Characterization of a putative α-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis

Biochemical Journal

Volumn 363, Issue 3, 2002, Pages 437-447

  Kremer, Laurent ^a   Gurcha, Sudagar S ^a   Bifani, Pablo ^a   Hitchen, Paul G ^a   Baulard, Alain ^a   Morris, Howard R ^a   Dell, Anne ^a   Brennan, Patrick J ^a   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Cell free; GDP mannose; Glycosyltransferases; Lipoarabinomannan; Lipomannan; Mycobacteria

Indexed keywords

BACTERIA; BIOASSAY; BIOSYNTHESIS; DISEASES; GENES; LIPIDS;

BACTERIAL FACTORS;

ENZYMES;

ALPHA MANNOSYLTRANSFERASE; AMFOMYCIN; CARBON 14; GENE PRODUCT; GUANOSINE DIPHOSPHATE; LIPOARABINOMANNAN; MANNAN; MANNOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL TRIMANNOSIDE; PROTEIN PIMC; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM ISOLATE; CARBOHYDRATE SYNTHESIS; CATALYSIS; CATALYST; CELL FREE SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; GENE INACTIVATION; LIPOGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DNA, BACTERIAL; GUANOSINE DIPHOSPHATE MANNOSE; LIPOPOLYSACCHARIDES; MANNOSYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PHOSPHATIDYLINOSITOLS; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0036565777     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630437     Document Type: Article

References (48)

1. Global surveillance for anti-tuberculosis-drug resistance, 1994-1997
2. Molecular action of anti-mycobacterial agents and mechanisms of drug resistance in Mycobacterium tuberculosis
3. The envelope of mycobacteria
4. Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor
5. Macrophage activation: Lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-α
6. Lipoarabinomannan from Mycobacterium tuberculosis modulates the generation of reactive nitrogen intermediates by γ-interferon-activated macrophages
7. Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages
8. Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls
9. Acylation state of the phosphatidyrinositol mannosides from Mycobacterium bovis bacillus Calmette Guerin and ability to induce granuloma and recruit natural killer T cells
10. Interactions between Mycobacterium tuberculosis and host cells: Are mycobacterial sugars the key?
11. Identification of phosphatidylinositol mannoside as a mycobacterial adhesin mediating both direct and opsonic binding to nonphagocytic mammalian cells
12. Evidence for the presence of a phosphatidylinositor anchor on the lipoarabinomannan of Mycobacterium tuberculosis
13. Structural features of lipoarabinomannan from Mycobacterium bovis BCG. Determination of molecular mass by laser desorption mass spectrometry
14. Structural definition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: Definition of a common anchor for lipomannan and lipoarabinomannan
15. The phosphatidyl-myo-inositol anchor of the lipoarabinomannans from Mycobacterium bovis bacillus Calmette-Guérin. Heterogeneity, structure, and role in the regulation of cytokine secretion
16. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
17. Synthesis of the mycobacterial arabinose donor β-D-arabinofuranosyl-1-monophosphoryldecaprenol, development of a basic arabinosyl-transferase assay and identification of ethambutol as an arabinosyl transferase inhibitor
18. Biosynthesis of mycobacterial lipoarabinomannan
19. Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains
20. The pimB gene of Mycobacteriurn tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis
21. Biosynthesis of mannophosphoinositides in Mycobacterium phlei
22. Mycobacterial lipoarabinomannan: An extraordinary lipoheteroglycan with profound physiological effects
23. Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis
24. New use of BCG for recombinant vaccines
25. Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates
26. Site-directed mutagenesis of the 19-kilodalton lipoprotein antigen reveals no essential role for the protein in the growth and virulence of Mycobacterium intracellulare
27. Mass spectrometry of carbohydrate-containing biopolymers
28. Analysis of the Mycobacterium tuberculosis 85A antigen promoter region
29. Disruption of the mycobacterial cell entry gene of Mycobacterium bovis BCG results in a mutant that exhibits a reduced invasiveness for epithelial cells
30. Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: Recommendations for a standardized methodology
31. Preparation of cell wall fractions
32. Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays
33. A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities
34. The Pfam protein families database
35. Towards a classification of glycosyltransferases based on amino acid sequence similarities: Prokaryotic α-mannosyltransferases
36. Identification of essential amino acids in the bacterial α-mannosyltransferase AceA
37. Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain
38. Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology
39. Comparison of various repetitive DNA elements as genetic markers for strain differentiation and epidemiology of Mycobacterium tuberculosis
40. Molecular strain typing of Mycobacterium tuberculosis to confirm cross-contamination in the mycobacteriology laboratory and modification of procedures to minimize occurrence of false-positive cultures
41. Genetics of cell wall biosynthesis
42. The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis
43. Biochemical characterization of the β-1,4-glucuronosyltransferase GelK in the gellan gum-producing strain Sphingomonas pauciomobilis A.T.C.C. 31461
44. The function of β-N-acetyl-D-glucosaminyl monophosphorylundecaprenol in biosynthesis of lipoteichoic acids in a group of Bacillus strains
45. Comparison of Mycobacterium tuberculosis genomes reveals frequent deletions in a 20 kb variable region in clinical isolates
46. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis
47. Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope