Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28745-28754

  Kandala, Prabodh K ^a   Srivastava, Sanjay K ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE INGREDIENTS; ANOIKIS; CONCENTRATION-DEPENDENT; DIINDOLYLMETHANE; EXTRACELLULAR MATRICES; IN-VITRO; IN-VIVO; MOUSE EMBRYONIC FIBROBLASTS; OVARIAN CANCER CELLS; OVARIAN CANCERS; POLY(ADP-RIBOSE) POLYMERASE; SONIC HEDGEHOGS; SUSPENSION CULTURES; TUMOR FORMATION;

CELL CULTURE; CELL DEATH; MAMMALS;

TUMORS;

ANTINEOPLASTIC AGENT; CYCLOPAMINE; DIINDOLYLMETHANE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOIKIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CANCER RESISTANCE; CARCINOGENESIS; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG SENSITIVITY; EMBRYO; FEMALE; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANOIKIS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; INDOLES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; OVARIAN NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; VERATRUM ALKALOIDS;

EID: 84865217843     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.351379     Document Type: Article

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