Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria. Implications for catalysis

Journal of Biological Chemistry

Volumn 284, Issue 32, 2009, Pages 21613-21625

  Guerin, Marcelo E ^a   Schaeffer, Francis ^b   Chaffotte, Alain ^b   Gest, Petra ^a   Giganti, David ^b   Korduláková, Jana ^c   van der Woerd, Mark ^a   Jackson, Mary ^a   Alzari, Pedro M ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b INSTITUT PASTEUR   (France)

^c Physics and Informatics   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CONFORMATIONAL TRANSITIONS; DONOR AND ACCEPTOR; EXPERIMENTAL DATA; GLYCOSYL TRANSFERASE; INTER-DOMAIN; KEY COMPONENT; MEMBRANE BINDING; MOLECULAR DOCKING; MOLECULAR LEVELS; MOLECULAR MECHANISM; MYCOBACTERIAL CELLS; MYO-INOSITOL; PERIPHERAL MEMBRANES; PHOSPHATE BINDING; SITE DIRECTED MUTAGENESIS; SUBSTRATE BINDING;

ABERRATIONS; ALCOHOLS; BINDING ENERGY; BIOCHEMISTRY; CATALYSIS; CELL MEMBRANES; SUBSTRATES; SUGARS;

BINDING SITES;

GLYCOSYLTRANSFERASE; GUANOSINE DIPHOSPHATE MANNOSE; PHOSPHATIDYL MYO INOSITOL MANNOSYLTRANSFERASE A; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENTHALPY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR DOCKING; MOLECULAR MECHANICS; MYCOBACTERIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

BACTERIAL PROTEINS; CALORIMETRY; CATALYSIS; CELL MEMBRANE; CIRCULAR DICHROISM; GUANOSINE DIPHOSPHATE; MANNOSYLTRANSFERASES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MYCOBACTERIUM SMEGMATIS; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

CORYNEBACTERINEAE; PIMA;

EID: 69249148625     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.003947     Document Type: Article

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