-
1
-
-
48349084189
-
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates
-
Dashwood R.H., and Ho E. Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev 66 Suppl. 1 (2008) S36-S38
-
(2008)
Nutr Rev
, vol.66
, Issue.SUPPL. 1
-
-
Dashwood, R.H.1
Ho, E.2
-
2
-
-
29044445222
-
Chemopreventive functions of isothiocyanates
-
Keum Y.S., Jeong W.S., and Kong A.N. Chemopreventive functions of isothiocyanates. Drug News Perspect 18 (2005) 445-451
-
(2005)
Drug News Perspect
, vol.18
, pp. 445-451
-
-
Keum, Y.S.1
Jeong, W.S.2
Kong, A.N.3
-
3
-
-
0035987188
-
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans
-
Conaway C.C., Yang Y.M., and Chung F.L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 3 (2002) 233-255
-
(2002)
Curr Drug Metab
, vol.3
, pp. 233-255
-
-
Conaway, C.C.1
Yang, Y.M.2
Chung, F.L.3
-
4
-
-
34047136753
-
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
-
Higdon J.V., Delage B., Williams D.E., and Dashwood R.H. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 55 (2007) 224-236
-
(2007)
Pharmacol Res
, vol.55
, pp. 224-236
-
-
Higdon, J.V.1
Delage, B.2
Williams, D.E.3
Dashwood, R.H.4
-
5
-
-
0028203252
-
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
-
Zhang Y., Kensler T.W., Cho C.G., Posner G.H., and Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A 91 (1994) 3147-3150
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 3147-3150
-
-
Zhang, Y.1
Kensler, T.W.2
Cho, C.G.3
Posner, G.H.4
Talalay, P.5
-
6
-
-
0028326168
-
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms
-
Zhang Y., and Talalay P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res 54 (1994) 1976s-1981s
-
(1994)
Cancer Res
, vol.54
-
-
Zhang, Y.1
Talalay, P.2
-
7
-
-
0034538640
-
Inhibition of carcinogenesis by isothiocyanates
-
Hecht S.S. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev 32 (2000) 395-411
-
(2000)
Drug Metab Rev
, vol.32
, pp. 395-411
-
-
Hecht, S.S.1
-
8
-
-
0035260034
-
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1,2-dimethiole-3-thione
-
Kwak M.K., Itoh K., Yamamoto M., Sutter T.R., and Kensler T.W. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1,2-dimethiole-3-thione. Mol Med 7 (2001) 135-145
-
(2001)
Mol Med
, vol.7
, pp. 135-145
-
-
Kwak, M.K.1
Itoh, K.2
Yamamoto, M.3
Sutter, T.R.4
Kensler, T.W.5
-
9
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236 (1997) 313-322
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
-
10
-
-
7244253081
-
Nrf2-Keap1 defines a physiologically important stress response mechanism
-
Motohashi H., and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10 (2004) 549-557
-
(2004)
Trends Mol Med
, vol.10
, pp. 549-557
-
-
Motohashi, H.1
Yamamoto, M.2
-
11
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi A., Kang M.I., Okawa H., Ohtsuji M., Zenke Y., Chiba T., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24 (2004) 7130-7139
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
-
12
-
-
33344469643
-
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
-
Kobayashi A., Kang M.I., Watai Y., Tong K.I., Shibata T., Uchida K., et al. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 26 (2006) 221-229
-
(2006)
Mol Cell Biol
, vol.26
, pp. 221-229
-
-
Kobayashi, A.1
Kang, M.I.2
Watai, Y.3
Tong, K.I.4
Shibata, T.5
Uchida, K.6
-
13
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
Zhang D.D., Lo S.C., Cross J.V., Templeton D.J., and Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24 (2004) 10941-10953
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
14
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A 99 (2002) 11908-11913
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
-
15
-
-
0141567455
-
Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)
-
Keum Y.S., Owuor E.D., Kim B.R., Hu R., and Kong A.N. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharm Res 20 (2003) 1351-1356
-
(2003)
Pharm Res
, vol.20
, pp. 1351-1356
-
-
Keum, Y.S.1
Owuor, E.D.2
Kim, B.R.3
Hu, R.4
Kong, A.N.5
-
16
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon M., Itoh K., Yamamoto M., and Hayes J.D. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278 (2003) 21592-21600
-
(2003)
J Biol Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
17
-
-
33748358379
-
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2
-
Xu C., Yuan X., Pan Z., Shen G., Kim J.H., Yu S., et al. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol Cancer Ther 5 (2006) 1918-1926
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1918-1926
-
-
Xu, C.1
Yuan, X.2
Pan, Z.3
Shen, G.4
Kim, J.H.5
Yu, S.6
-
18
-
-
0242580049
-
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
-
Zhang D.D., and Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23 (2003) 8137-8151
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8137-8151
-
-
Zhang, D.D.1
Hannink, M.2
-
19
-
-
0037188518
-
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
-
Fahey J.W., Haristoy X., Dolan P.M., Kensler T.W., Scholtus I., Stephenson K.K., et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A 99 (2002) 7610-7615
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 7610-7615
-
-
Fahey, J.W.1
Haristoy, X.2
Dolan, P.M.3
Kensler, T.W.4
Scholtus, I.5
Stephenson, K.K.6
-
20
-
-
32944461846
-
Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action
-
Zhang Y., Yao S., and Li J. Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action. Proc Nutr Soc 65 (2006) 68-75
-
(2006)
Proc Nutr Soc
, vol.65
, pp. 68-75
-
-
Zhang, Y.1
Yao, S.2
Li, J.3
-
21
-
-
33644646401
-
Chemoprotection by sulforaphane: keep one eye beyond Keap1
-
Myzak M.C., and Dashwood R.H. Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett 233 (2006) 208-218
-
(2006)
Cancer Lett
, vol.233
, pp. 208-218
-
-
Myzak, M.C.1
Dashwood, R.H.2
-
22
-
-
7444229836
-
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
-
Pham N.A., Jacobberger J.W., Schimmer A.D., Cao P., Gronda M., and Hedley D.W. The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Mol Cancer Ther 3 (2004) 1239-1248
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1239-1248
-
-
Pham, N.A.1
Jacobberger, J.W.2
Schimmer, A.D.3
Cao, P.4
Gronda, M.5
Hedley, D.W.6
-
23
-
-
4444239988
-
Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
-
Xiao D., Johnson C.S., Trump D.L., and Singh S.V. Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells. Mol Cancer Ther 3 (2004) 567-575
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 567-575
-
-
Xiao, D.1
Johnson, C.S.2
Trump, D.L.3
Singh, S.V.4
-
24
-
-
52649153465
-
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism
-
Trachootham D., Zhang H., Zhang W., Feng L., Du M., Zhou Y., et al. Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood 112 (2008) 1912-1922
-
(2008)
Blood
, vol.112
, pp. 1912-1922
-
-
Trachootham, D.1
Zhang, H.2
Zhang, W.3
Feng, L.4
Du, M.5
Zhou, Y.6
-
25
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
Trachootham D., Zhou Y., Zhang H., Demizu Y., Chen Z., Pelicano H., et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10 (2006) 241-252
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
-
26
-
-
33645825587
-
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
-
Myzak M.C., Dashwood W.M., Orner G.A., Ho E., and Dashwood R.H. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J 20 (2006) 506-508
-
(2006)
FASEB J
, vol.20
, pp. 506-508
-
-
Myzak, M.C.1
Dashwood, W.M.2
Orner, G.A.3
Ho, E.4
Dashwood, R.H.5
-
27
-
-
33846838750
-
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
-
Myzak M.C., Tong P., Dashwood W.M., Dashwood R.H., and Ho E. Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) 232 (2007) 227-234
-
(2007)
Exp Biol Med (Maywood)
, vol.232
, pp. 227-234
-
-
Myzak, M.C.1
Tong, P.2
Dashwood, W.M.3
Dashwood, R.H.4
Ho, E.5
-
28
-
-
0142185392
-
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
-
Srivastava S.K., Xiao D., Lew K.L., Hershberger P., Kokkinakis D.M., Johnson C.S., et al. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis 24 (2003) 1665-1670
-
(2003)
Carcinogenesis
, vol.24
, pp. 1665-1670
-
-
Srivastava, S.K.1
Xiao, D.2
Lew, K.L.3
Hershberger, P.4
Kokkinakis, D.M.5
Johnson, C.S.6
-
29
-
-
33750448018
-
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
-
Xiao D., Lew K.L., Zeng Y., Xiao H., Marynowski S.W., Dhir R., et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis 27 (2006) 2223-2234
-
(2006)
Carcinogenesis
, vol.27
, pp. 2223-2234
-
-
Xiao, D.1
Lew, K.L.2
Zeng, Y.3
Xiao, H.4
Marynowski, S.W.5
Dhir, R.6
-
30
-
-
0034125712
-
Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
-
Zhang Y. Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis 21 (2000) 1175-1182
-
(2000)
Carcinogenesis
, vol.21
, pp. 1175-1182
-
-
Zhang, Y.1
-
31
-
-
0035863273
-
Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro
-
Xu K., and Thornalley P.J. Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro. Biochem Pharmacol 61 (2001) 165-177
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 165-177
-
-
Xu, K.1
Thornalley, P.J.2
-
32
-
-
34447120145
-
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
-
Mi L., Wang X., Govind S., Hood B.L., Veenstra T.D., Conrads T.P., et al. The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Cancer Res 67 (2007) 6409-6416
-
(2007)
Cancer Res
, vol.67
, pp. 6409-6416
-
-
Mi, L.1
Wang, X.2
Govind, S.3
Hood, B.L.4
Veenstra, T.D.5
Conrads, T.P.6
-
33
-
-
52049113028
-
Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis
-
Mi L., Xiao Z., Hood B.L., Dakshanamurthy S., Wang X., Govind S., et al. Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem 283 (2008) 22136-22146
-
(2008)
J Biol Chem
, vol.283
, pp. 22136-22146
-
-
Mi, L.1
Xiao, Z.2
Hood, B.L.3
Dakshanamurthy, S.4
Wang, X.5
Govind, S.6
-
34
-
-
0035943597
-
Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
-
Heiss E., Herhaus C., Klimo K., Bartsch H., and Gerhauser C. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276 (2001) 32008-32015
-
(2001)
J Biol Chem
, vol.276
, pp. 32008-32015
-
-
Heiss, E.1
Herhaus, C.2
Klimo, K.3
Bartsch, H.4
Gerhauser, C.5
-
35
-
-
7244258809
-
Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism
-
Zhu M., Zhang Y., Cooper S., Sikorski E., Rohwer J., and Bowden G.T. Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism. Mol Carcinog 41 (2004) 179-186
-
(2004)
Mol Carcinog
, vol.41
, pp. 179-186
-
-
Zhu, M.1
Zhang, Y.2
Cooper, S.3
Sikorski, E.4
Rohwer, J.5
Bowden, G.T.6
-
36
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
37
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
38
-
-
40949142209
-
The role of hypoxia-inducible factors in tumorigenesis
-
Rankin E.B., and Giaccia A.J. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 15 (2008) 678-685
-
(2008)
Cell Death Differ
, vol.15
, pp. 678-685
-
-
Rankin, E.B.1
Giaccia, A.J.2
-
40
-
-
33750622643
-
Redox regulation of the hypoxia-inducible factor
-
Pouyssegur J., and Mechta-Grigoriou F. Redox regulation of the hypoxia-inducible factor. Biol Chem 387 (2006) 1337-1346
-
(2006)
Biol Chem
, vol.387
, pp. 1337-1346
-
-
Pouyssegur, J.1
Mechta-Grigoriou, F.2
-
42
-
-
0037200012
-
Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species
-
Gao N., Ding M., Zheng J.Z., Zhang Z., Leonard S.S., Liu K.J., et al. Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem 277 (2002) 31963-31971
-
(2002)
J Biol Chem
, vol.277
, pp. 31963-31971
-
-
Gao, N.1
Ding, M.2
Zheng, J.Z.3
Zhang, Z.4
Leonard, S.S.5
Liu, K.J.6
-
43
-
-
0035816732
-
Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase
-
Gorlach A., Diebold I., Schini-Kerth V.B., Berchner-Pfannschmidt U., Roth U., Brandes R.P., et al. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circ Res 89 (2001) 47-54
-
(2001)
Circ Res
, vol.89
, pp. 47-54
-
-
Gorlach, A.1
Diebold, I.2
Schini-Kerth, V.B.3
Berchner-Pfannschmidt, U.4
Roth, U.5
Brandes, R.P.6
-
44
-
-
12244267687
-
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells
-
Park J.H., Kim T.Y., Jong H.S., Chun Y.S., Park J.W., Lee C.T., et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Clin Cancer Res 9 (2003) 433-440
-
(2003)
Clin Cancer Res
, vol.9
, pp. 433-440
-
-
Park, J.H.1
Kim, T.Y.2
Jong, H.S.3
Chun, Y.S.4
Park, J.W.5
Lee, C.T.6
-
45
-
-
0038115172
-
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms
-
Shatrov V.A., Sumbayev V.V., Zhou J., and Brune B. Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood 101 (2003) 4847-4849
-
(2003)
Blood
, vol.101
, pp. 4847-4849
-
-
Shatrov, V.A.1
Sumbayev, V.V.2
Zhou, J.3
Brune, B.4
-
46
-
-
0034816327
-
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells
-
Tacchini L., Dansi P., Matteucci E., and Desiderio M.A. Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis 22 (2001) 1363-1371
-
(2001)
Carcinogenesis
, vol.22
, pp. 1363-1371
-
-
Tacchini, L.1
Dansi, P.2
Matteucci, E.3
Desiderio, M.A.4
-
47
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
-
Guzy R.D., Hoyos B., Robin E., Chen H., Liu L., Mansfield K.D., et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1 (2005) 401-408
-
(2005)
Cell Metab
, vol.1
, pp. 401-408
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
Chen, H.4
Liu, L.5
Mansfield, K.D.6
-
48
-
-
24144444133
-
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
-
Brunelle J.K., Bell E.L., Quesada N.M., Vercauteren K., Tiranti V., Zeviani M., et al. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 1 (2005) 409-414
-
(2005)
Cell Metab
, vol.1
, pp. 409-414
-
-
Brunelle, J.K.1
Bell, E.L.2
Quesada, N.M.3
Vercauteren, K.4
Tiranti, V.5
Zeviani, M.6
-
49
-
-
24144447915
-
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
-
Mansfield K.D., Guzy R.D., Pan Y., Young R.M., Cash T.P., Schumacker P.T., et al. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1 (2005) 393-399
-
(2005)
Cell Metab
, vol.1
, pp. 393-399
-
-
Mansfield, K.D.1
Guzy, R.D.2
Pan, Y.3
Young, R.M.4
Cash, T.P.5
Schumacker, P.T.6
-
50
-
-
0035877728
-
Rac1 activity is required for the activation of hypoxia-inducible factor 1
-
Hirota K., and Semenza G.L. Rac1 activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem 276 (2001) 21166-21172
-
(2001)
J Biol Chem
, vol.276
, pp. 21166-21172
-
-
Hirota, K.1
Semenza, G.L.2
-
52
-
-
33947244444
-
Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo
-
Xiao D., and Singh S.V. Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo. Cancer Res 67 (2007) 2239-2246
-
(2007)
Cancer Res
, vol.67
, pp. 2239-2246
-
-
Xiao, D.1
Singh, S.V.2
-
53
-
-
33645472584
-
Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
-
Bertl E., Bartsch H., and Gerhauser C. Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention. Mol Cancer Ther 5 (2006) 575-585
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 575-585
-
-
Bertl, E.1
Bartsch, H.2
Gerhauser, C.3
-
54
-
-
33845593776
-
Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization
-
Jackson S.J., Singletary K.W., and Venema R.C. Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization. Vascul Pharmacol 46 (2007) 77-84
-
(2007)
Vascul Pharmacol
, vol.46
, pp. 77-84
-
-
Jackson, S.J.1
Singletary, K.W.2
Venema, R.C.3
-
55
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A., Uranchimeg B., Scudiero D.A., Selby M., Sausville E.A., Shoemaker R.H., et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62 (2002) 4316-4324
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
-
56
-
-
0032749421
-
High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers
-
Brimmell M., Burns J.S., Munson P., McDonald L., O'Hare M.J., Lakhani S.R., et al. High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. Br J Cancer 81 (1999) 1042-1051
-
(1999)
Br J Cancer
, vol.81
, pp. 1042-1051
-
-
Brimmell, M.1
Burns, J.S.2
Munson, P.3
McDonald, L.4
O'Hare, M.J.5
Lakhani, S.R.6
-
57
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An W.G., Kanekal M., Simon M.C., Maltepe E., Blagosklonny M.V., and Neckers L.M. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392 (1998) 405-408
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
58
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
Shoshani T., Faerman A., Mett I., Zelin E., Tenne T., Gorodin S., et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22 (2002) 2283-2293
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
Faerman, A.2
Mett, I.3
Zelin, E.4
Tenne, T.5
Gorodin, S.6
-
59
-
-
4444231754
-
Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines
-
Tseng E., Scott-Ramsay E.A., and Morris M.E. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med (Maywood) 229 (2004) 835-842
-
(2004)
Exp Biol Med (Maywood)
, vol.229
, pp. 835-842
-
-
Tseng, E.1
Scott-Ramsay, E.A.2
Morris, M.E.3
-
60
-
-
58449110311
-
Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells
-
Lee J.W., and Cho M.K. Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells. Arch Pharm Res 31 (2008) 1604-1612
-
(2008)
Arch Pharm Res
, vol.31
, pp. 1604-1612
-
-
Lee, J.W.1
Cho, M.K.2
-
61
-
-
33751169387
-
Hypoxia-inducible factor-1 (HIF-1)
-
Ke Q., and Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70 (2006) 1469-1480
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1469-1480
-
-
Ke, Q.1
Costa, M.2
-
62
-
-
34247477207
-
Hypoxia inducible factor-2alpha in cancer
-
Lofstedt T., Fredlund E., Holmquist-Mengelbier L., Pietras A., Ovenberger M., Poellinger L., et al. Hypoxia inducible factor-2alpha in cancer. Cell Cycle 6 (2007) 919-926
-
(2007)
Cell Cycle
, vol.6
, pp. 919-926
-
-
Lofstedt, T.1
Fredlund, E.2
Holmquist-Mengelbier, L.3
Pietras, A.4
Ovenberger, M.5
Poellinger, L.6
-
63
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff R.J., Tian Y.M., Raval R.R., Turley H., Harris A.L., Pugh C.W., et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279 (2004) 38458-38465
-
(2004)
J Biol Chem
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
Turley, H.4
Harris, A.L.5
Pugh, C.W.6
-
64
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M., Haas R., Brauch H., Acker T., Flamme I., and Plate K.H. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19 (2000) 5435-5443
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.H.6
-
65
-
-
2442544693
-
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha
-
Uchida T., Rossignol F., Matthay M.A., Mounier R., Couette S., Clottes E., et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 279 (2004) 14871-14878
-
(2004)
J Biol Chem
, vol.279
, pp. 14871-14878
-
-
Uchida, T.1
Rossignol, F.2
Matthay, M.A.3
Mounier, R.4
Couette, S.5
Clottes, E.6
-
66
-
-
33750630119
-
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
-
Holmquist-Mengelbier L., Fredlund E., Lofstedt T., Noguera R., Navarro S., Nilsson H., et al. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 10 (2006) 413-423
-
(2006)
Cancer Cell
, vol.10
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
Fredlund, E.2
Lofstedt, T.3
Noguera, R.4
Navarro, S.5
Nilsson, H.6
-
67
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
68
-
-
45149100643
-
Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism
-
Zhang H., Trachootham D., Lu W., Carew J., Giles F.J., Keating M.J., et al. Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism. Leukemia 22 (2008) 1191-1199
-
(2008)
Leukemia
, vol.22
, pp. 1191-1199
-
-
Zhang, H.1
Trachootham, D.2
Lu, W.3
Carew, J.4
Giles, F.J.5
Keating, M.J.6
-
70
-
-
34248562302
-
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1
-
Hu J., Straub J., Xiao D., Singh S.V., Yang H.S., Sonenberg N., et al. Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. Cancer Res 67 (2007) 3569-3573
-
(2007)
Cancer Res
, vol.67
, pp. 3569-3573
-
-
Hu, J.1
Straub, J.2
Xiao, D.3
Singh, S.V.4
Yang, H.S.5
Sonenberg, N.6
-
71
-
-
49749150144
-
Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells
-
Yao H., Wang H., Zhang Z., Jiang B.H., Luo J., and Shi X. Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells. Int J Cancer 123 (2008) 1255-1261
-
(2008)
Int J Cancer
, vol.123
, pp. 1255-1261
-
-
Yao, H.1
Wang, H.2
Zhang, Z.3
Jiang, B.H.4
Luo, J.5
Shi, X.6
-
72
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
-
Ema M., Hirota K., Mimura J., Abe H., Yodoi J., Sogawa K., et al. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 18 (1999) 1905-1914
-
(1999)
EMBO J
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
Sogawa, K.6
-
73
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval R.R., Lau K.W., Tran M.G., Sowter H.M., Mandriota S.J., Li J.L., et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25 (2005) 5675-5686
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.L.6
-
74
-
-
33745685879
-
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway
-
Carroll V.A., and Ashcroft M. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Cancer Res 66 (2006) 6264-6270
-
(2006)
Cancer Res
, vol.66
, pp. 6264-6270
-
-
Carroll, V.A.1
Ashcroft, M.2
-
75
-
-
0141988698
-
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
-
Sowter H.M., Raval R.R., Moore J.W., Ratcliffe P.J., and Harris A.L. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 63 (2003) 6130-6134
-
(2003)
Cancer Res
, vol.63
, pp. 6130-6134
-
-
Sowter, H.M.1
Raval, R.R.2
Moore, J.W.3
Ratcliffe, P.J.4
Harris, A.L.5
-
76
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan J.D., Lal P., Dondeti V.R., Letrero R., Parekh K.N., Oquendo C.E., et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14 (2008) 435-446
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
-
77
-
-
33750044299
-
When translation meets transformation: the mTOR story
-
Averous J., and Proud C.G. When translation meets transformation: the mTOR story. Oncogene 25 (2006) 6423-6435
-
(2006)
Oncogene
, vol.25
, pp. 6423-6435
-
-
Averous, J.1
Proud, C.G.2
-
78
-
-
20144362478
-
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability
-
Dames S.A., Mulet J.M., Rathgeb-Szabo K., Hall M.N., and Grzesiek S. The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability. J Biol Chem 280 (2005) 20558-20564
-
(2005)
J Biol Chem
, vol.280
, pp. 20558-20564
-
-
Dames, S.A.1
Mulet, J.M.2
Rathgeb-Szabo, K.3
Hall, M.N.4
Grzesiek, S.5
-
79
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas G.V., Tran C., Mellinghoff I.K., Welsbie D.S., Chan E., Fueger B., et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 12 (2006) 122-127
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
Welsbie, D.S.4
Chan, E.5
Fueger, B.6
-
80
-
-
47649094400
-
Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor
-
Bhatt R.S., Landis D.M., Zimmer M., Torregrossa J., Chen S., Sukhatme V.P., et al. Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor. BJU Int 102 (2008) 358-363
-
(2008)
BJU Int
, vol.102
, pp. 358-363
-
-
Bhatt, R.S.1
Landis, D.M.2
Zimmer, M.3
Torregrossa, J.4
Chen, S.5
Sukhatme, V.P.6
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