Postgraduate symposium: Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: Potential implications for cancer chemoprevention

Proceedings of the Nutrition Society

Volumn 71, Issue 2, 2012, Pages 237-245

  Barrera, Lawrence N ^a,b   Cassidy, Aedin ^a   Johnson, Ian T ^b   Bao, Yongping ^a   Belshaw, Nigel J ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

Cancer chemoprevention; Epigenetics; Gastrointestinal glutathione peroxidase 2; Selenoproteins; Thioredoxin reductase 1

Indexed keywords

ALLYL ISOTHIOCYANIC ACID; DNA; ERUCIN; GLUTATHIONE PEROXIDASE 2; IBERIN; ISOTHIOCYANIC ACID DERIVATIVE; PHENETHYL ISOTHIOCYANIC ACID; SELENIUM; SULFORAPHANE; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG; ANTIOXIDANT; PLANT EXTRACT; SELENOPROTEIN;

ANTIOXIDANT ACTIVITY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; COLON POLYPOSIS; CONFERENCE PAPER; DIET SUPPLEMENTATION; DNA METHYLATION; DRUG MECHANISM; EPIGENETICS; GENE EXPRESSION; HUMAN; INTESTINE CANCER; NONHUMAN; BRASSICACEAE; CHEMISTRY; DIET; DRUG EFFECT; GENETIC EPIGENESIS; GENETICS; METABOLISM; NEOPLASM; PHYTOTHERAPY; REVIEW;

ANTIOXIDANTS; BRASSICACEAE; DIET; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; ISOTHIOCYANATES; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; SELENIUM; SELENOPROTEINS;

EID: 84860871066     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S002966511200016X     Document Type: Conference Paper

References (69)

1. WCRF/AICR (2007) Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research.
2. WCRF/AICR (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research.
3. Holmberg L, Ohlander EM, Byers T et al. (1996) A search for recall bias in a case-control study of diet and breast cancer. Int J Epidemiol 25, 235-244.
4. Willett WC (2010) Fruits, vegetables, and cancer prevention: turmoil in the produce section. J Natl Cancer Inst 102, 510-511.
5. IARC/WHO (2004) Cruciferous Vegetables, Isothiocyanates and Indoles. Lyon, France: IARC Handbooks of Cancer Prevention. IARC Press.
6. Holst B & Williamson G (2004) A critical review of the bioavailability of glucosinolates and related compounds. Nat Prod Rep 21, 425-447.
7. Combs GJ & Lu J (2006) Selenium as a cancer preventive agent. In Selenium: Its Molecular Biology and Role in Human Health, pp. 249-264 [DL Hatfield, MJ Berry & VN Gladyshev, editors]. Boston, MA: Springer Science Business Media, LLC.
8. Zhang Y & Talalay P (1994) Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res 54, 1976s-1981.
9. Fahey JW, Zalcmann AT & Talalay P (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56, 5-51.
10. Verhoeven DT, Goldbohm RA, Van Poppel G et al. (1996) Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 5, 733-748.
11. Arikawa AY & Gallaher DD (2008) Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine- treated rats. J Nutr 138, 526-532.
12. Yamaji T, Inoue M, Sasazuki S et al. (2008) Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. Int J Cancer 123, 1935-1940.
13. Zhang Y (2004) Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res 555, 173-190.
14. Johnson IT (2002) Glucosinolates: bioavailability and importance to health. Int J Vitam Nutr Res 72, 26-31.
15. Hecht SS (1999) Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen Metabolism. J Nutr 129, 768-774.
16. Juge N, Mithen RF & Traka M (2007) Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 64, 1105-1127.
17. Maheo K, Morel F, Langouet S et al. (1997) Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res 57, 3649-3652.
18. Talalay P, Fahey JW, Holtzclaw WD et al. (1995) Chemoprotection against cancer by phase 2 enzyme induction. Toxicol Lett 82-83, 173-179.
19. Kumar Kundu J, Na H-K & Surh Y-J (2009) Intracellular signaling molecules as targets of selected dietary chemopreventive agents. In Dietary Modulation of Cell Signaling Pathways, pp. 1-33 [Y-J Surh, editor]. Boca Raton, FL: CRC Press.
20. Basten GP, Bao Y & Williamson G (2002) Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis 23, 1399-1404.
21. Matusheski NV & Jeffery EH (2001) Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile. J Agric Food Chem 49, 5743-5749.
22. Petri N, Tannergren C, Holst B et al. (2003) Absorption/ metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. Drug Metab Dispos 31, 805-813.
23. Jiang Z-Q, Chen C, Yang B et al. (2003) Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers. Life Sci 72, 2243-2253.
24. Munday R & Munday CM (2004) Induction of Phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl Isothiocyanate with sulforaphane and related compounds. J Agric Food Chem 52, 1867-1871.
25. Zhang Y & Talalay P (1998) Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. Cancer Res 58, 4632-4639.
26. Shamberger RJ & Frost DV (1969) Possible protective effect of selenium against human cancer. Can Med Assoc J 100, 682.
27. Clark LC, Combs GF, Turnbull BW et al. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276, 1957-1963.
28. Rayman MP (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64, 527-542.
29. Lippman SM, Klein EA, Goodman PJ et al. (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301, 39-51.
30. Ip C, Thompson HJ, Zhu Z et al. (2000) In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Cancer Res 60, 2882-2886.
31. Ip C, Dong Y & Ganther HE (2002) New concepts in selenium chemoprevention. Cancer Metastasis Rev 21, 281-289.
32. Fairweather-Tait SJ, Bao Y, Broadley MR et al. (2011) Selenium in human health and disease. Antioxid Redox Signal 14, 1337-1383.
33. Dong Y, Lisk D, Block E et al. (2001) Characterization of the biological activity of gamma-glutamyl-Semethylselenocysteine: A novel, naturally occurring anticancer agent from garlic. Cancer Res 61, 2923-2928.
34. Ip C, Birringer M, Block E et al. (2000) Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention. J Agric Food Chem 48, 4452.
35. Finley JW, Davis CD & Feng Y (2000) Selenium from high selenium broccoli protects rats from colon cancer. J Nutr 130, 2384-2389.
36. Brigelius-FlohéR & Banning A (2009) Dietary factors in the regulation of seleneprotein biosynthesis. In Dietary Modulation of Cell Signaling Pathways, pp. 251-271 [Y-J Surh, editor]. Boca Raton, FL: CRC Press.
37. Jackson MI & Combs Jr GF (2008) Selenium and anticarcinogenesis: underlying mechanisms. Curr Opin Clin Nutr Metab Care 11, 718-726.
38. Kryukov GV, Castellano S, Novoselov SV et al. (2003) Characterization of Mammalian Selenoproteomes. Science 300, 1439-1443.
39. Bellinger FP, Raman AV, Reeves MA et al. (2009) Regulation and function of selenoproteins in human disease. Biochem J 422, 11-22.
40. Barrera LN (2010) Effect of isothiocyanates and selenium on antioxidant enzyme expression and DNA methylation in colon cancer cells in vitro. PhD Thesis, University of East Anglia. http://ueaeprints.uea.ac.uk/25641/25641/ Lawrence-Barrera?s-Final-Thesis.pdf
41. Stone WL, Krishnan K & Papas A (2004) Oxidants and antioxidants in the pathology of colon cancer. In Redox- Genome Interactions in Health and Disease, pp. 629 [JJ Fuchs, M Podda & L Packer, editors]. New York: Marcel Dekker.
42. Zhang J, Svehlikova V, Bao Y et al. (2003) Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24, 497-503.
43. Gallegos A, Berggren M, Gasdaska JR et al. (1997) Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium. Cancer Res 57, 4965-4970.
44. Brigelius-Flohe R & Banning A (2006) Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer. Free Radical Res 40, 775-787.
45. Campbell L, Howie F, Arthur JR et al. (2007) Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage. Nutrition 23, 138-144.
46. Yoo M-H, Xu X-M, Carlson BA et al. (2007) Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS ONE 2, e1112.
47. Lin YM, Furukawa Y, Tsunoda T et al. (2002) Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene 21, 4120-4128.
48. Rushworth SA, Bowles KM & MacEwan DJ (2011) High basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitors. Cancer Res 71, 1999-2009.
49. Esteller M (2005) Impact of DNA methylation on health and disease. In DNA Methylation: Approaches, Methods, and Applications, pp. 1-9 [M Esteller, editor]. Boca Raton, FL: CRC.
50. Herman JG & Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349, 2042-2054.
51. Esteller M (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8, 286-298.
52. Dashwood R & Ho E (2008) Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev 66 (Suppl. 1), S36-S38.
53. Myzak MC, Karplus PA, Chung F-L et al. (2004) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res 64, 5767-5774.
54. Myzak MC, Dashwood WM, Orner GA et al. (2006) Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice. FASEB J 20(3), 506-508.
55. Lu Q, Lin X, Feng J et al. (2008) Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. J Hematol Oncol 1, 6.
56. Wang LG, Beklemisheva A, Liu XM et al. (2007) Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. Mol Carcinog 46, 24-31.
57. Meeran SM, Patel SN & Tollefsbol TO (2010) Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS ONE 5, e11457.
58. Davis CD & Uthus EO (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med 229, 988-995.
59. Davis CD, Uthus EO & Finley JW (2000) Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 Cells and in vivo in rat liver and colon. J Nutr 130, 2903-2909.
60. Davis CD & Uthus EO (2003) Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats. J Nutr 133, 2907-2914.
61. Fiala ES, Staretz ME, Pandya GA et al. (1998) Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis 19, 597-604.
62. Cox R (1985) Selenite: a good inhibitor of rat-liver DNA methylase. Biochem Int 10, 63-69.
63. Cox R & Goorha S (1986) A study of the mechanism of selenite-induced hypomethylated DNA and differentiation of Friend erythroleukemic cells. Carcinogenesis 7, 2015-2018.
64. Xiang N, Zhao R, Song G et al. (2008) Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. Carcinogenesis 29, 2175-2181.
65. Pilsner JR, Hall MN, Liu X et al. (2011) Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh. Environ Health Perspect 119, 113-118.
66. Kim YI, Pogribny IP, Salomon RN et al. (1996) Exonspecific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. Am J Pathol 149, 1129-1137.
67. Belshaw NJ, Elliott GO, Williams EA et al. (2005) Methylation of the ESR1 CpG island in the colorectal mucosa is an ?all or nothing? process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse. Biochem Soc Trans 33, 709-711.
68. Mund C, Beier V, Bewerunge P et al. (2005) Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines. Nucl Acids Res 33, e73.
69. Feltus FA, Lee EK, Costello JF et al. (2003) Predicting aberrant CpG island methylation. Proc Natl Acad Sci USA 100, 12253-12258.