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Volumn 1846, Issue 2, 2014, Pages 405-424

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

Author keywords

Chemoprevention; Cruciferous vegetables; Isothiocyanates; PEITC; Reactive oxygen species

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MICRORNA; PHENETHYL ISOTHIOCYANATE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TUMOR MARKER; ANTINEOPLASTIC AGENT; ISOTHIOCYANIC ACID DERIVATIVE;

EID: 84907692711     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2014.08.003     Document Type: Review
Times cited : (183)

References (216)
  • 1
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30years from 1981 to 2010
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30years from 1981 to 2010. J. Nat. Prod. 2012, 75:311-335.
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 34047136753 scopus 로고    scopus 로고
    • Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    • Higdon J.V., Delage B., Williams D.E., Dashwood R.H. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol. Res. 2007, 55:224-236.
    • (2007) Pharmacol. Res. , vol.55 , pp. 224-236
    • Higdon, J.V.1    Delage, B.2    Williams, D.E.3    Dashwood, R.H.4
  • 6
    • 0022296370 scopus 로고
    • Diet, nutrition, and cancer
    • Palmer S. Diet, nutrition, and cancer. Progr. Food Nutr. Sci. 1985, 9:283-341.
    • (1985) Progr. Food Nutr. Sci. , vol.9 , pp. 283-341
    • Palmer, S.1
  • 8
    • 70350714439 scopus 로고    scopus 로고
    • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China
    • Moy K.A., Yuan J.M., Chung F.L., Wang X.L., Van Den Berg D., Wang R., Gao Y.T., Yu M.C. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China. Int. J. Cancer 2009, 125:2652-2659.
    • (2009) Int. J. Cancer , vol.125 , pp. 2652-2659
    • Moy, K.A.1    Yuan, J.M.2    Chung, F.L.3    Wang, X.L.4    Van Den Berg, D.5    Wang, R.6    Gao, Y.T.7    Yu, M.C.8
  • 9
    • 70449671061 scopus 로고    scopus 로고
    • Dietary isothiocyanates, glutathione S-transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California
    • Carpenter C.L., Yu M.C., London S.J. Dietary isothiocyanates, glutathione S-transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California. Nutr. Cancer 2009, 61:492-499.
    • (2009) Nutr. Cancer , vol.61 , pp. 492-499
    • Carpenter, C.L.1    Yu, M.C.2    London, S.J.3
  • 10
    • 77955713807 scopus 로고    scopus 로고
    • Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New Caledonia
    • Truong T., Baron-Dubourdieu D., Rougier Y., Guenel P. Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New Caledonia. Cancer Causes Control 2010, 21:1183-1192.
    • (2010) Cancer Causes Control , vol.21 , pp. 1183-1192
    • Truong, T.1    Baron-Dubourdieu, D.2    Rougier, Y.3    Guenel, P.4
  • 12
    • 84875576152 scopus 로고    scopus 로고
    • Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies
    • Wu Q.J., Yang Y., Vogtmann E., Wang J., Han L.H., Li H.L., Xiang Y.B. Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies. Ann. Oncol. 2013, 24:1079-1087.
    • (2013) Ann. Oncol. , vol.24 , pp. 1079-1087
    • Wu, Q.J.1    Yang, Y.2    Vogtmann, E.3    Wang, J.4    Han, L.H.5    Li, H.L.6    Xiang, Y.B.7
  • 13
    • 84883744692 scopus 로고    scopus 로고
    • Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis
    • Wu Q.J., Xie L., Zheng W., Vogtmann E., Li H.L., Yang G., Ji B.T., Gao Y.T., Shu X.O., Xiang Y.B. Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis. Ann. Oncol. 2013, 24:1918-1924.
    • (2013) Ann. Oncol. , vol.24 , pp. 1918-1924
    • Wu, Q.J.1    Xie, L.2    Zheng, W.3    Vogtmann, E.4    Li, H.L.5    Yang, G.6    Ji, B.T.7    Gao, Y.T.8    Shu, X.O.9    Xiang, Y.B.10
  • 18
    • 0037137902 scopus 로고    scopus 로고
    • Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: evidence for a protective effect of soy in nonsmokers
    • Seow A., Poh W.T., Teh M., Eng P., Wang Y.T., Tan W.C., Chia K.S., Yu M.C., Lee H.P. Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: evidence for a protective effect of soy in nonsmokers. Int. J. Cancer 2002, 97:365-371.
    • (2002) Int. J. Cancer , vol.97 , pp. 365-371
    • Seow, A.1    Poh, W.T.2    Teh, M.3    Eng, P.4    Wang, Y.T.5    Tan, W.C.6    Chia, K.S.7    Yu, M.C.8    Lee, H.P.9
  • 21
    • 17844392872 scopus 로고    scopus 로고
    • Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population
    • Wang L.I., Giovannucci E.L., Hunter D., Neuberg D., Su L., Christiani D.C. Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population. Cancer Causes Control 2004, 15:977-985.
    • (2004) Cancer Causes Control , vol.15 , pp. 977-985
    • Wang, L.I.1    Giovannucci, E.L.2    Hunter, D.3    Neuberg, D.4    Su, L.5    Christiani, D.C.6
  • 22
    • 22244477451 scopus 로고    scopus 로고
    • Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers
    • Raghavan M., Knapp D.W., Bonney P.L., Dawson M.H., Glickman L.T. Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers. J. Am. Vet. Med. Assoc. 2005, 227:94-100.
    • (2005) J. Am. Vet. Med. Assoc. , vol.227 , pp. 94-100
    • Raghavan, M.1    Knapp, D.W.2    Bonney, P.L.3    Dawson, M.H.4    Glickman, L.T.5
  • 23
    • 34147101044 scopus 로고    scopus 로고
    • Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk
    • Zhao H., Lin J., Grossman H.B., Hernandez L.M., Dinney C.P., Wu X. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int. J. Cancer 2007, 120:2208-2213.
    • (2007) Int. J. Cancer , vol.120 , pp. 2208-2213
    • Zhao, H.1    Lin, J.2    Grossman, H.B.3    Hernandez, L.M.4    Dinney, C.P.5    Wu, X.6
  • 29
    • 0034928041 scopus 로고    scopus 로고
    • Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans
    • Shapiro T.A., Fahey J.W., Wade K.L., Stephenson K.K., Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomark. Prev. 2001, 10:501-508.
    • (2001) Cancer Epidemiol. Biomark. Prev. , vol.10 , pp. 501-508
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 30
    • 0032406798 scopus 로고    scopus 로고
    • Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
    • Shapiro T.A., Fahey J.W., Wade K.L., Stephenson K.K., Talalay P. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol. Biomark. Prev. 1998, 7:1091-1100.
    • (1998) Cancer Epidemiol. Biomark. Prev. , vol.7 , pp. 1091-1100
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 31
    • 0032948428 scopus 로고    scopus 로고
    • Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress
    • Getahun S.M., Chung F.L. Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol. Biomark. Prev. 1999, 8:447-451.
    • (1999) Cancer Epidemiol. Biomark. Prev. , vol.8 , pp. 447-451
    • Getahun, S.M.1    Chung, F.L.2
  • 32
    • 34147097587 scopus 로고    scopus 로고
    • Kinetics of the stability of broccoli (Brassica oleracea Cv. Italica) myrosinase and isothiocyanates in broccoli juice during pressure/temperature treatments
    • Van Eylen D., Oey I., Hendrickx M., Van Loey A. Kinetics of the stability of broccoli (Brassica oleracea Cv. Italica) myrosinase and isothiocyanates in broccoli juice during pressure/temperature treatments. J. Agric. Food Chem. 2007, 55:2163-2170.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 2163-2170
    • Van Eylen, D.1    Oey, I.2    Hendrickx, M.3    Van Loey, A.4
  • 33
    • 0026893696 scopus 로고
    • Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal
    • Chung F.L., Morse M.A., Eklind K.I., Lewis J. Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. Cancer Epidemiol. Biomark. Prev. 1992, 1:383-388.
    • (1992) Cancer Epidemiol. Biomark. Prev. , vol.1 , pp. 383-388
    • Chung, F.L.1    Morse, M.A.2    Eklind, K.I.3    Lewis, J.4
  • 35
    • 25144443075 scopus 로고    scopus 로고
    • Pharmacokinetics of dietary phenethyl isothiocyanate in rats
    • Ji Y., Kuo Y., Morris M.E. Pharmacokinetics of dietary phenethyl isothiocyanate in rats. Pharm. Res. 2005, 22:1658-1666.
    • (2005) Pharm. Res. , vol.22 , pp. 1658-1666
    • Ji, Y.1    Kuo, Y.2    Morris, M.E.3
  • 36
    • 77649281731 scopus 로고    scopus 로고
    • Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats
    • Konsue N., Kirkpatrick J., Kuhnert N., King L.J., Ioannides C. Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats. Mol. Nutr. Food Res. 2010, 54:426-432.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 426-432
    • Konsue, N.1    Kirkpatrick, J.2    Kuhnert, N.3    King, L.J.4    Ioannides, C.5
  • 37
    • 0242438136 scopus 로고    scopus 로고
    • Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry
    • Ji Y., Morris M.E. Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry. Anal. Biochem. 2003, 323:39-47.
    • (2003) Anal. Biochem. , vol.323 , pp. 39-47
    • Ji, Y.1    Morris, M.E.2
  • 38
    • 66749170767 scopus 로고    scopus 로고
    • Are isothiocyanates potential anti-cancer drugs?
    • Wu X., Zhou Q.H., Xu K. Are isothiocyanates potential anti-cancer drugs?. Acta Pharmacol. Sin. 2009, 30:501-512.
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 501-512
    • Wu, X.1    Zhou, Q.H.2    Xu, K.3
  • 39
    • 84903588171 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention
    • Morris M.E., Dave R.A. Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014, 16(4):705-713.
    • (2014) AAPS J. , vol.16 , Issue.4 , pp. 705-713
    • Morris, M.E.1    Dave, R.A.2
  • 40
    • 0031711928 scopus 로고    scopus 로고
    • Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes
    • Seow A., Shi C.Y., Chung F.L., Jiao D., Hankin J.H., Lee H.P., Coetzee G.A., Yu M.C. Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes. Cancer Epidemiol. Biomark. Prev. 1998, 7:775-781.
    • (1998) Cancer Epidemiol. Biomark. Prev. , vol.7 , pp. 775-781
    • Seow, A.1    Shi, C.Y.2    Chung, F.L.3    Jiao, D.4    Hankin, J.H.5    Lee, H.P.6    Coetzee, G.A.7    Yu, M.C.8
  • 41
    • 0034718294 scopus 로고    scopus 로고
    • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China
    • London S.J., Yuan J.M., Chung F.L., Gao Y.T., Coetzee G.A., Ross R.K., Yu M.C. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 2000, 356:724-729.
    • (2000) Lancet , vol.356 , pp. 724-729
    • London, S.J.1    Yuan, J.M.2    Chung, F.L.3    Gao, Y.T.4    Coetzee, G.A.5    Ross, R.K.6    Yu, M.C.7
  • 43
    • 0036949607 scopus 로고    scopus 로고
    • Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study
    • Seow A., Yuan J.M., Sun C.L., Van Den Berg D., Lee H.P., Yu M.C. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 2002, 23:2055-2061.
    • (2002) Carcinogenesis , vol.23 , pp. 2055-2061
    • Seow, A.1    Yuan, J.M.2    Sun, C.L.3    Van Den Berg, D.4    Lee, H.P.5    Yu, M.C.6
  • 44
    • 2442587889 scopus 로고    scopus 로고
    • Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
    • Ambrosone C.B., McCann S.E., Freudenheim J.L., Marshall J.R., Zhang Y., Shields P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J. Nutr. 2004, 134:1134-1138.
    • (2004) J. Nutr. , vol.134 , pp. 1134-1138
    • Ambrosone, C.B.1    McCann, S.E.2    Freudenheim, J.L.3    Marshall, J.R.4    Zhang, Y.5    Shields, P.G.6
  • 45
    • 34247139131 scopus 로고    scopus 로고
    • GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans
    • Steck S.E., Gammon M.D., Hebert J.R., Wall D.E., Zeisel S.H. GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. J. Nutr. 2007, 137:904-909.
    • (2007) J. Nutr. , vol.137 , pp. 904-909
    • Steck, S.E.1    Gammon, M.D.2    Hebert, J.R.3    Wall, D.E.4    Zeisel, S.H.5
  • 49
    • 68949191152 scopus 로고    scopus 로고
    • Absorption of bioactive compounds from steamed broccoli and their effect on plasma glutathione S-transferase activity
    • Riso P., Brusamolino A., Moro M., Porrini M. Absorption of bioactive compounds from steamed broccoli and their effect on plasma glutathione S-transferase activity. Int. J. Food Sci. Nutr. 2009, 60(Suppl. 1):56-71.
    • (2009) Int. J. Food Sci. Nutr. , vol.60 , pp. 56-71
    • Riso, P.1    Brusamolino, A.2    Moro, M.3    Porrini, M.4
  • 51
    • 78649825400 scopus 로고    scopus 로고
    • Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juice
    • Dyba M., Wang A., Noone A.M., Goerlitz D., Shields P., Zheng Y.L., Rivlin R., Chung F.L. Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juice. Clin. Nutr. 2010, 29:813-818.
    • (2010) Clin. Nutr. , vol.29 , pp. 813-818
    • Dyba, M.1    Wang, A.2    Noone, A.M.3    Goerlitz, D.4    Shields, P.5    Zheng, Y.L.6    Rivlin, R.7    Chung, F.L.8
  • 52
    • 0023832341 scopus 로고
    • Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene
    • Vos R.M., Snoek M.C., van Berkel W.J., Muller F., van Bladeren P.J. Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene. Biochem. Pharmacol. 1988, 37:1077-1082.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 1077-1082
    • Vos, R.M.1    Snoek, M.C.2    van Berkel, W.J.3    Muller, F.4    van Bladeren, P.J.5
  • 53
    • 0024853911 scopus 로고
    • Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3',5'-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates
    • Hara A., Sakai N., Yamada H., Tanaka T., Kato K., Mori H., Sato K. Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3',5'-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanates. Acta Neuropathol. 1989, 79:144-148.
    • (1989) Acta Neuropathol. , vol.79 , pp. 144-148
    • Hara, A.1    Sakai, N.2    Yamada, H.3    Tanaka, T.4    Kato, K.5    Mori, H.6    Sato, K.7
  • 54
    • 0027327820 scopus 로고
    • Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats
    • Sugie S., Okumura A., Tanaka T., Mori H. Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats. Jpn. J. Cancer Res. 1993, 84:865-870.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 865-870
    • Sugie, S.1    Okumura, A.2    Tanaka, T.3    Mori, H.4
  • 55
    • 0028892567 scopus 로고
    • Isothiocyanates as substrates for human glutathione transferases: structure-activity studies
    • Kolm R.H., Danielson U.H., Zhang Y., Talalay P., Mannervik B. Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem. J. 1995, 311(Pt 2):453-459.
    • (1995) Biochem. J. , vol.311 , pp. 453-459
    • Kolm, R.H.1    Danielson, U.H.2    Zhang, Y.3    Talalay, P.4    Mannervik, B.5
  • 56
    • 0028919911 scopus 로고
    • Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanates
    • Meyer D.J., Crease D.J., Ketterer B. Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanates. Biochem. J. 1995, 306(Pt 2):565-569.
    • (1995) Biochem. J. , vol.306 , pp. 565-569
    • Meyer, D.J.1    Crease, D.J.2    Ketterer, B.3
  • 57
    • 0029901681 scopus 로고    scopus 로고
    • Effect of oltipraz, alpha-tocopherol, beta-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase
    • van Lieshout E.M., Peters W.H., Jansen J.B. Effect of oltipraz, alpha-tocopherol, beta-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase. Carcinogenesis 1996, 17:1439-1445.
    • (1996) Carcinogenesis , vol.17 , pp. 1439-1445
    • van Lieshout, E.M.1    Peters, W.H.2    Jansen, J.B.3
  • 58
    • 0032503571 scopus 로고    scopus 로고
    • Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model
    • Ogawa K., Futakuchi M., Hirose M., Boonyaphiphat P., Mizoguchi Y., Miki T., Shirai T. Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model. Int. J. Cancer 1998, 76:851-856.
    • (1998) Int. J. Cancer , vol.76 , pp. 851-856
    • Ogawa, K.1    Futakuchi, M.2    Hirose, M.3    Boonyaphiphat, P.4    Mizoguchi, Y.5    Miki, T.6    Shirai, T.7
  • 59
    • 0034285150 scopus 로고    scopus 로고
    • A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates
    • Nakamura Y., Morimitsu Y., Uzu T., Ohigashi H., Murakami A., Naito Y., Nakagawa Y., Osawa T., Uchida K. A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates. Cancer Lett. 2000, 157:193-200.
    • (2000) Cancer Lett. , vol.157 , pp. 193-200
    • Nakamura, Y.1    Morimitsu, Y.2    Uzu, T.3    Ohigashi, H.4    Murakami, A.5    Naito, Y.6    Nakagawa, Y.7    Osawa, T.8    Uchida, K.9
  • 60
    • 9744283511 scopus 로고    scopus 로고
    • Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    • McWalter G.K., Higgins L.G., McLellan L.I., Henderson C.J., Song L., Thornalley P.J., Itoh K., Yamamoto M., Hayes J.D. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J. Nutr. 2004, 134:3499S-3506S.
    • (2004) J. Nutr. , vol.134 , pp. 3499S-3506S
    • McWalter, G.K.1    Higgins, L.G.2    McLellan, L.I.3    Henderson, C.J.4    Song, L.5    Thornalley, P.J.6    Itoh, K.7    Yamamoto, M.8    Hayes, J.D.9
  • 61
    • 70449526203 scopus 로고    scopus 로고
    • Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells
    • Hofmann T., Kuhnert A., Schubert A., Gill C., Rowland I.R., Pool-Zobel B.L., Glei M. Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells. Eur. J. Nutr. 2009, 48:483-491.
    • (2009) Eur. J. Nutr. , vol.48 , pp. 483-491
    • Hofmann, T.1    Kuhnert, A.2    Schubert, A.3    Gill, C.4    Rowland, I.R.5    Pool-Zobel, B.L.6    Glei, M.7
  • 62
    • 79953182004 scopus 로고    scopus 로고
    • Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity
    • Sharma R., Ellis B., Sharma A. Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity. Phytother. Res. 2011, 25:563-568.
    • (2011) Phytother. Res. , vol.25 , pp. 563-568
    • Sharma, R.1    Ellis, B.2    Sharma, A.3
  • 63
    • 79955808888 scopus 로고    scopus 로고
    • Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate
    • Krajka-Kuzniak V., Szaefer H., Bartoszek A., Baer-Dubowska W. Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate. Br. J. Nutr. 2011, 105:816-826.
    • (2011) Br. J. Nutr. , vol.105 , pp. 816-826
    • Krajka-Kuzniak, V.1    Szaefer, H.2    Bartoszek, A.3    Baer-Dubowska, W.4
  • 64
    • 33646087882 scopus 로고    scopus 로고
    • The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
    • Tang L., Li G., Song L., Zhang Y. The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anti-Cancer Drugs 2006, 17:297-305.
    • (2006) Anti-Cancer Drugs , vol.17 , pp. 297-305
    • Tang, L.1    Li, G.2    Song, L.3    Zhang, Y.4
  • 65
    • 17644382339 scopus 로고    scopus 로고
    • Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport
    • Ji Y., Morris M.E. Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport. Pharm. Res. 2004, 21:2261-2269.
    • (2004) Pharm. Res. , vol.21 , pp. 2261-2269
    • Ji, Y.1    Morris, M.E.2
  • 66
    • 27144442001 scopus 로고    scopus 로고
    • Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein)
    • Ji Y., Morris M.E. Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein). Mol. Pharm. 2005, 2:414-419.
    • (2005) Mol. Pharm. , vol.2 , pp. 414-419
    • Ji, Y.1    Morris, M.E.2
  • 67
    • 4344649449 scopus 로고    scopus 로고
    • Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest
    • Chiao J.W., Wu H., Ramaswamy G., Conaway C.C., Chung F.L., Wang L., Liu D. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis 2004, 25:1403-1408.
    • (2004) Carcinogenesis , vol.25 , pp. 1403-1408
    • Chiao, J.W.1    Wu, H.2    Ramaswamy, G.3    Conaway, C.C.4    Chung, F.L.5    Wang, L.6    Liu, D.7
  • 68
    • 0034932451 scopus 로고    scopus 로고
    • Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate
    • Nakajima M., Yoshida R., Shimada N., Yamazaki H., Yokoi T. Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate. Drug Metab. Dispos. 2001, 29:1110-1113.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1110-1113
    • Nakajima, M.1    Yoshida, R.2    Shimada, N.3    Yamazaki, H.4    Yokoi, T.5
  • 69
    • 0032735407 scopus 로고    scopus 로고
    • Effects of watercress consumption on urinary metabolites of nicotine in smokers
    • Hecht S.S., Carmella S.G., Murphy S.E. Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol. Biomark. Prev. 1999, 8:907-913.
    • (1999) Cancer Epidemiol. Biomark. Prev. , vol.8 , pp. 907-913
    • Hecht, S.S.1    Carmella, S.G.2    Murphy, S.E.3
  • 70
    • 0034729280 scopus 로고    scopus 로고
    • Potentiation of benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis in mice by d,l-buthionine-S, R-sulfoximine-mediated tissue glutathione depletion
    • Srivastava S.K., Xia H., Pal A., Hu X., Guo J., Singh S.V. Potentiation of benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis in mice by d,l-buthionine-S, R-sulfoximine-mediated tissue glutathione depletion. Cancer Lett. 2000, 153:35-39.
    • (2000) Cancer Lett. , vol.153 , pp. 35-39
    • Srivastava, S.K.1    Xia, H.2    Pal, A.3    Hu, X.4    Guo, J.5    Singh, S.V.6
  • 71
    • 0036191958 scopus 로고    scopus 로고
    • Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage
    • Srivastava S.K., Watkins S.C., Schuetz E., Singh S.V. Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage. Mol. Carcinog. 2002, 33:156-162.
    • (2002) Mol. Carcinog. , vol.33 , pp. 156-162
    • Srivastava, S.K.1    Watkins, S.C.2    Schuetz, E.3    Singh, S.V.4
  • 72
    • 72749104168 scopus 로고    scopus 로고
    • Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes
    • Navarro S.L., Chang J.L., Peterson S., Chen C., King I.B., Schwarz Y., Li S.S., Li L., Potter J.D., Lampe J.W. Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes. Cancer Epidemiol. Biomark. Prev. 2009, 18:2974-2978.
    • (2009) Cancer Epidemiol. Biomark. Prev. , vol.18 , pp. 2974-2978
    • Navarro, S.L.1    Chang, J.L.2    Peterson, S.3    Chen, C.4    King, I.B.5    Schwarz, Y.6    Li, S.S.7    Li, L.8    Potter, J.D.9    Lampe, J.W.10
  • 73
    • 84889055531 scopus 로고    scopus 로고
    • Differential hepatic GSTA2 expression of arylalkyl isothiocyanates in vivo and in vitro: the molecular mechanism of gene induction by phenethyl isothiocyanate
    • Gum S.I., Cho M.K. Differential hepatic GSTA2 expression of arylalkyl isothiocyanates in vivo and in vitro: the molecular mechanism of gene induction by phenethyl isothiocyanate. Mol. Nutr. Food Res. 2013, 57:2223-2232.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 2223-2232
    • Gum, S.I.1    Cho, M.K.2
  • 75
    • 0035527472 scopus 로고    scopus 로고
    • Cruciferous vegetables and cancer prevention
    • Murillo G., Mehta R.G. Cruciferous vegetables and cancer prevention. Nutr. Cancer 2001, 41:17-28.
    • (2001) Nutr. Cancer , vol.41 , pp. 17-28
    • Murillo, G.1    Mehta, R.G.2
  • 76
    • 0034538640 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by isothiocyanates
    • Hecht S.S. Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev. 2000, 32:395-411.
    • (2000) Drug Metab. Rev. , vol.32 , pp. 395-411
    • Hecht, S.S.1
  • 77
    • 0037972262 scopus 로고    scopus 로고
    • Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis
    • Xiao D., Srivastava S.K., Lew K.L., Zeng Y., Hershberger P., Johnson C.S., Trump D.L., Singh S.V. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis. Carcinogenesis 2003, 24:891-897.
    • (2003) Carcinogenesis , vol.24 , pp. 891-897
    • Xiao, D.1    Srivastava, S.K.2    Lew, K.L.3    Zeng, Y.4    Hershberger, P.5    Johnson, C.S.6    Trump, D.L.7    Singh, S.V.8
  • 78
    • 0035170990 scopus 로고    scopus 로고
    • Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism
    • Talalay P., Fahey J.W. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J. Nutr. 2001, 131:3027S-3033S.
    • (2001) J. Nutr. , vol.131 , pp. 3027S-3033S
    • Talalay, P.1    Fahey, J.W.2
  • 79
    • 79953293746 scopus 로고    scopus 로고
    • Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway
    • Boreddy S.R., Pramanik K.C., Srivastava S.K. Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin. Cancer Res. 2011, 17:1784-1795.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1784-1795
    • Boreddy, S.R.1    Pramanik, K.C.2    Srivastava, S.K.3
  • 80
    • 59749104966 scopus 로고    scopus 로고
    • The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate
    • Sahu R.P., Srivastava S.K. The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl. Cancer Inst. 2009, 101:176-193.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 176-193
    • Sahu, R.P.1    Srivastava, S.K.2
  • 81
    • 84865217843 scopus 로고    scopus 로고
    • Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo
    • Kandala P.K., Srivastava S.K. Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo. J. Biol. Chem. 2012, 287:28745-28754.
    • (2012) J. Biol. Chem. , vol.287 , pp. 28745-28754
    • Kandala, P.K.1    Srivastava, S.K.2
  • 82
    • 0024360557 scopus 로고
    • Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
    • Morse M.A., Amin S.G., Hecht S.S., Chung F.L. Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Cancer Res. 1989, 49:2894-2897.
    • (1989) Cancer Res. , vol.49 , pp. 2894-2897
    • Morse, M.A.1    Amin, S.G.2    Hecht, S.S.3    Chung, F.L.4
  • 83
    • 0017328782 scopus 로고
    • Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds
    • Wattenberg L.W. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J. Natl. Cancer Inst. 1977, 58:395-398.
    • (1977) J. Natl. Cancer Inst. , vol.58 , pp. 395-398
    • Wattenberg, L.W.1
  • 84
    • 0027205325 scopus 로고
    • The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lung
    • Adam-Rodwell G., Morse M.A., Stoner G.D. The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lung. Cancer Lett. 1993, 71:35-42.
    • (1993) Cancer Lett. , vol.71 , pp. 35-42
    • Adam-Rodwell, G.1    Morse, M.A.2    Stoner, G.D.3
  • 85
    • 84874724917 scopus 로고    scopus 로고
    • Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in an N-methyl nitrosourea-induced breast cancer animal model
    • Aras U., Gandhi Y.A., Masso-Welch P.A., Morris M.E. Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in an N-methyl nitrosourea-induced breast cancer animal model. Biopharm. Drug Dispos. 2013, 34:98-106.
    • (2013) Biopharm. Drug Dispos. , vol.34 , pp. 98-106
    • Aras, U.1    Gandhi, Y.A.2    Masso-Welch, P.A.3    Morris, M.E.4
  • 87
    • 52449134789 scopus 로고    scopus 로고
    • Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications
    • Fimognari C., Lenzi M., Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr. Drug Metab. 2008, 9:668-678.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 668-678
    • Fimognari, C.1    Lenzi, M.2    Hrelia, P.3
  • 89
    • 84875849252 scopus 로고    scopus 로고
    • The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation
    • Yoshigae Y., Sridar C., Kent U.M., Hollenberg P.F. The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation. Drug Metab. Dispos. 2013, 41:858-869.
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 858-869
    • Yoshigae, Y.1    Sridar, C.2    Kent, U.M.3    Hollenberg, P.F.4
  • 90
    • 77955079408 scopus 로고    scopus 로고
    • Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression
    • Gross-Steinmeyer K., Stapleton P.L., Tracy J.H., Bammler T.K., Strom S.C., Eaton D.L. Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol. Sci. 2010, 116:422-432.
    • (2010) Toxicol. Sci. , vol.116 , pp. 422-432
    • Gross-Steinmeyer, K.1    Stapleton, P.L.2    Tracy, J.H.3    Bammler, T.K.4    Strom, S.C.5    Eaton, D.L.6
  • 91
    • 3042692972 scopus 로고    scopus 로고
    • Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3
    • Morris C.R., Chen S.C., Zhou L., Schopfer L.M., Ding X., Mirvish S.S. Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3. Nutr. Cancer 2004, 48:54-63.
    • (2004) Nutr. Cancer , vol.48 , pp. 54-63
    • Morris, C.R.1    Chen, S.C.2    Zhou, L.3    Schopfer, L.M.4    Ding, X.5    Mirvish, S.S.6
  • 92
    • 77449106593 scopus 로고    scopus 로고
    • Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    • Cheung K.L., Kong A.N. Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 2010, 12:87-97.
    • (2010) AAPS J. , vol.12 , pp. 87-97
    • Cheung, K.L.1    Kong, A.N.2
  • 93
    • 79959751713 scopus 로고    scopus 로고
    • Pharmacodynamics of dietary phytochemical indoles I3C and DIM: induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates
    • Saw C.L., Cintron M., Wu T.Y., Guo Y., Huang Y., Jeong W.S., Kong A.N. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm. Drug Dispos. 2011, 32:289-300.
    • (2011) Biopharm. Drug Dispos. , vol.32 , pp. 289-300
    • Saw, C.L.1    Cintron, M.2    Wu, T.Y.3    Guo, Y.4    Huang, Y.5    Jeong, W.S.6    Kong, A.N.7
  • 94
    • 79952196644 scopus 로고    scopus 로고
    • Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate
    • Konsue N., Ioannides C. Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate. Mol. Nutr. Food Res. 2010, 54:1477-1485.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1477-1485
    • Konsue, N.1    Ioannides, C.2
  • 95
    • 55949121573 scopus 로고    scopus 로고
    • Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate
    • Konsue N., Ioannides C. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate. Food Chem. Toxicol. 2008, 46:3677-3683.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 3677-3683
    • Konsue, N.1    Ioannides, C.2
  • 96
    • 33745265207 scopus 로고    scopus 로고
    • Reactive oxygen species: role in the development of cancer and various chronic conditions
    • Waris G., Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J. Carcinog. 2006, 5:14.
    • (2006) J. Carcinog. , vol.5 , pp. 14
    • Waris, G.1    Ahsan, H.2
  • 97
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 98
    • 0029953164 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1
    • Yu R., Jiao J.J., Duh J.L., Tan T.H., Kong A.N. Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1. Cancer Res. 1996, 56:2954-2959.
    • (1996) Cancer Res. , vol.56 , pp. 2954-2959
    • Yu, R.1    Jiao, J.J.2    Duh, J.L.3    Tan, T.H.4    Kong, A.N.5
  • 99
    • 0032007312 scopus 로고    scopus 로고
    • Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity
    • Yu R., Mandlekar S., Harvey K.J., Ucker D.S., Kong A.N. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998, 58:402-408.
    • (1998) Cancer Res. , vol.58 , pp. 402-408
    • Yu, R.1    Mandlekar, S.2    Harvey, K.J.3    Ucker, D.S.4    Kong, A.N.5
  • 100
    • 0032530999 scopus 로고    scopus 로고
    • Essential role of p53 in phenethyl isothiocyanate-induced apoptosis
    • Huang C., Ma W.Y., Li J., Hecht S.S., Dong Z. Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res. 1998, 58:4102-4106.
    • (1998) Cancer Res. , vol.58 , pp. 4102-4106
    • Huang, C.1    Ma, W.Y.2    Li, J.3    Hecht, S.S.4    Dong, Z.5
  • 101
    • 0027273265 scopus 로고
    • Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice
    • Guo Z., Smith T.J., Wang E., Eklind K.I., Chung F.L., Yang C.S. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis 1993, 14:1167-1173.
    • (1993) Carcinogenesis , vol.14 , pp. 1167-1173
    • Guo, Z.1    Smith, T.J.2    Wang, E.3    Eklind, K.I.4    Chung, F.L.5    Yang, C.S.6
  • 102
    • 84867888901 scopus 로고    scopus 로고
    • Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models
    • Gupta P., Srivastava S.K. Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Med. 2012, 10:80.
    • (2012) BMC Med. , vol.10 , pp. 80
    • Gupta, P.1    Srivastava, S.K.2
  • 103
    • 4444231754 scopus 로고    scopus 로고
    • Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines
    • Tseng E., Scott-Ramsay E.A., Morris M.E. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp. Biol. Med. 2004, 229:835-842.
    • (2004) Exp. Biol. Med. , vol.229 , pp. 835-842
    • Tseng, E.1    Scott-Ramsay, E.A.2    Morris, M.E.3
  • 104
    • 5144235166 scopus 로고    scopus 로고
    • Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms
    • Keum Y.S., Jeong W.S., Kong A.N. Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms. Mutat. Res. 2004, 555:191-202.
    • (2004) Mutat. Res. , vol.555 , pp. 191-202
    • Keum, Y.S.1    Jeong, W.S.2    Kong, A.N.3
  • 105
    • 0031892793 scopus 로고    scopus 로고
    • Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
    • Chen Y.R., Wang W., Kong A.N., Tan T.H. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem. 1998, 273:1769-1775.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1769-1775
    • Chen, Y.R.1    Wang, W.2    Kong, A.N.3    Tan, T.H.4
  • 106
    • 0036142924 scopus 로고    scopus 로고
    • Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis
    • Yang Y.M., Conaway C.C., Chiao J.W., Wang C.X., Amin S., Whysner J., Dai W., Reinhardt J., Chung F.L. Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. Cancer Res. 2002, 62:2-7.
    • (2002) Cancer Res. , vol.62 , pp. 2-7
    • Yang, Y.M.1    Conaway, C.C.2    Chiao, J.W.3    Wang, C.X.4    Amin, S.5    Whysner, J.6    Dai, W.7    Reinhardt, J.8    Chung, F.L.9
  • 108
    • 0032532317 scopus 로고    scopus 로고
    • Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes
    • Zhang Y., Talalay P. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. Cancer Res. 1998, 58:4632-4639.
    • (1998) Cancer Res. , vol.58 , pp. 4632-4639
    • Zhang, Y.1    Talalay, P.2
  • 109
    • 78049262629 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells
    • Lai K.C., Hsu S.C., Kuo C.L., Ip S.W., Yang J.S., Hsu Y.M., Huang H.Y., Wu S.H., Chung J.G. Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells. J. Agric. Food Chem. 2010, 58(20):11148-11155.
    • (2010) J. Agric. Food Chem. , vol.58 , Issue.20 , pp. 11148-11155
    • Lai, K.C.1    Hsu, S.C.2    Kuo, C.L.3    Ip, S.W.4    Yang, J.S.5    Hsu, Y.M.6    Huang, H.Y.7    Wu, S.H.8    Chung, J.G.9
  • 110
    • 77953186750 scopus 로고    scopus 로고
    • Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells
    • Wu X., Zhu Y., Yan H., Liu B., Li Y., Zhou Q., Xu K. Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells. BMC Cancer 2010, 10:269.
    • (2010) BMC Cancer , vol.10 , pp. 269
    • Wu, X.1    Zhu, Y.2    Yan, H.3    Liu, B.4    Li, Y.5    Zhou, Q.6    Xu, K.7
  • 111
    • 33751116940 scopus 로고    scopus 로고
    • Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells
    • Hwang E.S., Lee H.J. Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells. J. Nutr. Biochem. 2006, 17:837-846.
    • (2006) J. Nutr. Biochem. , vol.17 , pp. 837-846
    • Hwang, E.S.1    Lee, H.J.2
  • 112
  • 113
    • 33947244444 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo
    • Xiao D., Singh S.V. Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo. Cancer Res. 2007, 67:2239-2246.
    • (2007) Cancer Res. , vol.67 , pp. 2239-2246
    • Xiao, D.1    Singh, S.V.2
  • 115
    • 0028838588 scopus 로고
    • K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate
    • Matzinger S.A., Crist K.A., Stoner G.D., Anderson M.W., Pereira M.A., Steele V.E., Kelloff G.J., Lubet R.A., You M. K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate. Carcinogenesis 1995, 16:2487-2492.
    • (1995) Carcinogenesis , vol.16 , pp. 2487-2492
    • Matzinger, S.A.1    Crist, K.A.2    Stoner, G.D.3    Anderson, M.W.4    Pereira, M.A.5    Steele, V.E.6    Kelloff, G.J.7    Lubet, R.A.8    You, M.9
  • 116
    • 79959982112 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways
    • Gao N., Budhraja A., Cheng S., Liu E.H., Chen J., Yang Z., Chen D., Zhang Z., Shi X. Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. Cell Death Dis. 2011, 2:e140.
    • (2011) Cell Death Dis. , vol.2 , pp. e140
    • Gao, N.1    Budhraja, A.2    Cheng, S.3    Liu, E.H.4    Chen, J.5    Yang, Z.6    Chen, D.7    Zhang, Z.8    Shi, X.9
  • 117
    • 84865419430 scopus 로고    scopus 로고
    • Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model
    • Loganathan S., Kandala P.K., Gupta P., Srivastava S.K. Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model. PLoS One 2012, 7:e43577.
    • (2012) PLoS One , vol.7 , pp. e43577
    • Loganathan, S.1    Kandala, P.K.2    Gupta, P.3    Srivastava, S.K.4
  • 118
    • 77957059129 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages
    • Okubo T., Washida K., Murakami A. Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages. Mol. Nutr. Food Res. 2010, 54:1351-1360.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1351-1360
    • Okubo, T.1    Washida, K.2    Murakami, A.3
  • 119
    • 84879533925 scopus 로고    scopus 로고
    • Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel in vivo metastasis model
    • Gupta P., Adkins C., Lockman P., Srivastava S.K. Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel in vivo metastasis model. PLoS One 2013, 8.
    • (2013) PLoS One , vol.8
    • Gupta, P.1    Adkins, C.2    Lockman, P.3    Srivastava, S.K.4
  • 120
    • 34249695312 scopus 로고    scopus 로고
    • Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation
    • Beklemisheva A.A., Feng J., Yeh Y.A., Wang L.G., Chiao J.W. Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation. Prostate 2007, 67:863-870.
    • (2007) Prostate , vol.67 , pp. 863-870
    • Beklemisheva, A.A.1    Feng, J.2    Yeh, Y.A.3    Wang, L.G.4    Chiao, J.W.5
  • 121
    • 84864943298 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate (PEITC) inhibits the growth of human oral squamous carcinoma HSC-3 cells through G(0)/G(1) phase arrest and mitochondria-mediated apoptotic cell death
    • Chen P.Y., Lin K.C., Lin J.P., Tang N.Y., Yang J.S., Lu K.W., Chung J.G. Phenethyl isothiocyanate (PEITC) inhibits the growth of human oral squamous carcinoma HSC-3 cells through G(0)/G(1) phase arrest and mitochondria-mediated apoptotic cell death. Evid. Based Complement. Alternat. Med. 2012, 2012:718320.
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012 , pp. 718320
    • Chen, P.Y.1    Lin, K.C.2    Lin, J.P.3    Tang, N.Y.4    Yang, J.S.5    Lu, K.W.6    Chung, J.G.7
  • 123
    • 78349272434 scopus 로고    scopus 로고
    • Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells
    • (2011, pii: 462525)
    • Moon Y.J., Brazeau D.A., Morris M.E. Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells. Evid. Based Complement. Alternat. Med. 2011, (2011, pii: 462525).
    • (2011) Evid. Based Complement. Alternat. Med.
    • Moon, Y.J.1    Brazeau, D.A.2    Morris, M.E.3
  • 124
    • 79958158211 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells
    • Tang N.Y., Huang Y.T., Yu C.S., Ko Y.C., Wu S.H., Ji B.C., Yang J.S., Yang J.L., Hsia T.C., Chen Y.Y., Chung J.G. Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells. Anticancer Res. 2011, 31:1691-1702.
    • (2011) Anticancer Res. , vol.31 , pp. 1691-1702
    • Tang, N.Y.1    Huang, Y.T.2    Yu, C.S.3    Ko, Y.C.4    Wu, S.H.5    Ji, B.C.6    Yang, J.S.7    Yang, J.L.8    Hsia, T.C.9    Chen, Y.Y.10    Chung, J.G.11
  • 125
    • 79958859670 scopus 로고    scopus 로고
    • Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells
    • Wu C.L., Huang A.C., Yang J.S., Liao C.L., Lu H.F., Chou S.T., Ma C.Y., Hsia T.C., Ko Y.C., Chung J.G. Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells. J. Orthop. Res. 2011, 29:1199-1209.
    • (2011) J. Orthop. Res. , vol.29 , pp. 1199-1209
    • Wu, C.L.1    Huang, A.C.2    Yang, J.S.3    Liao, C.L.4    Lu, H.F.5    Chou, S.T.6    Ma, C.Y.7    Hsia, T.C.8    Ko, Y.C.9    Chung, J.G.10
  • 127
    • 79251567380 scopus 로고    scopus 로고
    • Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells
    • Mi L., Gan N., Chung F.L. Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. Carcinogenesis 2011, 32:216-223.
    • (2011) Carcinogenesis , vol.32 , pp. 216-223
    • Mi, L.1    Gan, N.2    Chung, F.L.3
  • 129
    • 77149141425 scopus 로고    scopus 로고
    • Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis
    • Mukherjee S., Bhattacharya R.K., Roy M. Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis. J. Environ. Pathol. Toxicol. Oncol. 2009, 28:269-282.
    • (2009) J. Environ. Pathol. Toxicol. Oncol. , vol.28 , pp. 269-282
    • Mukherjee, S.1    Bhattacharya, R.K.2    Roy, M.3
  • 130
    • 73349137931 scopus 로고    scopus 로고
    • Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells
    • Mukherjee S., Dey S., Bhattacharya R.K., Roy M. Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells. Mol. Cell. Biochem. 2009, 330:9-22.
    • (2009) Mol. Cell. Biochem. , vol.330 , pp. 9-22
    • Mukherjee, S.1    Dey, S.2    Bhattacharya, R.K.3    Roy, M.4
  • 131
    • 58449110311 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells
    • Lee J.W., Cho M.K. Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells. Arch. Pharm. Res. 2008, 31:1604-1612.
    • (2008) Arch. Pharm. Res. , vol.31 , pp. 1604-1612
    • Lee, J.W.1    Cho, M.K.2
  • 132
    • 33750448018 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
    • Xiao D., Lew K.L., Zeng Y., Xiao H., Marynowski S.W., Dhir R., Singh S.V. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis 2006, 27:2223-2234.
    • (2006) Carcinogenesis , vol.27 , pp. 2223-2234
    • Xiao, D.1    Lew, K.L.2    Zeng, Y.3    Xiao, H.4    Marynowski, S.W.5    Dhir, R.6    Singh, S.V.7
  • 133
    • 84889077267 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells
    • Tusskorn O., Senggunprai L., Prawan A., Kukongviriyapan U., Kukongviriyapan V. Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells. BMC Cancer 2013, 13:571.
    • (2013) BMC Cancer , vol.13 , pp. 571
    • Tusskorn, O.1    Senggunprai, L.2    Prawan, A.3    Kukongviriyapan, U.4    Kukongviriyapan, V.5
  • 134
    • 84899952561 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model
    • Stan S.D., Singh S.V., Whitcomb D.C., Brand R.E. Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model. Nutr. Cancer 2014, 66:747-755.
    • (2014) Nutr. Cancer , vol.66 , pp. 747-755
    • Stan, S.D.1    Singh, S.V.2    Whitcomb, D.C.3    Brand, R.E.4
  • 135
    • 84885958511 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate induces apoptosis of cholangiocarcinoma cells through interruption of glutathione and mitochondrial pathway
    • Tusskorn O., Prawan A., Senggunprai L., Kukongviriyapan U., Kukongviriyapan V. Phenethyl isothiocyanate induces apoptosis of cholangiocarcinoma cells through interruption of glutathione and mitochondrial pathway. Naunyn Schmiedeberg's Arch. Pharmacol. 2013, 386:1009-1016.
    • (2013) Naunyn Schmiedeberg's Arch. Pharmacol. , vol.386 , pp. 1009-1016
    • Tusskorn, O.1    Prawan, A.2    Senggunprai, L.3    Kukongviriyapan, U.4    Kukongviriyapan, V.5
  • 136
    • 84859922968 scopus 로고    scopus 로고
    • Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells
    • Hahm E.R., Singh S.V. Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells. Mol. Carcinog. 2012, 51:465-474.
    • (2012) Mol. Carcinog. , vol.51 , pp. 465-474
    • Hahm, E.R.1    Singh, S.V.2
  • 137
    • 15944377864 scopus 로고    scopus 로고
    • Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds
    • Wu X., Kassie F., Mersch-Sundermann V. Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds. Mutat. Res. 2005, 589:81-102.
    • (2005) Mutat. Res. , vol.589 , pp. 81-102
    • Wu, X.1    Kassie, F.2    Mersch-Sundermann, V.3
  • 138
    • 34548290810 scopus 로고    scopus 로고
    • Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound
    • Wu X.J., Hua X. Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound. Cancer Biol. Ther. 2007, 6:646-647.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 646-647
    • Wu, X.J.1    Hua, X.2
  • 140
    • 84862820023 scopus 로고    scopus 로고
    • Beta-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38
    • Huong L.D., Shin J.A., Choi E.S., Cho N.P., Kim H.M., Leem D.H., Cho S.D. beta-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38. Oral Dis. 2012, 18:513-519.
    • (2012) Oral Dis. , vol.18 , pp. 513-519
    • Huong, L.D.1    Shin, J.A.2    Choi, E.S.3    Cho, N.P.4    Kim, H.M.5    Leem, D.H.6    Cho, S.D.7
  • 141
    • 79961147942 scopus 로고    scopus 로고
    • Effect of beta-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5
    • Huong le D., Shim J.H., Choi K.H., Shin J.A., Choi E.S., Kim H.S., Lee S.J., Kim S.J., Cho N.P., Cho S.D. Effect of beta-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5. J. Agric. Food Chem. 2011, 59:8124-8131.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 8124-8131
    • Huong le, D.1    Shim, J.H.2    Choi, K.H.3    Shin, J.A.4    Choi, E.S.5    Kim, H.S.6    Lee, S.J.7    Kim, S.J.8    Cho, N.P.9    Cho, S.D.10
  • 143
    • 84901462769 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspases
    • Wang Y., Wei S., Wang J., Fang Q., Chai Q. Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspases. Mol. Med. Rep. 2014, 10:543-549.
    • (2014) Mol. Med. Rep. , vol.10 , pp. 543-549
    • Wang, Y.1    Wei, S.2    Wang, J.3    Fang, Q.4    Chai, Q.5
  • 144
    • 84861570467 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo
    • Sakao K., Desineni S., Hahm E.R., Singh S.V. Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo. Prostate 2012, 72:1104-1116.
    • (2012) Prostate , vol.72 , pp. 1104-1116
    • Sakao, K.1    Desineni, S.2    Hahm, E.R.3    Singh, S.V.4
  • 145
    • 77950994646 scopus 로고    scopus 로고
    • Autophagy: cellular and molecular mechanisms
    • Glick D., Barth S., Macleod K.F. Autophagy: cellular and molecular mechanisms. J. Pathol. 2010, 221:3-12.
    • (2010) J. Pathol. , vol.221 , pp. 3-12
    • Glick, D.1    Barth, S.2    Macleod, K.F.3
  • 146
    • 84899140781 scopus 로고    scopus 로고
    • Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate
    • Xue C., Pasolli H.A., Piscopo I., Gros D.J., Liu C., Chen Y., Chiao J.W. Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate. Cancer Cell Int. 2014, 14:30.
    • (2014) Cancer Cell Int. , vol.14 , pp. 30
    • Xue, C.1    Pasolli, H.A.2    Piscopo, I.3    Gros, D.J.4    Liu, C.5    Chen, Y.6    Chiao, J.W.7
  • 147
    • 65949086045 scopus 로고    scopus 로고
    • Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells
    • Bommareddy A., Hahm E.R., Xiao D., Powolny A.A., Fisher A.L., Jiang Y., Singh S.V. Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res. 2009, 69:3704-3712.
    • (2009) Cancer Res. , vol.69 , pp. 3704-3712
    • Bommareddy, A.1    Hahm, E.R.2    Xiao, D.3    Powolny, A.A.4    Fisher, A.L.5    Jiang, Y.6    Singh, S.V.7
  • 148
    • 79953838313 scopus 로고    scopus 로고
    • Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer
    • Powolny A.A., Bommareddy A., Hahm E.R., Normolle D.P., Beumer J.H., Nelson J.B., Singh S.V. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer. J. Natl. Cancer Inst. 2011, 103:571-584.
    • (2011) J. Natl. Cancer Inst. , vol.103 , pp. 571-584
    • Powolny, A.A.1    Bommareddy, A.2    Hahm, E.R.3    Normolle, D.P.4    Beumer, J.H.5    Nelson, J.B.6    Singh, S.V.7
  • 149
    • 69249206518 scopus 로고    scopus 로고
    • Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery
    • Mi L., Gan N., Chung F.L. Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery. Biochem. Biophys. Res. Commun. 2009, 388:456-462.
    • (2009) Biochem. Biophys. Res. Commun. , vol.388 , pp. 456-462
    • Mi, L.1    Gan, N.2    Chung, F.L.3
  • 150
    • 14044271973 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial growth factor in cancer
    • Loureiro R.M., D'Amore P.A. Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev. 2005, 16:77-89.
    • (2005) Cytokine Growth Factor Rev. , vol.16 , pp. 77-89
    • Loureiro, R.M.1    D'Amore, P.A.2
  • 151
    • 77955126128 scopus 로고    scopus 로고
    • Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36
    • Kang L., Wang Z.Y. Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36. J. Cell. Mol. Med. 2010, 14:1485-1493.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 1485-1493
    • Kang, L.1    Wang, Z.Y.2
  • 152
    • 78149477498 scopus 로고    scopus 로고
    • In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study
    • Syed Alwi S.S., Cavell B.E., Telang U., Morris M.E., Parry B.M., Packham G. In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study. Br. J. Nutr. 2010, 104:1288-1296.
    • (2010) Br. J. Nutr. , vol.104 , pp. 1288-1296
    • Syed Alwi, S.S.1    Cavell, B.E.2    Telang, U.3    Morris, M.E.4    Parry, B.M.5    Packham, G.6
  • 153
    • 82755161957 scopus 로고    scopus 로고
    • Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung
    • Izzotti A., Larghero P., Balansky R., Pfeffer U., Steele V.E., De Flora S. Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung. Mutat. Res. 2011, 717:17-24.
    • (2011) Mutat. Res. , vol.717 , pp. 17-24
    • Izzotti, A.1    Larghero, P.2    Balansky, R.3    Pfeffer, U.4    Steele, V.E.5    De Flora, S.6
  • 154
    • 84879042158 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1alpha and VEGF expression in human glioma cells
    • Gupta B., Chiang L., Chae K., Lee D.H. Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1alpha and VEGF expression in human glioma cells. Food Chem. 2013, 141:1841-1846.
    • (2013) Food Chem. , vol.141 , pp. 1841-1846
    • Gupta, B.1    Chiang, L.2    Chae, K.3    Lee, D.H.4
  • 155
    • 84872679732 scopus 로고    scopus 로고
    • Beta-phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotype
    • Wu W.J., Zhang Y., Zeng Z.L., Li X.B., Hu K.S., Luo H.Y., Yang J., Huang P., Xu R.H. beta-phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotype. Biochem. Pharmacol. 2013, 85:486-496.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 486-496
    • Wu, W.J.1    Zhang, Y.2    Zeng, Z.L.3    Li, X.B.4    Hu, K.S.5    Luo, H.Y.6    Yang, J.7    Huang, P.8    Xu, R.H.9
  • 156
    • 84878609926 scopus 로고    scopus 로고
    • In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells
    • Sakao K., Hahm E.R., Singh S.V. In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells. Nutr. Cancer 2013, 65(Suppl. 1):61-67.
    • (2013) Nutr. Cancer , vol.65 , pp. 61-67
    • Sakao, K.1    Hahm, E.R.2    Singh, S.V.3
  • 157
    • 84879667745 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling
    • Chen H.J., Lin C.M., Lee C.Y., Shih N.C., Amagaya S., Lin Y.C., Yang J.S. Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling. Int. J. Oncol. 2013, 43:629-637.
    • (2013) Int. J. Oncol. , vol.43 , pp. 629-637
    • Chen, H.J.1    Lin, C.M.2    Lee, C.Y.3    Shih, N.C.4    Amagaya, S.5    Lin, Y.C.6    Yang, J.S.7
  • 159
    • 77952476911 scopus 로고    scopus 로고
    • Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages
    • Tsai J.T., Liu H.C., Chen Y.H. Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. Mediat. Inflamm. 2010, 2010:293642.
    • (2010) Mediat. Inflamm. , vol.2010 , pp. 293642
    • Tsai, J.T.1    Liu, H.C.2    Chen, Y.H.3
  • 161
    • 84876432645 scopus 로고    scopus 로고
    • Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate
    • Li R.W., Li C., Wang T.T. Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate. Mol. Carcinog. 2013, 52:426-437.
    • (2013) Mol. Carcinog. , vol.52 , pp. 426-437
    • Li, R.W.1    Li, C.2    Wang, T.T.3
  • 162
    • 84874207990 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI-3 cells, and stimulates immunomodulations in vivo
    • Tsou M.F., Tien N., Lu C.C., Chiang J.H., Yang J.S., Lin J.P., Fan M.J., Lu J.J., Yeh S.P., Chung J.G. Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI-3 cells, and stimulates immunomodulations in vivo. Environ. Toxicol. 2011, 28(3):127-136.
    • (2011) Environ. Toxicol. , vol.28 , Issue.3 , pp. 127-136
    • Tsou, M.F.1    Tien, N.2    Lu, C.C.3    Chiang, J.H.4    Yang, J.S.5    Lin, J.P.6    Fan, M.J.7    Lu, J.J.8    Yeh, S.P.9    Chung, J.G.10
  • 163
    • 84875976154 scopus 로고    scopus 로고
    • Differential effects of phenethyl isothiocyanate and D, L-sulforaphane on TLR3 signaling
    • Zhu J., Ghosh A., Coyle E.M., Lee J., Hahm E.R., Singh S.V., Sarkar S.N. Differential effects of phenethyl isothiocyanate and D, L-sulforaphane on TLR3 signaling. J. Immunol. 2013, 190:4400-4407.
    • (2013) J. Immunol. , vol.190 , pp. 4400-4407
    • Zhu, J.1    Ghosh, A.2    Coyle, E.M.3    Lee, J.4    Hahm, E.R.5    Singh, S.V.6    Sarkar, S.N.7
  • 164
    • 84875718894 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate regulates inflammation through suppression of the TRIF-dependent signaling pathway of Toll-like receptors
    • Park H.J., Kim S.J., Park S.J., Eom S.H., Gu G.J., Kim S.H., Youn H.S. Phenethyl isothiocyanate regulates inflammation through suppression of the TRIF-dependent signaling pathway of Toll-like receptors. Life Sci. 2013, 92:793-798.
    • (2013) Life Sci. , vol.92 , pp. 793-798
    • Park, H.J.1    Kim, S.J.2    Park, S.J.3    Eom, S.H.4    Gu, G.J.5    Kim, S.H.6    Youn, H.S.7
  • 165
    • 77953174656 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo
    • Xiao D., Singh S.V. Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo. Pharm. Res. 2010, 27:722-731.
    • (2010) Pharm. Res. , vol.27 , pp. 722-731
    • Xiao, D.1    Singh, S.V.2
  • 166
    • 84860871066 scopus 로고    scopus 로고
    • Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention
    • Barrera L.N., Cassidy A., Johnson I.T., Bao Y., Belshaw N.J. Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention. Proc. Nutr. Soc. 2012, 71:237-245.
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 237-245
    • Barrera, L.N.1    Cassidy, A.2    Johnson, I.T.3    Bao, Y.4    Belshaw, N.J.5
  • 167
    • 0038714509 scopus 로고    scopus 로고
    • Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates
    • Manesh C., Kuttan G. Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates. J. Exp. Clin. Cancer Res. 2003, 22:193-199.
    • (2003) J. Exp. Clin. Cancer Res. , vol.22 , pp. 193-199
    • Manesh, C.1    Kuttan, G.2
  • 168
    • 43349098881 scopus 로고    scopus 로고
    • Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression
    • Prawan A., Keum Y.S., Khor T.O., Yu S., Nair S., Li W., Hu L., Kong A.N. Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression. Pharm. Res. 2008, 25:836-844.
    • (2008) Pharm. Res. , vol.25 , pp. 836-844
    • Prawan, A.1    Keum, Y.S.2    Khor, T.O.3    Yu, S.4    Nair, S.5    Li, W.6    Hu, L.7    Kong, A.N.8
  • 169
    • 80155134262 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by beta-phenethyl isothiocyanate: mechanisms for anti-leukemia activity
    • Chen G., Chen Z., Hu Y., Huang P. Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by beta-phenethyl isothiocyanate: mechanisms for anti-leukemia activity. Antioxid. Redox Signal. 2011, 15:2911-2921.
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 2911-2921
    • Chen, G.1    Chen, Z.2    Hu, Y.3    Huang, P.4
  • 170
    • 77951029200 scopus 로고    scopus 로고
    • P66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells
    • Xiao D., Singh S.V. p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells. Cancer Res. 2010, 70:3150-3158.
    • (2010) Cancer Res. , vol.70 , pp. 3150-3158
    • Xiao, D.1    Singh, S.V.2
  • 171
    • 84865148762 scopus 로고    scopus 로고
    • Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent
    • Syed Alwi S.S., Cavell B.E., Donlevy A., Packham G. Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent. Cell Stress Chaperones 2012, 17:529-538.
    • (2012) Cell Stress Chaperones , vol.17 , pp. 529-538
    • Syed Alwi, S.S.1    Cavell, B.E.2    Donlevy, A.3    Packham, G.4
  • 172
    • 78651312053 scopus 로고    scopus 로고
    • Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes
    • Powolny A.A., Singh S.V. Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes. Pharm. Res. 2010, 27:2766-2775.
    • (2010) Pharm. Res. , vol.27 , pp. 2766-2775
    • Powolny, A.A.1    Singh, S.V.2
  • 173
    • 84864339496 scopus 로고    scopus 로고
    • Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidants
    • (author reply E2029)
    • Kojo S. Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidants. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E2028. (author reply E2029).
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. E2028
    • Kojo, S.1
  • 174
    • 84865417726 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis
    • Pramanik K.C., Srivastava S.K. Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid. Redox Signal. 2012, 17:1417-1432.
    • (2012) Antioxid. Redox Signal. , vol.17 , pp. 1417-1432
    • Pramanik, K.C.1    Srivastava, S.K.2
  • 176
    • 84863551515 scopus 로고    scopus 로고
    • Proteomic analysis of covalent modifications of tubulins by isothiocyanates
    • Xiao Z., Mi L., Chung F.L., Veenstra T.D. Proteomic analysis of covalent modifications of tubulins by isothiocyanates. J. Nutr. 2012, 142:1377S-1381S.
    • (2012) J. Nutr. , vol.142 , pp. 1377S-1381S
    • Xiao, Z.1    Mi, L.2    Chung, F.L.3    Veenstra, T.D.4
  • 177
    • 53849093043 scopus 로고    scopus 로고
    • PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway
    • Cheung K.L., Khor T.O., Yu S., Kong A.N. PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. AAPS J. 2008, 10:277-281.
    • (2008) AAPS J. , vol.10 , pp. 277-281
    • Cheung, K.L.1    Khor, T.O.2    Yu, S.3    Kong, A.N.4
  • 178
    • 38949099990 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications
    • Hollenberg P.F., Kent U.M., Bumpus N.N. Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications. Chem. Res. Toxicol. 2008, 21:189-205.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 189-205
    • Hollenberg, P.F.1    Kent, U.M.2    Bumpus, N.N.3
  • 179
    • 84863371275 scopus 로고    scopus 로고
    • Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment
    • Hudson T.S., Perkins S.N., Hursting S.D., Young H.A., Kim Y.S., Wang T.C., Wang T.T. Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. Int. J. Oncol. 2012, 40:1113-1121.
    • (2012) Int. J. Oncol. , vol.40 , pp. 1113-1121
    • Hudson, T.S.1    Perkins, S.N.2    Hursting, S.D.3    Young, H.A.4    Kim, Y.S.5    Wang, T.C.6    Wang, T.T.7
  • 180
    • 77952304948 scopus 로고    scopus 로고
    • Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
    • Izzotti A., Larghero P., Cartiglia C., Longobardi M., Pfeffer U., Steele V.E., De Flora S. Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung. Carcinogenesis 2010, 31:894-901.
    • (2010) Carcinogenesis , vol.31 , pp. 894-901
    • Izzotti, A.1    Larghero, P.2    Cartiglia, C.3    Longobardi, M.4    Pfeffer, U.5    Steele, V.E.6    De Flora, S.7
  • 182
    • 0032968691 scopus 로고    scopus 로고
    • Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats
    • Conaway C.C., Jiao D., Kohri T., Liebes L., Chung F.L. Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats. Drug Metab. Dispos. 1999, 27:13-20.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 13-20
    • Conaway, C.C.1    Jiao, D.2    Kohri, T.3    Liebes, L.4    Chung, F.L.5
  • 183
    • 84884918893 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF
    • Yu C., Gong A.Y., Chen D., Solelo Leon D., Young C.Y., Chen X.M. Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF. Mol. Nutr. Food Res. 2013, 57:1825-1833.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 1825-1833
    • Yu, C.1    Gong, A.Y.2    Chen, D.3    Solelo Leon, D.4    Young, C.Y.5    Chen, X.M.6
  • 185
    • 77957340079 scopus 로고    scopus 로고
    • Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro
    • Yu Z., Xu H. Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro. Wei Sheng Yan Jiu 2008, 37:693-696.
    • (2008) Wei Sheng Yan Jiu , vol.37 , pp. 693-696
    • Yu, Z.1    Xu, H.2
  • 186
    • 84880330400 scopus 로고    scopus 로고
    • Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
    • Gerhauser C. Epigenetic impact of dietary isothiocyanates in cancer chemoprevention. Curr. Opin. Clin. Nutr. Metab. Care 2013, 16:405-410.
    • (2013) Curr. Opin. Clin. Nutr. Metab. Care , vol.16 , pp. 405-410
    • Gerhauser, C.1
  • 187
    • 77956544792 scopus 로고    scopus 로고
    • Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review)
    • Wang L.G., Chiao J.W. Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review). Int. J. Oncol. 2010, 37:533-539.
    • (2010) Int. J. Oncol. , vol.37 , pp. 533-539
    • Wang, L.G.1    Chiao, J.W.2
  • 188
    • 82555189785 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates
    • Yan H., Zhu Y., Liu B., Wu H., Li Y., Wu X., Zhou Q., Xu K. Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates. Br. J. Nutr. 2011, 106:1779-1791.
    • (2011) Br. J. Nutr. , vol.106 , pp. 1779-1791
    • Yan, H.1    Zhu, Y.2    Liu, B.3    Wu, H.4    Li, Y.5    Wu, X.6    Zhou, Q.7    Xu, K.8
  • 189
    • 84878384521 scopus 로고    scopus 로고
    • Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells
    • Liu Y., Chakravarty S., Dey M. Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells. PLoS One 2013, 8:e64535.
    • (2013) PLoS One , vol.8 , pp. e64535
    • Liu, Y.1    Chakravarty, S.2    Dey, M.3
  • 190
    • 84873336329 scopus 로고    scopus 로고
    • Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells
    • Liu K., Cang S., Ma Y., Chiao J.W. Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells. Cancer Cell Int. 2013, 13:10.
    • (2013) Cancer Cell Int. , vol.13 , pp. 10
    • Liu, K.1    Cang, S.2    Ma, Y.3    Chiao, J.W.4
  • 191
    • 84978023495 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells
    • Cang S., Ma Y., Chiao J.W., Liu D. Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells. Exp. Hematol. Oncol. 2014, 3:5.
    • (2014) Exp. Hematol. Oncol. , vol.3 , pp. 5
    • Cang, S.1    Ma, Y.2    Chiao, J.W.3    Liu, D.4
  • 192
    • 84876098921 scopus 로고    scopus 로고
    • Targeting heat shock proteins by phenethyl isothiocyanate results in cell-cycle arrest and apoptosis of human breast cancer cells
    • Sarkars R., Mukherjee S., Roy M. Targeting heat shock proteins by phenethyl isothiocyanate results in cell-cycle arrest and apoptosis of human breast cancer cells. Nutr. Cancer 2013, 65:480-493.
    • (2013) Nutr. Cancer , vol.65 , pp. 480-493
    • Sarkars, R.1    Mukherjee, S.2    Roy, M.3
  • 193
    • 84893945845 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways
    • Huang S.H., Hsu M.H., Hsu S.C., Yang J.S., Huang W.W., Huang A.C., Hsiao Y.P., Yu C.C., Chung J.G. Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways. Hum. Exp. Toxicol. 2014, 33:270-283.
    • (2014) Hum. Exp. Toxicol. , vol.33 , pp. 270-283
    • Huang, S.H.1    Hsu, M.H.2    Hsu, S.C.3    Yang, J.S.4    Huang, W.W.5    Huang, A.C.6    Hsiao, Y.P.7    Yu, C.C.8    Chung, J.G.9
  • 194
    • 84866435678 scopus 로고    scopus 로고
    • Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2
    • Cavell B.E., Syed Alwi S.S., Donlevy A.M., Proud C.G., Packham G. Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2. J. Nat. Prod. 2012, 75:1051-1057.
    • (2012) J. Nat. Prod. , vol.75 , pp. 1051-1057
    • Cavell, B.E.1    Syed Alwi, S.S.2    Donlevy, A.M.3    Proud, C.G.4    Packham, G.5
  • 196
    • 84904649739 scopus 로고    scopus 로고
    • Molecular targets of isothiocyanates in cancer: recent advances
    • Gupta P., Kim B., Kim S.H., Srivastava S.K. Molecular targets of isothiocyanates in cancer: recent advances. Mol. Nutr. Food Res. 2014, 58(8):1685-1707.
    • (2014) Mol. Nutr. Food Res. , vol.58 , Issue.8 , pp. 1685-1707
    • Gupta, P.1    Kim, B.2    Kim, S.H.3    Srivastava, S.K.4
  • 197
    • 84863583356 scopus 로고    scopus 로고
    • Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures
    • Chan D.K., Miskimins W.K. Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures. J. Ovarian Res. 2012, 5:19.
    • (2012) J. Ovarian Res. , vol.5 , pp. 19
    • Chan, D.K.1    Miskimins, W.K.2
  • 198
    • 0036805387 scopus 로고    scopus 로고
    • Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine
    • Tseng E., Kamath A., Morris M.E. Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine. Pharm. Res. 2002, 19:1509-1515.
    • (2002) Pharm. Res. , vol.19 , pp. 1509-1515
    • Tseng, E.1    Kamath, A.2    Morris, M.E.3
  • 199
  • 200
    • 80053931057 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin
    • Wang X., Govind S., Sajankila S.P., Mi L., Roy R., Chung F.L. Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. Mol. Nutr. Food Res. 2011, 55:1572-1581.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1572-1581
    • Wang, X.1    Govind, S.2    Sajankila, S.P.3    Mi, L.4    Roy, R.5    Chung, F.L.6
  • 201
    • 84895874955 scopus 로고    scopus 로고
    • PEITC reverse multi-drug resistance of human gastric cancer SGC7901/DDP cell line
    • Tang T., Song X., Liu Y.F., Wang W.Y. PEITC reverse multi-drug resistance of human gastric cancer SGC7901/DDP cell line. Cell Biol. Int. 2014, 38:502-510.
    • (2014) Cell Biol. Int. , vol.38 , pp. 502-510
    • Tang, T.1    Song, X.2    Liu, Y.F.3    Wang, W.Y.4
  • 202
    • 0034007594 scopus 로고    scopus 로고
    • Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Hecht S.S., Kenney P.M., Wang M., Trushin N., Upadhyaya P. Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Lett. 2000, 150:49-56.
    • (2000) Cancer Lett. , vol.150 , pp. 49-56
    • Hecht, S.S.1    Kenney, P.M.2    Wang, M.3    Trushin, N.4    Upadhyaya, P.5
  • 203
    • 0028566646 scopus 로고
    • Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents
    • Hecht S.S., Isaacs S., Trushin N. Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. Carcinogenesis 1994, 15:2721-2725.
    • (1994) Carcinogenesis , vol.15 , pp. 2721-2725
    • Hecht, S.S.1    Isaacs, S.2    Trushin, N.3
  • 204
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • Conaway C.C., Wang C.X., Pittman B., Yang Y.M., Schwartz J.E., Tian D., McIntee E.J., Hecht S.S., Chung F.L. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res. 2005, 65:8548-8557.
    • (2005) Cancer Res. , vol.65 , pp. 8548-8557
    • Conaway, C.C.1    Wang, C.X.2    Pittman, B.3    Yang, Y.M.4    Schwartz, J.E.5    Tian, D.6    McIntee, E.J.7    Hecht, S.S.8    Chung, F.L.9
  • 205
    • 0031431664 scopus 로고    scopus 로고
    • Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats
    • Staretz M.E., Koenig L.A., Hecht S.S. Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats. Carcinogenesis 1997, 18:1715-1722.
    • (1997) Carcinogenesis , vol.18 , pp. 1715-1722
    • Staretz, M.E.1    Koenig, L.A.2    Hecht, S.S.3
  • 206
    • 0036712961 scopus 로고    scopus 로고
    • Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
    • Sticha K.R., Kenney P.M., Boysen G., Liang H., Su X., Wang M., Upadhyaya P., Hecht S.S. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis 2002, 23:1433-1439.
    • (2002) Carcinogenesis , vol.23 , pp. 1433-1439
    • Sticha, K.R.1    Kenney, P.M.2    Boysen, G.3    Liang, H.4    Su, X.5    Wang, M.6    Upadhyaya, P.7    Hecht, S.S.8
  • 208
    • 0037358448 scopus 로고    scopus 로고
    • Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats
    • Boysen G., Kenney P.M., Upadhyaya P., Wang M., Hecht S.S. Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis 2003, 24:517-525.
    • (2003) Carcinogenesis , vol.24 , pp. 517-525
    • Boysen, G.1    Kenney, P.M.2    Upadhyaya, P.3    Wang, M.4    Hecht, S.S.5
  • 209
    • 0031023711 scopus 로고    scopus 로고
    • Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate
    • Staretz M.E., Foiles P.G., Miglietta L.M., Hecht S.S. Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate. Cancer Res. 1997, 57:259-266.
    • (1997) Cancer Res. , vol.57 , pp. 259-266
    • Staretz, M.E.1    Foiles, P.G.2    Miglietta, L.M.3    Hecht, S.S.4
  • 210
    • 77956270068 scopus 로고    scopus 로고
    • Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination
    • Kassie F., Melkamu T., Endalew A., Upadhyaya P., Luo X., Hecht S.S. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis 2010, 31:1634-1641.
    • (2010) Carcinogenesis , vol.31 , pp. 1634-1641
    • Kassie, F.1    Melkamu, T.2    Endalew, A.3    Upadhyaya, P.4    Luo, X.5    Hecht, S.S.6
  • 211
    • 61549130956 scopus 로고    scopus 로고
    • Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-l-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice
    • Kassie F., Matise I., Negia M., Lahti D., Pan Y., Scherber R., Upadhyaya P., Hecht S.S. Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-l-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice. Cancer Prev. Res. 2008, 1:285-297.
    • (2008) Cancer Prev. Res. , vol.1 , pp. 285-297
    • Kassie, F.1    Matise, I.2    Negia, M.3    Lahti, D.4    Pan, Y.5    Scherber, R.6    Upadhyaya, P.7    Hecht, S.S.8
  • 212
    • 34447105898 scopus 로고    scopus 로고
    • Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate
    • Ye B., Zhang Y.X., Yang F., Chen H.L., Xia D., Liu M.Q., Lai B.T. Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate. BMC Cancer 2007, 7:90.
    • (2007) BMC Cancer , vol.7 , pp. 90
    • Ye, B.1    Zhang, Y.X.2    Yang, F.3    Chen, H.L.4    Xia, D.5    Liu, M.Q.6    Lai, B.T.7
  • 213
    • 74049137804 scopus 로고    scopus 로고
    • Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine
    • Balansky R., Ganchev G., Iltcheva M., Steele V.E., De Flora S. Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine. Int. J. Cancer 2010, 126:1047-1054.
    • (2010) Int. J. Cancer , vol.126 , pp. 1047-1054
    • Balansky, R.1    Ganchev, G.2    Iltcheva, M.3    Steele, V.E.4    De Flora, S.5
  • 214
    • 68949194440 scopus 로고    scopus 로고
    • Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice
    • D'Agostini F., Mastracci L., Izzotti A., Balansky R., Pennisi T.M., Steele V.E., De Flora S. Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice. Cancer Prev. Res. 2009, 2:546-556.
    • (2009) Cancer Prev. Res. , vol.2 , pp. 546-556
    • D'Agostini, F.1    Mastracci, L.2    Izzotti, A.3    Balansky, R.4    Pennisi, T.M.5    Steele, V.E.6    De Flora, S.7
  • 215
    • 57449106112 scopus 로고    scopus 로고
    • Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke
    • Micale R.T., D'Agostini F., Steele V.E., La Maestra S., De Flora S. Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke. Curr. Cancer Drug Targets 2008, 8:703-708.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 703-708
    • Micale, R.T.1    D'Agostini, F.2    Steele, V.E.3    La Maestra, S.4    De Flora, S.5


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