Structural insights into the interaction of IL-33 with its receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 37, 2013, Pages 14918-14923

  Liu, Xi ^a   Hammel, Michal ^b   He, Yanfeng ^a   Tainer, John A ^b,c   Jeng, U Ser ^d   Zhang, Linqi ^e   Wang, Shuying ^f,g   Wang, Xinquan ^a  

^a TSINGHUA UNIVERSITY   (China)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER   (Taiwan)

^e Tsinghua University   (China)

^f NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^g NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Cytokine signaling; Protein protein interaction; SAXS; X ray crystallography

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 33; INTERLEUKIN RECEPTOR; LIGAND; ST2 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; BINDING SITE; CELL SURFACE; CRYSTAL STRUCTURE; HUMAN; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; RADIATION SCATTERING; SIGNAL TRANSDUCTION; SURFACE CHARGE; X RAY CRYSTALLOGRAPHY;

CYTOKINE SIGNALING; PROTEIN-PROTEIN INTERACTION; SAXS; X-RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; STATIC ELECTRICITY; SURFACE PLASMON RESONANCE; X-RAY DIFFRACTION;

EID: 84883815093     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308651110     Document Type: Article

References (44)

1. Liew FY, Pitman NI, McInnes IB (2010) Disease-associated functions of IL-33: The new kid in the IL-1 family. Nat Rev Immunol 10(2):103-110.
2. Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S (2010) IL-33 and IL-33 receptors in host defense and diseases. Allergol Int 59(2):143-160.
3. Smith DE (2010) IL-33: A tissue derived cytokine pathway involved in allergic inflammation and asthma. Clin Exp Allergy 40(2):200-208.
4. Palmer G, Gabay C (2011) Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol 7(6):321-329.
5. Milovanovic M, et al. (2012) IL-33/ST2 axis in inflammation and immunopathology. Immunol Res 52(1-2):89-99.
6. Onda H, et al. (1999) Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. J Cereb Blood Flow Metab 19(11):1279-1288. (Pubitemid 30176457)
7. Baekkevold ES, et al. (2003) Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am J Pathol 163(1):69-79. (Pubitemid 36759592)
8. Schmitz J, et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23(5):479-490. (Pubitemid 41587888)
9. Spits H, Cupedo T (2012) Innate lymphoid cells: Emerging insights in development, lineage relationships, and function. Annu Rev Immunol 30:647-675.
10. Scanlon ST, McKenzie AN (2012) Type 2 innate lymphoid cells: New players in asthma and allergy. Curr Opin Immunol 24(6):707-712.
11. Neill DR, et al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464(7293):1367-1370.
12. Moro K, et al. (2010) Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463(7280):540-544.
13. Price AE, et al. (2010) Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci USA 107(25):11489-11494.
14. Moussion C, Ortega N, Girard JP (2008) The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: A novel 'alarmin' ? PLoS ONE 3(10):e3331.
15. Küchler AM, et al. (2008) Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. Am J Pathol 173(4):1229-1242.
16. Haraldsen G, Balogh J, Pollheimer J, Sponheim J, Küchler AM (2009) Interleukin-33 - cytokine of dual function or novel alarmin? Trends Immunol 30(5):227-233.
17. Cayrol C, Girard JP (2009) The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA 106(22):9021-9026.
18. Lefrançais E, et al. (2012) IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci USA 109(5):1673-1678.
19. Bae S, et al. (2012) Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity. J Biol Chem 287(11):8205-8213.
20. Lüthi AU, et al. (2009) Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 31(1):84-98.
21. Talabot-Ayer D, Lamacchia C, Gabay C, Palmer G (2009) Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem 284(29):19420-19426.
22. Ali S, et al. (2007) IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci USA 104(47):18660-18665. (Pubitemid 350210753)
23. Chackerian AA, et al. (2007) IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol 179(4):2551-2555.
24. Dunne A, O'Neill LA (2003) The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense. Sci STKE 2003(171):re3.
25. Wang D, et al. (2010) Structural insights into the assembly and activation of IL-1β with its receptors. Nat Immunol 11(10):905-911.
26. Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519-550.
27. Sims JE, Smith DE (2010) The IL-1 family: Regulators of immunity. Nat Rev Immunol 10(2):89-102.
28. Dinarello C, et al. (2010) IL-1 family nomenclature. Nat Immunol 11(11):973.
29. Thomas C, Bazan JF, Garcia KC (2012) Structure of the activating IL-1 receptor signaling complex. Nat Struct Mol Biol 19(4):455-457.
30. Lingel A, et al. (2009) Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors-insight into heterotrimeric IL-1 signaling complexes. Structure 17(10):1398-1410.
31. Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997) Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. Nature 386(6621):190-194. (Pubitemid 27131448)
32. Schreuder H, et al. (1997) A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature 386(6621):194-200. (Pubitemid 27131449)
33. Kato Z, et al. (2003) The structure and binding mode of interleukin-18. Nat Struct Biol 10(11):966-971. (Pubitemid 37386108)
34. Kim SH, et al. (2002) Identification of amino acid residues critical for biological activity in human interleukin-18. J Biol Chem 277(13):10998-11003.
35. Putnam CD, Hammel M, Hura GL, Tainer JA (2007) X-ray solution scattering (SAXS) combined with crystallography and computation: Defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys 40(3):191-285. (Pubitemid 350261954)
36. Pelikan M, Hura GL, Hammel M (2009) Structure and flexibility within proteins as identified through small angle X-ray scattering. Gen Physiol Biophys 28(2):174-189.
37. Schneidman-Duhovny D, Hammel M, Sali A (2010) FoXS: A web server for rapid computation and fitting of SAXS profiles. Nucleic Acids Res 38(Web Server issue): W540-W544.
38. Hammel M (2012) Validation of macromolecular flexibility in solution by small-angle X-ray scattering (SAXS). Eur Biophys J 41(10):789-799.
39. Yang Z, et al. (2012) UCSF Chimera, MODELLER, and IMP: An integrated modeling system. J Struct Biol 179(3):269-278.
40. Vigers GP, Dripps DJ, Edwards CK, 3rd, Brandhuber BJ (2000) X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. J Biol Chem 275(47):36927-36933. (Pubitemid 32002106)
41. Rambo RP, Tainer JA (2013) Accurate assessment of mass, models and resolution by small-angle scattering. Nature 496(7446):477-481.
42. Wang X, Lupardus P, Laporte SL, Garcia KC (2009) Structural biology of shared cytokine receptors. Annu Rev Immunol 27:29-60.
43. Hura GL, et al. (2009) Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS). Nat Methods 6(8):606-612.
44. Classen S, et al. (2013) Implementation and performance of SIBYLS: A dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source. J Appl Cryst 46(Pt 1):1-13.