Structures and interface mapping of the TIR domaincontaining adaptor molecules involved in interferon signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 49, 2013, Pages 19908-19913

  Enokizono, Yoshiaki ^a   Kumeta, Hiroyuki ^a   Funami, Kenji ^b   Horiuchi, Masataka ^a   Sarmiento, Joy ^c   Yamashita, Kazuo ^c   Standley, Daron M ^c   Matsumoto, Misako ^b   Seya, Tsukasa ^b   Inagaki, Fuyuhiko ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Innate immunity; MyD88 independent pathway; TLR signaling; TRAM; TRIF

Indexed keywords

ADAPTOR PROTEIN; DIMER; INTERFERON; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2;

AMINO TERMINAL SEQUENCE; AQUEOUS SOLUTION; ARTICLE; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOSOME; MUTAGENESIS; MUTATIONAL ANALYSIS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; REPORTER GENE; SIGNAL TRANSDUCTION; SURFACE PROPERTY; WILD TYPE;

INNATE IMMUNITY; MYD88-INDEPENDENT PATHWAY; TLR SIGNALING; TRAM; TRIF;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; DIMERIZATION; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84889642191     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222811110     Document Type: Article

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