Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45

Journal of Biological Chemistry

Volumn 288, Issue 42, 2013, Pages 30309-30319

  Ishizaki, Yoshimasa ^a   Hayashi, Chigusa ^a   Inoue, Kunio ^a   Igarashi, Masayuki ^a   Takahashi, Yoshiaki ^a   Pujari, Venugopal ^b   Crick, Dean C ^b   Brennan, Patrick J ^b   Nomoto, Akio ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS SUBTILIS; CELL WALL ASSEMBLY; CELL WALL SYNTHESIS; DRUG CANDIDATES; MYCOBACTERIAL CELLS; MYCOBACTERIUM TUBERCULOSIS;

BIOCHEMISTRY;

BIOLOGY;

ARABINOGALACTAN; BACTERIAL ENZYME; CAPRAZAMYCIN A; CAPRAZAMYCIN B; CAPRAZAMYCIN C; CAPRAZAMYCIN D; CAPRAZAMYCIN DERIVATIVE; CAPRAZAMYCIN E; CAPRAZAMYCIN F; CAPRAZAMYCIN G; CAPRAZENE; CAPRAZENE 4 BUTYLANILIDE; CPZEN 45; GLYCEROL; HYGROMYCIN; KANAMYCIN; MYCOLYLARABINOGALACTAN; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE 1 PHOSPHATE TRANSFERASE; PEPTIDOGLYCAN; PROTEIN MRAY; PROTEIN TAGO; PROTEIN WECA; TEICHOIC ACID; TRANSFERASE; TUBERCULOSTATIC AGENT; TUNICAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ACTINOBACTERIA; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; ISOTOPE LABELING; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TAGO GENE; TARGET CELL;

ANTIBIOTICS ACTION; BACILLUS; CAPRAZAMYCIN B; CELL WALL; CPZEN-45; MYCOLYLARABINOGALACTAN; TAGO; TEICHOIC ACID; TUBERCULOSIS; WECA;

ANTITUBERCULAR AGENTS; AZEPINES; BACILLUS SUBTILIS; BACTERIAL PROTEINS; CELL WALL; GALACTANS; MYCOBACTERIUM TUBERCULOSIS; TRANSFERASES; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS); TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84886920443     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.492173     Document Type: Article

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