The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation

Drug Metabolism and Disposition

Volumn 41, Issue 4, 2013, Pages 858-869

  Yoshigae, Yasushi ^a,b   Sridar, Chitra ^a   Kent, Ute M ^a   Hollenberg, Paul F ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b DAIICHI SANKYO CO   (Japan)

^c 2301 MSRB III ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPROTEIN; CYTOCHROME P450 2E1; GLUTATHIONE; HEME; PHENETHYL ISOTHIOCYANATE; PHENETHYLAMINE; RECOMBINANT CYTOCHROME P450 2E1; RECOMBINANT ENZYME; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DESULFURIZATION; DIALYSIS; DRUG BINDING; DRUG MECHANISM; DRUG OXIDATION; ENZYME INACTIVATION; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION;

ANTICARCINOGENIC AGENTS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2E1; HUMANS; ISOCYANATES; ISOTHIOCYANATES; MICROSOMES, LIVER; OXIDATION-REDUCTION;

EID: 84875849252     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.050609     Document Type: Article

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