Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism

Journal of Nutrition

Volumn 131, Issue 11 SUPPL., 2001, Pages

  Talalay, P ^a   Fahey, J W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Brassica vegetables; Chemoprotection; Glucosinolates; Isothiocyanates; Phase 2 enzyme induction; Sulforaphane

Indexed keywords

ANTIOXIDANT; CARCINOGEN; GLUCOSINOLATE; ISOTHIOCYANIC ACID DERIVATIVE; VEGETABLE PROTEIN;

CANCER PREVENTION; CANCER RISK; CARCINOGENESIS; CONFERENCE PAPER; DIET; EXPOSURE; FOOD COMPOSITION; FOOD INTAKE; FRUIT; HUMAN; KNOCKOUT MOUSE; NONHUMAN; PHYTOCHEMISTRY; PROTECTION; PROTEIN INDUCTION; VEGETABLE;

ANIMALIA; BRASSICA;

EID: 0035170990     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.11.3027s     Document Type: Conference Paper

References (81)

1. Projected number of cancer cases in the US elderly population, 1990 through 2030
2. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
3. Vegetables, fruits, and carotenoids and the risk of cancer
4. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
5. Vegetables, fruit and cancer. I. Epidemiology
6. Vegetables, fruit and cancer. II. Mechanisms
7. Vegetables, fruit, and cancer prevention: A review
8. Combinatorial chemoprevention of intestinal neoplasia
9. Multiagent chemopreventative agent combinations
10. A review of mechanisms underlying anticarcinogenicity by brassica vegetables
11. Diet in the epidemiology of cancer of the colon and rectum
12. Epidemiological studies on brassica vegetables and cancer risk
13. Plant foods, antioxidants, and prostate cancer risk: Findings from case-control studies in Canada
14. Vegetables, fruits, legumes and prostate cancer: A multicenter case-control study
15. Brassica vegetables and breast cancer risk
16. Intake of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women
17. Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort
18. Fruit and vegetable intakes and prostate cancer risk
19. Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas
20. Dietary isothiocyanates as confounding factors in the molecular epidemiology of colon cancer
21. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: A prospective study of men in Shanghai, China
22. Using isothiocyanate excretion as a biological marker of Brassica vegetable consumption in epidemiological studies: Evaluating the source of variability
23. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
24. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans
25. Glucosinolates in crop plants
26. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
27. Safety assessment and potential health benefits of food components based on selected scientific criteria. Isothiocyanates
28. Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
29. Chemoprevention by isothiocyanates
30. Chemoprevention by modifiers of carcinogen metabolism
31. Inhibition of neoplasia by minor dietary constituents
32. Inhibition of carcinogenesis by some minor dietary constituents
33. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
34. Chemoprotection against cancer by isothiocyanates and glucosinolates
35. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
36. Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol
37. Mechanisms of the differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes
38. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
39. Chemical and molecular regulation of enzymes that detoxify carcinogens
40. The electrophile counterattack response: Protection against neoplasia and toxicity
41. Dietary carotenoids and their metabolites as potentially useful chemoprotective agents against cancer
42. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver
43. Chemoprevention by inducers of carcinogen detoxication enzymes
44. The war against cancer: New hope
45. Chemoprotection against cancer by induction of Phase 2 enzymes
46. Chemoprotection against cancer by Phase 2 enzyme induction
47. Glutathione and glutathione-dependent enzymes represent a co-ordinated regulated defence against oxidative stress
48. 1 by oltipraz in residents of Qidong, People's Republic of China
49. Direct measurement of NAD(P)H:quinone oxidoreductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers
50. Rapid detection of inducers of enzymes that protect against carcinogens
51. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
52. Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: Correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes
53. Antioxidant response element
54. Cellular response to cancer chemopreventive agents: Contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress
55. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
56. Keap 1 represses nuclear activation of antioxidant response elements by Nrf2 through binding to the amino-terminal Neh2 domain
57. Role of transcription factor Nrf2 in the induction of hepatic Phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1,2-dithiole-3-thione
58. The Cap 'n' Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related Factor 2) controls both constitutive and induced expression of intestinal detoxification and glutathione biosynthetic enzymes
59. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
60. Comparative patterns of drug metabolism
61. Detoxication of base propenals and other α, β-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases
62. Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases
63. Human glutathione transferase A4-4: An alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
64. Human class mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome
65. Biotransformation of xenobiotics
66. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen
67. The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems
68. The reduction of α-tocopherolquinone by human NAD(P)H:quinone oxidoreductase: The role of α-tocopherolhydroquinone as a cellular antioxidant
69. Pyrrolidine dithiocarbamate upregulates the expression of the genes encoding the catalytic and regulatory subunits of γ-glutamylcysteine synthetase and increases intracellular glutathione levels
70. Regulation of γ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defense
71. Expression of multidrug resistance protein/GS-X pump and γ-glutamylcysteine synthetase genes is regulated by oxidative stress
72. Parallel induction of heme oxygenase-1 and chemoprotective Phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
73. Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones
74. Carbon monoxide provides protection against hyperoxic lung injury
75. 4 12-hydroxydehydrogenase: Implications for chemoprevention
76. Antioxidant functions of sulforaphane: A potent inducer of Phase II detoxication enzymes