Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-d-ribofuranose 2′-oxidase DprE1

Journal of the American Chemical Society

Volumn 134, Issue 2, 2012, Pages 912-915

  Trefzer, Claudia ^a,b   Škovierová, Henrieta ^a,c   Buroni, Silvia ^a,d   Bobovská, Adela ^a,c   Nenci, Simone ^a,d   Molteni, Elisabetta ^a,d   Pojer, Florence ^a,b   Pasca, Maria R ^a,d   Makarov, Vadim ^a,e   Cole, Stewart T ^a,b   Riccardi, Giovanna ^a,d   Mikušová, Katarína ^a,c   Johnsson, Kai ^a,b  

^a More Medicines for Tuberculosis ^*  (Slovakia)

^b EPFL   (Switzerland)

^c Physics and Informatics   (Slovakia)

^d UNIVERSITY OF PAVIA   (Italy)

^e BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUBERCULOSIS AGENTS; BACTERICIDAL ACTIVITY; DRUG CANDIDATES; DRUG SENSITIVITY; ELECTROPHILES; MYCOBACTERIAL; NANOMOLAR; RIBOFURANOSE; SUICIDE INHIBITOR;

AMINO ACIDS; BACTERICIDES;

ENZYMES;

BENZOTHIAZINONE; CYSTEINE; DECAPRENYLPHOSPHORYL BETA DEXTRO RIBOFURANOSE 2' OXIDASE; DPRE1 PROTEIN; ELECTROPHILE; OXIDOREDUCTASE; PROTEIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BIOGENESIS; CELL WALL; DRUG POTENCY; DRUG SENSITIVITY; METABOLITE; SUICIDE SUBSTRATE;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; MOLECULAR STRUCTURE; MYCOBACTERIUM; OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855948516     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja211042r     Document Type: Article

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