Atg5 regulates Phenethyl isothiocyanate-lnduced autophagic and apoptotic cell death in human prostate cancer cells

Cancer Research

Volumn 69, Issue 8, 2009, Pages 3704-3712

  Bommareddy, Ajay ^a   Hahm, Eun Ryeong ^a   Xiao, Dong ^a   Powolny, Anna A ^a   Fisher, Alfred L ^b   Jiang, Yu ^a   Singh, Shivendra V ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ATG5 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G1; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; PHENETHYL ISOTHIOCYANATE; PROTEIN KINASE B; PROTEIN P53; REGULATOR PROTEIN; RHEB PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CANCER CELL; CANCER MODEL; CELL DIVISION; CELL ORGANELLE; CELL STRAIN LNCAP; CELL VACUOLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGHT CHAIN; MALE; MOUSE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; WILD TYPE; XENOGRAFT;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL LINE, TUMOR; HUMANS; ISOTHIOCYANATES; MALE; MICE; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 65949086045     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-4344     Document Type: Article

References (47)

1. Nelson WG, De Marzo AM, Isaacs WB. Prostate cancer. N Engl J. Med 2003; 349: 366-81. (Pubitemid 36886244)
2. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA, Epidemiological studies on brassiea vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 1996; 5: 733-48 (Pubitemid 26304649)
3. Kolonel LN, Hankin JH, Whittemore AS. et al. Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev 2000; 9: 795-804. (Pubitemid 30660052)
4. Hecht SS, Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev 2000; 32: 395-411. (Pubitemid 32001915)
5. Conaway CC, Yang YM, Chung FL. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab. 2002; 3: 233-55. (Pubitemid 34625038)
6. Morse MA, Wang C, Stoner GD. et al. Inhibition of 4- (methylnitrosamino}- l- (3-pyridyl}-l-hutanone-indueed DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. Cancer Res 1989; 49: 549-53. (Pubitemid 19050313)
7. Pereira MA. Chemoprevention of diethylmtrosamineinduced liver foci and hepatocellular adenomas in C3H mice. Anticancer Res 1995; 15: 1953-6. (Pubitemid 26031264)
8. Stoner GD, Morrissey DT, Heur YH, Daniel EM, Galati AJ, Wagner SA, Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus. Cancer Res 1991; 51: 2063-8.
9. Yang YM, Conaway CC, Chiao JW. et al. Inhibition of benzo (a) pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. Cancer Res 2002; 62: 2-7. (Pubitemid 34073975)
10. Chen YR, Han J, Kori R, Kong AN, Tan TH. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun. N- terminal kinase. J. Biol. Chem 2002; 277: 39334-42. (Pubitemid 35190906)
11. Xiao D, Singh SV. Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Res 2002; 62: 3615-9. (Pubitemid 34728834)
12. 12, Xu C, Shen G, Yuan X. et al. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis 2006; 27: 437-45. (Pubitemid 43372873)
13. 2-M-phase cell cycle arrest in PC-3 human prostate cancer cells. Mol. Cancer Ther. 2004; 3: 567-75. (Pubitemid 39193735)
14. 14- Xu C, Shen G, Chen C, Gelinas C, Kong AN. Suppression of NF-κB and NF-κB-regulated gene expression hy sulforaphane and PEITC through 1κBα, IKK pathway in human prostate cancer PC-3 cells. Oncogene 2005; 24: 4486-95. (Pubitemid 41032612)
15. Xiao D, Zeng Y, Choi S, Lew KL, Nelson JR, Singh SV. Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax, Clin. Cancer Res 2005; 11: 2670-9. (Pubitemid 40569468)
16. Xiao D, Lew KL, Zeng Y. et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated hy reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis 2006; 27: 2223-34. (Pubitemid 44644811)
17. Kim JH, Xu C, Keum YS, Reddy B, Conney A, Kong AN. Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with β- phenylethyl isothiocyanate and curcumin. Carcinogenesis 2006; 27: 475-82. (Pubitemid 43372876)
18. Wang LG, Liu XM, Chiao JW. Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate. Carcinogenesis 2006; 27: 2124-32. (Pubitemid 44530587)
19. Hu J, Straub J, Xiao D. et al. Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP-1. Cancer Res 2007; 67: 3569-73. (Pubitemid 46762140)
20. Xiao D, Singh SV. Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo. Cancer Res 2007; 67: 2239-46.
21. Yorimitsu T, Klionsky DJ. Autophagy; molecular machinery for self-eating. Cell Death Differ 2005; 12: 1542-52. (Pubitemid 41553991)
22. Bergamini E. Autophagy: a cell repair mechanism that retards aging and age-associated diseases and can be intensified pharmacologically. Mol. Aspects Med 2006; 27: 403-10. (Pubitemid 44466651)
23. Meijer AJ, Codogno P. Signaling and autophagy regulation in health, aging and disease. Mol. Aspects Med 2006; 27: 411-25. (Pubitemid 44466652)
24. Kim YA, Xiao D, Xiao H. et al. Mitochondriamediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak. Mol. Cancer Ther. 2007; 6: 1599-609. (Pubitemid 46954027)
25. 2/M arrest and inducing apoptosis. Carcinogenesis 2003; 24: 891-7. (Pubitemid 36748905)
26. H-ras processing. Biochem Biophys Res Commun 1996; 225: 660-5. (Pubitemid 26355654)
27. Paglin S, Hollister T, Delohery T. et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439-44. (Pubitemid 32128593)
28. Iwamaru A, Kondo Y, Iwado E. et al. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007; 26: 1840-51. (Pubitemid 46474638)
29. Kabeya Y, Mizushima N, Ueno T. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000; 21: 5720-8.
30. Chiang GG, Abraham RT. Targeting the mTOR signaling network in cancer. Trends Mol. Med 2007; 13: 433-42. (Pubitemid 47570021)
31. Bai X, Ma D, Liu A. et al. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 2007; 318: 977-80. (Pubitemid 350098994)
32. Mizushima K, Yamamoto A, Hatano M. et al. Dissection of autophagosome formation using Apg5- deficient mouse embryonic stem cells. J. Cell Biol. 2001; 152: 657-68.
33. Herman-Antosiewicz A, Johnson DE, Singh SV. Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res 2006; 66: 5828-35. (Pubitemid 43927137)
34. Amaravadi RK, Yu D, Lum JJ. et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest 2007; 117: 326-36. (Pubitemid 46203961)
35. Han j, Hou W, Goldstein LA. et al. Involvement of protective autophagy in TRAIL resistance of apoptosisdefective tumor cells. J. Biol. Chem 2008; 283: 19665-77.
36. Takeuchi H, Kondo Y, Fujiwara K. et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3- kinase/protein kinase B inhibitors. Cancer Res 2005; 65: 3336-46. (Pubitemid 40524618)
37. Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63: 2103-8. (Pubitemid 36538613)
38. Kang C, You YJ, Avery L. Dual roles of autophagy in the survival of Caenorhahditis elegans during starvation. Genes Dev 2007; 21: 2161-71. (Pubitemid 47360838)
39. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine R. Autophagy genes are essential for dauer development and life-span extension In C. elegans. Science 2003; 301: 1387-91. (Pubitemid 37075816)
40. Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 2007; 3: 597-9. (Pubitemid 350060057)
41. Chung FL, Morse MA, Eklind KL Lewis J. Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. Cancer Epidemiol Biomarkers Prev 1992; 1: 383-8.
42. Hecht SS, Chung FL, Richie JP. et al. Effects of watercress consumption on metabolism of a tobaccospecific lung carcinogen in smokers. Cancer Epidemiol Biomarkers Prev 1995; 4: 877-84.
43. Tasdemir E, Maiuri CM, Galluzzi L. et al. Regulation of autophagy by cytoplasmic p53. Nat Cell Riol 2008; 10: 676-87.
44. Suzuki K, Kubota Y, Sekito T, Ohsumi Y. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 2007; 12: 209-18. (Pubitemid 46152659)
45. Huang S, Houghton PJ. Targeting m-TOR signaling for cancer therapy. Curr Opin Pharmacol 2003; 3: 371-7. (Pubitemid 36908940)
46. Carew JS, Nawrocki ST, Kaliue CN. et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr- Abl mediated drug resistance. Blood 2007; 110: 313-22. (Pubitemid 47026849)
47. Yousefi S, Perozzo R, Schmid I. et al. Calpainmediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 2006; 8: 1124-32. (Pubitemid 44473608)