Cutting Edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

Journal of Immunology

Volumn 184, Issue 6, 2010, Pages 2756-2760

  Schoenen, Hanne ^a   Bodendorfer, Barbara ^a   Hitchens, Kelly ^d   Manzanero, Silvia ^d   Werninghaus, Kerstin ^a   Nimmerjahn, Falk ^a   Agger, Else Marie ^e   Stenger, Steffen ^b   Andersen, Peter ^e   Ruland, Jürgen ^c   Brown, Gordon D ^f   Wells, Christine ^d   Lang, Roland ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d GRIFFITH UNIVERSITY   (Australia)

^e STATENS SERUM INSTITUT   (Denmark)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CORD FACTOR; GLYCOSPHINGOLIPID; HYBRID PROTEIN; IMMUNOLOGICAL ADJUVANT; LECTIN RECEPTOR; LIPID BINDING PROTEIN; MINCLE RECEPTOR; PROTEIN KINASE SYK; TREHALOSE 6,6 DIBEHENATE; UNCLASSIFIED DRUG; CLECSF8 PROTEIN, MOUSE; FC RECEPTOR; FCGR1 PROTEIN, MOUSE; GLYCOLIPID; IL17A PROTEIN, MOUSE; INTERLEUKIN 17; LECTIN; MEMBRANE PROTEIN; TREHALOSE 6,6' DIBEHENATE; TREHALOSE 6,6'-DIBEHENATE;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TH1 CELL; TH17 CELL; TUBERCULOSIS; UPREGULATION; VACCINATION; ANIMAL; BIOSYNTHESIS; CELL LINE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; STAPHYLOCOCCUS AUREUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL LINE; CORD FACTORS; GLYCOLIPIDS; HUMANS; INTERLEUKIN-17; LECTINS, C-TYPE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MYCOBACTERIUM BOVIS; RECEPTORS, IGG; STAPHYLOCOCCUS AUREUS; TH1 CELLS;

EID: 77951932177     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0904013     Document Type: Article

References (26)

1. Jo, E. K., C. S. Yang, C. H. Choi, and C. V. Harding. 2007. Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors. Cell. Microbiol. 9: 1087-1098.
2. Gross, O., A. Gewies, K. Finger, M. Schäfer, T. Sparwasser, C. Peschel, I. Förster, and J. Ruland. 2006. Card9 controls a non-TLR signalling pathway for innate antifungal immunity. Nature 442: 651-656.
3. Hara, H., C. Ishihara, A. Takeuchi, T. Imanishi, L. Xue, S. W. Morris, M. Inui, T. Takai, A. Shibuya, S. Saijo, et al. 2007. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 8: 619-629.
4. Werninghaus, K., A. Babiak, O. Gross, C. Hölscher, H. Dietrich, E. M. Agger, J. Mages, A. Mocsai, H. Schoenen, K. Finger, et al. 2009. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J. Exp. Med. 206: 89-97.
5. Underhill, D. M., E. Rossnagle, C. A. Lowell, and R. M. Simmons. 2005. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106: 2543-2550.
6. Rogers, N. C., E. C. Slack, A. D. Edwards, M. A. Nolte, O. Schulz, E. Schweighoffer, D. L. Williams, S. Gordon, V. L. Tybulewicz, G. D. Brown, and C. Reis e Sousa. 2005. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22: 507-517.
7. Robinson, M. J., F. Osorio, M. Rosas, R. P. Freitas, E. Schweighoffer, O. Gross, J. S. Verbeek, J. Ruland, V. Tybulewicz, G. D. Brown, et al. 2009. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 206: 2037-2051.
8. Sato, K., X. L. Yang, T. Yudate, J. S. Chung, J. Wu, K. Luby-Phelps, R. P. Kimberly, D. Underhill, P. D. Cruz, Jr., and K. Ariizumi. 2006. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J. Biol. Chem. 281: 38854-38866.
9. Yamasaki, S., E. Ishikawa, M. Sakuma, H. Hara, K. Ogata, and T. Saito. 2008. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat. Immunol. 9: 1179-1188.
10. Chen, S. T., Y. L. Lin, M. T. Huang, M. F. Wu, S. C. Cheng, H. Y. Lei, C. K. Lee, T. W. Chiou, C. H. Wong, and S. L. Hsieh. 2008. CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453: 672-676.
11. Barrett, N. A., A. Maekawa, O. M. Rahman, K. F. Austen, and Y. Kanaoka. 2009. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J. Immunol. 182: 1119-1128.
12. LeibundGut-Landmann, S., O. Gross, M. J. Robinson, F. Osorio, E. C. Slack, S. V. Tsoni, E. Schweighoffer, V. Tybulewicz, G. D. Brown, J. Ruland, and C. Reis e Sousa. 2007. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8: 630-638.
13. Agger, E. M., I. Rosenkrands, J. Hansen, K. Brahimi, B. S. Vandahl, C. Aagaard, K. Werninghaus, C. Kirschning, R. Lang, D. Christensen, et al. 2008. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PLoS One 3: e3116.
14. Khader, S. A., G. K. Bell, J. E. Pearl, J. J. Fountain, J. Rangel-Moreno, G. E. Cilley, F. Shen, S. M. Eaton, S. L. Gaffen, S. L. Swain, et al. 2007. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat. Immunol. 8: 369-377.
15. Davidsen, J., I. Rosenkrands, D. Christensen, A. Vangala, D. Kirby, Y. Perrie, E. M. Agger, and P. Andersen. 2005. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6′-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim. Biophys. Acta 1718: 22-31.
16. Kaifu, T., J. Nakahara, M. Inui, K. Mishima, T. Momiyama, M. Kaji, A. Sugahara, H. Koito, A. Ujike-Asai, A. Nakamura, et al. 2003. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111: 323-332.
17. Takai, T., M. Li, D. Sylvestre, R. Clynes, and J. V. Ravetch. 1994. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 76: 519-529. (Pubitemid 24064172)
18. Wells, C. A., J. A. Salvage-Jones, X. Li, K. Hitchens, S. Butcher, R. Z. Murray, A. G. Beckhouse, Y. L. Lo, S. Manzanero, C. Cobbold, et al. 2008. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J. Immunol. 180: 7404-7413.
19. Ozeki, Y., H. Tsutsui, N. Kawada, H. Suzuki, M. Kataoka, T. Kodama, I. Yano, K. Kaneda, and K. Kobayashi. 2006. Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages. Microb. Pathog. 40: 171-176.
20. Mold, C., and T. W. Du Clos. 2009. C-reactive protein increases cytokine responses to Streptococcus pneumoniae through interactions with Fc gamma receptors. J. Immunol. 176: 7598-7604.
21. Yamasaki, S., M. Matsumoto, O. Takeuchi, T. Matsuzawa, E. Ishikawa, M. Sakuma, H. Tateno, J. Uno, J. Hirabayashi, Y. Mikami, et al. 2009. C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA 106: 1897-1902.
22. Guidry, T. V., R. L. Hunter, Jr., and J. K. Actor. 2007. Mycobacterial glycolipid trehalose 6,69-dimycolate-induced hypersensitive granulomas: contribution of CD4+ lymphocytes. Microbiology 153: 3360-3369.
23. Ishikawa, E., T. Ishikawa, Y. S. Morita, K. Toyonaga, H. Yamada, O. Takeuchi, T. Kinoshita, S. Akira, Y. Yoshikai, and S. Yamasaki. 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 206: 2879-2888.
24. McGreal, E. P., M. Rosas, G. D. Brown, S. Zamze, S. Y. Wong, S. Gordon, L. Martinez-Pomares and P. R. Taylor. 2006. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16: 422-430.
25. Bowdish, D. M., K. Sakamoto, M. J. Kim, M. Kroos, S. Mukhopadhyay, C. A. Leifer, K. Tryggvason, S. Gordon, and D. G. Russell. 2009. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog. 5: e1000474.
26. Zhang, X., L. Majlessi, E. Deriaud, C. Leclerc, and R. Lo-Man. 2009. Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity 31: 761-771.