Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex: Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene

Journal of Biological Chemistry

Volumn 277, Issue 41, 2002, Pages 38148-38158

  Constant, Patricia ^a   Perez, Esther ^a   Malaga, Wladimir ^a   Lanéelle, Marie Antoinette ^a   Saurel, Olivier ^a   Daffé, Mamadou ^a   Guilhot, Christophe ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DERIVATIVES; ESTERS; GENES; MUTAGENESIS;

PATHOGENS;

LIPIDS;

4 HYDROXYBENZOIC ACID; ALKANOIC ACID; ESTER; GLYCOLIPID; METHYL PARABEN; PHENOL DERIVATIVE; PHENOLPHTHIOCEROL; PHTHIOCEROL; SYNTHETASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; FRAMESHIFT MUTATION; GENE FUSION; GENETIC COMPLEMENTATION; GENETIC VARIABILITY; GLYCOSYLATION; LIPOGENESIS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPEN READING FRAME; PKS 15 1 GENE; PRECURSOR; PRIORITY JOURNAL; STANDARD;

ANIMALS; ANTIGENS, BACTERIAL; BASE SEQUENCE; ESTERS; GENES, BACTERIAL; LIPIDS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; PARABENS; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VIRULENCE;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS COMPLEX;

EID: 0037064003     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206538200     Document Type: Article

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