Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma

Haematologica

Volumn 96, Issue 8, 2011, Pages 1170-1179

  Jakubikova, Jana ^a,b,c   Cervi, David ^a,b   Ooi, Melissa ^a,b   Kim, Kihyun ^a,b   Nahar, Sabikun ^a,b   Klippel, Steffen ^a,b   Cholujova, Dana ^c   Leiba, Merav ^a,b   Daley, John F ^a,b   Delmore, Jake ^a,b   Negri, Joseph ^a,b   Blotta, Simona ^a,b   Mcmillin, Douglas W ^a,b   Hideshima, Teru ^a,b   Richardson, Paul G ^a,b   Sedlak, Jan ^c   Anderson, Kenneth C ^a,b   Mitsiades, Constantine S ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Bone marrow microenvironment; Isothiocyanates; Multiple myeloma; PEITC; Phenethyl isothiocyanate; Signaling pathways; Sulforaphane

Indexed keywords

BORTEZOMIB; CASPASE 3; CASPASE 9; DEXAMETHASONE; DOXORUBICIN; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 27; HISTONE H3; INHIBITOR OF APOPTOSIS PROTEIN; LENALIDOMIDE; MELPHALAN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENETHYL ISOTHIOCYANATE; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN P53; SULFORAPHANE; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS; MOUSE; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; SIGNAL TRANSDUCTION; STROMA CELL; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOTHIOCYANATES; MICE; MICE, SCID; MULTIPLE MYELOMA; SIGNAL TRANSDUCTION; STROMAL CELLS; THIOCYANATES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79961075772     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.029363     Document Type: Article

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