The cell envelope glycoconjugates of Mycobacterium tuberculosis

Critical Reviews in Biochemistry and Molecular Biology

Volumn 49, Issue 5, 2014, Pages 361-399

  Angala, Shiva Kumar ^a   Belardinelli, Juan Manuel ^a   Huc Claustre, Emilie ^a   Wheat, William H ^a   Jackson, Mary ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

(lipo)polysaccharides; Acyltrehaloses; Arabinogalactan; Flippase; Glycosyltransferase; Lipoarabinomannan; Peptidoglycan; Phosphatidylinositol mannosides

Indexed keywords

4 HYDROXYBENZOIC ACID; ACYLTREHALOSE; ALPHA DEXTRO GLUCAN; ARABINOGALACTAN; CORD FACTOR; DIACYLTREHALOSE; GLYCOCONJUGATE; GLYCOPROTEIN; KETONE DERIVATIVE; LIPID; LIPOOLIGOSACCHARIDE; LIPOPROTEIN; MANNOSYL BETA 1 PHOSPHOMYCOKETIDE; MULTIPROTEIN COMPLEX; MYCOLIC ACID; PEPTIDOGLYCAN; PHENOLIC GLYCOLIPID; POLYACYLTREHALOSE; POLYSACCHARIDE; SERODIAGNOSUS; SULFOLIPID; TREHALOSE; TREHALOSE MONOMYCOLATE; UNCLASSIFIED DRUG; VACCINE;

BACTERIAL CELL WALL; BACTERIAL MEMBRANE; BACTERIAL TRANSLOCATION; BACTERIAL VIRULENCE; BIOGENESIS; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; EPIMERIZATION; MACROMOLECULE; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REGULATORY MECHANISM; REVIEW; TURNOVER TIME; BACTERIAL CAPSULE; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMISTRY; HUMAN; METABOLISM;

BACTERIAL CAPSULES; CELL MEMBRANE; GLYCOCONJUGATES; GLYCOPROTEINS; HUMANS; MODELS, BIOLOGICAL; MYCOBACTERIUM TUBERCULOSIS;

EID: 84907506664     PISSN: 10409238     EISSN: 15497798     Source Type: Journal    
DOI: 10.3109/10409238.2014.925420     Document Type: Review

References (433)

1. Afonso-Barroso A, Clark SO, Williams A, et al. (2012). Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses. Cell Microbiol 15: 660-74.
2. Alaimo C, Catrein I, Morf L, et al. (2006). Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides. EMBO J 25: 967-76.
3. Albesa-Jove D, Giganti D, Jackson M, et al. (2014). Structure-function relationships of membrane-associated GT-B glycosyltransferases. Glycobiology 24: 108-24.
4. Alderwick LJ, Dover LG, Seidel M, et al. (2006b). Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism. Glycobiology 16: 1073-81.
5. Alderwick LJ, Lloyd GS, Ghadbane H, et al. (2011b). The C-terminal domain of the arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module. PLoS Pathog 7: e1001299.
6. Alderwick LJ, Lloyd GS, Lloyd AJ, et al. (2011a). Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl- 1-pyrophosphate synthetase. Glycobiology 21: 410-25.
7. Alderwick LJ, Molle V, Kremer L, et al. (2006c). Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 103: 2558-63.
8. Alderwick LJ, Radmacher E, Seidel M, et al. (2005). Deletion of Cg-emb in Corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinandeficient mutant with a cell wall galactan core. J Biol Chem 280: 32362-71.
9. Alderwick LJ, Seidel M, Sahm H, et al. (2006a). Identification of a novel arabinosyl transferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis. J Biol Chem 281: 15653-61.
10. Alibaud L, Pawelczyk J, Gannoun-Zaki L, et al. (2014). Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study. J Biol Chem 289: 215-28.
11. Amin AG, Goude R, Shi L, et al. (2008). EmbA is an essential arabinosyltransferase in Mycobacterium tuberculosis. Microbiology 154: 240-8.
12. Anderson RJ, Roberts EG. (1930). The chemistry of the lipoids of tubercle bacilli. XIV. The occurence of inosite in the phosphatide from human tubercle bacilli. J Am Chem Soc 52: 5023-9.
13. Appelmelk BJ, Den Dunnen J, Driessen NN, et al. (2008). The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction. Cell Microbiol 10: 930-44.
14. Armitige LY, Jagannath C, Wanger AR, Norris SJ. (2000). Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophages. Infect Immun 68: 767-78.
15. Axelrod S, Oschkinat H, Enders J, et al. (2008). Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide. Cell Microbiol 10: 1530-45.
16. Barry CE, Crick DC, McNeil MR. (2007). Targeting the formation of the cell wall core of Mycobacterium tuberculosis. Infect Disord Drug Targets 7: 182-202.
17. Barry III CE, Lee RE, Mdluli K, et al. (1998). Mycolic acids: structure, biosynthesis and physiological functions. Prog Lipid Res 37: 143-79.
18. Batt SM, Jabeen T, Bhowruth V, et al. (2012). Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc Natl Acad Sci USA 109: 11354-9.
19. Batt SM, Jabeen T, Mishra AK, et al. (2010). Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'. J Biol Chem 285: 37741-52.
20. Bay DC, Rommens KL, Turner RJ. (2008). Small multidrug resistance proteins: a multidrug transporter family that continues to grow. Biochim Biophys Acta 1778: 1814-38.
21. Behrends V, Williams KJ, Jenkins VA, et al. (2012). Free glucosylglycerate is a novel marker of nitrogen stress in Mycobacterium smegmatis. J Proteome Res 11: 3888-96.
22. Belanger AE, Besra GS, Ford ME, et al. (1996). The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc Natl Acad Sci USA 93: 11919-24.
23. Belanova M, Dianiskova P, Brennan PJ, et al. (2008). Galactosyl transferases in mycobacterial cell wall synthesis. J Bacteriol 190: 1141-5.
24. Belisle JT, Brennan PJ. (1989). Chemical basis of rough and smooth variation in mycobacteria. J Bacteriol 171: 3465-70.
25. Berg S, Kaur D, Jackson M, Brennan PJ. (2007). The glycosyltransferases of Mycobacterium tuberculosis-roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 17: 35R-56R.
26. Berg S, Starbuck J, Torrelles JB, et al. (2005). Roles of the conserved proline and glycosyltransferase motifs of EmbC in biosynthesis of lipoarabinomannan. J Biol Chem 280: 5651-63.
27. Bertozzi CR, Schelle MW. (2008). Sulfated metabolites from Mycobacterium tuberculosis: sulfolipid-1 and beyond. In: Daffé M, Reyrat J-M, eds. The mycobacterial cell envelope. Washington DC: ASM Press.
28. Besra GS, Bolton R, McNeil MR, et al. (1992). Structure elucidation and antigenicity of a novel family of glycolipid antigens from Mycobacterium tuberculosis H37Rv. Biochemistry 31: 9832-7.
29. Bhamidi S, Scherman MS, Jones V, et al. (2011). Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis. J Biol Chem 286: 23168-77.
30. Bhamidi S, Scherman MS, Rithner CD, et al. (2008). The identification and location of succinyl residues and the characterization of the interior arabinan region allows for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactan. J Biol Chem 283: 12992-3000.
31. Bhatt K, Gurcha SS, Bhatt A, et al. (2007). Two polyketide-synthaseassociated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis. Microbiology 153: 513-20.
32. Birch HL, Alderwick LJ, Appelmelk BJ, et al. (2010). A truncated lipoglycan from mycobacteria with altered immunological properties. Proc Natl Acad Sci USA 107: 2634-9.
33. Birch HL, Alderwick LJ, Bhatt A, et al. (2008). Biosynthesis of mycobacterial arabinogalactan: identification of a novel a (1-43) arabinofuranosyltransferase. Mol Microbiol 69: 1191-1206.
34. Blattes E, Vercellone A, Eutamene H, et al. (2013). Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment. Proc Natl Acad Sci USA 110: 8795-800.
35. Bloch H. (1950). Studies on the virulence of tubercle bacilli; isolation and biological properties of a constituent of virulent organisms. J Exp Med 91: 197-218.
36. Both D, Schneider G, Schnell R. (2011). Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB. J Mol Biol 413: 247-60.
37. Boucau J, Sanki AK, Voss BJ, et al. (2009). A coupled enzymatic assay measuring Mycobacterium tuberculosis antigen 85C enzymatic activity. Anal Biochem 385: 120-7.
38. Briken V, Porcelli SA, Besra GS, Kremer L. (2004). Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol Microbiol 53: 391-403.
39. Brodin P, Poquet Y, Levillain F, et al. (2010). High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. PLoS Pathog 6: e1001100.
40. Brozna JP, Horan M, Rademacher JM, et al. (1991). Monocyte responses to sulfolipid from Mycobacterium tuberculosis: inhibition of priming for enhanced release of superoxide, associated with increased secretion of interleukin-1 and tumor necrosis factor alpha and altered protein phosphorylation. Infect Immun 59: 2542-8.
41. Bruning JB, Murillo AC, Chacon O, et al. (2011). Structure of the Mycobacterium tuberculosis D-alanine: D-alanine ligase, a target of the antituberculosis drug D-cycloserine. Antimicrob Agents Chemother 55: 291-301.
42. Burguiere A, Hitchen P, Dover LG, et al. (2005). LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum. J Biol Chem 280: 42124-33.
43. Cala-De Paepe D, Layre E, Giacometti G, et al. (2012). Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes. J Biol Chem 287: 31494-502.
44. Camacho LR, Constant P, Raynaud C, et al. (2001). Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J Biol Chem 276: 19845-54.
45. Caner S, Nguyen N, Aguda A, et al. (2013). The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode. Glycobiology 23: 1075-83.
46. Chapman TM, Bouloc N, Buxton RS, et al. (2012). Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett 22: 3349-53.
47. Chatterjee D, Hunter SW, McNeil M, Brennan PJ. (1992). Lipoarabinomannan. Multiglycosylated form of the mycobacterial mannosylphosphatidylinositols. J Biol Chem 267: 6228-33.
48. Chatterjee D, Khoo KH, McNeil MR, et al. (1993). Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry. Glycobiology 3: 497-506.
49. Chesne-Seck ML, Barilone N, Boudou F, et al. (2008). A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. J Bacteriol 190: 1329-34.
50. Chopra T, Banerjee S, Gupta S, et al. (2008). Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase. PLoS Biol 6: 1584-98.
51. Christophe T, Jackson M, Jeon HK, et al. (2009). High content screening identifies decaprenyl-phosphoribose 20 epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog 5: e1000645.
52. Cimino M, Thomas C, Namouchi A, et al. (2012). Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system. PLoS One 7: e42876.
53. Clarke BR, Greenfield LK, Bouwman C, Whitfield C. (2009). Coordination of polymerization, chain termination, and export in assembly of the Escherichia coli lipopolysaccharide O9a antigen in an ABC-transporter-dependent pathway. J Biol Chem 284: 30662-72.
54. Cole ST, Brosch R, Parkhill J, et al. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537-44.
55. Constant P, Perez E, MalagaW, et al. (2002). Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. J Biol Chem 277: 38148-58.
56. Converse SE, Mougous JD, Leavell MD, et al. (2003). MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci USA 100: 6121-6.
57. Cordillot M, Dubee V, Triboulet S, et al. (2013). In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L, D-transpeptidases and inactivation of these enzymes by carbapenems. Antimicrob Agents Chemother 57: 5940-5.
58. Coulombe F, Divangahi M, Veyrier F, et al. (2009). Increased NOD2- mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med 206: 1709-16.
59. Crellin PK, Brammananth R, Coppel RL. (2011). Decaprenylphosphoryl-beta-D-ribose 20-epimerase, the target of benzothiazinones and dinitrobenzamides, is an essential enzyme in Mycobacterium smegmatis. PLoS One 6: e16869.
60. Crellin PK, Kovacevic S, Martin KL, et al. (2008). Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutant. J Bacteriol 190: 3690-9.
61. Cywes C, Hoppe HC, Daffé M, Ehlers MRW. (1997). Nonopsonic binding of Mycobacterium tuberculosis to human complement receptor type 3 is mediated by capsular polysaccharides and is strain dependent. Infect Immun 65: 4258-66.
62. Daffé M, Crick DC, Jackson M. (2014). Genetics of capsular polysaccharides and cell envelope (glyco)lipids. Microbiol Spectrum 2: MGM2-0021-2013.
63. Daffé M, Draper P. (1998). The envelope layers of mycobacteria with reference to their pathogenicity. Adv Microb Physiol 39: 131-203.
64. Daffé M, Etienne G. (1999). The capsule of Mycobacterium tuberculosis and its implications for pathogenicity. Tuber Lung Dis 79: 153-69.
65. Daffé M, Lacave C, Lanéelle M-A, et al. (1988). Polyphthienoyl trehalose, glycolipids specific for virulent strains of the tubercle bacillus. Eur J Biochem 172: 579-84.
66. Daffé M, Lacave C, Laneelle MA, Laneelle G. (1987). Structure of the major triglycosyl phenol-phthiocerol of Mycobacterium tuberculosis (strain Canetti). Eur J Biochem 167: 155-60.
67. Daffé M, Lanéelle M-A. (1988). Distribution of phthiocerol diester, phenolic mycosides and related compounds in mycobacteria. J Gen Microbiol 134: 2049-55.
68. Daffé M, Lemassu A. (2000). Glycobiology of the mycobacterial surface. Structures and biological activities of the cell envelope glycoconjugates. In: Doyle RJ, ed. Glycomicrobiology. New York (NY): Kluwer Academic/Plenum Publishers.
69. Daffé M, McNeil MR, Brennan PJ. (1991). Novel type-specific lipooligosaccharides from Mycobacterium tuberculosis. Biochemistry 30: 378-88.
70. Daleke DD. (2007). Phospholipid flippases. J Biol Chem 282: 821-5.
71. Danilenko VN, Osolodkin DI, Lakatosh SA, et al. (2011). Bacterial eukaryotic type serine-threonine protein kinases: from structural biology to targeted anti-infective drug design. Curr Top Med Chem 11: 1352-69.
72. Datta P, Dasgupta A, Bhakta S, Basu J. (2002). Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J Biol Chem 277: 24983-7.
73. Datta P, Dasgupta A, Singh AK, et al. (2006). Interaction between FtsW and penicillin-binding protein 3 (PBP3) directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria. Mol Microbiol 62: 1655-73.
74. De La Salle H, Mariotti S, Angenieux C, et al. (2005). Assistance of microbial glycolipid antigen processing by CD1e. Science 310: 1321-4.
75. De Smet KAL, Weston A, Brown IN, et al. (2000). Three pathways for trehalose biosynthesis in mycobacteria. Microbiology 146: 199-208.
76. Delmas C, Gilleron M, Brando T, et al. (1997). Comparative structural study of the mannosylated-lipoarabinomannans from Mycobacterium bovis BCG vaccine strains: characterization and localization of succinates. Glycobiology 7: 811-17.
77. Deng LL, Humphries DE, Arbeit RD, et al. (2005). Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis. Biochim Biophys Acta 1747: 57-66.
78. Dhiman RK, Dinadayala P, Ryan GJ, et al. (2011). Lipoarabinomannan localization and abundance during growth of Mycobacterium smegmatis. J Bacteriol 193: 5802-9.
79. Dianišková P, Korduláková J, Škovierová H, et al. (2011). Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster. Gen Physiol Biophys 30: 239-50.
80. Dinadayala P, Kaur D, Berg S, et al. (2006). Genetic basis for the synthesis of the immunomodulatory mannose caps of lipoarabinomannan in Mycobacterium tuberculosis. J Biol Chem 281: 20027-35.
81. Dinadayala P, Lemassu A, Granovski P, et al. (2004). Revisiting the structure of the anti-neoplastic glucans of Mycobacterium bovis bacille Calmette-Guérin. J Biol Chem 279: 12369-78.
82. Dinadayala P, Sambou T, Daffé M, Lemassu A. (2008). Comparative structural analyses of the alpha-glucan and glycogen from Mycobacterium bovis. Glycobiology 18: 502-8.
83. Dobos KM, Khoo KH, Swiderek KM, et al. (1996). Definition of the full extent of glycosylation of the 45-Kilodalton glycoprotein of Mycobacterium tuberculosis. J Bacteriol 178: 2498-506.
84. Domenech P, Reed MB, Barry III CE. (2005). Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance. Infect Immun 73: 3492-501.
85. Domenech P, Reed MB, Dowd CS, et al. (2004). The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. J Biol Chem 279: 21257-65.
86. Drage MG, Tsai HC, Pecora ND, et al. (2010). Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat Struct Mol Biol 17: 1088-95.
87. Draper P, Khoo K-H, Chatterjee D, et al. (1997). Galactosamine in walls of slow-growing mycobacteria. Biochem J 327: 519-25.
88. Driessen NN, Ummels R, Maaskant JJ, et al. (2009). Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN. Infect Immun 77: 4538-47.
89. Dubey VS, Sirakova TD, Cynamon MH, Kolattukudy PE. (2003). Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids. J Bacteriol 185: 4620-5.
90. Dubey VS, Sirakova TD, Kolattukudy PE. (2002). Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation. Mol Microbiol 45: 1451-9.
91. Ehlers MRW, Daffé M. (1998). Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key? Trends Microbiol 6: 328-35.
92. Elamin AA, Stehr M, Oehlmann W, Singh M. (2009). The mycolyltransferase 85A, a putative drug target of Mycobacterium tuberculosis: development of a novel assay and quantification of glycolipid-status of the mycobacterial cell wall. J Microbiol Methods 79: 358-63.
93. Elbein AD, Pastuszak I, Tackett AJ, et al. (2010). The last step in the conversion of trehalose to glycogen: a mycobacterial enzyme that transfers maltose from maltose-1-phosphate to glycogen. J Biol Chem 285: 9803-12.
94. England K, Boshoff HI, Arora K, et al. (2012). Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo. Antimicrob Agents Chemother 56: 3384-7.
95. Eoh H, Brown AC, Buetow L, et al. (2007). Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-Derythitol synthase: potential for drug development. J Bacteriol 189: 8922-7.
96. Erdemli SB, Gupta R, Bishai WR, et al. (2012). Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L, Dtranspeptidase 2. Structure 20: 2103-15.
97. Escuyer VE, Lety M-A, Torrelles JB, et al. (2001). The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan. J Biol Chem 276: 48854-62.
98. Espitia C, Mancilla R. (1989). Identification, isolation and partial characterization of Mycobacterium tuberculosis glycoprotein antigens. Clin Exp Immunol 77: 378-83.
99. Etienne G, Malaga W, Laval F, et al. (2009). Identification of the polyketide synthase involved in the biosynthesis of the surfaceexposed lipooligosaccharides in mycobacteria. J Bacteriol 191: 2613-21.
100. Favrot L, Grzegorzewicz AE, Lajiness DH, et al. (2013). Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun 4: 2748. doi: 10.1038/ncomms3748.
101. Fenton MJ, Riley LW, Schlesinger LS. (2005). Receptor-mediated recognition of Mycobacterium tuberculosis by host cells. In: Cole ST, Davis Eisenach K, Mcmurray DN, Jacobs Jr WR, eds. Tuberculosis and the tubercle bacillus. Washington, DC: ASM Press.
102. Ferreras JA, Stirrett KL, Lu X, et al. (2008). Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and smallmolecule inhibition of polyketide chain initiation. Chem Biol 15: 51-61.
103. Fischer K, Scotet E, Niemeyer M, et al. (2004). Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1drestricted T cells. Proc Natl Acad Sci USA 101: 10685-90.
104. Frigui W, Bottai D, Majlessi L, et al. (2008). Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog 4: e33.
105. Fukuda T, Matsumura T, Ato M, et al. (2013). Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis. MBio 4: e00472-12.
106. Gagliardi MC, Lemassu A, Teloni R, et al. (2007). Cell wall-associated alpha-glucan is instrumental for Mycobacterium tuberculosis to block CD1 molecule expression and disable the fucntion of dendritic cells derived from infected monocyte. Cell Microbiol 9: 2081-92.
107. Gagneux S, Small PM. (2007). Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development. Lancet Infect Dis 7: 328-37.
108. Garbe T, Harris D, Vordermeier M, et al. (1993). Expression of the Mycobacterium tuberculosis 19-Kilodalton antigen in M. smegmatis: immunological analysis and evidence of glycosylation. Infect Immun 61: 260-7.
109. Garcia-Alles LF, Collmann A, Versluis C, et al. (2011). Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids. Proc Natl Acad Sci USA 108: 17755-60.
110. Garg SK, Alam MS, Kishan KVR, Agrawal P. (2007). Expression and characterization of a-(1, 4)-glucan branching enzyme Rv1326c of Mycobacterium tuberculosis H37Rv. Protein Expr Purif 51: 198-208.
111. Gee CL, Papavinasasundaram KG, Blair SR, et al. (2012). A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal 5: ra7. doi: 10.1126/scisignal.2002525.
112. Geurtsen J, Chedammi S, Mesters J, et al. (2009). Identification of mycobacterial a-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation. J Immunol 183: 5221-31.
113. Giganti D, Alegre-Cebollada J, Urresti S, et al. (2013). Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria. J Biol Chem 288: 29797-808.
114. Gilleron M, Jackson M, Nigou J, Puzo G. (2008). Structure, activities and biosynthesis of the phosphatidyl-myo-inositol-based lipoglycans. In: Daffé M, Reyrat J-M, eds. The mycobacterial cell envelope. Washington, DC: ASM Press.
115. Gilleron M, Lindner B, Puzo G. (2006a). MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol mannosides. Anal Chem 78: 8543-8.
116. Gilleron M, Nigou J, Nicolle D, et al. (2006b). The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2. Chem Biol 13: 39-47.
117. Gilleron M, Quesniaux VFJ, Puzo G. (2003). Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis Bacillus Calmette Guérin and Mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response. J Biol Chem 278: 29880-9.
118. Gilleron M, Ronet C, Mempel M, et al. (2001). Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis Bacillus Calmette Guérin and ability to induce granuloma and recruit natural killer T cells. J Biol Chem 276: 34896-904.
119. Gilleron M, Stenger S, Mazorra Z, et al. (2004). Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1- restricted T cells during infection with Mycobacterium tuberculosis. J Exp Med 199: 649-59.
120. Gilmore SA, Schelle MW, Holsclaw CM, et al. (2012). Sulfolipid-1 biosynthesis restricts Mycobacterium tuberculosis growth in human macrophages. ACS Chem Biol 7: 863-70.
121. Glatman-Freedman A, Casadevall A. (1998). Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis. Clin Microbiol Rev 11: 514-32.
122. Goffin C, Ghuysen JM. (2002). Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent. Microbiol Mol Biol Rev 66: 702-38, table of contents.
123. Gonzalez-Zamorano M, Mendoza-Hernandez G, Xolalpa W, et al. (2009). Mycobacterium tuberculosis glycoproteomics based on ConAlectin affinity capture of mannosylated proteins. J Proteome Res 8: 721-33.
124. Gonzalo-Asensio J, Maia C, Ferrer NL, et al. (2006). The virulenceassociated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J Biol Chem 281: 1313-16.
125. Gonzalo-Asensio J, Mostowy S, Harders-Westerveen J, et al. (2008). PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence. PLoS One 3: e3496.
126. Goren MB. (1984). Biosynthesis and structures of phospholipids and sulfatides. In: Kubica GP, Wayne LG, eds. The mycobacteria. A sourcebook. New York/Basel: Marcel Dekker, Inc.
127. Goren MB. (1990). Mycobacterial fatty acid esters of sugars and sulfosugars. In: Kates M, ed. Handbook of lipid research. Glycolipids, phosphoglycolipids and sulfoglycolipids. New York, London: Plenum Press.
128. Goren MB, Brennan PJ. (1979). Mycobacterial lipids: chemistry and biologic activities. In: Youmans GP, ed. Tuberculosis. Philadelphia, London, Toronto: W. B. Saunders Company.
129. Goren MB, Brokl O, Roller P, et al. (1976). Sulfatides of Mycobacterium tuberculosis: the structure of the principal sulfatide (SL-I). Biochemistry 15: 2728-34.
130. Goren MB, Brokl O, Schaefer WB. (1974a). Lipids of putative relevance to virulence in Mycobacterium tuberculosis: correlation of virulence with elaboration of sulfatides and strongly acidic lipids. Infect Immun 9: 142-9.
131. Goren MB, Brokl O, Schaefer WB. (1974b). Lipids of putative relevance to virulence in Mycobacterium tuberculosis: phthiocerol dimycocerosate and the attenuation indicator lipid. Infect Immun 9: 150-8.
132. Goude R, Amin AG, Chatterjee D, Parish T. (2008). The critical role of embC in Mycobacterium tuberculosis. J Bacteriol 190: 4335-41.
133. Goude R, Amin AG, Chatterjee D, Parish T. (2009). The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemother 53: 4138-46.
134. Goyal R, Das AK, Singh R, et al. (2011). Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis. J Biol Chem 286: 45197-208.
135. Graham JE, Clark-Curtiss JE. (1999). Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Proc Natl Acad Sci USA 96: 11554-9.
136. Grzegorzewicz AE, Pham H, Gundi VAKB, et al. (2012). Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8: 334-41.
137. Guan S, Bastin DA, Verma NK. (1999). Functional analysis of the O antigen glucosylation gene cluster of Shigella flexneri bacteriophage SfX. Microbiology 145: 1263-73.
138. Guérardel Y, Maes E, Briken V, et al. (2003). Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties. J Biol Chem 278: 36637-51.
139. Guérardel Y, Maes E, Elass E, et al. (2002). Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. J Biol Chem 277: 30635-48.
140. Guerin ME, Kaur D, Somashekar BS, et al. (2009a). New insights into the early steps of phosphatidylinositol mannosides biosynthesis in mycobacteria. PimB' is an essential enzyme of Mycobacterium smegmatis. J Biol Chem 284: 25687-96.
141. Guerin ME, Schaeffer F, Chaffotte A, et al. (2009b). Substrate-induced conformational changes in the essential peripheral membraneassociated mannosyltransferase PimA from mycobacteria: implications for catalysis. J Biol Chem 284: 21613-25.
142. Guerin ME, Kordulakova J, Alzari PM, et al. (2010). Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria. J Biol Chem 285: 33577-83.
143. Guerin ME, Kordulakova J, Schaeffer F, et al. (2007). Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. J Biol Chem 282: 20705-14.
144. Guiard J, Collmann A, Garcia-Alles LF, et al. (2009). Fatty acyl structures of Mycobacterium tuberculosis sulfoglycolipid govern T cell response. J Immunol 182: 7030-7.
145. Guilhot C, Chalut C, Daffé M. (2008). Biosynthesis and roles of phenolic glycolipids and related molecules in Mycobacterium tuberculosis. In: Daffé M, Reyrat J-M, eds. The mycobacterial cell envelope. Washington DC: ASM Press.
146. Gupta R, Lavollay M, Mainardi JL, et al. (2010). The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin. Nat Med 16: 466-9.
147. Gurcha SS, Baulard AR, Kremer L, et al. (2002). Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem J 365: 441-50.
148. Guzman JD, Wube A, Evangelopoulos D, et al. (2011). Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J Antimicrob Chemother 66: 1766-72.
149. Hamad MA, Di Lorenzo F, Molinaro A, Valvano MA. (2012). Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance in Burkholderia cenocepacia (dagger). Mol Microbiol 85: 962-74.
150. Hamasaki N, Isowa K, Kamada K, et al. (2000). In vivo administration of mycobacterial cord factor (Trehalose 6, 60-dimycolate) can induce lung and liver granulomas and thymic atrophy in rabbits. Infect Immun 68: 3704-9.
151. Hancock IC, Carman S, Besra GS, et al. (2002). Ligation of arabinogalactan to peptidoglycan in the cell wall of Mycobacterium smegmatis requires concomitant synthesis of the two wall polymers. Microbiology 148: 3059-67.
152. Hansen JM, Golchin SA, Veyrier FJ, et al. (2013). N-Glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis. J Infect Dis 209: 1045-54.
153. Hatzios SK, Schelle MW, Holsclaw CM, et al. (2009). PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem 284: 12745-51.
154. Heitmann L, Schoenen H, Ehlers S, et al. (2013). Mincle is not essential for controlling Mycobacterium tuberculosis infection. Immunobiology 218: 506-16.
155. Henriques AO, Glaser P, Piggot PJ, Moran Jr CP. (1998). Control of cell shape and elongation by the rodA gene in Bacillus subtilis. Mol Microbiol 28: 235-47.
156. Herrmann J-L, O'Gaora P, Gallagher A, et al. (1996). Bacterial glycoproteins: a link between glycosylation and proteolytic cleavage of a 19 kDa antigen from Mycobacterium tuberculosis. EMBO J 15: 3547-54.
157. Hoang TT, Ma Y, Stern RJ, et al. (1999). Construction and use of lowcopy number T7 expression vectors for purification of problem proteins: purification of Mycobacterium tuberculosis RmlD and Pseudomonas aeruginosa LasI and Rh1I proteins, and functional analysis of purified Rh1I. Gene 237: 361-71.
158. Hoffmann C, Leis A, Niederweis M, et al. (2008). Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure. Proc Natl Acad Sci USA 105: 3963-7.
159. Horn C, Namane A, Pescher P, et al. (1999). Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern. J Biol Chem 274: 32023-30.
160. Hsu FF, Turk J, Owens RM, et al. (2007a). Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. I. PIMs and lyso-PIMs. J Am Soc Mass Spectrom 18: 466-78.
161. Hsu FF, Turk J, Owens RM, et al. (2007b). Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. II. Monoacyl- and diacyl- PIMs. J Am Soc Mass Spectrom 18: 479-92.
162. Huang H, Berg S, Spencer JS, et al. (2008). Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis. Microbiology 154: 736-43.
163. Huang H, Scherman MS, D'Haeze W, et al. (2005). Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-a-D-ribose-1-diphosphate: decaprenylphosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-D-arabinose synthesis. J Biol Chem 280: 24539-43.
164. Huet G, Constant P, Malaga W, et al. (2009). A lipid profile typifies the Beijing strains of Mycobacterium tuberculosis: identification of a mutation responsible for a modification of the structures of phthiocerol dimycocerosates and phenolic glycolipids. J Biol Chem 284: 27101-13.
165. Hugonnet JE, Tremblay LW, Boshoff HI, et al. (2009). Meropenemclavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science 323: 1215-18.
166. Hunter SW, Brennan PJ. (1990). Evidence for the presence of a phosphatidylinositol anchor on the lipoarabinomannan and lipomannan of Mycobacterium tuberculosis. J Biol Chem 265: 9272-9.
167. Hunter SW, Gaylord H, Brennan PJ. (1986). Structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli. J Biol Chem 261: 12345-51.
168. Hunter SW, Murphy RC, Clay K, et al. (1983). Trehalose-containing lipooligosaccharides. A new class of species-specific antigens from Mycobacterium. J Biol Chem 258: 10481-7.
169. Husseini H, Elberg S. (1952). Cellular reactions to phthienoic acid and related branched-chain acids. Am Rev Tuberc 65: 655-72.
170. Hvorup RN, Winnen B, Chang AB, et al. (2003). The multidrug/ oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem 270: 799-813.
171. Indrigo J, Hunter Jr RL, Actor JK. (2002). Influence of trehalose 6, 60- dimycolate (TDM) during mycobacterial infection of bone marrow macrophages. Microbiology 148: 1991-8.
172. Indrigo J, Hunter Jr RL, Actor JK. (2003). Cord factor trehalose 6, 60- dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology 149: 2049-59.
173. Ioerger TR, O'Malley T, Liao R, et al. (2013). Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One 8: e75245.
174. Ishikawa E, Ishikawa T, Morita YS, et al. (2009). Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med 206: 2879-88.
175. Ishizaki Y, Hayashi C, Inoue K, et al. (2013). Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45. J Biol Chem 288: 30309-19.
176. Jackson M, Brennan PJ. (2009). Polymethylated polysaccharides from Mycobacterium species revisited. J Biol Chem 284: 1949-53.
177. Jackson M, McNeil MR, Brennan PJ. (2013). Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis. Future Microbiol 8: 855-75.
178. Jackson M, Raynaud C, Lanéelle MA, et al. (1999). Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope. Mol Microbiol 31: 1573-87.
179. Jackson M, Stadthagen G, Gicquel B. (2007). Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities. Tuberculosis 87: 78-86.
180. Jain M, Cox JS. (2005). Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis. PLoS Pathog 1: e2.
181. Jang J, Stella A, Boudou F, et al. (2010). Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ. Microbiology 156: 1619-31.
182. Jarlier V, Nikaido H. (1994). Mycobacterial cell wall: structure and role in natural resistance to antibiotics. FEMS Microbiol Lett 123: 11-8.
183. Jiang T, He L, Zhan Y, et al. (2011). The effect of MSMEG-6402 gene disruption on the cell wall structure of Mycobacterium smegmatis. Microb Pathog 51: 156-60.
184. Jin Y, Xin Y, Zhang W, Ma Y. (2010). Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG-4947 have WecA function and MSMEG-4947 is required for the growth of M. smegmatis. FEMS Microbiol Lett 310: 54-61.
185. Joe M, Sun D, Taha H, et al. (2006). The 5-deoxy-5-methylthioxylofuranose residue in mycobacterial lipoarabinomannan. Absolute stereochemistry, linkage position, conformation, and immunomodulatory activity. J Am Chem Soc 128: 5059-72.
186. Julian E, Matas L, Alcaide J, Luquin M. (2004). Comparison of antibody responses to a potential combination of specific glycolipids and proteins for test sensitivity improvement in tuberculosis serodiagnosis. Clin Diagn Lab Immunol 11: 70-6.
187. Julian E, Matas L, Perez A, et al. (2002). Serodiagnosis of tuberculosis: comparison of immunoglobulin A (IgA) response to sulfolipid I with IgG and IgM responses to 2, 3-diacyltrehalose, 2, 3, 6-triacyltrehalose, and cord factor antigens. J Clin Microbiol 40: 3782-8.
188. Kaasen I, Falkenberg P, Styrvold OB, Strom AR. (1992). Molecular cloning and physical mapping of the otsBA genes, which encode the osmoregulatory trehalose pathway of Escherichia coli: evidence that transcription is activated by katF (AppR). J Bacteriol 174: 889-98.
189. Kalscheuer R, Syson K, Veeraraghavan U, et al. (2010). Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nat Chem Biol 6: 376-84.
190. Kalscheuer R, Weinrick B, Veeraraghavan U, et al. (2011). Trehaloserecycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 107: 21761-6.
191. Kanistanon D, Hajjar AM, Pelletier MR, et al. (2008). A Francisella mutant in lipid A carbohydrate modification elicits protective immunity. PLoS Pathog 4: e24.
192. Kaprelyants AS, Mukamolova GV, Ruggiero A, et al. (2012). Resuscitation-promoting factors (Rpf): in search of inhibitors. Protein Pept Lett 19: 1026-34.
193. Katti MK, Dai G, Armitige LY, et al. (2008). The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells. Cell Microbiol 10: 1286-303.
194. Kaur D, Berg S, Dinadayala P, et al. (2006). Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase. Proc Natl Acad Sci USA 103: 13664-9.
195. Kaur D, Guerin ME, Skovierova H, et al. (2009). Chapter 2. Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis. Adv Appl Microbiol 69: 23-78.
196. Kaur D, McNeil MR, Khoo K-H, et al. (2007). New insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene. J Biol Chem 282: 27133-40.
197. Kaur D, Obregón-Henao A, Pham H, et al. (2008). Lipoarabinomannan of Mycobacterium; mannose capping by a multifunctional terminal mannosyltransferase. Proc Natl Acad Sci USA 105: 17973-7.
198. Khasnobis S, Zhang J, Angala SK, et al. (2006). Characterization of a specific arabinosyltransferase activity involved in mycobacterial arabinan synthesis. Chem Biol 13: 787-95.
199. Khoo K-H, Dell A, Morris HR, et al. (1995a). Structural definition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: definition of a common anchor for lipomannan and lipoarabinomannan. Glycobiology 5: 117-27.
200. Khoo KH, Dell A, Morris HR, et al. (1995b). Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium. J Biol Chem 270: 12380-9.
201. Koga T, Fukuoka T, Doi N, et al. (2004). Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo. J Antimicrob Chemother 54: 755-60.
202. Kolly GS, Boldrin F, Sala C, et al. (2014). Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants. Mol Microbiol 92: 194-211.
203. Kondreddi RR, Jiricek J, Rao SP, et al. (2013). Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents. J Med Chem 56: 8849-59.
204. Korduláková J, Gilleron M, Mikusova K, et al. (2002). Definition of the first mannosylation step in phosphatidylinositol synthesis: PimA is essential for growth of mycobacteria. J Biol Chem 277: 31335-44.
205. Korduláková J, Gilleron M, Puzo G, et al. (2003). Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species. J Biol Chem 278: 36285-95.
206. Korres H, Mavris M, Morona R, et al. (2005). Topological analysis of GtrA and GtrB proteins encoded by the serotype-converting cassette of Shigella flexneri. Biochem Biophys Res Commun 328: 1252-60.
207. Kovacevic S, Anderson D, Morita YS, et al. (2006). Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria. J Biol Chem 281: 9011-17.
208. Kremer L, Dover LG, Morehouse C, et al. (2001). Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDPgalactofuranosyltransferase. J Biol Chem 276: 26430-40.
209. Kremer L, Gurcha SS, Bifani P, et al. (2002). Characterization of a putative a-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis. Biochem J, 363: 437-47.
210. Krishnan N, Malaga W, Constant P, et al. (2011). Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles. PLoS One 6: e23870.
211. Kumar P, Arora K, Lloyd JR, et al. (2012). Meropenem inhibits D, Dcarboxypeptidase activity in Mycobacterium tuberculosis. Mol Microbiol 86: 367-81.
212. Kumar P, Schelle MW, Jain M, et al. (2007). PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc Natl Acad Sci USA 104: 11221-6.
213. La Rosa V, Poce G, Canseco JO, et al. (2012). MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother 56: 324-31.
214. Lai X, Wu J, Chen S, et al. (2008). Expression, purification, and characterization of a functionally active Mycobacterium tuberculosis UDP-glucose pyrophosphorylase. Protein Expr Purif 61: 50-6.
215. Lamichhane G, Tyagi S, Bishai WR. (2005). Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs. Infect Immun 73: 2533-40.
216. Lang R. (2013). Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis. Front Immunol 4: 5. doi: 10.3389/fimmu.2013.0005.
217. Larrouy-Maumus G, Škovierová H, Dhouib R, et al. (2012). A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria. J Biol Chem 287: 39933-41.
218. Lavollay M, Arthur M, Fourgeaud M, et al. (2008). The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L, D-transpeptidation. J Bacteriol 190: 4360-6.
219. Lea-Smith DJ, Martin KL, Pyke JS, et al. (2008). Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarabinomannan reveals two lipomannan pools in Corynebacterineae. J Biol Chem 283: 6773-82.
220. Lee A, Wu S-W, Scherman MS, et al. (2006). Sequencing of the oligoarabinosyl units released from mycobacterial arabinogalactan by endogenous arabinanase: identification of distinctive and novel structural motifs. Biochemistry 45: 15817-28.
221. Lee JS, Krause R, Schreiber J, et al. (2008). Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain. Cell Host Microbe 3: 97-103.
222. Lee KS, Dubey VS, Kolattukudy PE, et al. (2007). Diacyltrehalose of Mycobacterium tuberculosis inhibits lipopolysaccharide- and mycobacteria-induced proinflammatory cytokine production in human monocytic cells. FEMS Microbiol Lett 267: 121-8.
223. Lee RE, Brennan PJ, Besra GS. (1997). Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay. Glycobiology 7: 1121-8.
224. Lee RE, Brennan PJ, Besra GS. (1998). Synthesis of b-D-arabinofuranosyl- 1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors. Biorog Med Chem Lett 8: 951-4.
225. Lee W, Vanderven BC, Fahey RJ, Russell DG. (2013a). Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. J Biol Chem 288: 6788-800.
226. Lee Y, Mootien S, Shoen C, et al. (2013b). Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones. Biochem Pharmacol 86: 222-30.
227. Leiba J, Syson K, Baronian G, et al. (2013). Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation. J Biol Chem 288: 16546-56.
228. Lemassu A, Daffé M. (1994). Structural features of the exocellular polysaccharides of Mycobacterium tuberculosis. Biochem J 297: 351-7.
229. Lemassu A, Lanéelle M-A, Daffé M. (1991). Revised structure of a trehalose-containing immunoreactive glycolipid of Mycobacterium tuberculosis. FEMS Microbiol Lett 78: 171-6.
230. Lemassu A, Levy-Frebault VV, Laneelle MA, Daffe M. (1992). Lack of correlation between colony morphology and lipooligosaccharide content in the Mycobacterium tuberculosis complex. J Gen Microbiol 138: 1535-41.
231. Lengeler KB, Tielker D, Ernst JF. (2007). Protein-Omannosyltransferases in virulence and development. Cell Mol Life Sci 65: 528-44.
232. Li S, Kang J, Yu W, et al. (2012). Identification of M. tuberculosis Rv3441c and M. smegmatis MSMEG-1556 and essentiality of M. smegmatis MSMEG-1556. PLoS One 7: e42769.
233. Li W, Xin Y, McNeil MR, Ma Y. (2006). rmlB and rmlC genes are essential for growth of mycobacteria. Biochem Biophys Res Commun 342: 170-8.
234. Linares C, Bernabeu A, Luquin M, Valero-Guillen PL. (2012). Cord factors from atypical mycobacteria (Mycobacterium alvei, Mycobacterium brumae) stimulate the secretion of some pro-inflammatory cytokines of relevance in tuberculosis. Microbiology 158: 2878-85.
235. Liu CF, Tonini L, Malaga W, et al. (2013). Bacterial protein-Omannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 110: 6560-5.
236. Lougheed KE, Osborne SA, Saxty B, et al. (2011). Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents. Tuberculosis (Edinb) 91: 277-86.
237. Ludwiczak P, Gilleron M, Bordat Y, et al. (2002). Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure. Microbiology 148: 3029-37.
238. Lun S, Guo H, Onajole OK, et al. (2013). Indoleamides are active against drug-resistant Mycobacterium tuberculosis. Nat Commun 4: 2907. doi: 10.1038/ncomms3907.
239. Ly D, Kasmar AG, Cheng TY, et al. (2013). CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med 210: 729-41.
240. Lynett J, Stokes RW. (2007). Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages. Microbiology 153: 3133-40.
241. Ma Y, Mills JA, Belisle JT, et al. (1997). Determination of the pathway for rhamnose biosynthesis in mycobacteria: cloning, sequencing and expression of the Mycobacterium tuberculosis gene encoding alpha-D-glucose-1-phosphate thymidylyltransferase. Microbiology 143: 937-45.
242. Ma Y, Pan F, McNeil MR. (2002). Formation of dTDP-rhamnose is essential for growth of mycobacteria. J Bacteriol 184: 3392-5.
243. Ma Y, Stern RJ, Scherman MS, et al. (2001). Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-Rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother 45: 1407-16.
244. Magnet S, Hartkoorn RC, Szekely R, et al. (2010). Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis (Edinb) 90: 354-60.
245. Mahapatra S, Basu J, Brennan PJ, Crick DC. (2005). Structure, biosynthesis and genetics of the mycolic acid-arabinogalactanpeptidoglycan complex. In: Cole ST, Eisenach KD, McMurray DN, Jacobs Jr WR, eds. Tuberculosis and the Tubercle Bacillus. Washington, DC: ASM Press.
246. Makarov V, Manina G, Mikusova K, et al. (2009). Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324: 801-4.
247. Malaga W, Constant P, Euphrasie D, et al. (2008). Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex. J Biol Chem 283: 15177-84.
248. Marland Z, Beddoe T, Zaker-Tabrizi L, et al. (2006). Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis. J Mol Biol 359: 983-97.
249. Marolda CL, Tatar LD, Alaimo C, et al. (2006). Interplay of the Wzx translocase and the corresponding polymerase and chain length regulator proteins in the translocation and periplasmic assembly of lipopolysaccharide O antigen. J Bacteriol 188: 5124-35.
250. Marrakchi H, Bardou F, Laneelle M-A, Daffé M. (2008). A comprehensive overview of mycolic acid structure and biosynthesis. In: Daffé M, Reyrat J-M, eds. The mycobacterial cell envelope. Washington, DC: ASM Press.
251. Maruta K, Hattori K, Nakada T, et al. (1996a). Cloning and sequencing of trehalose biosynthesis genes from Rhizobium sp. M-11. Biosci Biotechnol Biochem 60: 717-20.
252. Maruta K, Hattori K, Nakada T, et al. (1996b). Cloning and sequencing of trehalose biosynthesis genes from Arthrobacter sp. Q36. Biochim Biophys Acta 1289: 10-3.
253. Maruta K, Mitsuzumi H, Nakada T, et al. (1996c). Cloning and sequencing of a cluster of genes encoding novel enzymes of trehalose biosynthesis from thermophilic archaebacterium Sulfolobus acidocaldarius. Biochim Biophys Acta 1291: 177-81.
254. Matsuhashi M. (1966). Biosynthesis in the bacterial cell wall. Tanpakushitsu Kakusan Koso 11: 875-86.
255. Matsunaga I, Bhatt A, Young DC, et al. (2004). Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med 200: 1559-69.
256. Matsunaga I, Sugita M. (2012). Mycoketide: a CD1c-presented antigen with important implications in mycobacterial infection. Clin Dev Immunol 2012: 981821. doi: 10.1155/2012/981821.
257. McNeil M, Daffe M, Brennan PJ. (1990). Evidence for the nature of the link between the arabinogalactan and peptidoglycan of mycobacterial cell walls. J Biol Chem 265: 18200-6.
258. McNeil MR, Daffé M, Brennan PJ. (1991). Location of the mycolyl ester substituents in the cell walls of mycobacteria. J Biol Chem 266: 13217-23.
259. Mendes V, Maranha A, Lamosa P, et al. (2010). Biochemical characterization of the maltokinase from Mycobacterium bovis BCG. BMC Biochem 11: 21.
260. Miah F, Koliwer-Brandl H, Rejzek M, et al. (2013). Flux through trehalose synthase flows from trehalose to the alpha anomer of maltose in mycobacteria. Chem Biol 20: 487-93.
261. Michell SL, Whelan AO, Wheeler PR, et al. (2003). The MBP83 antigen from Mycobacterium bovis contains O-linked mannose and (1-43)- mannobiose moieties. J Biol Chem 278: 16423-32.
262. Mikusova K, Huang H, Yagi T, et al. (2005). Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose. J Bacteriol 187: 8020-5.
263. Mikusova K, Mikus M, Besra GS, et al. (1996). Biosynthesis of the linkage region of the mycobacterial cell wall. J Biol Chem 271: 7820-8.
264. Mikusova K, Yagi T, Stern R, et al. (2000). Biosynthesis of the galactan component of the mycobacterial cell wall. J Biol Chem 275: 33890-7.
265. Mills JA, Motichka K, Jucker M, et al. (2004). Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability. J Biol Chem 279: 43540-6.
266. Minnikin DE. (1982). Lipids: complex lipids, their chemistry, biosynthesis and roles. In: Ratledge C, Stanford J, eds. The biology of Mycobacteria. London: Academic Press.
267. Minnikin DE, Dobson G, Sesardic D, Ridell M. (1985). Mycolipenates and mycolipanolates of trehalose from Mycobacterium tuberculosis. J Gen Microbiol 131: 1369-74.
268. Mir M, Asong J, Li X, et al. (2011). The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog 7: e1002182.
269. Mishra AK, Alderwick LJ, Rittmann D, et al. (2007). Identification of an alpha(1-46) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomannan biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis. Mol Microbiol 65: 1503-17.
270. Mishra AK, Alderwick LJ, Rittmann D, et al. (2008b). Identification of a novel alpha(1-46) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol Microbiol 68: 1595-613.
271. Mishra AK, Driessen NN, Appelmelk BJ, Besra GS. (2011). Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction. FEMS Microbiol Rev 35: 1126-57.
272. Mishra AK, Klein C, Gurcha SS, et al. (2008a). Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant. Antonie Van Leeuwenhoek 94: 277-87.
273. Miyake Y, Toyonaga K, Mori D, et al. (2013). C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity 38: 1050-62.
274. Mohammadi T, Van Dam V, Sijbrandi R, et al. (2011). Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane. EMBO J 30: 1425-32.
275. Molle V, Kremer L. (2010). Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way. Mol Microbiol 75: 1064-77.
276. Molle V, Kremer L, Girard-Blanc C, et al. (2003). An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis. Biochemistry 42: 15300-9.
277. Moody DB, Ulrichs T, Muhlecker W, et al. (2000). CD1c-mediated Tcell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404: 884-8.
278. Morita YS, Fukuda T, Sena CB, et al. (2011). Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms. Biochim Biophys Acta 1810: 630-41.
279. Morita YS, Sena CCB, Waller RF, et al. (2006). PimE is a polyprenolphosphate- mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria. J Biol Chem 281: 25143-55.
280. Morita YS, Velasquez R, Taig E, et al. (2005). Compartmentalization of lipid biosynthesis in mycobacteria. J Biol Chem 280: 21645-52.
281. Mougous JD, Petzold CJ, Seraratne RH, et al. (2004). Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol 11: 721-9.
282. Munoz M, Lanéelle M-A, Luquin M, et al. (1997). Occurence of an antigenic triacyl trehalose in clinical isolates and reference strains of Mycobacterium tuberculosis. FEMS Microbiol Lett 157: 251-9.
283. Murakami S. (2008). Multidrug efflux transporter, AcrB-the pumping mechanism. Curr Opin Struct Biol 18: 459-65.
284. Murphy HN, Stewart GR, Mischenko VV, et al. (2005). The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem 280: 14524-9.
285. Nakada T, Maruta K, Tsusaki K, et al. (1995). Purification and properties of a novel enzyme, maltooligosyl trehalose synthase, from Arthrobacter sp. Q36. Biosci Biotechnol Biochem 59: 2210-14.
286. Nambiar JK, Pinto R, Aguilo JI, et al. (2012). Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory. Eur J Immunol 42: 385-92.
287. Neres J, Pojer F, Molteni E, et al. (2012). Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Sci Transl Med 4: 150ra121. doi: 10.1126/scitranslmed.3004395.
288. Newton GL, Buchmeier N, Fahey RC. (2008). Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev 72: 471-94.
289. Neyrolles O, Guilhot C. (2011). Recent advances in deciphering the contribution of Mycobacterium tuberculosis lipids to pathogenesis. Tuberculosis (Edinb) 91: 187-95.
290. Nigou J, Gilleron M, Cahuzac B, et al. (1997). The phosphatidylmyo- inositol anchor of the lipoarabinomannans from Mycobacterium bovis bacillus Calmette-Guérin. Heterogeneity, structure, and role in the regulation of cytokine secretion. J Biol Chem 272: 23094-103.
291. Nigou J, Vasselon T, Ray A, et al. (2008). Mannan chain length controls lipoglycans signaling via and binding to TLR2. J Immunol 180: 6696-702.
292. Nikonenko BV, Reddy VM, Protopopova M, et al. (2009). Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis. Antimicrob Agents Chemother 53: 3138-9.
293. Nishimoto T, Nakano M, Nakada T, et al. (1996). Purification and properties of a novel enzyme, trehalose synthase, from Pimelobacter sp. R48. Biosci Biotechnol Biochem 60: 640-4.
294. Noll H, Bloch H, Asselineau J, Lederer E. (1956). The chemical structure of the cord factor of Mycobacterium tuberculosis. Biochim Biophys Acta 20: 299-309.
295. North EJ, Jackson M, Lee RE. (2013). New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics. Curr Pharm Des. [Epub ahead of print].
296. Onajole OK, Pieroni M, Tipparaju S K, et al. (2013). Preliminary structure-activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. J Med Chem 56: 4093-103.
297. Ortalo-Magné A, Dupont MA, Lemassu A, et al. (1995). Molecular composition of the outermost capsular material of the tubercle bacillus. Microbiology 141: 1609-20.
298. Ortalo-Magné A, Lemassu A, Lanéelle MA, et al. (1996). Identification of the surface-exposed lipids on the cell envelopes of Mycobacterium tuberculosis and other mycobacterial species. J Bacteriol 178: 456-61.
299. Pabst MJ, Gross JM, Brozna JP, Goren MB. (1988). Inhibition of macrophage priming by sulfatide from Mycobacterium tuberculosis. J Immunol 140: 634-40.
300. Palma-Nicolas JP, Hernandez-Pando R, Segura E, et al. (2010). Mycobacterial di-O-acyl trehalose inhibits Th-1 cytokine gene expression in murine cells by down-modulation of MAPK signaling. Immunobiology 215: 143-52.
301. Pan F, Jackson M, Ma Y, McNeil M. (2001). Cell wall core galactofuran synthesis is essential for growth of mycobacteria. J Bacteriol 183: 3991-8.
302. Pan Y-T, Carroll JD, Asano N, et al. (2008). Trehalose synthase converts glycogen to trehalose. FEBS J 275: 3408-20.
303. Pan YT, Koroth Edavana V, Jourdian WJ, et al. (2004). Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme. Eur J Biochem 271: 4259-69.
304. Parish T, Liu J, Nikaido H, Stoker NG. (1997). A Mycobacterium smegmatis mutant with a defective inositol monophosphate phosphatase gene homolog has altered cell envelope permeability. J Bacteriol 179: 7827-33.
305. Passemar C, Arbues A, MalagaW, et al. (2013). Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions. Cell Microbiol 16: 195-213.
306. Pastoret S, Fraipont C, Den Blaauwen T, et al. (2004). Functional analysis of the cell division protein FtsW of Escherichia coli. J Bacteriol 186: 8370-9.
307. Patterson JH, Waller RF, Jeevarajah D, et al. (2003). Mannose metabolism is required for mycobacterial growth. Biochem J 372: 77-86.
308. Paulsen IT, Brown MH, Skurray RA. (1996). Proton-dependent multidrug efflux systems. Microbiol Rev 60: 575-608.
309. Pavelka Jr MS, Mahapatra S, Crick DC. (2014). Genetics of peptidoglycan biosynthesis. Microbiol Spectrum 2: MGM2-0034-2013.
310. Peng W, Zou L, Bhamidi S, et al. (2012). The galactosamine residue in mycobacterial arabinogalactan is alpha-linked. J Org Chem 77: 9826-32.
311. Penumarti N, Khuller GK. (1983). Subcellular distribution of mannophosphoinositides in Mycobacterium smegmatis during growth. Experientia 39: 882-4.
312. Pitarque S, Herrmann JL, Duteyrat JL, et al. (2005). Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity. Biochem J 392: 615-24.
313. Pitarque S, Larrouy-Maumus G, Payré B, et al. (2008). The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface. Tuberculosis 88: 560-5.
314. Poce G, Bates RH, Alfonso S, et al. (2013). Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One 8: e56980.
315. Porcelli SA, Modlin RL. (1999). The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 17: 297-329.
316. Prigozhin DM, Mavrici D, Huizar JP, et al. (2013). Structural and biochemical analyses of Mycobacterium tuberculosis N-acetylmuramyl- L-alanine amidase Rv3717 point to a role in peptidoglycan fragment recycling. J Biol Chem 288: 31549-55.
317. Puech V, Guilhot C, Perez E, et al. (2002). Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis. Mol Microbiol 44: 1109-22.
318. Raetz CRH, Reynolds CM, Trent MS, Bishop RE. (2007). Lipid A modification systems in Gram-negative bacteria. Annu Rev Biochem 76: 295-329.
319. Raetz CRH, Whitfield C. (2002). Lipopolysaccharide endotoxins. Annu Rev Biochem 71: 635-700.
320. Ragas A, Roussel L, Puzo G, Riviere M. (2007). The Mycobacterium tuberculosis cell-surface glycoprotein Apa as a potential adhesin to colonize target cells via the innate immune system pulmonary C-type lectin surfactant protein A. J Biol Chem 282: 5133-42.
321. Rainczuk AK, Yamaryo-Botte Y, Brammananth R, et al. (2012). The lipoprotein LpqW is essential for the mannosylation of periplasmic glycolipids in Corynebacteria. J Biol Chem 287: 42726-38.
322. Rana AK, Singh A, Gurcha SS, et al. (2012). Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteria. PLoS One 7: e48211.
323. Rao SP, Lakshminarayana SB, Kondreddi RR, et al. (2013). Indolcarboxamide is a preclinical candidate for treating multidrugresistant tuberculosis. Sci Transl Med 5: 214ra168. doi: 10.1126/scitranslmed.3007355.
324. Rao V, Fujiwara N, Porcelli SA, Glickman MS. (2005). Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. J Exp Med 201: 535-43.
325. Raymond JB, Mahapatra S, Crick DC, Pavelka Jr MS. (2005). Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. J Biol Chem 280: 326-33.
326. Real G, Fay A, Eldar A, et al. (2008). Determinants for the subcellular localization and function of a nonessential SEDS protein. J Bacteriol 190: 363-76.
327. Reddy VM, Einck L, Nacy CA. (2008). In vitro antimycobacterial activities of capuramycin analogues. Antimicrob Agents Chemother 52: 719-21.
328. Reed MB, Domenech P, Manca C, et al. (2004). A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature 431: 84-7.
329. Remuinan MJ, Perez-Herran E, Rullas J, et al. (2013). Tetrahydropyrazolo[1, 5-a]pyrimidine-3-carboxamide and N-benzyl- 60, 70-dihydrospiro[piperidine-4, 40-thieno[3, 2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PLoS One 8: e60933.
330. Ren H, Dover LG, Islam ST, et al. (2007). Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum. Mol Microbiol 63: 1345-59.
331. Richmond JM, Lee J, Green DS, et al. (2012). Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells. J Immunol 189: 5886-95.
332. Rick PD, Barr K, Sankaran K, et al. (2003). Evidence that the wzxE gene of Escherichia coli K-12 encodes a protein involved in the transbilayer movement of a trisaccharide-lipid intermediate in the assembly of enterobacterial common antigen. J Biol Chem 278: 16534-42.
333. Rodriguez JE, Ramirez AS, Salas LP, et al. (2013). Transcription of genes involved in sulfolipid and polyacyltrehalose biosynthesis of Mycobacterium tuberculosis in experimental latent tuberculosis infection. PLoS One 8: e58378.
334. Romain F, Horn C, Pescher P, et al. (1999). Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses. Infect Immun 67: 5567-72.
335. Rombouts Y, Alibaud L, Carrere-Kremer S, et al. (2011). Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: structure, localization and acylation by PapA4 (MMAR-2343) protein. J Biol Chem 286: 33678-88.
336. Rombouts Y, Burguiere A, Maes E, et al. (2009). Mycobacterium marinum lipooligosaccharides are unique caryophyllose-containing cell wall glycolipids that inhibit tumor necrosis factor-alpha secretion in macrophages. J Biol Chem 284: 20975-88.
337. Rose NL, Completo GC, Lin S-J, et al. (2006). Expression, purification and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabongalactan biosynthesis. J Am Chem Soc 128: 6721-9.
338. Rousseau C, Neyrolles O, Bordat Y, et al. (2003b). Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells. Cell Microbiol 5: 405-15.
339. Rousseau C, Turner OC, Rush E, et al. (2003a). Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs. Infect Immun 71: 4684-90.
340. Roy R, Usha V, Kermani A, et al. (2013). Synthesis of alpha-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2. ACS Chem Biol 8: 2245-55.
341. Ruiz N. (2008). Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coli. Proc Natl Acad Sci USA 105: 15553-7.
342. Russell DG. (2011). Mycobacterium tuberculosis and the intimate discourse of a chronic infection. Immunol Rev 240: 252-68.
343. Ryndak M, Wang S, Smith I. (2008). PhoP, a key player in Mycobacterium tuberculosis virulence. Trends Microbiol 16: 528-34.
344. Saadat S, Ballou CE. (1983). Pyruvylated glycolipids from Mycobacterium smegmatis. Structures of two oligosaccharide components. J Biol Chem 258: 1813-18.
345. Saavedra R, Segura E, Leyva R, et al. (2001). Mycobacterial di-O-acyl-trehalose inhibits mitogen- and antigen-induced proliferation of murine T cells in vitro. Clin Diagn Lab Immunol 8: 1081-8.
346. +T-cells. Microbes Infect 8: 533-40.
347. Sacksteder KA, Protopopova M, Barry III CE, et al. (2012). Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action. Future Microbiol 7: 823-37.
348. Sakaguchi I, Ikeda N, Nakayama M, et al. (2000). Trehalose 6, 60-dimycolate (Cord factor) enhances neovascularization through vascular endothelial growth factor production by neutrophils and macrophages. Infect Immun 68: 2043-52.
349. Sambou T, Dinadayala P, Stadthagen G, et al. (2008). Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice. Mol Microbiol 70: 762-74.
350. Sani M, Houben ENG, Geurtsen J, et al. (2010). Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog 6: e1000794.
351. Sanki AK, Boucau J, Ronning DR, Sucheck SJ. (2009). Antigen 85Cmediated acyl-transfer between synthetic acyl donors and fragments of the arabinan. Glycoconj J 26: 589-96.
352. Sanyal S, Frank CG, Menon AK. (2008). Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry 47: 7937-46.
353. Sartain MJ, Belisle JT. (2009). N-Terminal clustering of the Oglycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC. Glycobiology 19: 38-51.
354. Sassetti CM, Rubin EJ. (2003). Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci USA 100: 12989-94.
355. Scherman MS, Kalbe-Bournonville L, Bush D, et al. (1996). Polyprenylphosphate-pentoses in mycobacteria are synthesized from 5-phosphoribose pyrophosphate. J Biol Chem 271: 29652-8.
356. Scherman MS, Weston A, Duncan K, et al. (1995). Biosynthetic origin of mycobacterial cell wall arabinosyl residues. J Bacteriol 177: 7125-30.
357. Schoenen H, Bodendorfer B, Hitchens K, et al. (2010). Cutting edge: mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 184: 2756-60.
358. Schwebach JR, Casadevall A, Schneerson R, et al. (2001). Expression of a Mycobacterium tuberculosis arabinomannan antigen in vitro and in vivo. Infect Immun 69: 5671-8.
359. Schwebach JR, Glatman-Freedman A, Gunther-Cummins L, et al. (2002). Glucan is a component of the Mycobacterium tuberculosis surface that is expressed in vitro and in vivo. Infect Immun 70: 2566-75.
360. Seeliger JC, Holsclaw CM, Schelle MW, et al. (2012). Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis. J Biol Chem 287: 7990-8000.
361. Seidel M, Alderwick LJ, Birch HL, et al. (2007). Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis. J Biol Chem 282: 14729-40.
362. Sena CBC, Fukuda T, Miyanagi K, et al. (2010). Controlled expression of branch-forming mannosyltransferase is critical for mycobacterial lipoarabinomannan biosynthesis. J Biol Chem 285: 13326-36.
363. Shabaana AK, Kulangara K, Semac I, et al. (2005). Mycobacterial lipoarabinomannans modulate cytokine production in human T helper cells by interfering with raft/microdomain signalling. Cell Mol Life Sci 62: 179-87.
364. Sharma K, Gupta M, Krupa A, et al. (2006b). EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/ threonine kinases and phosphatase in Mycobacterium tuberculosis. FEBS J 273: 2711-21.
365. Sharma K, Gupta M, Pathak M, et al. (2006a). Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J Bacteriol 188: 2936-44.
366. Shi L, Berg S, Lee A, et al. (2006). The carboxy terminus of EmbC from Mycobacterium smegmatis mediates chain length extension of the arabinan in lipoarabinomannan. J Biol Chem 281: 19512-26.
367. Shi L, Zhou R, Liu Z, et al. (2008). Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability. J Bacteriol 190: 5248-55.
368. Sieger B, Schubert K, Donovan C, Bramkamp M. (2013). The lipid II flippase RodA determines morphology and growth in Corynebacterium glutamicum. Mol Microbiol 90: 966-82.
369. Silva CL, Ekizlerian SM, Fazioli RA. (1985). Role of cord factor in the modulation of infection caused by mycobacteria. Am J Pathol 118: 238-47.
370. Simonney N, Molina JM, Molimard M, et al. (1996). Comparison of A60 and three glycolipid antigens in an ELISA test for tuberculosis. Clin Microbiol Infect 2: 214-22.
371. Simonney N, Molina JM, Molimard M, et al. (1995). Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-seropositive and -seronegative patients. Eur J Clin Microbiol Infect Dis 14: 883-91.
372. Singh A, Crossman DK, Mai D, et al. (2009). Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. PLoS Pathog 5: e1000545.
373. Singla D, Anurag M, Dash D, Raghava GP. (2011). A web server for predicting inhibitors against bacterial target GlmU protein. BMC Pharmacol 11: 5.
374. Sirakova TD, Thirumala AK, Dubey VS, et al. (2001). The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl branched fatty acids required for sulfolipid synthesis. J Biol Chem 276: 16833-9.
375. Škovierová H, Larrouy-Maumus G, Pham H, et al. (2010). Biosynthetic origin of the galactosamine substituent of arabinogalactan in Mycobacterium tuberculosis. J Biol Chem 285: 41348-55.
376. Škovierová H, Larrouy-Maumus G, Zhang J, et al. (2009). AftD, a novel essential arabinofuranosyltransferase from mycobacteria. Glycobiology 19: 1235-47.
377. Slayden RA, Jackson M, Zucker J, et al. (2013). Updating and curating metabolic pathways of TB. Tuberculosis (Edinb) 93: 47-59.
378. Smith GT, Sweredoski MJ, Hess S. (2013). O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. J Proteomics 97: 296-306.
379. Song F, Guan Z, Raetz CRH. (2009). Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida. Biochemistry 48: 1173-82.
380. Sperandeo P, Deho G, Polissi A. (2009). The lipopolysaccharide transport system of Gram-negative bacteria. Biochim Biophys Acta 1791: 594-602.
381. Stadthagen G, Sambou T, Guerin M, et al. (2007). Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis. J Biol Chem 282: 27270-6.
382. Stanley SA, Grant SS, Kawate T, et al. (2012). Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol 7: 1377-84.
383. Stern RJ, Lee TY, Lee TJ, et al. (1999). Conversion of dTDP-4-keto-6- deoxyglucose to free dTDP-4-keto-rhamnose by the rmlC gene products of Escherichia coli and Mycobacterium tuberculosis. Microbiology 145: 663-71.
384. Stokes RW, Norris-Jones R, Brooks DE, et al. (2004). The glycan-rich outer layer of the cell wall of Mycobacterium tuberculosis acts as an antiphagocytic capsule limiting the association of the bacterium with macrophages. Infect Immun 72: 5676-86.
385. Stoop EJ, Mishra AK, Driessen NN, et al. (2013). Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity. Cell Microbiol 15: 2093-108.
386. Sulzenbacher G, Canaan S, Bordat Y, et al. (2006). LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis. EMBO J 25: 1436-44.
387. Supply P, Marceau M, Mangenot S, et al. (2013). Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet 45: 172-9.
388. Tahlan K, Wilson R, Kastrinsky DB, et al. (2012). SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother 56: 1797-809.
389. Takayama K, Wang C, Besra GS. (2005). Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev 18: 81-101.
390. Teitelbaum R, Glatman-Freedman A, Chen B, et al. (1998). A monoclonal antibody recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival. Proc Natl Acad Sci USA 95: 15688-93.
391. Torrelles JB, Azad AK, Schlesinger LS. (2006). Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors. J Immunol 177: 1805-16.
392. Torrelles JB, Khoo KH, Sieling PA, et al. (2004). Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis. J Biol Chem 279: 41227-39.
393. Torrelles JB, Schlesinger LS. (2010). Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host. Tuberculosis (Edinb) 90: 84-93.
394. Torrelles JB, Sieling PA, Arcos J, et al. (2011). Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses. J Biol Chem 286: 35438-46.
395. Torrelles JB, Sieling PA, Zhang N, et al. (2012). Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology 22: 1118-27.
396. Tran AT, Wen D, West NP, et al. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Org Biomol Chem 11: 8113-26.
397. Trefzer C, Rengifo-Gonzalez M, Hinner MJ, et al. (2010). Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl- beta-D-ribose 20-epimerase DprE1 of Mycobacterium tuberculosis. J Am Chem Soc 132: 13663-5.
398. Trefzer C, Skovierova H, Buroni S, et al. (2012). Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphorylbeta- D-ribofuranose 20-oxidase DprE1. J Am Chem Soc 134: 912-15.
399. Treumann A, Xidong F, McDonnell L, et al. (2002). 5-methylthiopentose: a new substituent on liporabinomannan in Mycobacterium tuberculosis. J Mol Biol 316: 89-100.
400. Tseng TT, Gratwick KS, Kollman J, et al. (1999). The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol 1: 107-25.
401. Turnbull WB, Shimizu KH, Chatterjee D, et al. (2004). Identification of the 5-methylthiopentose substituent in Mycobacterium tuberculosis lipoarabinomannan. Angew Chem Int Ed 43: 3918-22.
402. Turnbull WB, Stalford SA. (2012). Methylthioxylose-a jewel in the mycobacterial crown? Org Biomol Chem 10: 5698-706.
403. Ugalde JE, Parodi AJ, Ugalde RA. (2003). De novo synthesis of bacterial glycogen: Agrobacterium tumefaciens glycogen synthase is involved in glucan initiation and elongation. Proc Natl Acad Sci USA 100: 10659-63.
404. Uh E, Jackson ER, San Jose G, et al. (2011). Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs. Bioorg Med Chem Lett 21: 6973-6.
405. Van Der Woude AD, Sarkar D, Bhatt A, et al. (2012). Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum. J Biol Chem 287: 20417-29.
406. Vander Ven BC, Harder JD, Crick DC, Belisle JT. (2005). Export-mediated assembly of mycobacterial glycoproteins parallels eukaryotic pathways. Science 309: 941-3.
407. Wallis RS, Kim P, Cole S, et al. (2013). Tuberculosis biomarkers discovery: developments, needs, and challenges. Lancet Infect Dis 13: 362-72.
408. Walters SB, Dubnau E, Kolesnikova I, et al. (2006). The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol Microbiol 60: 312-30.
409. Wang F, Sambandan D, Halder R, et al. (2013). Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci USA 110: E2510-7.
410. Wang R, Klegerman ME, Marsden I, et al. (1995). An anti-neoplastic glycan isolated from Mycobacterium bovis (BCG vaccine). Biochem J 311: 867-72.
411. Wang X, Ribeiro AA, Guan Z, Raetz CRH. (2009). Identification of undecaprenyl phosphate-b-D-galactosamine in Francisella novicida and its function in lipid A modification. Biochemistry 48: 1162-72.
412. Warrier T, Tropis M, Werngren J, et al. (2012). Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis. Antimicrob Agents Chemother 56: 1735-43.
413. Welin A, Winberg ME, Abdalla H, et al. (2008). Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block. Infect Immun 76: 2882-7.
414. Weston AR, Stern RJ, Lee RE, et al. (1997). Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues. Tuber Lung Dis 78: 123-31.
415. Wheatley RW, Zheng RB, Richards MR, et al. (2012). Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan. J Biol Chem 287: 28132-43.
416. Whitfield C. (2006). Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Annu Rev Biochem 75: 39-68.
417. Wilkinson KA, Newton SM, Stewart GR, et al. (2009). Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis. BMC Microbiol 9: 93.
418. Wolucka BA, McNeil MR, De Hoffmann E, et al. (1994). Recognition of the lipid intermediate for arbinogalactan/arabinomannan biosynthesis and its relation to the mode of action of ethambutol on mycobacteria. J Biol Chem 269: 23328-35.
419. Woodruff PJ, Carlson BL, Siridechadilok B, et al. (2004). Trehalose is required for growth of Mycobacterium smegmatis. J Biol Chem 279: 28835-43.
420. Yagi T, Mahapatra S, Mikusova K, et al. (2003). Polymerization of mycobacterial arabinogalactan and ligation to peptidoglycan. J Biol Chem 278: 26497-504.
421. Yan A, Guan Z, Raetz CRH. (2007). An undecaprenyl phosphateaminoarabinose flippase required for polymyxin resistance in Escherichia coli. J Biol Chem 282: 36077-89.
422. Yang L, Sinha T, Carlson TK, et al. (2013). Changes in the major cell envelope components of Mycobacterium tuberculosis during in vitro growth. Glycobiology 23: 926-34.
423. Zhang J, Amin AG, Holemann A, et al. (2010). Development of a platebased scintillation proximity assay for the mycobacterial AftB enzyme involved in cell wall arabinan biosynthesis. Bioorg Med Chem 18: 7121-31.
424. Zhang J, Angala SK, Pramanik PK, et al. (2011). Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors. ACS Chem Biol 6: 819-28.
425. Zhang J, Khoo K-H, Wu S-W, Chatterjee C. (2007). Characterization of a distinct arabinofuranosyltransferase in Mycobacterium smegmatis. J Am Chem Soc 129: 9650-62.
426. Zhang L, English D, Andersen BR. (1991). Activation of human neutrophils by Mycobacterium tuberculosis-derived sulfolipid I. J Immunol 146: 2730-6.
427. Zhang L, Goren MB, Holzer TJ, Andersen BR. (1988). Effect of Mycobacterium tuberculosis-derived sulfolipid I on human phagocytic cells. Infect Immun 56: 2876-83.
428. Zhang N, Torrelles JB, McNeil MR, et al. (2003). The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region. Mol Microbiol 50: 69-76.
429. Zhang W, Jones VC, Scherman MS, et al. (2008). Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase. Int J Biochem Cell Biol 40: 2560-71.
430. Zhang YJ, Ioerger TR, Huttenhower C, et al. (2012). Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog 8: e1002946.
431. Zheng J, Wei C, Zhao L, et al. (2011). Combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem mass spectrometry as an effective strategy for analyzing potential membrane protein complexes of Mycobacterium bovis bacillus Calmette-Guerin. BMC Genomics 12: 40.
432. Zlotta AR, Van Vooren J-P, Denis O, et al. (2000). What are the immunologically active components of bacille Calmette-Guérin in therapy of superficial bladder cancer? Int J Cancer 87: 844-52.
433. Zuber B, Chami M, Houssin C, et al. (2008). Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state. J Bact 190: 5672-80.