Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: Pharmacological and toxicological implications

Current Drug Metabolism

Volumn 9, Issue 7, 2008, Pages 668-678

  Fimognari, Carmela ^a   Lenzi, M ^a   Hrelia, P ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antioxidant activity; Cancer chemotherapy; Cytochrome P 450; Drug metabolizing enzymes; Glutathione S transferase; Isothiocyanates; NF E2 related factor 2; Sulforaphane

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARCINOGEN; CYTOCHROME P450; DAUNORUBICIN; DOXORUBICIN; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; ISOTHIOCYANIC ACID; MIDAZOLAM; MULTIDRUG RESISTANCE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RIFAMPICIN; SIMVASTATIN; SULFORAPHANE; TRIAZOLAM; VERAPAMIL; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; BRAIN ISCHEMIA; BREAST CANCER; BROCCOLI; CARDIOTOXICITY; DETOXIFICATION; DRUG ANTAGONISM; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; DRUG RESISTANCE; ENZYME INDUCTION; ENZYME REGULATION; FOOD INTAKE; GENE INDUCTION; HEART INJURY; HEART PROTECTION; HUMAN; LUNG ADENOMA; NONHUMAN; PANCREAS TUMOR; REVIEW; SINGLE DRUG DOSE; SKIN CANCER;

ANIMALS; ANTIOXIDANTS; CLINICAL TRIALS AS TOPIC; CYTOPROTECTION; DNA REPAIR; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; THIOCYANATES;

EID: 52449134789     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008785821675     Document Type: Review

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