Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 43, 2011, Pages 17755-17760

  Garcia Alles, Luis F ^a,b   Collmann, Anthony ^c   Versluis, Cees ^d   Lindner, Buko ^e   Guiard, Julie ^a,b   Maveyraud, Laurent ^a,b   Huca, Emilie ^a,b   Im, Jin S ^f   Sansano, Sebastiano ^c   Brando, Thérèse ^a,b   Julien, Sylviane ^a,b   Prandi, Jacques ^a,b   Gilleron, Martine ^a,b   Porcelli, Steven A ^f   De La Salle, Henri ^g,h,i   Heck, Albert J R ^d   Mori, Lucia ^c,j   Puzo, Germain ^a,b   Mourey, Lionel ^a,b   De Libero, Gennaro ^c  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UTRECHT UNIVERSITY   (Netherlands)

^e RESEARCH CENTER BORSTEL   (Germany)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^g INSERM   (France)

^h UNIVERSITÉ DE STRASBOURG   (France)

ⁱ ETABLISSEMENT FRANÇAIS DU SANG   (France)

^j AGENCY FOR SCIENCE   (Singapore)

more..

Author keywords

CD1b mutant transfectant; Diacylglycerol endogenous ligand; Groove shrinking; T lymphocyte activation; Three dimensional structure

Indexed keywords

CD1B ANTIGEN; LIPID BINDING PROTEIN; SULFATIDE; T LYMPHOCYTE RECEPTOR;

ANTIGEN BINDING; ARTICLE; CELL STIMULATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; MOUSE; MYCOBACTERIUM; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; T LYMPHOCYTE;

ANTIGENS, CD1; CHROMATOGRAPHY, THIN LAYER; CRYSTALLOGRAPHY, X-RAY; FOURIER ANALYSIS; GLYCOLIPIDS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80055065064     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110118108     Document Type: Article

References (32)

1. De Libero G, Mori L (2005) Recognition of lipid antigens by T cells. Nat Rev Immunol 5:485-496. (Pubitemid 40835036)
2. McFarland BJ, Beeson C (2002) Binding interactions between peptides and proteins of the class II major histocompatibility complex. Med Res Rev 22:168-203. (Pubitemid 34160584)
3. Barral DC, Brenner MB (2007) CD1 antigen presentation: How it works. Nat Rev Immunol 7:929-941. (Pubitemid 350166056)
4. Silk JD, Salio M, Brown J, Jones EY, Cerundolo V (2008) Structural and functional aspects of lipid binding by CD1 molecules. Annu Rev Cell Dev Biol 24:369-395.
5. McCarthy C, et al. (2007) The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med 204:1131-1144. (Pubitemid 46798156)
6. Gadola SD, et al. (2002) Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. Nat Immunol 3:721-726.
7. Sieling PA, et al. (1995) CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269:227-230.
8. Gilleron M, et al. (2001) Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette Guérin and ability to induce granuloma and recruit natural killer T cells. J Biol Chem 276:34896-34904.
9. de la Salle H, et al. (2005) Assistance of microbial glycolipid antigen processing by CD1e. Science 310:1321-1324.
10. Gilleron M, et al. (2004) Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J Exp Med 199:649-659. (Pubitemid 38316432)
11. Beckman EM, et al. (1994) Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature 372:691-694.
12. Layre E, et al. (2009) Mycolic acids constitute a scaffold for mycobacterial lipid antigens stimulating CD1-restricted T cells. Chem Biol 16:82-92.
13. Moody DB, et al. (1997) Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 278:283-286. (Pubitemid 27450874)
14. Shamshiev A, et al. (2000) The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides. Immunity 13:255-264.
15. Shamshiev A, et al. (2002) Presentation of the same glycolipid by different CD1 molecules. J Exp Med 195:1013-1021. (Pubitemid 34412003)
16. de Jong A, et al. (2007) CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs. Chem Biol 14:1232-1242. (Pubitemid 350102239)
17. Guiard J, et al. (2009) Fatty acyl structures of mycobacterium tuberculosis sulfoglycolipid govern T cell response. J Immunol 182:7030-7037.
18. Cheng TY, et al. (2006) Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J 25:2989-2999.
19. Heck AJ (2008) Native mass spectrometry: A bridge between interactomics and structural biology. Nat Methods 5:927-933.
20. Garcia-Alles LF, et al. (2006) Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. EMBO J 25:3684-3692. (Pubitemid 44264878)
21. Benesch JL, Ruotolo BT, Simmons DA, Robinson CV (2007) Protein complexes in the gas phase: Technology for structural genomics and proteomics. Chem Rev 107:3544-3567. (Pubitemid 47322744)
22. Batuwangala T, et al. (2004) The crystal structure of human CD1b with a bound bacterial glycolipid. J Immunol 172:2382-2388. (Pubitemid 38182387)
23. Zajonc DM, Ainge GD, Painter GF, Severn WB, Wilson IA (2006) Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d. J Immunol 177:4577-4583. (Pubitemid 44469789)
24. Zajonc DM, et al. (2005) Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol 6:810-818. (Pubitemid 43090467)
25. Zajonc DM, et al. (2005) Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med 202:1517-1526. (Pubitemid 41746598)
26. Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L (2008) Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol 377:1104-1116.
27. Koch M, et al. (2005) The crystal structure of human CD1d with and without alpha-galactosylceramide. Nat Immunol 6:819-826. (Pubitemid 43090468)
28. Giabbai B, et al. (2005) Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol 175:977-984. (Pubitemid 41094982)
29. Zajonc DM, Elsliger MA, Teyton L, Wilson IA (2003) Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat Immunol 4: 808-815. (Pubitemid 36986766)
30. Jones DR, Pettitt TR, Sanjuán MA, Mérida I, Wakelam MJ (1999) Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol. J Biol Chem 274:16846-16852.
31. Girardi E, et al. (2010) Crystal structure of bovine CD1b3 with endogenously bound ligands. J Immunol 185:376-386.
32. Borbulevych OY, et al. (2009) T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity 31:885-896.