Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 30, 2012, Pages

  Kojo, Shosuke ^a  

^a OPEN UNIVERSITY OF JAPAN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAHYDROQUINONE DERIVATIVE; ANTIOXIDANT; ASCORBIC ACID; BAICALEIN; GENISTEIN; HYDROGEN PEROXIDE; HYDROQUINONE DERIVATIVE; OXYGEN; POLYPHENOL; RESVERATROL; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DEATH; CONCENTRATION RESPONSE; DNA DAMAGE; DRUG EFFECT; IN VITRO STUDY; IN VIVO STUDY; LETTER; NONHUMAN; PRIORITY JOURNAL; VENOUS OXYGEN TENSION;

ANTIOXIDANTS; CELL DEATH; DNA DAMAGE; HUMANS; MUTAGENICITY TESTS;

EID: 84864339496     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205916109     Document Type: Letter

References (2)

1. Fox JT, et al. (2012) High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci USA 109:5423-5428.
2. Wada Y, et al. (2002) Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions. Arterioscler Thromb Vasc Biol 22:1712-1719.