Phenethyl isothiocyanate (PEITC) inhibits the growth of human oral squamous carcinoma hsc-3 cells through g 0 / g 1 phase arrest and mitochondria-mediated apoptotic cell death

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Chen, Po Yuan ^a   Lin, Kai Chun ^a   Lin, Jing Pin ^a   Tang, Nou Ying ^a   Yang, Jai Sing ^a   Lu, Kung Wen ^a   Chung, Jing Gung ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME C; PHENETHYL ISOTHIOCYANATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN P17; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL STRAIN; CELL STRAIN HSC 3; CELL STRUCTURE; CELL VIABILITY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ENZYME RELEASE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL;

EID: 84864943298     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/718320     Document Type: Article

References (41)

1. Franco E. L., Kowalski L. P., Oliveira B. V., Curado M. P., Pereira R. N., Silva M. E., Fava A. S., Torloni H., Risk factors for oral cancer in Brazil: a case-control study International Journal of Cancer 1989 43 6 992 1000 (Pubitemid 19158027)
2. Schlecht N. F., Franco E. L., Pintos J., Negassa A., Kowalski L. P., Oliveira B. V., Curado M. P., Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil American Journal of Epidemiology 1999 150 11 1129 1137
3. Franceschi S., Bidoli E., Baron A. E., Barra S., Talamini R., Serraino D., La Vecchia C., Nutrition and cancer of the oral cavity and pharynx in north-east Italy International Journal of Cancer 1991 47 1 20 25
4. Pintos J., Franco E. L., Kowalski L. P., Oliveira B. V., Curado M. P., Use of wood stoves and risk of cancers of the upper aero-digestive tract: a case-control study International Journal of Epidemiology 1998 27 6 936 940 (Pubitemid 29026740)
5. Velly A. M., Franco E. L., Schlecht N., Pintos J., Kowalski L. P., Oliveira B. V., Curado M. P., Relationship between dental factors and risk of upper aerodigestive tract cancer Oral Oncology 1998 34 4 284 291 (Pubitemid 28318255)
6. Ko Y. C., Huang Y. L., Lee C. H., Chen M. J., Lin L., Tsai C. C., Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan Journal of Oral Pathology and Medicine 1995 24 10 450 453
7. Ichimiya Y., Fuwa N., Kamata M., Kodaira T., Furutani K., Tachibana H., Tomita N., Hidano S., Treatment results of stage I oral tongue cancer with definitive radiotherapy Oral Oncology 2005 41 5 520 525 (Pubitemid 40692854)
8. Kumar B., Kumar A., Pandey B. N., Mishra K. P., Hazra B., Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells Molecular and Cellular Biochemistry 2009 320 1-2 185 195
9. Galluzzi L., Larochette N., Zamzami N., Kroemer G., Mitochondria as therapeutic targets for cancer chemotherapy Oncogene 2006 25 34 4812 4830 (Pubitemid 44192089)
10. Armstrong J. S., Mitochondrial medicine: pharmacological targeting of mitochondria in disease British Journal of Pharmacology 2007 151 8 1154 1165 (Pubitemid 47255892)
11. Li D., Das S., Yamada T., Samuels H. H., The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells Molecular and Cellular Biology 2004 24 9 3838 3848 (Pubitemid 38496162)
12. Danial N. N., Korsmeyer S. J., Cell death: critical control points Cell 2004 116 2 205 219 (Pubitemid 38167313)
13. Conaway C. C., Yang Y. M., Chung F. L., Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans Current Drug Metabolism 2002 3 3 233 255 (Pubitemid 34625038)
14. Kumar A., Sabbioni G., New biomarkers for monitoring the levels of isothiocyanates in humans Chemical Research in Toxicology 2010 23 4 756 765
15. Stoner G. D., Morrissey D. T., Heur Y. H., Daniel E. M., Galati A. J., Wagner S. A., Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus Cancer Research 1991 51 8 2063 2068
16. Zhang Y., Kensler T. W., Cho C. G., Posner G. H., Talalay P., Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates Proceedings of the National Academy of Sciences of the United States of America 1994 91 8 3147 3150 (Pubitemid 24130192)
17. Zhang Y., Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action Mutation Research 2004 555 1-2 173 190 (Pubitemid 39345403)
18. Xiao D., Powolny A. A., Moura M. B., Kelley E. E., Bommareddy A., Kim S. H., Hahm E. R., Normolle D., Van Houten B., Singh S. V., Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells Journal of Biological Chemistry 2010 285 34 26558 26569
19. Wu C. L., Huang A. C., Yang J. S., Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells Journal of Orthopaedic Research 2011 29 8 1199 1209
20. Lai K. C., Huang A. N. C., Hsu S. C., Kuo C. L., Yang J. S., Wu S. H., Chung J. G., Benzyl Lsothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway Journal of Agricultural and Food Chemistry 2010 58 5 2935 2942
21. Ho C. C., Lai K. C., Hsu S. C., Kuo C. L., Ma C. Y., Lin M. L., Yang J. S., Chung J. G., Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways Human Experimental Toxicology 2011 30 4 296 306
22. Lin C. C., Yang J. S., Chen J. T., Fan S., Yu F. S., Yang J. L., Lu C. C., Kao M. C., Huang A. C., Lu H. F., Chung J. G., Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway Anticancer Research 2007 27 5 3371 3378 (Pubitemid 47607564)
23. Yu F. S., Yang J. S., Yu C. S., Lu C. C., Chiang J. H., Lin C. W., Chung J. G., Safrole induces apoptosis in human oral cancer HSC-3 cells Journal of Dental Research 2011 90 2 168 174
24. Yang J. S., Chen G. W., Hsia T. C., Ho H. C., Ho C. C., Lin M. W., Lin S. S., Yeh R. D., Ip S. W., Lu H. F., Chung J. G., Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways Food and Chemical Toxicology 2009 47 1 171 179
25. Chiu T. H., Lai W. W., Hsia T. C., Yang J. S., Lai T. Y., Wu P. P., Ma C. Y., Yeh C. C., Ho C. C., Lu H. F., Wood W. G., Chung J. G., Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells Anticancer Research 2009 29 11 4503 4511
26. Chiang J. H., Yang J. S., Ma C. Y., Yang M. D., Huang H. Y., Hsia T. C., Kuo H. M., Wu P. P., Lee T. H., Chung J. G., Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways Chemical Research in Toxicology 2011 24 1 20 29
27. Lu C. C., Yang J. S., Huang A. C., Hsia T. C., Chou S. T., Kuo C. L., Lu H. F., Lee T. H., Wood W. G., Chung J. G., Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells Molecular Nutrition and Food Research 2010 54 7 967 976
28. Wu S. H., Hang L. W., Yang J. S., Chen H. Y., Lin H. Y., Chiang J. H., Lu C. C., Yang J. L., Lai T. Y., Ko Y. C., Chung J. G., Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways Anticancer Research 2010 30 6 2125 2133
29. Venkatachalam C. M., Jiang X., Oldfield T., Waldman M., LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites Journal of Molecular Graphics and Modelling 2003 21 4 289 307 (Pubitemid 35441326)
30. Anukanth A., Ponnuswamy P. K., Conformational characteristics of the dinucleoside triphosphate pCpGp from energy-minimization studies Biophysical Chemistry 1983 17 1 1 11
31. Xiao D., Powolny A. A., Moura M. B., Kelley E. E., Bommareddy A., Kim S. H., Hahm E. R., Normolle D., Van Houten B., Singh S. V., Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells Journal of Biological Chemistry 2010 285 34 26558 26569
32. Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., Chiao P. J., Achanta G., Arlinghaus R. B., Liu J., Huang P., Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by -phenylethyl isothiocyanate Cancer Cell 2006 10 3 241 252 (Pubitemid 44311067)
33. Lee J. W., Cho M. K., Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells Archives of Pharmacal Research 2008 31 12 1604 1612
34. Collins K., Jacks T., Pavletich N. P., The cell cycle and cancer Proceedings of the National Academy of Sciences of the United States of America 1997 94 7 2776 2778 (Pubitemid 27157209)
35. Jacks T., Weinberg R. A., Cell-cycle control and its watchman Nature 1996 381 6584 643 644 (Pubitemid 26196558)
36. Macleod K. F., Sherry N., Hannon G., Beach D., Tokino T., Kinzler K., Vogelstein B., Jacks T., p53-Dependent and independent expression of p21 during cell growth, differentiation, and DNA damage Genes and Development 1995 9 8 935 944
37. Sherr C. J., G1 phase progression: cycling on cue Cell 1994 79 4 551 555 (Pubitemid 24363798)
38. Xiao D., Jonhson C. S., Trump D. L., Singh S. V., Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells Molecular Cancer Therapeutics 2004 3 5 567 575 (Pubitemid 39193735)
39. Jakubikova J., Bao Y., Sedlak J., Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines Anticancer Research 2005 25 5 3375 3386 (Pubitemid 41105214)
40. Cheung K. L., Khor T. O., Yu S., Kong A. N. T., PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway AAPS Journal 2008 10 2 277 281
41. Kirkland R. A., Franklin J. L., Bax, reactive oxygen, and cytochrome c release in neuronal apoptosis Antioxidants and Redox Signaling 2003 5 5 589 596 (Pubitemid 37315147)