Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 27, 2013, Pages

  Wang, Feng ^a,b   Sambandan, Dhinakaran ^c   Halder, Rajkumar ^a   Wang, Jianing ^a   Batt, Sarah M ^d   Weinrick, Brian ^c   Ahmad, Insha ^a   Yang, Pengyu ^a   Zhang, Yong ^a   Kim, John ^c   Hassani, Morad ^c   Huszar, Stanislav ^e   Trefzer, Claudia ^f   Ma, Zhenkun ^g   Kaneko, Takushi ^g   Mdluli, Khisi E ^g   Franzblau, Scott ^h   Chatterjee, Arnab K ^b   Johnson, Kai ^f   Mikusova, Katarina ^e   Besra, Gurdyal S ^d   Fütterer, Klaus ^d   Jacobs, William R ^c   Schultz, Peter G ^a,b   more..

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b California Institute for Biomedical Research   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e Physics and Informatics   (Slovakia)

^f EPFL   (Switzerland)

^g Global Alliance for Tuberculosis Drug Development   (United States)

^h UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Drug resistance; Dual mechanism

Indexed keywords

ANTIINFECTIVE AGENT; DECAPRENYL PHOSPHORYL BETA D RIBOFURANOSE OXIDOREDUCTASE DPRE1; DECAPRENYL PHOSPHORYL BETA D RIBOFURANOSE OXIDOREDUCTASE MOEW; ISONIAZID; OXIDOREDUCTASE; RIFAMPICIN; SMALL MOLECULE TCA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; BIOFILM; BIOSYNTHESIS; CELL WALL; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84879707160     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309171110     Document Type: Article

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