Synthesis of β-d-arabinofuranosyl-1-monophosphoryl polyprenols: Examination of their function as mycobacterial arabinosyl transferase donors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 951-954

  Lee, R E ^a,b   Brennan, P J ^a   Besra, G S ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABINOGALACTAN; ARABINOMANNAN; ARABINOSYL TRANSFERASE; POLYSACCHARIDE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL WALL; MYCOBACTERIUM; NONHUMAN; SYNTHESIS;

EID: 0032554707     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00147-4     Document Type: Article

References (12)

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3. 3. Lee, R. E.; Brennan, P. J.; Besra, G. S. Current Topics in Microbiology and Immunology 1996, 215, 1.
4. 4. Wolucka, B. A.; McNeil, M. R.; Hoffman, E.; Chojnacki, T.; Brennan, P. J. J. Biol. Chem. 1994, 269, 23328.
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7. 7. Lee R. E.; Brennan P. J.; Besra G. S. Glycobiology 1997, 7, 1121.
8. 8 Aoki, S.; Kondo, H.; Wong, C-H. Methods in Enzymology 1994, 247, 193.
9. 7 to afford the α and β-arabinofuranosyl-monophosphorylpolyprenols (cpm): 1α (28,176,900), 1β (4,312,410); 2α (30,925,000), 2β(7,462,940); 3α (10,730,800), 3β (2,106,890); 4α (79,245,000), 4β (16,595,000); 5α (20,676,600), 5β (5,141,250); 6α (62,660,000); 6β (10,112,500). All samples co-migrated with cold synthetic standards and were assessed as pure using TLC autoradiography.
10. 14C]Araf was determined by subtracting the radioactivity in control tubes from that of the test tubes.
11. 11. Danilov, L. L.; Druzhinina, T. N.; Kalinchuk, N. A.; Maltsev S. D.; Shibaev V.N. Chem. Phys. Lipids 1989, 51, 191.
12. 12 Kalinchuk, N. A.; Danilov, L. L.; Druzhinina, T. N.; Shibaev V. N.; Kochetkov N. K. Bioorg. Khim. 1985, 11, 219.