The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode

Glycobiology

Volumn 23, Issue 9, 2013, Pages 1075-1083

  Caner, Sami ^a   Nguyen, Nham ^a   Aguda, Adeleke ^a   Zhang, Ran ^a   Pan, Yuan T ^b   Withers, Stephen G ^a   Brayer, Gary D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Drug design; Enzyme inhibition; GH13 glycoside hydrolase; Trehalose synthase; Tuberculosis

Indexed keywords

ACARBOSE; BACTERIAL ENZYME; SYNTHETASE; TREHALOSE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME ISOLATION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; STRUCTURE ANALYSIS;

DRUG DESIGN; ENZYME INHIBITION; GH13 GLYCOSIDE HYDROLASE; TREHALOSE SYNTHASE; TUBERCULOSIS;

ACARBOSE; AMINO ACID SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; GLUCOSYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM SMEGMATIS; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880926719     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwt044     Document Type: Article

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