insights into the interaction of IL-33 with its receptors
-
Liu X, Hammel M, He Y, Tainer JA, Jeng U-S, et al. 2013. Structural insights into the interaction of IL-33 with its receptors. PNAS 110:14918-23
-
(2013)
PNAS
, vol.110
, pp. 14918-14923
-
-
Liu, X.1
Hammel, M.2
He, Y.3
Tainer, J.A.4
Jeng, U.-S.5
-
44
-
-
45549086115
-
The crystal structure of the human Toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer
-
NymanT, Stenmark P, Flodin S, Johansson I,Hammarstrom M, Nordlund P. 2008. The crystal structure of the human Toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J. Biol. Chem. 283:11861-65
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 11861-11865
-
-
Nyman, T.1
Stenmark, P.2
Flodin, S.3
Johansson, I.4
Hammarstrom, M.5
Nordlund, P.6
-
45
-
-
3843055773
-
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
-
Khan JA, Brint EK, O'Neill LA, Tong L. 2004. Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J. Biol. Chem. 279:31664-70
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31664-31670
-
-
Khan, J.A.1
Brint, E.K.2
O'neill, L.A.3
Tong, L.4
-
46
-
-
67649865588
-
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
-
Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, et al. 2009. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. PNAS 106:10260-65
-
(2009)
PNAS
, vol.106
, pp. 10260-10265
-
-
Ohnishi, H.1
Tochio, H.2
Kato, Z.3
Orii, K.E.4
Li, A.5
-
47
-
-
80052578340
-
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
-
Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, et al. 2011. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. PNAS 108:14879-84
-
(2011)
PNAS
, vol.108
, pp. 14879-14884
-
-
Valkov, E.1
Stamp, A.2
Dimaio, F.3
Baker, D.4
Verstak, B.5
-
48
-
-
84889642191
-
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling
-
Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, et al. 2013. Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. PNAS 110:19908-13
-
(2013)
PNAS
, vol.110
, pp. 19908-19913
-
-
Enokizono, Y.1
Kumeta, H.2
Funami, K.3
Horiuchi, M.4
Sarmiento, J.5
-
49
-
-
84899491083
-
Structural basis for assembly and function of a heterodimeric plant immune receptor
-
Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, et al. 2014. Structural basis for assembly and function of a heterodimeric plant immune receptor. Science 344:299-303
-
(2014)
Science
, vol.344
, pp. 299-303
-
-
Williams, S.J.1
Sohn, K.H.2
Wan, L.3
Bernoux, M.4
Sarris, P.F.5
-
50
-
-
79960897879
-
Transforming binding affinities from three dimensions to two with application to cadherin clustering
-
Wu Y, Vendome J, Shapiro L, Ben-Shaul A, Honig B. 2011. Transforming binding affinities from three dimensions to two with application to cadherin clustering. Nature 475:510-13
-
(2011)
Nature
, vol.475
, pp. 510-513
-
-
Wu, Y.1
Vendome, J.2
Shapiro, L.3
Ben-Shaul, A.4
Honig, B.5
-
51
-
-
77953714711
-
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
-
Lin SC, Lo YC,Wu H. 2010. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 465:885-90
-
(2010)
Nature
, vol.465
, pp. 885-890
-
-
Lin, S.C.1
Lo, Y.C.2
Wu, H.3
-
52
-
-
33846702221
-
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex
-
Park HH, Logette E, Rauser S, Cuenin S, Walz T, et al. 2007. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128:533-46
-
(2007)
Cell
, vol.128
, pp. 533-546
-
-
Park, H.H.1
Logette, E.2
Rauser, S.3
Cuenin, S.4
Walz, T.5
-
53
-
-
78549236456
-
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
-
Wang L, Yang JK, Kabaleeswaran V, Rice AJ, Cruz AC, et al. 2010. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol. 17:1324-29
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1324-1329
-
-
Wang, L.1
Yang, J.K.2
Kabaleeswaran, V.3
Rice, A.J.4
Cruz, A.C.5
-
54
-
-
84907975948
-
IRAK4 dimerization and transautophosphorylation are induced by Myddosome assembly
-
Ferrao R, Zhou H, Shan Y, Li Q, Shaw DE, et al. 2014. IRAK4 dimerization and transautophosphorylation are induced by Myddosome assembly. Mol. Cell 55:891-903
-
(2014)
Mol. Cell
, vol.55
, pp. 891-903
-
-
Ferrao, R.1
Zhou, H.2
Shan, Y.3
Li, Q.4
Shaw, D.E.5
-
55
-
-
79956314622
-
Immune signaling by RIG-I-like receptors
-
Loo YM, Gale M Jr. 2011. Immune signaling by RIG-I-like receptors. Immunity 34:680-92
-
(2011)
Immunity
, vol.34
, pp. 680-692
-
-
Loo, Y.M.1
Gale, M.2
-
56
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, et al. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-5
-
(2006)
Nature
, vol.441
, pp. 101-105
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
Yoneyama, M.4
Yamamoto, M.5
-
57
-
-
60749124538
-
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA
-
Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, et al. 2009. Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science 323:1070-74
-
(2009)
Science
, vol.323
, pp. 1070-1074
-
-
Myong, S.1
Cui, S.2
Cornish, P.V.3
Kirchhofer, A.4
Gack, M.U.5
-
58
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF
-
Seth RB, Sun L, Ea CK, Chen ZJ. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF. Cell 122:669-82
-
(2005)
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
59
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-beta signaling
-
Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB. 2005. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19:727-40
-
(2005)
Mol. Cell
, vol.19
, pp. 727-740
-
-
Xu, L.G.1
Wang, Y.Y.2
Han, K.J.3
Li, L.Y.4
Zhai, Z.5
Shu, H.B.6
-
60
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, et al. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437:1167-72
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
-
61
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-Iand Mda5-mediated type i interferon induction
-
Kawai T, Takahashi K, Sato S, Coban C, Kumar H, et al. 2005. IPS-1, an adaptor triggering RIG-Iand Mda5-mediated type I interferon induction. Nat. Immunol. 6:981-88
-
(2005)
Nat. Immunol.
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
-
62
-
-
80054703126
-
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA
-
Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, et al. 2011. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell 147:423-35
-
(2011)
Cell
, vol.147
, pp. 423-435
-
-
Kowalinski, E.1
Lunardi, T.2
McCarthy, A.A.3
Louber, J.4
Brunel, J.5
-
63
-
-
81555204380
-
Structural basis ofRNArecognition and activation by innate immune receptor RIG-I
-
Jiang F,RamanathanA,MillerMT, Tang GQ,GaleMJr, et al. 2011. Structural basis ofRNArecognition and activation by innate immune receptor RIG-I. Nature 479:423-27
-
(2011)
Nature
, vol.479
, pp. 423-427
-
-
Jiang, F.1
Ramanathan, A.2
Miller, M.T.3
Tang, G.Q.4
Gale, M.5
-
64
-
-
80054685883
-
Structural insights into RNA recognition by RIG-I
-
Luo D, Ding SC, Vela A, Kohlway A, Lindenbach BD, Pyle AM. 2011. Structural insights into RNA recognition by RIG-I. Cell 147:409-22
-
(2011)
Cell
, vol.147
, pp. 409-422
-
-
Luo, D.1
Ding, S.C.2
Vela, A.3
Kohlway, A.4
Lindenbach, B.D.5
Pyle, A.M.6
-
65
-
-
84883488816
-
Defining the functional determinants for RNA surveillance by RIG-I
-
Kohlway A, Luo D, Rawling DC, Ding SC, Pyle AM. 2013. Defining the functional determinants for RNA surveillance by RIG-I. EMBO Rep. 14:772-79
-
(2013)
EMBO Rep.
, vol.14
, pp. 772-779
-
-
Kohlway, A.1
Luo, D.2
Rawling, D.C.3
Ding, S.C.4
Pyle, A.M.5
-
66
-
-
80255141860
-
The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
-
Civril F, Bennett M, MoldtM, Deimling T,Witte G, et al. 2011. The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling. EMBO Rep. 12:1127-34
-
(2011)
EMBO Rep.
, vol.12
, pp. 1127-1134
-
-
Civril, F.1
Bennett, M.2
Moldt, M.3
Deimling, T.4
Witte, G.5
-
67
-
-
38649089789
-
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I
-
Cui S, Eisenacher K, Kirchhofer A, Brzozka K, Lammens A, et al. 2008. The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol. Cell 29:169-79
-
(2008)
Mol. Cell
, vol.29
, pp. 169-179
-
-
Cui, S.1
Eisenacher, K.2
Kirchhofer, A.3
Brzozka, K.4
Lammens, A.5
-
68
-
-
84868553355
-
Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I
-
Luo D, Kohlway A, Vela A, Pyle AM. 2012. Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I. Structure 20:1983-88
-
(2012)
Structure
, vol.20
, pp. 1983-1988
-
-
Luo, D.1
Kohlway, A.2
Vela, A.3
Pyle, A.M.4
-
69
-
-
84872604349
-
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5
-
Wu B, Peisley A, Richards C, Yao H, Zeng X, et al. 2013. Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell 152:276-89
-
(2013)
Cell
, vol.152
, pp. 276-289
-
-
Wu, B.1
Peisley, A.2
Richards, C.3
Yao, H.4
Zeng, X.5
-
70
-
-
77954386541
-
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I
-
Wang Y, Ludwig J, Schuberth C, Goldeck M, Schlee M, et al. 2010. Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat. Struct. Mol. Biol. 17:781-87
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 781-787
-
-
Wang, Y.1
Ludwig, J.2
Schuberth, C.3
Goldeck, M.4
Schlee, M.5
-
71
-
-
77955481642
-
The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain
-
Lu C, Xu H, Ranjith-Kumar CT, BrooksMT, HouTY, et al. 2010. The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure 18:1032-43
-
(2010)
Structure
, vol.18
, pp. 1032-1043
-
-
Lu, C.1
Xu, H.2
Ranjith-Kumar, C.T.3
Brooks, M.T.4
Hou, T.Y.5
-
72
-
-
67650510680
-
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: Identification of the RNA recognition loop in RIG-I-like receptors
-
Takahasi K, Kumeta H, Tsuduki N, Narita R, Shigemoto T, et al. 2009. Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J. Biol. Chem. 284:17465-74
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17465-17474
-
-
Takahasi, K.1
Kumeta, H.2
Tsuduki, N.3
Narita, R.4
Shigemoto, T.5
-
73
-
-
84873523444
-
Paramyxovirus v proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling
-
Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, et al. 2013. Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Science 339:690-93
-
(2013)
Science
, vol.339
, pp. 690-693
-
-
Motz, C.1
Schuhmann, K.M.2
Kirchhofer, A.3
Moldt, M.4
Witte, G.5
-
74
-
-
84862909216
-
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
-
Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, et al. 2011. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. PNAS 108:21010-15
-
(2011)
PNAS
, vol.108
, pp. 21010-21015
-
-
Peisley, A.1
Lin, C.2
Wu, B.3
Orme-Johnson, M.4
Liu, M.5
-
75
-
-
84859427527
-
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA
-
Berke IC, Modis Y. 2012. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J. 31:1714-26
-
(2012)
EMBO J.
, vol.31
, pp. 1714-1726
-
-
Berke, I.C.1
Modis, Y.2
-
76
-
-
84868538362
-
MDA5 assembles into a polar helical filament on dsRNA
-
Berke IC, Yu X, Modis Y, Egelman EH. 2012. MDA5 assembles into a polar helical filament on dsRNA. PNAS 109:18437-41
-
(2012)
PNAS
, vol.109
, pp. 18437-18441
-
-
Berke, I.C.1
Yu, X.2
Modis, Y.3
Egelman, E.H.4
-
77
-
-
84883759334
-
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner
-
Peisley A, Wu B, Yao H, Walz T, Hur S. 2013. RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol. Cell 51:573-83
-
(2013)
Mol. Cell
, vol.51
, pp. 573-583
-
-
Peisley, A.1
Wu, B.2
Yao, H.3
Walz, T.4
Hur, S.5
-
78
-
-
84890851204
-
Parts, assembly and operation of the RIG-I family of motors
-
Rawling DC, Pyle AM. 2014. Parts, assembly and operation of the RIG-I family of motors. Curr. Opin. Struct. Biol. 25:25-33
-
(2014)
Curr. Opin. Struct. Biol.
, vol.25
, pp. 25-33
-
-
Rawling, D.C.1
Pyle, A.M.2
-
79
-
-
84926104091
-
The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly
-
Bruns AM, LeserGP, Lamb RA,Horvath CM. 2014. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol. Cell 55:771-81
-
(2014)
Mol. Cell
, vol.55
, pp. 771-781
-
-
Bruns, A.M.1
Leser, G.P.2
Lamb, R.A.3
Horvath, C.M.4
-
80
-
-
77951708374
-
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
-
Zeng W, Sun L, Jiang X, Chen X, Hou F, et al. 2010. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell 141:315-30
-
(2010)
Cell
, vol.141
, pp. 315-330
-
-
Zeng, W.1
Sun, L.2
Jiang, X.3
Chen, X.4
Hou, F.5
-
81
-
-
34247341367
-
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
-
Gack MU, Shin YC, Joo CH, Urano T, Liang C, et al. 2007. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446:916-20
-
(2007)
Nature
, vol.446
, pp. 916-920
-
-
Gack, M.U.1
Shin, Y.C.2
Joo, C.H.3
Urano, T.4
Liang, C.5
-
82
-
-
84899957213
-
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I
-
Peisley A, Wu B, Xu H, Chen ZJ, Hur S. 2014. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature 509:110-14
-
(2014)
Nature
, vol.509
, pp. 110-114
-
-
Peisley, A.1
Wu, B.2
Xu, H.3
Chen, Z.J.4
Hur, S.5
-
83
-
-
84906342978
-
Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I
-
Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, et al. 2014. Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I. Mol. Cell 55:511-23
-
(2014)
Mol. Cell
, vol.55
, pp. 511-523
-
-
Wu, B.1
Peisley, A.2
Tetrault, D.3
Li, Z.4
Egelman, E.H.5
-
85
-
-
84901310586
-
Mechanisms and functions of inflammasomes
-
Lamkanfi M, Dixit VM. 2014. Mechanisms and functions of inflammasomes. Cell 157:1013-22
-
(2014)
Cell
, vol.157
, pp. 1013-1022
-
-
Lamkanfi, M.1
Dixit, V.M.2
-
86
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, et al. 2009. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323:1057-60
-
(2009)
Science
, vol.323
, pp. 1057-1060
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
Kelly, G.M.4
Burnton, C.M.5
-
87
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. 2009. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509-13
-
(2009)
Nature
, vol.458
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
Wu, J.4
Alnemri, E.S.5
-
88
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, et al. 2009. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514-18
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
-
89
-
-
60749136484
-
An orthogonal proteomicgenomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, et al. 2009. An orthogonal proteomicgenomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10:266-72
-
(2009)
Nat. Immunol.
, vol.10
, pp. 266-272
-
-
Burckstummer, T.1
Baumann, C.2
Bluml, S.3
Dixit, E.4
Durnberger, G.5
-
90
-
-
40449140937
-
The NLR gene family: A standard nomenclature
-
Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, et al. 2008. The NLR gene family: a standard nomenclature. Immunity 28:285-87
-
(2008)
Immunity
, vol.28
, pp. 285-287
-
-
Ting, J.P.1
Lovering, R.C.2
Alnemri, E.S.3
Bertin, J.4
Boss, J.M.5
-
91
-
-
82955173740
-
Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: Design and implementation of the CORE320 multicenter, multinational diagnostic study
-
Vavere AL, Simon GG, George RT, Rochitte CE, Arai AE, et al. 2011. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study. J. Cardiovasc. Comput. Tomogr. 5:370-81
-
(2011)
J. Cardiovasc. Comput. Tomogr.
, vol.5
, pp. 370-381
-
-
Vavere, A.L.1
Simon, G.G.2
George, R.T.3
Rochitte, C.E.4
Arai, A.E.5
-
92
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao Y, Yang J, Shi J, Gong YN, Lu Q, et al. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477:596-600
-
(2011)
Nature
, vol.477
, pp. 596-600
-
-
Zhao, Y.1
Yang, J.2
Shi, J.3
Gong, Y.N.4
Lu, Q.5
-
93
-
-
47149108866
-
Interferon-inducible Ifi200-family genes in systemic lupus erythematosus
-
Choubey D, Panchanathan R. 2008. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol. Lett. 119:32-41
-
(2008)
Immunol. Lett.
, vol.119
, pp. 32-41
-
-
Choubey, D.1
Panchanathan, R.2
-
94
-
-
84859986329
-
Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
-
Jin T, Perry A, Jiang J, Smith P, Curry JA, et al. 2012. Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36:561-71
-
(2012)
Immunity
, vol.36
, pp. 561-571
-
-
Jin, T.1
Perry, A.2
Jiang, J.3
Smith, P.4
Curry, J.A.5
-
95
-
-
84880818953
-
Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation
-
YinQ, SesterDP, Tian Y, Hsiao YS, Lu A, et al. 2013. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Cell Rep. 4:327-39
-
(2013)
Cell Rep.
, vol.4
, pp. 327-339
-
-
Yin, Q.1
Sester, D.P.2
Tian, Y.3
Hsiao, Y.S.4
Lu, A.5
-
96
-
-
84878745041
-
Structural basis for termination of AIM2-mediated signaling by p202
-
Ru H, Ni X, Zhao L, CrowleyC,DingW, et al. 2013. Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 23:855-58
-
(2013)
Cell Res.
, vol.23
, pp. 855-858
-
-
Ru, H.1
Ni, X.2
Zhao, L.3
Crowley, C.4
Ding, W.5
-
97
-
-
84865753053
-
Crystallographic characterization of mouse AIM2 HIN-200 domain bound to a 15 bp and an 18 bp double-stranded DNA
-
Sung MW, Watts T, Li P. 2012. Crystallographic characterization of mouse AIM2 HIN-200 domain bound to a 15 bp and an 18 bp double-stranded DNA. Acta Crystallogr. Sect. F 68:1081-84
-
(2012)
Acta Crystallogr. Sect. F
, vol.68
, pp. 1081-1084
-
-
Sung, M.W.1
Watts, T.2
Li, P.3
-
98
-
-
18544372595
-
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
-
Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, et al. 2002. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 297:1837-48
-
(2002)
Science
, vol.297
, pp. 1837-1848
-
-
Yang, H.1
Jeffrey, P.D.2
Miller, J.3
Kinnucan, E.4
Sun, Y.5
-
99
-
-
84891933102
-
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
-
Morrone SR, Wang T, Constantoulakis LM, Hooy RM, Delannoy MJ, Sohn J. 2014. Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy. PNAS 111:E62-71
-
(2014)
PNAS
, vol.111
, pp. E62-71
-
-
Morrone, S.R.1
Wang, T.2
Constantoulakis, L.M.3
Hooy, R.M.4
Delannoy, M.J.5
Sohn, J.6
-
100
-
-
84877692253
-
Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly
-
Jin T, Perry A, Smith P, Jiang J, Xiao TS. 2013. Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. J. Biol. Chem. 288:13225-35
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 13225-13235
-
-
Jin, T.1
Perry, A.2
Smith, P.3
Jiang, J.4
Xiao, T.S.5
-
101
-
-
84895923768
-
Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions
-
Lu A, Kabaleeswaran V, Fu T, Magupalli VG,Wu H. 2014. Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions. J. Mol. Biol. 426:1420-27
-
(2014)
J. Mol. Biol.
, vol.426
, pp. 1420-1427
-
-
Lu, A.1
Kabaleeswaran, V.2
Fu, T.3
Magupalli, V.G.4
Wu, H.5
-
102
-
-
84880280093
-
Crystal structure of NLRC4 reveals its autoinhibition mechanism
-
Hu Z, Yan C, Liu P, Huang Z,Ma R, et al. 2013. Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science 341:172-75
-
(2013)
Science
, vol.341
, pp. 172-175
-
-
Hu, Z.1
Yan, C.2
Liu, P.3
Huang, Z.4
Ma, R.5
-
103
-
-
84869044838
-
Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N-and C-terminal regions of flagellin
-
Halff EF, Diebolder CA, Versteeg M, Schouten A, Brondijk TH, Huizinga EG. 2012. Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N-and C-terminal regions of flagellin. J. Biol. Chem. 287:38460-72
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 38460-38472
-
-
Halff, E.F.1
Diebolder, C.A.2
Versteeg, M.3
Schouten, A.4
Brondijk, T.H.5
Huizinga, E.G.6
-
104
-
-
84896332642
-
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
-
Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, et al. 2014. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156:1193-206
-
(2014)
Cell
, vol.156
, pp. 1193-1206
-
-
Lu, A.1
Magupalli, V.G.2
Ruan, J.3
Yin, Q.4
Atianand, M.K.5
-
105
-
-
77957578665
-
Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
-
Wu J, Fernandes-Alnemri T, Alnemri ES. 2010. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J. Clin. Immunol. 30:693-702
-
(2010)
J. Clin. Immunol.
, vol.30
, pp. 693-702
-
-
Wu, J.1
Fernandes-Alnemri, T.2
Alnemri, E.S.3
-
106
-
-
70450250064
-
Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC)
-
de Alba E. 2009. Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC). J. Biol. Chem. 284:32932-41
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 32932-32941
-
-
De Alba, E.1
-
107
-
-
0042386425
-
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
-
Liepinsh E, Barbals R, Dahl E, Sharipo A, Staub E, Otting G. 2003. The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. J. Mol. Biol. 332:1155-63
-
(2003)
J. Mol. Biol.
, vol.332
, pp. 1155-1163
-
-
Liepinsh, E.1
Barbals, R.2
Dahl, E.3
Sharipo, A.4
Staub, E.5
Otting, G.6
-
108
-
-
12144284412
-
Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC
-
Moriya M, Taniguchi S, Wu P, Liepinsh E, Otting G, Sagara J. 2005. Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC. Biochemistry 44:575-83
-
(2005)
Biochemistry
, vol.44
, pp. 575-583
-
-
Moriya, M.1
Taniguchi, S.2
Wu, P.3
Liepinsh, E.4
Otting, G.5
Sagara, J.6
-
109
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa H, Barber GN. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674-78
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
110
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type i interferondependent innate immunity
-
Ishikawa H,Ma Z, Barber GN. 2009. STING regulates intracellular DNA-mediated, type I interferondependent innate immunity. Nature 461:788-92
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
111
-
-
53349168904
-
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
-
Zhong B, Yang Y, Li S, Wang YY, Li Y, et al. 2008. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29:538-50
-
(2008)
Immunity
, vol.29
, pp. 538-550
-
-
Zhong, B.1
Yang, Y.2
Li, S.3
Wang, Y.Y.4
Li, Y.5
-
112
-
-
49449115516
-
MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
-
Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC. 2008. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol. Cell. Biol. 28:5014-26
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 5014-5026
-
-
Jin, L.1
Waterman, P.M.2
Jonscher, K.R.3
Short, C.M.4
Reisdorph, N.A.5
Cambier, J.C.6
-
113
-
-
66649109939
-
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
-
Sun W, Li Y, Chen L, Chen H, You F, et al. 2009. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. PNAS 106:8653-58
-
(2009)
PNAS
, vol.106
, pp. 8653-8658
-
-
Sun, W.1
Li, Y.2
Chen, L.3
Chen, H.4
You, F.5
-
114
-
-
80054966913
-
STING is a direct innate immune sensor of cyclic di-GMP
-
Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, et al. 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478:515-18
-
(2011)
Nature
, vol.478
, pp. 515-518
-
-
Burdette, D.L.1
Monroe, K.M.2
Sotelo-Troha, K.3
Iwig, J.S.4
Eckert, B.5
-
115
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Wu J, Sun L, Chen X, Du F, Shi H, et al. 2013. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339:826-30
-
(2013)
Science
, vol.339
, pp. 826-830
-
-
Wu, J.1
Sun, L.2
Chen, X.3
Du, F.4
Shi, H.5
-
116
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
-
Sun L,Wu J, Du F, Chen X, Chen ZJ. 2013. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339:786-91
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
117
-
-
84878309796
-
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Gao P, AscanoM,Wu Y, Barchet W, Gaffney BL, et al. 2013. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153:1094-107
-
(2013)
Cell
, vol.153
, pp. 1094-1107
-
-
Gao, P.1
Ascano, M.2
Wu, Y.3
Barchet, W.4
Gaffney, B.L.5
-
118
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, et al. 2013. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3:1355-61
-
(2013)
Cell Rep.
, vol.3
, pp. 1355-1361
-
-
Diner, E.J.1
Burdette, D.L.2
Wilson, S.C.3
Monroe, K.M.4
Kellenberger, C.A.5
-
119
-
-
84879385334
-
CGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
-
Ablasser A,Goldeck M, Cavlar T, Deimling T,Witte G, et al. 2013. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498:380-84
-
(2013)
Nature
, vol.498
, pp. 380-384
-
-
Ablasser, A.1
Goldeck, M.2
Cavlar, T.3
Deimling, T.4
Witte, G.5
-
120
-
-
84878592773
-
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
-
Kranzusch PJ, Lee AS, Berger JM, Doudna JA. 2013. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 3:1362-68
-
(2013)
Cell Rep.
, vol.3
, pp. 1362-1368
-
-
Kranzusch, P.J.1
Lee, A.S.2
Berger, J.M.3
Doudna, J.A.4
-
121
-
-
84879408976
-
Structural mechanism of cytosolic DNA sensing by cGAS
-
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A,Moldt M, et al. 2013. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498:332-37
-
(2013)
Nature
, vol.498
, pp. 332-337
-
-
Civril, F.1
Deimling, T.2
De Oliveira Mann, C.C.3
Ablasser, A.4
Moldt, M.5
-
122
-
-
84885037202
-
Structural and functional analyses of DNA-sensing and immune activation by human cGAS
-
Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O. 2013. Structural and functional analyses of DNA-sensing and immune activation by human cGAS. PLOS ONE 8:e76983
-
(2013)
PLOS ONE
, vol.8
, pp. e76983
-
-
Kato, K.1
Ishii, R.2
Goto, E.3
Ishitani, R.4
Tokunaga, F.5
Nureki, O.6
-
123
-
-
84890235012
-
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
-
Li X, Shu C, Yi G, Chaton CT, Shelton CL, et al. 2013. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 39:1019-31
-
(2013)
Immunity
, vol.39
, pp. 1019-1031
-
-
Li, X.1
Shu, C.2
Yi, G.3
Chaton, C.T.4
Shelton, C.L.5
-
124
-
-
84893863593
-
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
-
Zhang X,Wu J, Du F, Xu H, Sun L, et al. 2014. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 6:421-30
-
(2014)
Cell Rep.
, vol.6
, pp. 421-430
-
-
Zhang, X.1
Wu, J.2
Du, F.3
Xu, H.4
Sun, L.5
-
125
-
-
84873142658
-
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase
-
Donovan J, DufnerM, Korennykh A. 2013. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase. PNAS 110:1652-57
-
(2013)
PNAS
, vol.110
, pp. 1652-1657
-
-
Donovan, J.1
Dufner, M.2
Korennykh, A.3
-
126
-
-
84896045262
-
Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response
-
Han Y, Donovan J, Rath S, Whitney G, Chitrakar A, Korennykh A. 2014. Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science 343:1244-48
-
(2014)
Science
, vol.343
, pp. 1244-1248
-
-
Han, Y.1
Donovan, J.2
Rath, S.3
Whitney, G.4
Chitrakar, A.5
Korennykh, A.6
-
127
-
-
84892890442
-
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity
-
Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, et al. 2014. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol. Cell 53:221-34
-
(2014)
Mol. Cell
, vol.53
, pp. 221-234
-
-
Huang, H.1
Zeqiraj, E.2
Dong, B.3
Jha, B.K.4
Duffy, N.M.5
-
128
-
-
84863009492
-
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
-
Ouyang S, Song X, Wang Y, Ru H, ShawN, et al. 2012. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity 36:1073-86
-
(2012)
Immunity
, vol.36
, pp. 1073-1086
-
-
Ouyang, S.1
Song, X.2
Wang, Y.3
Ru, H.4
Shaw, N.5
-
129
-
-
84862996389
-
Cyclic di-GMP sensing via the innate immune signaling protein STING
-
Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, et al. 2012. Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol. Cell 46:735-45
-
(2012)
Mol. Cell
, vol.46
, pp. 735-745
-
-
Yin, Q.1
Tian, Y.2
Kabaleeswaran, V.3
Jiang, X.4
Tu, D.5
-
130
-
-
84863726252
-
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
-
Shu C, Yi G, Watts T, Kao CC, Li P. 2012. Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19:722-24
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 722-724
-
-
Shu, C.1
Yi, G.2
Watts, T.3
Kao, C.C.4
Li, P.5
-
131
-
-
84863717085
-
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
-
Shang G, Zhu D, Li N, Zhang J, Zhu C, et al. 2012. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat. Struct. Mol. Biol. 19:725-27
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 725-727
-
-
Shang, G.1
Zhu, D.2
Li, N.3
Zhang, J.4
Zhu, C.5
-
132
-
-
84863722786
-
The structural basis for the sensing and binding of cyclic di-GMP by STING
-
Huang YH, Liu XY, Du XX, Jiang ZF, Su XD. 2012. The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19:728-30
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 728-730
-
-
Huang, Y.H.1
Liu, X.Y.2
Du, X.X.3
Jiang, Z.F.4
Su, X.D.5
-
133
-
-
84880508067
-
Cyclic GMP-AMP containingmixed phosphodiester linkages is an endogenous high-affinity ligand for STING
-
Zhang X, Shi H,WuJ, Zhang X, Sun L, et al. 2013. Cyclic GMP-AMP containingmixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51:226-35
-
(2013)
Mol. Cell
, vol.51
, pp. 226-235
-
-
Zhang, X.1
Shi, H.2
Wu, J.3
Zhang, X.4
Sun, L.5
-
134
-
-
84882815198
-
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
-
Gao P, Ascano M, Zillinger T, Wang W, Dai P, et al. 2013. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 154:748-62
-
(2013)
Cell
, vol.154
, pp. 748-762
-
-
Gao, P.1
Ascano, M.2
Zillinger, T.3
Wang, W.4
Dai, P.5
-
135
-
-
84875421431
-
Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
-
Chin KH, Tu ZL, Su YC, Yu YJ, Chen HC, et al. 2013. Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING. Acta Crystallogr. D 69:352-66
-
(2013)
Acta Crystallogr. D
, vol.69
, pp. 352-366
-
-
Chin, K.H.1
Tu, Z.L.2
Su, Y.C.3
Yu, Y.J.4
Chen, H.C.5
-
136
-
-
84878638162
-
Species-specific detection of the antiviral small-molecule compound CMA by STING
-
Cavlar T, Deimling T, Ablasser A, Hopfner KP, Hornung V. 2013. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32:1440-50
-
(2013)
EMBO J.
, vol.32
, pp. 1440-1450
-
-
Cavlar, T.1
Deimling, T.2
Ablasser, A.3
Hopfner, K.P.4
Hornung, V.5
-
137
-
-
84880522115
-
Anticancer flavonoids are mouse-selective STING agonists
-
Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ. 2013. Anticancer flavonoids are mouse-selective STING agonists. ACS Chem. Biol. 8:1396-401
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 1396-1401
-
-
Kim, S.1
Li, L.2
Maliga, Z.3
Yin, Q.4
Wu, H.5
Mitchison, T.J.6
-
138
-
-
84862976890
-
Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB
-
Paul S, Kashyap AK, Jia W, He YW, Schaefer BC. 2012. Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. Immunity 36:947-58
-
(2012)
Immunity
, vol.36
, pp. 947-958
-
-
Paul, S.1
Kashyap, A.K.2
Jia, W.3
He, Y.W.4
Schaefer, B.C.5
-
139
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1βproduction
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, et al. 2008. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1βproduction. Nature 456:264-68
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
-
140
-
-
79961133270
-
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
-
Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ. 2011. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 146:448-61
-
(2011)
Cell
, vol.146
, pp. 448-461
-
-
Hou, F.1
Sun, L.2
Zheng, H.3
Skaug, B.4
Jiang, Q.X.5
Chen, Z.J.6
-
141
-
-
84896381627
-
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation
-
CaiX,Chen J,XuH,Liu S, JiangQX, et al. 2014. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell 156:1207-22
-
(2014)
Cell
, vol.156
, pp. 1207-1222
-
-
Cai, X.1
Chen, J.2
Xu, H.3
Liu, S.4
Jiang, Q.X.5
-
142
-
-
84904646033
-
TheNLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
-
Baroja-Mazo A, Martin-Sanchez F, Gomez AI, Martinez CM, Amores-Iniesta J, et al. 2014. TheNLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat. Immunol. 15:738-48
-
(2014)
Nat. Immunol.
, vol.15
, pp. 738-748
-
-
Baroja-Mazo, A.1
Martin-Sanchez, F.2
Gomez, A.I.3
Martinez, C.M.4
Amores-Iniesta, J.5
-
143
-
-
84904692363
-
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
-
Franklin BS, Bossaller L,DeNardo D, Ratter JM, Stutz A, et al. 2014. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat. Immunol. 15:727-37
-
(2014)
Nat. Immunol.
, vol.15
, pp. 727-737
-
-
Franklin, B.S.1
Bossaller, L.2
Denardo, D.3
Ratter, J.M.4
Stutz, A.5
-
144
-
-
84876221513
-
Higher-order assemblies in a new paradigm of signal transduction
-
Wu H. 2013. Higher-order assemblies in a new paradigm of signal transduction. Cell 153:287-92
-
(2013)
Cell
, vol.153
, pp. 287-292
-
-
Wu, H.1
|