Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11354-11359

  Batt, Sarah M ^a   Jabeen, Talat ^a   Bhowruth, Veemal ^a   Quill, Lee ^a   Lund, Peter A ^a   Eggeling, Lothar ^b   Alderwick, Luke J ^a   Fuẗterer, Klaus ^a   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Arabinan; Decaprenylphosphoryl D arabinose; Multi drug resistance; Mycobacterial cell wall; X ray crystallography

Indexed keywords

BACTERIAL ENZYME; BENZOTHIAZINONE INHIBITOR; CHAPERONIN; DPRE1 ENZYME; FLAVINE ADENINE NUCLEOTIDE; METHYL GROUP; THIAZINA; TRIFLUOROMETHYL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL VIABILITY; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; EPIMERIZATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; ARABINOSE; BENZAMIDES; CATALYTIC DOMAIN; CELL WALL; CHAPERONINS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; ESCHERICHIA COLI; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN BINDING; PROTEIN CONFORMATION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84863919677     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205735109     Document Type: Article

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