Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

Tuberculosis

Volumn 91, Issue 4, 2011, Pages 277-286

  Lougheed, Kathryn E A ^a,c   Osborne, Simon A ^b   Saxty, Barbara ^b   Whalley, David ^b   Chapman, Tim ^b   Bouloc, Nathalie ^b   Chugh, Jasveen ^b   Nott, Timothy J ^a   Patel, Dony ^a   Spivey, Vicky L ^a   Kettleborough, Catherine A ^b   Bryans, Justin S ^b   Taylor, Debra L ^b   Smerdon, Stephen J ^a   Buxton, Roger S ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Inhibitors; Kinases; Mycobacterium tuberculosis; PknB

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMYCOBACTERIAL AGENT; CYCLIC GMP DEPENDENT PROTEIN KINASE; ETHAMBUTOL; ISONIAZID; MRT 67127; MRT 67131; MRT 67150; MRT 67153; MRT 67155; MRT 67156; MRT 67319; MRT 68572; MRT 68606; MRT 68634; MRT 68664; MRT 68667; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE F; PROTEIN SERINE THREONINE KINASE; RIFAMPICIN; STREPTOMYCIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL GROWTH; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIGH THROUGHPUT SCREENING; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; CELL DIVISION; CELLS, CULTURED; DRUG DISCOVERY; HUMANS; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUBERCULOSIS;

EID: 79960271757     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2011.03.005     Document Type: Article

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