Crystal structure of toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 36, 2011, Pages 14879-14884

  Valkov, Eugene ^a,d   Stamp, Anna ^a   DiMaio, Frank ^b   Baker, David ^b   Verstak, Brett ^c,d   Roversi, Pietro ^e   Kellie, Stuart ^a   Sweet, Matthew J ^a   Mansell, Ashley ^c   Gay, Nicholas J ^d   Martin, Jennifer L ^a   Kobe, Bostjan ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Innate immunity; Protein protein interactions; X ray crystallography

Indexed keywords

ADAPTOR PROTEIN; ARGININE; ASPARTIC ACID; CYSTEINE; MYELOID DIFFERENTIATION FACTOR 88; MYELOID DIFFERENTIATION FACTOR ADAPTOR LIKE PROTEIN; PROLINE; SERINE; TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA SHEET; CELL STRAIN HEK293; CRYSTAL STRUCTURE; DIMERIZATION; DISULFIDE BOND; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; HUMANS; IMMUNITY, INNATE; INFECTION; MEMBRANE GLYCOPROTEINS; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN MULTIMERIZATION; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS);

EID: 80052578340     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104780108     Document Type: Article

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