IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly

Molecular Cell

Volumn 55, Issue 6, 2014, Pages 891-903

  Ferrao, Ryan ^a,b,c   Zhou, Hao ^d   Shan, Yibing ^e   Liu, Qun ^f   Li, Qiubai ^a,b   Shaw, David E ^e,g   Li, Xiaoxia ^d   Wu, Hao ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e D E SHAW RESEARCH   (United States)

^f BROOKHAVEN NATIONAL LABORATORY   (United States)

^g Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MONOMER; MYELOID DIFFERENTIATION FACTOR 88; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK4 PROTEIN, HUMAN; MYD88 PROTEIN, HUMAN;

ALLOSTERISM; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE COMPLEX; FOURIER TRANSFORMATION; IN VITRO STUDY; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; OLIGOMERIZATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; RADIATION SCATTERING;

CATALYTIC DOMAIN; CELLS, CULTURED; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; SCATTERING, RADIATION; SUBSTRATE SPECIFICITY;

EID: 84907975948     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.08.006     Document Type: Article

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