Inhibition of Benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis

Cancer Research

Volumn 62, Issue 1, 2002, Pages 2-7

  Yang, Yang Ming ^a   Conaway, C Clifford ^a   Dai, Wei ^a   Amin, Shantu ^a   Chung, Fung Lung ^a   Wang, Chung Xiou ^b   Whysner, John ^b   Reinhardt, Joel ^b   Chiao, J W ^c  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b Department of Pathology and Toxicology ^*  (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BENZO[A]PYRENE; BENZYL ISOTHIOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PHENETHYL ISOTHIOCYANATE; PROTEIN P53;

ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER PREVENTION; CONTROLLED STUDY; ENZYME ACTIVATION; LUNG CARCINOGENESIS; LUNG TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ACETYLCYSTEINE; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZO(A)PYRENE; CARCINOGENS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; ISOTHIOCYANATES; LUNG; LUNG NEOPLASMS; MICE; MICE, INBRED A; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTION FACTOR AP-1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036142924     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

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3. Effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo(a)pyrene on pulmonary and forestomach neoplasia in A/J mice
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11. Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis
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13. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome P450 isozymes
14. Essential role of p53 in phenethyl isothiocyanate-induced apoptosis
15. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
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17. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity
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