Transcription of Genes Involved in Sulfolipid and Polyacyltrehalose Biosynthesis of Mycobacterium tuberculosis in Experimental Latent Tuberculosis Infection

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Rodríguez, Jimmy E ^a   Ramírez, Ana S ^a,d   Salas, Laura P ^b   Helguera Repetto, Cecilia ^b   Gonzalez y Merchand, Jorge ^b   Soto, Carlos Y ^a   Hernández Pando, Rogelio ^c  

^a UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOLIPID; POLYACYLTREHALOSE; POLYKETIDESYNTHASE; SULFOLIPID; SYNTHETASE; TREHALOSE; UNCLASSIFIED DRUG; LIPID; MEMBRANE PROTEIN; MMPL8 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; OXYGEN; POLYKETIDE SYNTHASE; RNA 16S; SULFOLIPIDS;

ANAEROBIC GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; DISEASE COURSE; ENZYME STRUCTURE; ENZYME SYNTHESIS; FEMALE; GENE ACTIVITY; GENE FUNCTION; GENETIC ANALYSIS; GENETIC REGULATION; GENETIC TRANSCRIPTION; LATENT TUBERCULOSIS; MALE; MMPL10 GENE; MMPL8 GENE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PKS GENE; STRUCTURE ANALYSIS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL WALL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; LUNG TUBERCULOSIS; METABOLISM; MICROBIOLOGY; THIN LAYER CHROMATOGRAPHY;

ANIMALS; CELL WALL; CHROMATOGRAPHY, THIN LAYER; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, BACTERIAL; LIPIDS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; OXYGEN; POLYKETIDE SYNTHASES; RNA, RIBOSOMAL, 16S; TREHALOSE; TUBERCULOSIS, PULMONARY;

EID: 84874610656     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058378     Document Type: Article

References (43)

1. World Health Organization (2011) Global tuberculosis control: WHO report 2011. Geneva: WHO Press.
2. Parrish NM, Dick JD, Bishai WR, (1998) Mechanisms of latency in Mycobacterium tuberculosis. Trends Microbiol 6: 107-112.
3. Tufariello JM, Chan J, Flynn JL, (2003) Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. Lancet Infect Dis 3: 578-590.
4. Kaufmann SH, (2001) How can immunology contribute to the control of tuberculosis? Nat Rev Immunol 1: 20-30.
5. Fritz C, Maass S, Kreft A, Bange FC, (2002) Dependence of Mycobacterium bovis BCG on anaerobic nitrate reductase for persistence is tissue specific. Infect Immun 70: 286-291.
6. Seiler P, Ulrichs T, Bandermann S, Pradl L, Jorg S, et al. (2003) Cell-wall alterations as an attribute of Mycobacterium tuberculosis in latent infection. J Infect Dis 188: 1326-1331.
7. Wayne LG, Sohaskey CD, (2001) Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol 55: 139-163.
8. Wayne LG, Hayes LG, (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64: 2062-2069.
9. Arriaga AK, Orozco EH, Aguilar LD, Rook GA, Hernandez-Pando R, (2002) Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis. Clin Exp Immunol 128: 229-237.
10. Hernández-Pando R, Orozco EH, Sampieri A, Pavón L, Velasquillo C, et al. (1996) Correlation between kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. Immunology 89: 26-33.
11. Starck J, Kallenius G, Marklund BI, Andersson DI, Akerlund T, (2004) Comparative proteome analysis of Mycobacterium tuberculosis grown under aerobic and anaerobic conditions. Microbiology 150: 3821-3829.
12. Kim SY, Lee BS, Shin SJ, Kim HJ, Park JK, (2008) Differentially expressed genes in Mycobacterium tuberculosis H37Rv under mild acidic and hypoxic conditions. J Med Microbiol 57: 1473-1480.
13. Gomez JE, McKinney JD, (2004) M. tuberculosis persistence, latency, and drug tolerance. Tuberculosis (Edinb) 84: 29-44.
14. Yu G, Fu X, Jin K, Zhang L, Wu W, et al. (2011) Integrative analysis of transcriptome and genome indicates two potential genomic islands are associated with pathogenesis of Mycobacterium tuberculosis. Gene 489: 21-29.
15. Dubey VS, Sirakova TD, Kolattukudy PE, (2002) Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation. Mol Microbiol 45: 1451-1459.
16. Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, et al. (2007) PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc Natl Acad Sci U S A 104: 11221-11226.
17. Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, et al. (2009) PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem 284: 12745-12751.
18. Sirakova TD, Thirumala AK, Dubey VS, Sprecher H, Kolattukudy PE, (2001) The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis. J Biol Chem 276: 16833-16839.
19. Domenech P, Reed MB, Dowd CS, Manca C, Kaplan G, et al. (2004) The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis. J Biol Chem 279: 21257-21265.
20. Gonzalo-Asensio J, Maia C, Ferrer NL, Barilone N, Laval F, et al. (2006) The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J Biol Chem 281: 1313-1316.
21. Brennan P, (2003) Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis 83: 91-97.
22. Jackson M, Stadthagen G, Gicquel B, (2007) Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities. Tuberculosis (Edinb) 87: 78-86.
23. Gilleron M, Stenger S, Mazorra Z, Wittke F, Mariotti S, et al. (2004) Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with Mycobacterium tuberculosis. J Exp Med 199: 649-659.
24. Muñoz M, Laneelle MA, Luquin M, Torrelles J, Julian E, et al. (1997) Occurrence of an antigenic triacyl trehalose in clinical isolates and reference strains of Mycobacterium tuberculosis. FEMS Microbiol Lett 157: 251-259.
25. Soto CY, Cama M, Gibert I, Luquin M, (2000) Application of an easy and reliable method for Sulfolipid-I detection in the study of its distribution in Mycobacterium tuberculosis strains. FEMS Microbiol Lett 187: 103-107.
26. Luquin M, Laneelle MA, Ausina V, Garcia Barceló M, Belda F, et al. (1999) Distribution of a novel mycolic acid in species of the genus Mycobacterium. Int J Syst Bacteriol 41: 390-394.
27. Soto CY, Andreu N, Gibert I, Luquin M, (2002) Simple and rapid differentiation of Mycobacterium tuberculosis H37Ra from M. tuberculosis clinical isolates through two cytochemical tests using neutral red and nile blue stains. J Clin Microbiol 40: 3021-3024.
28. Shi L, Jung YJ, Tyagi S, Gennaro ML, North RJ, (2003) Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence. Proc Natl Acad Sci U S A 100: 241-246.
29. Gonzalez-y-Merchand JA, Colston MJ, Cox RA, (1996) The rRNA operons of Mycobacterium smegmatis and Mycobacterium tuberculosis: comparison of promoter elements neighbouring upstream genes. Microbiology 142: 667-674.
30. Badillo-López C, González-Mejía A, Helguera-Repetto C, Salas-Rangel LP, Rivera-Gutiérrez S, et al. (2010) Differential expression of dnaA and dosR genes among members of Mycobacterium tuberculosis complex under oxic and hypoxic conditions. Intl Microbiol 13: 9-13.
31. Daniel J, Deb C, Dubey VS, Sirakova TD, Abomoelak B, et al. (2004) Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture. J Bacteriol 186: 5017-5030.
32. Cardona PJ, Soto CY, Martin C, Giquel B, Agusti G, et al. (2006) Neutral-red reaction is related to virulence and cell wall methyl-branched lipids in Mycobacterium tuberculosis. Microbes Infect 8: 183-190.
33. Layre E, Paepe D, Larrouy-Maumus G, Vaubourgeix J, Mundayoor S, et al. (2011) Deciphering sulfoglycolipids of Mycobacterium tuberculosis. J Lipid Res 52: 1098-1110.
34. Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi CR, et al. (2003) MmpL8 is required for sulfolipid-I biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci U S A 100: 6121-6126.
35. Muñoz-Elias EJ, McKinney JD, (2006) Carbon metabolism of intracellular bacteria. Cell microbiol 8: 10-22.
36. Ouellet H, Johnston JB, Ortiz de Montellano PR, (2011) Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis. Trends microbiol 19: 530-539.
37. Singh A, Crossman DK, Mai D, Guidry L, Voskuil MI, et al. (2009) Mycobacterium tuberculosis WhiB3 manteins redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. PLoS Pathog 5: e1000545.
38. Timm JF, Post FA, Bekker LG, Walther GB, Manganelli R, et al. (2003) Differential expression of iron, carbon and oxygen-responsive mycobacterial genes in the lung of chronically infected mice and tuberculosis patients. Proc Natl Acad Sci U S A 100: 14321-14326.
39. Hernández-Pando R, Schön T, Orozco EH, Serafín J, Estrada-García I, (2001) Expression of nitric oxide synthase and nitrotyrosine during the evolution of experimental pulmonary tuberculosis. Exp Toxicol Pathol 53: 257-265.
40. Hett EC, Chao MC, Deng LL, Rubin EJ, (2008) A mycobacterial enzyme essential for cell division synergizes with the resuscitation-promoting factor. PLoS Pathog 4: e1000001.
41. Gonzalo-Asensio J, Mostowy S, Harders-Westerveen J, Huygen K, Hernández-Pando R, et al. (2008) PhoP: a missing piece in the intrincate puzzle of Mycobacterium tuberculosis virulence. PLoS One 3: e3496.
42. Sherman DR, Voskuil M, Schnappinger D, Liao R, Harrell MI, et al. (2001) Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin. Proc Natl Acad Sci U S A 98: 7534-7539.
43. Rustad TR, Harrell MI, Liao R, Sherman DR, (2008) The enduring hypoxic response of Mycobacterium tuberculosis. PLoS One 3: e1502.