Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening

ACS Chemical Biology

Volumn 7, Issue 8, 2012, Pages 1377-1384

  Stanley, Sarah A ^a,b,c   Grant, Sarah Schmidt ^a,b,c   Kawate, Tomohiko ^a,b,c   Iwase, Noriaki ^a   Shimizu, Motohisa ^a   Wivagg, Carl ^a,c   Silvis, Melanie ^a   Kazyanskaya, Edward ^a   Aquadro, John ^a   Golas, Aaron ^a   Fitzgerald, Michael ^a   Dai, Huanqin ^d   Zhang, Lixin ^d   Hung, Deborah T ^a,b,c  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BENZIMIDAZOLE; DECAPRENYLPHOSPHORYL BETA DEXTRO 2 EPIMERASE; EPIMERASE; GLIOTOXIN; MYCOBACTERIAL MEMBRANE PROTEIN LARGE 3; MYCOLIC ACID; TRIAZOLE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CELL WALL; CHEMICAL GENETICS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG TARGETING; ENZYME INHIBITION; GENE SEQUENCE; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; WHOLE CELL;

ANTITUBERCULAR AGENTS; BIOCHEMISTRY; CELL WALL; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GLYCEROL; GREEN FLUORESCENT PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MUTATION; MYCOBACTERIUM TUBERCULOSIS;

EID: 84865253965     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300151m     Document Type: Article

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