Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways

Human and Experimental Toxicology

Volumn 33, Issue 3, 2014, Pages 270-283

  Huang, S H ^a   Hsu, M H ^a   Hsu, S C ^b   Yang, J S ^b   Huang, W W ^b   Huang, A C ^c   Hsiao, Y P ^d,e   Yu, C C ^b   Chung, J G ^a,b  

^a ASIA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c Saint Mary's Medicine Nursing and Management College   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

A375.S2 melanoma cells; apoptosis; mitochondria; PEITC; ROS

Indexed keywords

A375.S2 MELANOMA CELLS; APOPTOSIS; MITOCHONDRIA; PEITC; ROS;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CARDIOLIPINS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELL SHAPE; COMET ASSAY; DNA DAMAGE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INDICATORS AND REAGENTS; ISOTHIOCYANATES; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NITRIC OXIDE; REACTIVE OXYGEN SPECIES;

EID: 84893945845     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113491508     Document Type: Article

References (44)

1. Bergomi M, Pellacani G, Vinceti M, et al. Trace elements and melanoma. J Trace Elem Med Biol. 2005 ; 19: 69-73 (Pubitemid 41253920)
2. Chi Z, Li S, Sheng X, et al. Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: a study of 522 consecutive cases. BMC Canc. 2011 ; 11: 85
3. Potter JD. Nutrition and colorectal cancer. Canc Causes Contr. 1996 ; 7: 127-146 (Pubitemid 26066852)
4. Conaway CC, Yang YM, Chung FL. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab. 2002 ; 3: 233-255 (Pubitemid 34625038)
5. Stoner GD, Morrissey DT, Heur YH, et al. Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus. Canc Res. 1991 ; 51: 2063-2068
6. Mi L, Wang X, Govind S, et al. The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Canc Res. 2007 ; 67: 6409-6416 (Pubitemid 47037525)
7. Zhang H, Trachootham D, Lu W, et al. Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism. Leukemia. 2008 ; 22: 1191-1199 (Pubitemid 351833787)
8. Cheung KL, Khor TO, Yu S, et al. PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. AAPS J. 2008 ; 10: 277-281
9. Lee JW, Cho MK. Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells. Arch Pharm Res. 2008 ; 31: 1604-1612
10. Xiao D, Singh SV. Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo. Pharm Res. 2010 ; 27: 722-731
11. Zhang Y. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res. 2004 ; 555: 173-190 (Pubitemid 39345403)
12. Wu CL, Huang AC, Yang JS, et al. Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and Nitric Oxide (NO) in human osteogenic sarcoma U-2 OS cells. J Orthop Res. 2011 ; 29: 1199-1209
13. Xiao D, Lew KL, Zeng Y, et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis. 2006 ; 27: 2223-2234 (Pubitemid 44644811)
14. Xiao D, Singh SV. Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo. Canc Res. 2007 ; 67: 2239-2246 (Pubitemid 46424243)
15. Powolny AA, Bommareddy A, Hahm ER, et al. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer. J Natl Canc Inst. 2011 ; 103: 571-584
16. Gao N, Budhraja A, Cheng S, et al. Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. Cell Death Dis. 2011 ; 2: e140
17. Lin JG, Chen GW, Li TM, et al. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. J Urol. 2006 ; 175: 343-347
18. Yang JS, Hour MJ, Huang WW, et al. MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther. 2010 ; 334: 477-488
19. Chiang JH, Yang JS, Ma CY, et al. Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways. Chem Res Toxicol. 2011 ; 24: 20-29
20. Lu CC, Yang JS, Huang AC, et al. Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res. 2010 ; 54: 967-976
21. Kuo CL, Wu SY, Ip SW, et al. Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. Int J Oncol. 2011 ; 39: 319-328
22. Lo C, Lai TY, Yang JH, et al. Gallic acid induces apoptosis in A375.S2 human melanoma cells through caspase-dependent and -independent pathways. Int J Oncol. 2010 ; 37: 377-385
23. Huang WW, Chiu YJ, Fan MJ, et al. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol Nutr Food Res. 2010 ; 54: 1585-1595
24. Lan YH, Wu YC, Wu KW, et al. Death receptor 5-mediated TNFR family signaling pathways modulate gamma-humulene-induced apoptosis in human colorectal cancer HT29 cells. Oncol Rep. 2011 ; 25: 419-424
25. Tang NY, Huang YT, Yu CS, et al. Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells. Anticanc Res. 2011 ; 31: 1691-1702
26. Jeong HW, Han DC, Son KH, et al. Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase. Biochem Pharmacol. 2003 ; 65: 1343-1350 (Pubitemid 36407785)
27. Buolamwini JK. Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Des. 2000 ; 6: 379-392 (Pubitemid 30396403)
28. Simbula G, Columbano A, Ledda-Columbano GM, et al. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis. 2007 ; 12: 113-123 (Pubitemid 46009508)
29. Masgras I, Carrera S, de Verdier PJ, et al. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012 ; 287: 9845-9854
30. Makovski A, Yaffe E, Shpungin S, et al. Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells. Cell Signal. 2012 ; 24: 1369-1374
31. Kaufmann SH, Hengartner MO. Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 2001 ; 11: 526-534 (Pubitemid 33079147)
32. Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer. 1994 ; 73: 2013-2026 (Pubitemid 24107952)
33. Rogalska A, Koceva-Chyla A, Jozwiak Z. Aclarubicin-induced ROS generation and collapse of mitochondrial membrane potential in human cancer cell lines. Chem Biol Interact. 2008 ; 176: 58-70
34. Han J, Goldstein LA, Gastman BR, et al. Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis. J Biol Chem. 2006 ; 281: 10153-10163 (Pubitemid 43864551)
35. Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 1997 ; 275: 1129-1132 (Pubitemid 27097312)
36. Korge P, Honda HM, Weiss JN. Regulation of the mitochondrial permeability transition by matrix Ca(2+) and voltage during anoxia/reoxygenation. Am J Physiol Cell Physiol. 2001 ; 280: C517 - C526
37. Bustamante J, Caldas Lopes E, Garcia M, et al. Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug-resistant lymphoid leukemia. Toxicol Appl Pharmacol. 2004 ; 199: 44-51 (Pubitemid 39099454)
38. Cohen GM. Caspases: the executioners of apoptosis. Biochem J. 1997 ; 326 (Pt 1). 1-16 (Pubitemid 27386911)
39. Burkle A. Physiology and pathophysiology of poly (ADP-ribosyl)ation. Bioessays. 2001 ; 23: 795-806
40. Thati B, Noble A, Creaven BS, et al. Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells. Eur J Pharmacol. 2009 ; 602: 203-214
41. Sergeev IN. Genistein induces Ca2+ -mediated, calpain/caspase-12- dependent apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2004 ; 321: 462-467 (Pubitemid 39055768)
42. Klein CB, King AA. Genistein genotoxicity: critical considerations of in vitro exposure dose. Toxicol Appl Pharmacol. 2007 ; 224: 1-11 (Pubitemid 47404623)
43. Kingston DG. Taxol: the chemistry and structure-activity relationships of a novel anticancer agent. Trends Biotechnol. 1994 ; 12: 222-227 (Pubitemid 24190549)
44. Wu Y, Shen D, Chen Z, et al. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007 ; 12: 593-612