Design, synthesis, and biological evaluation of indole-2-carboxamides: A promising class of antituberculosis agents

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8849-8859

  Kondreddi, Ravinder Reddy ^a   Jiricek, Jan ^a   Rao, Srinivasa P S ^a   Lakshminarayana, Suresh B ^a   Camacho, Luis R ^a   Rao, Ranga ^a   Herve, Maxime ^a   Bifani, Pablo ^a   Ma, Ngai Ling ^a   Kuhen, Kelli ^b   Goh, Anne ^a   Chatterjee, Arnab K ^b   Dick, Thomas ^a   Diagana, Thierry T ^a   Manjunatha, Ujjini H ^a   Smith, Paul W ^a  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 6 FLUORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4 CHLORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4 CYANO 6 ISOCYANO N (4 METHYL CYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DICHLORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DICHLORO N (4,4 DIFLUOROLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DICHLORO N (4,4 DIMETHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DICHLORO N (TRANS 4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIFLUORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIFLUORO N (4,4 DIMETHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIMETHYL N (1 METHYLPIPERIDIN 4 YL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIMETHYL N (2 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIMETHYL N (PENTAN 3 YL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIMETHYL N (TETRAHYDRO 2H PYRAN 4 YL) 1H INDOLE 2 CARBOXAMIDE; 4,6 DIMETHYL N PHENYL 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 6 CHLORO 4 FLUORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; 6 CHLORO N (4 METHYLCYCLOHEXYL) 1H INDOLE 2 CARBOXAMIDE; AMIDE; INDOLE 2 CARBOXAMIDE; N (2 HYDROXYCYCLOHEXYL) 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N (2 METHOXYETHYL) 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N (SEC BUTYL) 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N CYCLOHEPTYL 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N CYCLOHEXYL 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N CYCLOHEXYL N,4,6 TRIMETHYL 1H INDOLE 2 CARBOXAMIDE; N ISOBUTYL 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N ISOPENTYL 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; N ISOPROPYL 4,6 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; COLONY FORMING UNIT; DRUG DESIGN; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MINIMUM BACTERICIDAL CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; INDOLES; MICE; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS;

EID: 84887929742     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4012774     Document Type: Article

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