Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

Carcinogenesis

Volumn 24, Issue 5, 2003, Pages 891-897

  Xiao, Dong ^a   Srivastava, Sanjay K ^a   Lew, Karen L ^a   Zeng, Yan ^a   Hershberger, Pamela ^a   Johnson, Candace S ^a,b   Trump, Donald L ^a,b   Singh, Shivendra V ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; CELL CYCLE PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; PROTEIN BCL XL; PROTEIN CDC25B; PROTEIN CDC25C; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL SURVIVAL; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPOTHESIS; IC 50; MALE; METAPHASE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; TREATMENT FAILURE; VEGETABLE;

APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN B; EPITHELIAL CELLS; G2 PHASE; HUMANS; ISOTHIOCYANATES; MALE; MITOSIS; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; VEGETABLES;

EID: 0037972262     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg023     Document Type: Article

References (34)

1. Fahey,J.W., Zalcmann,A.T. and Talalay,P. (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry, 56, 5-51.
2. Zhang,Y. and Talalay,P. (1994) Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res., 54, 1976s 1981s.
3. Hecht,S.S. (2000) Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev., 32, 395-411.
4. Talalay,P. and Fahey,J.W. (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J. Nutr., 131 (suppl.), 3027s-3033s.
5. Wattenberg,L.W. (1987) Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. Carcinogenesis, 8, 1971-1973.
6. Stoner,G.D., Morrissey,D.T., Heur,Y.-H, Daniel,E.M., Galati,A.J. and Wagner,S.A. (1991) Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzy1methylamine carcinogenesis in the rat esophagus. Cancer Res., 51, 2063-2068.
7. Morse,M.A., Wang,C.-X, Stoner,G.D., Mandal,S., Conran,P.B., Amin,S.G., Hecht,S.S. and Chung,F.-L. (1989) Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-l-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. Cancer Res., 49, 549-553.
8. Chung,F.-L., Conaway,C.C., Rao,C.V. and Reddy,B.S. (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis, 21, 2287 2291.
9. Jiao,D., Smith,T.J., Yang,C.S., Pittman,B., Desai,D., Amin,S. and Chung,F.-L. (1997) Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis. Carcinogenesis, 18, 2143-2147.
10. O Yang,Y.-M., Conaway,C.C., Chiao,J.W., Wang,C.-X., Amin,S., Whysner,J., Dai,W., Reinhardt,J. and Chung,F.-L. (2002) Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. Cancer Res., 62, 2-7.
11. Yu,R., Mandlekar,S., Harvey,K.J., Ucker,D.S. and Kong,A.-N.T. (1998) Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res., 58, 402-408.
12. Chen,Y.-R., Wang,W.F., Kong,A.-N.T. and Tan,T.H. (1998) Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem., 273, 1769-1775.
13. Xu,K. and Thornalley,P.J. (2000) Studies on the mechanism of the inhibition of human leukemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. Biochem. Pharmacol., 60, 221-231.
14. Huang,C., Ma,W.-Y., Li,J., Hecht,S.S. and Dong,Z. (1998) Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res., 58, 4102-4106.
15. Gamet-Payrastre,L., Li,P., Lumeau,S., Cassar,G., Dupont,M.-A., Chevolleau,S., Gasc,N., Tulliez,J. and Terce,F. (2000) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res., 60, 1426-1433.
16. Xu,K. and Thornalley,P.J. (2001) Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK. Br. J. Cancer, 84, 670-673.
17. Cohen,J.H., Kristal,A.R. and Stanford,J.L. (2000) Fruit and vegetable intakes and prostate cancer risk. J. Natl Cancer Inst., 92, 61-68.
18. Kolonel,L.N., Hankin,J.H., Whittemore,A.S. et al. (2000) Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol. Biomarkers Prev., 9, 795-804.
19. Xiao,D. and Singh,S.V. (2002) Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Res., 62, 3615 3619.
20. Bradford,M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
21. Laemmli,U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
22. Towbin,H., Staehelin,T. and Gordon,J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA, 76, 4350-4354.
23. Fadok,V.A., Voelker,D.R., Campbell,P.A., Cohen,J.J., Bratton,D.L. and Henson,P.M. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol., 148, 2207-2216.
24. Martin,S.J., Reutelingsperger,C.P.M., McGahon,A.J., Rader, J.A., van Schie,R.C.A.A., LaFace,D.M. and Green,D.R. (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med., 182, 1545-1556.
25. Thornberry,N. and Lazebnik,Y. (1998) Caspases: enemies within. Science, 281, 1312-1316.
26. Morgan,D.O. (1992) Cell cycle control in normal and neoplastic cells. Curr. Opin. Genet. Dev., 2, 33-37.
27. Molinari,M. (2000) Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif., 33, 261-274.
28. Adams,J.M. and Cory,S. (1998) The Bcl-2 protein family: arbiters of cell survival. Science, 281, 1322-1326.
29. Hartwell,L.H. and Kastan,M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
30. Draetta,G. and Eckstein,J. (1997) Cdc25 protein phosphatase in cell proliferation. Biochim. Biophys. Acta, 1322, M53-M63.
31. Chiao,J.W., Chung,F.-L., Kancherla,R., Ahmed,T., Mittelman,A. and Conaway,C.C. (2002) Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int. J. Oncol., 20, 631-636.
32. Chung,F.-L., Morse,M.A., Eklind,K.I. and Lewis,J. (1992) Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. Cancer Epidemiol. Biomarkers Prev., 1, 383-388.
33. Hecht,S.S., Chung,F.-L., Richie,J.P. Jr, Akerkar,S.A., Borukhova,A., Skowronski,L. and Carmella,S.G. (1995) Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol. Biomarkers Prev., 4, 877-884.
34. Ye,L., Dinkova-Kostova,A.T., Wade,K.L., Zhang,Y., Shapiro,T.A. and Talalay,P. (2002) Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin. Chim. Acta, 316, 43 53.