-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
2
-
-
0037505362
-
The Toll-IL-1 receptor adaptor family grows to five members
-
O'Neill, L. A., Fitzgerald, K. A. & Bowie, A. G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 24, 286-290 (2003).
-
(2003)
Trends Immunol
, vol.24
, pp. 286-290
-
-
O'Neill, L.A.1
Fitzgerald, K.A.2
Bowie, A.G.3
-
3
-
-
33750995860
-
-
Sodergren, E. et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314, 941-952 (2006). This paper reports the striking observation that the sea urchin is predicted to contain 222 TLRs and 26 TIR-domain-containing adaptors. The reason for this diversity is as yet unclear.
-
Sodergren, E. et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314, 941-952 (2006). This paper reports the striking observation that the sea urchin is predicted to contain 222 TLRs and 26 TIR-domain-containing adaptors. The reason for this diversity is as yet unclear.
-
-
-
-
4
-
-
33750980112
-
Genomic insights into the immune system of the sea urchin
-
Rast, J. P., Smith, L. C., Loza-Coll, M., Hibino, T. & Litman, G. W. Genomic insights into the immune system of the sea urchin. Science 314, 952-956 (2006).
-
(2006)
Science
, vol.314
, pp. 952-956
-
-
Rast, J.P.1
Smith, L.C.2
Loza-Coll, M.3
Hibino, T.4
Litman, G.W.5
-
5
-
-
33748871187
-
-
Carty, M. et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nature Immunol. 7, 1074-1081 (2006). A key functional aspect of SARM is reported here - inhibition of signalling by TRIF.
-
Carty, M. et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nature Immunol. 7, 1074-1081 (2006). A key functional aspect of SARM is reported here - inhibition of signalling by TRIF.
-
-
-
-
6
-
-
33745679123
-
Targeting signal transduction as a strategy to treat inflammatory diseases
-
O'Neill, L. A. J. Targeting signal transduction as a strategy to treat inflammatory diseases. Nature Rev. Drug Discov. 5, 549-563 (2006).
-
(2006)
Nature Rev. Drug Discov
, vol.5
, pp. 549-563
-
-
O'Neill, L.A.J.1
-
7
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
-
Ozinsky, A. et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl Acad. Sci. USA 97, 13766-13771 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
-
8
-
-
33846000646
-
The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
-
Wang, J. et al. The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J. Biol. Chem. 281, 37427-37434 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 37427-37434
-
-
Wang, J.1
-
9
-
-
33745048928
-
The dsRNA binding site of human Toll-like receptor 3
-
Bell, J. K., Askins, J., Hall, P. R., Davies, D. R. & Segal, D. M. The dsRNA binding site of human Toll-like receptor 3. Proc. Natl Acad. Sci. USA 103, 8792-8797 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 8792-8797
-
-
Bell, J.K.1
Askins, J.2
Hall, P.R.3
Davies, D.R.4
Segal, D.M.5
-
10
-
-
0025290213
-
Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6
-
Lord, K. A., Hoffman-Liebermann, B. & Liebermann, D. A. Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene 5, 1095-1097 (1990).
-
(1990)
Oncogene
, vol.5
, pp. 1095-1097
-
-
Lord, K.A.1
Hoffman-Liebermann, B.2
Liebermann, D.A.3
-
11
-
-
0028278884
-
Interspecific comparisons reveal conserved features of the Drosophila Toll protein
-
Yamagata, M., Merlie, J. P. & Sanes, J. R. Interspecific comparisons reveal conserved features of the Drosophila Toll protein. Gene 139, 223-228 (1994).
-
(1994)
Gene
, vol.139
, pp. 223-228
-
-
Yamagata, M.1
Merlie, J.P.2
Sanes, J.R.3
-
12
-
-
0028237775
-
Macrophage differentiation marker myd88 is a member of the Toll/IL-1 receptor family
-
Hultmark, D. Macrophage differentiation marker myd88 is a member of the Toll/IL-1 receptor family. Biochem. Biophys. Res. Commun. 199, 144-146 (1994).
-
(1994)
Biochem. Biophys. Res. Commun
, vol.199
, pp. 144-146
-
-
Hultmark, D.1
-
13
-
-
0031423761
-
MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847 (1997).
-
(1997)
Immunity
, vol.7
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
Li, S.4
Cao, Z.5
-
14
-
-
0030694108
-
IRAK (pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
-
Muzio, M., Ni, J., Feng, P. & Dixit, V. M. IRAK (pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615 (1997).
-
(1997)
Science
, vol.278
, pp. 1612-1615
-
-
Muzio, M.1
Ni, J.2
Feng, P.3
Dixit, V.M.4
-
15
-
-
0032133278
-
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
-
Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2, 253-258 (1998).
-
(1998)
Mol. Cell
, vol.2
, pp. 253-258
-
-
Medzhitov, R.1
-
16
-
-
0032526861
-
The human Toll signaling pathway: Divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
-
Muzio, M., Natoli, G., Saccani, S., Levrero, M. & Mantovani, A. The human Toll signaling pathway: Divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187, 2097-2101 (1998).
-
(1998)
J. Exp. Med
, vol.187
, pp. 2097-2101
-
-
Muzio, M.1
Natoli, G.2
Saccani, S.3
Levrero, M.4
Mantovani, A.5
-
17
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
18
-
-
0033968625
-
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
-
Takeuchi, O. et al. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12, 113-117 (2000).
-
(2000)
Int. Immunol
, vol.12
, pp. 113-117
-
-
Takeuchi, O.1
-
19
-
-
0034669910
-
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
-
Takeuchi, O., Hoshino, K. & Akira, S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165, 5392-5396 (2000).
-
(2000)
J. Immunol
, vol.165
, pp. 5392-5396
-
-
Takeuchi, O.1
Hoshino, K.2
Akira, S.3
-
20
-
-
0035889873
-
Plasmodium berghei infection in mice induces liver injury by an IL-12- and Toll-like receptor/myeloid differentiation factor 88-dependent mechanism
-
Adachi, K. et al. Plasmodium berghei infection in mice induces liver injury by an IL-12- and Toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J. Immunol. 167, 5928-5934 (2001).
-
(2001)
J. Immunol
, vol.167
, pp. 5928-5934
-
-
Adachi, K.1
-
21
-
-
0037097795
-
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
-
Scanga, C. A. et al. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J. Immunol. 168, 5997-6001 (2002).
-
(2002)
J. Immunol
, vol.168
, pp. 5997-6001
-
-
Scanga, C.A.1
-
22
-
-
0036785557
-
MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: No role for either in macrophage listericidal activity
-
Edelson, B. T. & Unanue, E. R. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: No role for either in macrophage listericidal activity. J. Immunol. 169, 3869-3875 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 3869-3875
-
-
Edelson, B.T.1
Unanue, E.R.2
-
23
-
-
0036785637
-
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways
-
Henneke, P. et al. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J. Immunol. 169, 3970-3977 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 3970-3977
-
-
Henneke, P.1
-
24
-
-
0037446651
-
Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response
-
Muraille, E. et al. Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J. Immunol. 170, 4237-4241 (2003).
-
(2003)
J. Immunol
, vol.170
, pp. 4237-4241
-
-
Muraille, E.1
-
25
-
-
33749515463
-
Absence of innate MyD88 signaling promotes inducible allograft acceptance
-
Walker, W. E. et al. Absence of innate MyD88 signaling promotes inducible allograft acceptance. J. Immunol. 177, 5307-5316 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 5307-5316
-
-
Walker, W.E.1
-
26
-
-
14944375918
-
MyD88-dependent induction of allergic Th2 responses to intranasal antigen
-
Piggott, D. A. et al. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest. 115, 459-467 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 459-467
-
-
Piggott, D.A.1
-
27
-
-
0032127279
-
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
-
Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150 (1998).
-
(1998)
Immunity
, vol.9
, pp. 143-150
-
-
Adachi, O.1
-
28
-
-
0037454946
-
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
-
Burns, K. et al. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197, 263-268 (2003).
-
(2003)
J. Exp. Med
, vol.197
, pp. 263-268
-
-
Burns, K.1
-
29
-
-
0042236366
-
-
Janssens, S., Burns, K., Vercammen, E., Tschopp, J. & Beyaert, R. MyD88s, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression. FEBS Lett. 548, 103-107 (2003).
-
Janssens, S., Burns, K., Vercammen, E., Tschopp, J. & Beyaert, R. MyD88s, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression. FEBS Lett. 548, 103-107 (2003).
-
-
-
-
30
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
Kobayashi, K. et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191-202 (2002).
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
-
31
-
-
23144449789
-
Ubiquitin signalling in the NF-κB pathway
-
Chen, Z. J. Ubiquitin signalling in the NF-κB pathway. Nature Cell Biol. 7, 758-765 (2005).
-
(2005)
Nature Cell Biol
, vol.7
, pp. 758-765
-
-
Chen, Z.J.1
-
32
-
-
20644469429
-
CD14 is required for MyD88-independent LPS signaling
-
Jiang, Z. et al. CD14 is required for MyD88-independent LPS signaling. Nature Immunol. 6, 565-570 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 565-570
-
-
Jiang, Z.1
-
33
-
-
7444250116
-
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
-
Honda, K. et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl Acad. Sci. USA 101, 15416-15421 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 15416-15421
-
-
Honda, K.1
-
34
-
-
5444274514
-
-
Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nature Immunol. 5, 1061-1068 (2004). This paper expanded the function of MyD88 from activation of NF-κB to another transcription factor, IRF7. MyD88 was shown to occur in a complex with IRF7 and IRAK1.
-
Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nature Immunol. 5, 1061-1068 (2004). This paper expanded the function of MyD88 from activation of NF-κB to another transcription factor, IRF7. MyD88 was shown to occur in a complex with IRF7 and IRAK1.
-
-
-
-
35
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF7 signalling for robust type-I interferon induction
-
Honda, K. et al. Spatiotemporal regulation of MyD88-IRF7 signalling for robust type-I interferon induction. Nature 434, 1035-1040 (2005).
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
-
36
-
-
3843103508
-
Herpes simplex virus type-1 induces IFN-α production via Toll-like receptor 9-dependent and-independent pathways
-
Hochrein, H. et al. Herpes simplex virus type-1 induces IFN-α production via Toll-like receptor 9-dependent and-independent pathways. Proc. Natl Acad. Sci. USA 101, 11416-11421 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11416-11421
-
-
Hochrein, H.1
-
37
-
-
20244388983
-
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction
-
Uematsu, S. et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J. Exp. Med. 201, 915-923 (2005).
-
(2005)
J. Exp. Med
, vol.201
, pp. 915-923
-
-
Uematsu, S.1
-
38
-
-
15044345461
-
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
-
Takaoka, A. et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434, 243-249 (2005).
-
(2005)
Nature
, vol.434
, pp. 243-249
-
-
Takaoka, A.1
-
39
-
-
33750064259
-
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
-
Negishi, H. et al. Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc. Natl Acad. Sci. USA 103, 15136-15141 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 15136-15141
-
-
Negishi, H.1
-
40
-
-
33645101274
-
-
Sun, D. & Ding, A. MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA. Nature Immunol. 7, 375-381 (2006). A role for MyD88, independent of TLR signalling, is reported here. MyD88 is shown to be recruited by the IFNγ receptor to the plasma membrane, where it signals for chemokine production.
-
Sun, D. & Ding, A. MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA. Nature Immunol. 7, 375-381 (2006). A role for MyD88, independent of TLR signalling, is reported here. MyD88 is shown to be recruited by the IFNγ receptor to the plasma membrane, where it signals for chemokine production.
-
-
-
-
41
-
-
5044228305
-
Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation
-
Ma, Y. et al. Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation. Nature Immunol. 5, 380-387 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 380-387
-
-
Ma, Y.1
-
42
-
-
2942721674
-
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
-
Brint, E. K. et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nature Immunol. 5, 373-379 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 373-379
-
-
Brint, E.K.1
-
43
-
-
14044251499
-
Transforming growth factor-β differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide- induced TLR4 signaling
-
Naiki, Y. et al. Transforming growth factor-β differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide- induced TLR4 signaling. J. Biol. Chem. 280, 5491-5495 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 5491-5495
-
-
Naiki, Y.1
-
44
-
-
30544451546
-
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
-
Hacker, H. et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439, 204-207 (2006).
-
(2006)
Nature
, vol.439
, pp. 204-207
-
-
Hacker, H.1
-
45
-
-
30544447047
-
Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response
-
Oganesyan, G. et al. Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response. Nature 439, 208-211 (2006).
-
(2006)
Nature
, vol.439
, pp. 208-211
-
-
Oganesyan, G.1
-
46
-
-
24944586285
-
Achieving stability of lipopolysaccharide-induced NF-κB activation
-
Covert, M. W., Leung, T. H., Gaston, J. E. & Baltimore, D. Achieving stability of lipopolysaccharide-induced NF-κB activation. Science 309, 1854-1857 (2005).
-
(2005)
Science
, vol.309
, pp. 1854-1857
-
-
Covert, M.W.1
Leung, T.H.2
Gaston, J.E.3
Baltimore, D.4
-
47
-
-
24944489952
-
-
Werner, S. L., Barken, D. & Hoffmann, A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309, 1857-1861 (2005). References 46 and 47 report the modelling of NF-κB activation by LPS. Two waves of activation occur - an early wave activated by MyD88, and a later wave activated by TRIF, which is required for autocrine TNF production, leading to the later NF-κB activation. These two responses stabilize the activation process.
-
Werner, S. L., Barken, D. & Hoffmann, A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309, 1857-1861 (2005). References 46 and 47 report the modelling of NF-κB activation by LPS. Two waves of activation occur - an early wave activated by MyD88, and a later wave activated by TRIF, which is required for autocrine TNF production, leading to the later NF-κB activation. These two responses stabilize the activation process.
-
-
-
-
48
-
-
0034597766
-
-
Xu, Y. et al. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408, 111-115 (2000). This was the first report of a crystal structure for a TIR domain and as such paved the way for most of our current understanding about how TIR adaptors associate during signalling.
-
Xu, Y. et al. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408, 111-115 (2000). This was the first report of a crystal structure for a TIR domain and as such paved the way for most of our current understanding about how TIR adaptors associate during signalling.
-
-
-
-
49
-
-
16744364738
-
Structural complementarity of Toll/interleukin1 receptor identity regions in Toll-like receptors and the adaptors Mal and MyD88
-
Dunne, A., Ejdeback, M., Ludidi, P. L., O'Neill, L. A. J. & Gay, N. J. Structural complementarity of Toll/interleukin1 receptor identity regions in Toll-like receptors and the adaptors Mal and MyD88. J. Biol. Chem. 278, 41443-41451 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41443-41451
-
-
Dunne, A.1
Ejdeback, M.2
Ludidi, P.L.3
O'Neill, L.A.J.4
Gay, N.J.5
-
50
-
-
33749574498
-
Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling
-
Gautam, J. K., Ashish, Comeau, L. D., Krueger, J. K. & Smith, M. F. Jr. Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling. J. Biol. Chem. 281, 30132-30142 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 30132-30142
-
-
Gautam, J.1
Ashish, K.2
Comeau, L.D.3
Krueger, J.K.4
Smith Jr, M.F.5
-
51
-
-
21244503817
-
Differential involvement of BB loops of Toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction
-
Toshchakov, V. U., Basu, S., Fenton, M. J. & Vogel, S. N. Differential involvement of BB loops of Toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J Immunol 175, 494-500 (2005).
-
(2005)
J Immunol
, vol.175
, pp. 494-500
-
-
Toshchakov, V.U.1
Basu, S.2
Fenton, M.J.3
Vogel, S.N.4
-
52
-
-
0037596457
-
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
-
Bartfai, T. et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc. Natl Acad. Sci. USA 100, 7971-7976 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7971-7976
-
-
Bartfai, T.1
-
53
-
-
33746631265
-
-
Jiang, Z. et al. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc. Natl Acad. Sci. USA 103, 10961-10966 (2006). This paper reports how germ-line mutagenesis uncovered a mutant form of MyD88 that was unable to signal in response to all TLRs, with the exception of TLR2-TLR6 dimers, pointing to specificity in the structural requirements of MyD88 recruitment by TLRs.
-
Jiang, Z. et al. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc. Natl Acad. Sci. USA 103, 10961-10966 (2006). This paper reports how germ-line mutagenesis uncovered a mutant form of MyD88 that was unable to signal in response to all TLRs, with the exception of TLR2-TLR6 dimers, pointing to specificity in the structural requirements of MyD88 recruitment by TLRs.
-
-
-
-
54
-
-
0035555301
-
TIRAP: An adapter molecule in the Toll signaling pathway
-
Horng, T., Barton, G. M. & Medzhitov, R. TIRAP: An adapter molecule in the Toll signaling pathway. Nature Immunol. 2, 835-841 (2001).
-
(2001)
Nature Immunol
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
55
-
-
0035817925
-
Mal (myd88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald, K. A. et al. Mal (myd88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83 (2001).
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
-
56
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for toll-like receptors
-
Horng, T., Barton, G. M., Flavell, R. A. & Medzhitov, R. The adaptor molecule TIRAP provides signalling specificity for toll-like receptors. Nature 420, 329-333 (2002).
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
57
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
Yamamoto, M. et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420, 324-329 (2002).
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
-
58
-
-
33646908228
-
-
2-binding domain, which localizes MAL to membrane microdomains, where it acts to recruit MyD88 to the TLR4 signalling complex.
-
2-binding domain, which localizes MAL to membrane microdomains, where it acts to recruit MyD88 to the TLR4 signalling complex.
-
-
-
-
59
-
-
28244432857
-
Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli
-
Jeyaseelan, S. et al. Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J. Immunol. 175, 7484-7495 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 7484-7495
-
-
Jeyaseelan, S.1
-
60
-
-
33745316754
-
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa
-
Jeyaseelan, S. et al. Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa. J. Immunol. 177, 538-547 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 538-547
-
-
Jeyaseelan, S.1
-
61
-
-
33750291430
-
Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways
-
Togbe, D. et al. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab. Invest. 86, 1126-1135 (2006).
-
(2006)
Lab. Invest
, vol.86
, pp. 1126-1135
-
-
Togbe, D.1
-
62
-
-
33846204374
-
Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury
-
Sakata, Y. et al. Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 292, H503-H509 (2006).
-
(2006)
Am. J. Physiol. Heart Circ. Physiol
, vol.292
-
-
Sakata, Y.1
-
63
-
-
4444258208
-
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-κB activation by Toll-like receptor (TLR)-2 and TLR4
-
Mansell, A., Brint, E., Gould, J. A., O'Neill, L. A. & Hertzog, P. J. Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-κB activation by Toll-like receptor (TLR)-2 and TLR4. J. Biol. Chem. 279, 37227-37230 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 37227-37230
-
-
Mansell, A.1
Brint, E.2
Gould, J.A.3
O'Neill, L.A.4
Hertzog, P.J.5
-
64
-
-
0037492123
-
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4
-
Jefferies, C. A. et al. Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4. J. Biol. Chem. 278, 26258-26264 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 26258-26264
-
-
Jefferies, C.A.1
-
65
-
-
33846246989
-
Bruton's tyrosine kinase together with PI3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages
-
Liljeroos, M. et al. Bruton's tyrosine kinase together with PI3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages. Cell. Signal. 19, 625-633 (2006).
-
(2006)
Cell. Signal
, vol.19
, pp. 625-633
-
-
Liljeroos, M.1
-
66
-
-
33744543517
-
MyD88 adapter-like (MAL) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
-
Gray, P. et al. MyD88 adapter-like (MAL) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J. Biol. Chem. 281, 10489-10495 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10489-10495
-
-
Gray, P.1
-
67
-
-
21244503601
-
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide
-
Doyle, S. L., Jefferies, C. A. & O'Neill, L. A. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide. J. Biol. Chem. 280, 23496-23501 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23496-23501
-
-
Doyle, S.L.1
Jefferies, C.A.2
O'Neill, L.A.3
-
68
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating mal degradation
-
Mansell, A. et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating mal degradation. Nature Immunol. 7, 148-155 (2006).
-
(2006)
Nature Immunol
, vol.7
, pp. 148-155
-
-
Mansell, A.1
-
69
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa, R. et al. SOCS-1 participates in negative regulation of LPS responses. Immunity 17, 677-687 (2002).
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
-
70
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo, I. et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17, 583-591 (2002).
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
-
71
-
-
34247613349
-
Impaired Toll-like receptor 8-mediated IL-6 and TNF-α production in antigen presenting cells from patients with X-linked agammaglobulinaemia
-
7 November, doi:10.1182/blood- 2006-07-037960
-
Sochorova, K. et al. Impaired Toll-like receptor 8-mediated IL-6 and TNF-α production in antigen presenting cells from patients with X-linked agammaglobulinaemia. Blood, 7 November 2006 (doi:10.1182/blood- 2006-07-037960).
-
(2006)
Blood
-
-
Sochorova, K.1
-
72
-
-
33847672241
-
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
-
Miggin, S. M. et al. NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc. Natl Acad. Sci. USA 104, 3372-3377 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 3372-3377
-
-
Miggin, S.M.1
-
73
-
-
34047098731
-
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
-
25 February, doi:10.1038/ng
-
Khor, C. C. et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature Genet. 25 February 2007 (doi:10.1038/ng1976).
-
(1976)
Nature Genet
-
-
Khor, C.C.1
-
74
-
-
33749586453
-
A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
-
Hawn, T. R. et al. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. J. Infect. Dis. 194, 1127-1134 (2006).
-
(2006)
J. Infect. Dis
, vol.194
, pp. 1127-1134
-
-
Hawn, T.R.1
-
75
-
-
0037114185
-
Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling
-
Yamamoto, M. et al. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169, 6668-6672 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
-
76
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction
-
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nature Immunol. 4, 161-167 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
77
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway
-
Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301, 640-643 (2003).
-
(2003)
Science
, vol.301
, pp. 640-643
-
-
Yamamoto, M.1
-
78
-
-
13444257582
-
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β
-
Hirotani, T. et al. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β. Biochem. Biophys. Res. Commun. 328, 383-392 (2005).
-
(2005)
Biochem. Biophys. Res. Commun
, vol.328
, pp. 383-392
-
-
Hirotani, T.1
-
79
-
-
0042679529
-
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
-
Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743-748 (2003).
-
(2003)
Nature
, vol.424
, pp. 743-748
-
-
Hoebe, K.1
-
80
-
-
12144286763
-
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
-
Tabeta, K. et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl Acad. Sci. USA 101, 3516-3521 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3516-3521
-
-
Tabeta, K.1
-
81
-
-
0141959224
-
LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF
-
Fitzgerald, K. A. et al. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055 (2003).
-
(2003)
J. Exp. Med
, vol.198
, pp. 1043-1055
-
-
Fitzgerald, K.A.1
-
82
-
-
0347146027
-
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by TRIF-dependent and TRIF-independent pathways
-
Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by TRIF-dependent and TRIF-independent pathways. Nature Immunol. 4, 1223-1229 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 1223-1229
-
-
Hoebe, K.1
-
83
-
-
0141923690
-
Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and tank-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling
-
Sato, S. et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and tank-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171, 4304-4310 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 4304-4310
-
-
Sato, S.1
-
84
-
-
0345827590
-
IFN-regulatory factor 3-dependent gene expression is defective in TBK1-deficient mouse embryonic fibroblasts
-
McWhirter, S. M. et al. IFN-regulatory factor 3-dependent gene expression is defective in TBK1-deficient mouse embryonic fibroblasts. Proc. Natl Acad. Sci. USA 101, 233-238 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 233-238
-
-
McWhirter, S.M.1
-
85
-
-
10844219793
-
NF-κB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation
-
Sasai, M. et al. NF-κB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J. Immunol. 174, 27-30 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 27-30
-
-
Sasai, M.1
-
86
-
-
1542723466
-
Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β
-
Jiang, Z., Mak, T. W., Sen, G. & Li, X. Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β. Proc. Natl Acad. Sci. USA 101, 3533-3538 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3533-3538
-
-
Jiang, Z.1
Mak, T.W.2
Sen, G.3
Li, X.4
-
87
-
-
4344613405
-
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF)-dependent pathway in TLR signaling
-
Gohda, J., Matsumura, T. & Inoue, J.-i. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF)-dependent pathway in TLR signaling. J. Immunol. 173, 2913-2917 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 2913-2917
-
-
Gohda, J.1
Matsumura, T.2
Inoue, J.-I.3
-
88
-
-
2442642691
-
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
-
Meylan, E. et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nature Immunol. 5, 503-507 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 503-507
-
-
Meylan, E.1
-
89
-
-
27744561393
-
RIP1 mediates the TRIF-dependent Toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation
-
Cusson-Hermance, N., Khurana, S., Lee, T. H., Fitzgerald, K. A. & Kelliher, M. A. RIP1 mediates the TRIF-dependent Toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation. J. Biol. Chem. 280, 36560-36566 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 36560-36566
-
-
Cusson-Hermance, N.1
Khurana, S.2
Lee, T.H.3
Fitzgerald, K.A.4
Kelliher, M.A.5
-
90
-
-
0347065364
-
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-κB
-
Wietek, C., Miggin, S. M., Jefferies, C. A. & O'Neill, L. A. J. Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-κB. J. Biol. Chem. 278, 50923-50931 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 50923-50931
-
-
Wietek, C.1
Miggin, S.M.2
Jefferies, C.A.3
O'Neill, L.A.J.4
-
91
-
-
17144413785
-
Apoptosis induced by the Toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
-
Kaiser, W. J. & Offermann, M. K. Apoptosis induced by the Toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J. Immunol. 174, 4942-4952 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 4942-4952
-
-
Kaiser, W.J.1
Offermann, M.K.2
-
92
-
-
2442605662
-
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-κB activation and apoptosis pathways
-
Han, K.-J. et al. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-κB activation and apoptosis pathways. J. Biol. Chem. 279, 15652-15661 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 15652-15661
-
-
Han, K.-J.1
-
93
-
-
4344622049
-
Signaling of apoptosis through TLRs critically involves Toll/IL-1 receptor domain-containing adapter inducing IFN-β, but not MyD88, in bacteria-infected murine macrophages
-
Ruckdeschel, K. et al. Signaling of apoptosis through TLRs critically involves Toll/IL-1 receptor domain-containing adapter inducing IFN-β, but not MyD88, in bacteria-infected murine macrophages. J. Immunol. 173, 3320-3328 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 3320-3328
-
-
Ruckdeschel, K.1
-
94
-
-
23244465355
-
TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-β, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo
-
De Trez, C. et al. TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-β, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo. J. Immunol. 175, 839-846 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 839-846
-
-
De Trez, C.1
-
95
-
-
33748350079
-
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation
-
Kamon, H. et al. TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J. 25, 4108-4119 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 4108-4119
-
-
Kamon, H.1
-
96
-
-
30944431519
-
TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling
-
Su, X. et al. TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling. Eur. J. Immunol. 36, 199-206 (2006).
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 199-206
-
-
Su, X.1
-
97
-
-
5444223519
-
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
-
Boone, D. L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nature Immunol. 5, 1052-1060 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 1052-1060
-
-
Boone, D.L.1
-
98
-
-
28644433321
-
SIKE is an IKKε/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
-
Huang, J. et al. SIKE is an IKKε/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 24, 4018-4028 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 4018-4028
-
-
Huang, J.1
-
99
-
-
33744499683
-
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1
-
Saitoh, T. et al. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nature Immunol. 7, 598-605 (2006).
-
(2006)
Nature Immunol
, vol.7
, pp. 598-605
-
-
Saitoh, T.1
-
100
-
-
22544445221
-
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4
-
Aksoy, E. et al. Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4. Eur. J. Immunol. 35, 2200-2209 (2005).
-
(2005)
Eur. J. Immunol
, vol.35
, pp. 2200-2209
-
-
Aksoy, E.1
-
101
-
-
33845438110
-
SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
-
An, H. et al. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity 25, 919-928 (2006).
-
(2006)
Immunity
, vol.25
, pp. 919-928
-
-
An, H.1
-
102
-
-
17144366260
-
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
-
Stack, J. et al. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med. 201, 1007-1018 (2005).
-
(2005)
J. Exp. Med
, vol.201
, pp. 1007-1018
-
-
Stack, J.1
-
103
-
-
0037415598
-
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense
-
Harte, M. T. et al. The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J. Exp. Med. 197, 343-351 (2003).
-
(2003)
J. Exp. Med
, vol.197
, pp. 343-351
-
-
Harte, M.T.1
-
104
-
-
14544280209
-
Immune evasion by hepatitis C virus NS3/4a protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
-
Li, K. et al. Immune evasion by hepatitis C virus NS3/4a protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl Acad. Sci. USA 102, 2992-2997 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 2992-2997
-
-
Li, K.1
-
105
-
-
29144462494
-
From the cover: Hepatitis C virus protease N3/4a cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
-
Li, X.-D., Sun, L., Seth, R. B., Pineda, G. & Chen, Z. J. From the cover: Hepatitis C virus protease N3/4a cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc. Natl Acad. Sci. USA 102, 17717-17722 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 17717-17722
-
-
Li, X.-D.1
Sun, L.2
Seth, R.B.3
Pineda, G.4
Chen, Z.J.5
-
106
-
-
0242624622
-
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
-
Yamamoto, M. et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nature Immunol. 4, 1144-1150 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 1144-1150
-
-
Yamamoto, M.1
-
107
-
-
0345991221
-
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
-
Oshiumi, H. et al. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β. J. Biol. Chem. 278, 49751-49762 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 49751-49762
-
-
Oshiumi, H.1
-
108
-
-
33646567507
-
The myristoylation of TRIF-related adaptor molecule is essential for toll-like receptor 4 signal transduction
-
Rowe, D. C. et al. The myristoylation of TRIF-related adaptor molecule is essential for toll-like receptor 4 signal transduction. Proc. Natl Acad. Sci. USA 103, 6299-6304 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 6299-6304
-
-
Rowe, D.C.1
-
109
-
-
33745124663
-
-
McGettrick, A. F. et al. TRIF-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling. Proc. Natl Acad. Sci. USA 103, 9196-9201 (2006). This paper describes the targeting of TRAM by PKCε in TLR4 signalling. This process is required for LPS action, and TRAM may be the key target for PKCε in macrophages during activation with LPS.
-
McGettrick, A. F. et al. TRIF-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling. Proc. Natl Acad. Sci. USA 103, 9196-9201 (2006). This paper describes the targeting of TRAM by PKCε in TLR4 signalling. This process is required for LPS action, and TRAM may be the key target for PKCε in macrophages during activation with LPS.
-
-
-
-
110
-
-
0034746792
-
Protein kinase Cε is required for macrophage activation and defense against bacterial infection
-
Castrillo, A. et al. Protein kinase Cε is required for macrophage activation and defense against bacterial infection. J. Exp. Med. 194, 1231-1242 (2001).
-
(2001)
J. Exp. Med
, vol.194
, pp. 1231-1242
-
-
Castrillo, A.1
-
111
-
-
0035367786
-
A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to armadillo/β-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans
-
Mink, M., Fogelgren, B., Olszewski, K., Maroy, P. & Csiszar, K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to armadillo/β-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics 74, 234-244 (2001).
-
(2001)
Genomics
, vol.74
, pp. 234-244
-
-
Mink, M.1
Fogelgren, B.2
Olszewski, K.3
Maroy, P.4
Csiszar, K.5
-
112
-
-
0344196904
-
Sam domains: Uniform structure, diversity of function
-
Kim, C. A. & Bowie, J. U. Sam domains: Uniform structure, diversity of function. Trends Biochem. Sci. 28, 625-628 (2003).
-
(2003)
Trends Biochem. Sci
, vol.28
, pp. 625-628
-
-
Kim, C.A.1
Bowie, J.U.2
-
113
-
-
2442664007
-
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
-
Couillault, C. et al. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nature Immunol. 5, 488-494 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 488-494
-
-
Couillault, C.1
-
114
-
-
2342475724
-
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response
-
Liberati, N. T. et al. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc. Natl Acad. Sci. USA 101, 6593-6598 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 6593-6598
-
-
Liberati, N.T.1
-
115
-
-
12144283454
-
Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling
-
Chuang, C. F. & Bargmann, C. I. A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. Genes Dev. 19, 270-281 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 270-281
-
-
Chuang, C.F.1
Bargmann, C.I.A.2
|