Epigenetic impact of dietary isothiocyanates in cancer chemoprevention

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 16, Issue 4, 2013, Pages 405-410

  Gerhauser, Clarissa ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

DNA methylation; Epithelialmesenchymal transition (emt); Histone deacetylase (hdac); Keap1 nrf2 are pathway; Microrna; Phenethylisothiocyanate (peitc); Sulforaphane (sfn)

Indexed keywords

CORTICOSTEROID; CYCLIN D2; DNA METHYLTRANSFERASE 1; EPIGALLOCATECHIN GALLATE; ESTROGEN RECEPTOR; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; ISOTHIOCYANIC ACID; ISOTHIOCYANIC ACID DERIVATIVE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MICRORNA 141; MICRORNA 200C; PHENETHYL ISOTHIOCYANATE; SULFORAPHANE; TAMOXIFEN; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR SP1; UVOMORULIN;

ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; BREAST CANCER; BROCCOLI; CANCER INCIDENCE; CANCER PREVENTION; CELL CYCLE ARREST; CHEMOPROPHYLAXIS; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DIETARY INTAKE; DNA BINDING; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; HISTONE ACETYLATION; HUMAN; HYPERTENSION; METABOLITE; METASTASIS; NONHUMAN; ONCOGENE C MYC; OXIDATIVE STRESS; PROSTATE CANCER; PROTEIN BINDING; PROTEIN FUNCTION; PROTEOMICS; REVIEW; SPROUT; TUMOR VOLUME; URINARY EXCRETION; VEGETABLE; WATERCRESS;

ANIMALS; ANTICARCINOGENIC AGENTS; BRASSICA; CATECHIN; CHEMOPREVENTION; DIET; DNA METHYLATION; EPIGENESIS, GENETIC; EPITHELIAL-MESENCHYMAL TRANSITION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOTHIOCYANATES; MICRORNAS; NEOPLASMS; NF-E2-RELATED FACTOR 2; SIGNAL TRANSDUCTION;

ANIMALIA; BRASSICA OLERACEA VAR. ITALICA; NASTURTIUM OFFICINALE; RATTUS;

EID: 84880330400     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328362014e     Document Type: Review

References (25)

1. Gerhauser C. Cancer chemoprevention and nutriepigenetics:state of the art and future challenges. Top Curr Chem 2013; 329:73-132.
2. Huang J, Plass C, Gerhauser C. Cancer chemoprevention by targeting the epigenome. Curr Drug Targets 2011; 12:1925-1956.
3. Singh SV, Singh K. Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research. Carcinogenesis 2012; 33:1833-1842.
4. Navarro SL, Li F, Lampe JW. Mechanisms of action of isothiocyanates in cancer chemoprevention:an update. Food Funct 2011; 2:579-587.
5. Nian H, Delage B, Ho E, Dashwood RH. Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides:studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen 2009; 50:213-221.
6. Clarke JD, Riedl K, Bella D, et al. Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem 2011; 59:10955-10963.
7. Mi L, Hood BL, Stewart NA, et al. Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol 2011; 24:1735-1743.
8. Sporn MB, Liby KT. NRF2 and cancer:the good, the bad and the importance of context. Nat Rev Cancer 2012; 12:564-571.
9. Chorley BN, Campbell MR, Wang X, et al. Identification of novel NRF2-regulated genes by ChIP-Seq:influence on retinoid X receptor alpha. Nucleic Acids Res 2012; 40:7416-7429. Unbiased approach to identify genes regulated by the KEAP1/Nrf2/ARE pathway reveals novel targets.
10. Zhang C, Su ZY, Khor TO, et al. Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. Biochem Pharmacol 2013; 85:1398-1404. Study showing that epigenetically silenced Nrf2 can be reactivated by a combination of mechanisms.
11. Malhotra D, Thimmulappa RK, Mercado N, et al. Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J Clin Invest 2011; 121:4289-4302.
12. Wagner AE, Boesch-Saadatmandi C, Dose J, et al. Anti-inflammatory role of Nrf2, NF-kB and microRNA-155. J Cell Mol Med 2012; 16:836-843. Ref. [12 ] might be functionally relevant for [11].
13. Senanayake GV, Banigesh A, Wu L, et al. The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. Am J Hypertens 2012; 25:229-235. This study is of relevance as it demonstrated that prevention of oxidative stress leads to normalization of disease (hypertension)-associated hypomethylation.
14. Hsu A, Wong CP, Yu Z, et al. Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics 2011; 3:3.
15. Sporn MB. Combination chemoprevention of cancer. Nature 1980; 287:107-108.
16. Barrera LN, Johnson IT, Bao Y, et al. Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro. Eur J Nutr 2012. 10.1007/s00394-012-0442-1. [Epub ahead of print].
17. Meeran SM, Patel SN, Li Y, et al. Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One 2012; 7:e37748.
18. Chen H, Landen CN, Li Y, et al. Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation. Exp Cell Res 2013; 319:697-706. Another example of improved efficacy by targeted combination.
19. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420-1428.
20. Zhang J, Ma L. MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metastasis Rev 2012; 31:653-662.
21. Shan Y, Zhang L, Bao Y, et al. Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells. J Nutr Biochem 2012. 10.1016/ j.jnutbio.2012.08.004. [Epub ahead of print]. If confirmed in vivo, this study might provide an interesting new direction for translational cancer (prevention) research targeting metastasis formation.
22. Powolny AA, Bommareddy A, Hahm ER, et al. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer. J Natl Cancer Inst 2011; 103:571-584.
23. Xiao J, Gong AY, Eischeid AN, et al. miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate 2012; 72:1514-1522. Ref. [23 ] might be of relevance for [22].
24. Hessvik NP, Sandvig K, Llorente A. Exosomal miRNAs as Biomarkers for Prostate Cancer. Front Genet 2013; 4:36.
25. Williams Z, Ben-Dov IZ, Elias R, et al. Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc Natl Acad Sci U S A 2013; 110:4255-4260.