Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability

Journal of Biological Chemistry

Volumn 279, Issue 42, 2004, Pages 43540-43546

  Mills, Jonathan A ^a,e   Motichka, Kelly ^b   Jucker, Markus ^a   Wu, Henry P ^a   Uhlik, Brian C ^a   Stern, Richard J ^b   Scherman, Michael S ^b   Vissa, Varalakshmi D ^b   Pan, Fei ^b   Kundu, Manikuntala ^c   Yu, Fang Ma ^b,d   McNeil, Michael ^b  

^a Chugai Biopharmaceuticals Inc   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c BOSE INSTITUTE   (India)

^d DALIAN MEDICAL UNIVERSITY   (China)

^e Ilypsa Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; DISEASES; DNA; ENZYMES; GENES; POLYPEPTIDES;

MYOBACTERIA; POLYPRENOL; TEMPERATURE SENSITIVE MUTANTS;

ESCHERICHIA COLI;

ARABINOGALACTAN; BACTERIAL ENZYME; PEPTIDOGLYCAN; RHAMNOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIAL GROWTH; ENZYME ACTIVITY; ENZYME INACTIVATION; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TEMPERATURE DEPENDENCE;

BACTERIAL PROTEINS; BASE SEQUENCE; CARBON RADIOISOTOPES; CELL DIVISION; CELL SURVIVAL; CLONING, MOLECULAR; DNA PRIMERS; ESCHERICHIA COLI; GALACTANS; HEXOSYLTRANSFERASES; KINETICS; MUTAGENESIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDOGLYCAN; POLYMERASE CHAIN REACTION;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 6344270257     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407782200     Document Type: Article

References (28)

1. McNeil, M., Besra, G. S., and Brennan, P. J. (1996) in Tuberculosis (Rom, W. N., and Garay, S. M., eds) pp. 171-186, Little, Brown, and Co., Boston
2. Besra, G. S., Khoo, K.-H., McNeil, M., Dell, A., Morris, H. R., and Brennan, P. J. (1995) Biochemistry 34, 4257-4266
3. McNeil, M., Daffe, M., and Brennan, P. J. (1991) J. Biol. Chem. 266, 13217-13223
4. Daffe, M., Brennan, P. J., and McNeil, M. (1990) J. Biol. Chem. 265, 6734-6743
5. McNeil, M., Daffe, M., and Brennan, P. J. (1990) J. Biol. Chem. 265, 18200-18206
6. Mikusova, K., Mikus, M., Besra, G., Hancock, I., and Brennan, P. J. (1996) J. Biol. Chem. 271, 7820-7828
7. Snapper, S. B., Melton, R. E., Mustafa, S., Kieser, T., and Jacobs, W. R. (1990) Mol. Microbiol. 4, 1911-1919
8. Hooke, A. M. (1994) Methods Enzymol. 235, 448-457
9. Pascopella, L., Collins, F. M., Martin, J. M., Lee, M. H., Hatfull, G. F., Stover, C. K., Bloom, B. R., and Jacobs, W. R., Jr. (1994) Infect. Immun. 62, 1313-1319
10. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M. A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Nature 393, 537-544
11. Stevenson, G., Neal, B., Liu, D., Hobbs, M., Packer, N. H., Batley, M., Redmond, J. W., Lindquist, L., and Reeves, P. R. (1994) J. Bacteriol. 176, 4144-4156
12. Reeves, P. R., Hobbs, M., Valvano, M. A., Skurnik, M., Whitfield, C., Coplin, D., Kido, N., Klena, J., Maskell, D., Raetz, C. R., and Rick, P. D. (1996) Trends. Microbiol. 4, 495-503
13. Hitchcock, P. J., and Brown, T. M. (1983) J. Bacteriol. 154, 269-277
14. Tsai, C. M., and Frasch, C. E. (1982) Anal. Biochem. 119, 115-119
15. Jann, B., Shashkov, A. S., Kochanowski, H., and Jann, K. (1994) Carbahydr. Res. 265, 305-311
16. Ma, Y., Mills, J. A., Belisle, J. T., Vissa, V., Howell, M., Bowlin, K., Scherman, M. S., and McNeil, M. (1997) Microbiology 143, 937-945
17. Stern, R. J., Lee, T. Y., Lee, T. J., Yan, W., Scherman, M. S., Vissa, V. D., Kim, S. K., Wanner, B. L., and McNeil, M. R. (1999) Microbiology 145, 663-671
18. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410
19. Liu, D., and Keeves, P. R. (1994) Microbiology 140, 49-57
20. Jackson, M., Raynaud, C., Laneelle, M. A., Gullhot, C., Laurent-Winter, C., Ensergueix, D., Gicquel, B., and Daffe, M. (1999) Mol. Microbiol. 31, 1573-1587
21. Khoo, K. H., Suzuki, R., Dell, A., Morris, H. R., McNeil, M. R., Brennan, P. J., and Besra, G. S. (1996) Biochemistry 35, 11812-11819
22. Danner, M., and Seckler, R. (1993) Protein. Sci. 2, 1869-1881
23. McNeil, M. (1996) in Mycobacterium Avium Complex Infection (Korvick, J. A., and Benson, C. A., eds) pp. 263-283, Marcel Dekker, Inc., New York
24. Ma, Y., Pan, F., and McNeil, M. R. (2002) J. Bacteriol. 184, 3392-3395
25. Eckstein, T. M., Silbaq, F. S., Chatterjee, D., Kelly, N. J., Brennan, P. J., and Belisle, J. T. (1998) J. Bacteriol. 180, 5567-5573
26. Philipp, W. J., Poulet, S., Eiglmeier, K., Pascopella, L., Balasubramanian, V., Heym, B., Bergh, S., Bloom, B. R., Jacobs, W. R., and Cole, S. T. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3132-3137
27. Sassetti, C. M., Boyd, D. H., and Rubin, E. J. (2003) Mol. Microbiol. 48, 77-84
28. Garbe, T. R., Barathi, J., Barnini, S., Zhang, Y., Abou-Zeid, C., Tang, D., Mukherjee, R., and Young, D. B. (1994) Microbiology 140, 133-138