메뉴 건너뛰기




Volumn 85, Issue , 2014, Pages 147-178

A comprehensive review on synthetic approach for antimalarial agents

Author keywords

Antimalarial; Heterocyclic; Malaria; Plasmodium; Synthesis

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; CHALCONE DERIVATIVE; HETEROCYCLIC COMPOUND; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; THIAZOLE DERIVATIVE; TRIAZINE DERIVATIVE; ALDEHYDE DERIVATIVE; BENZIMIDAZOLE; CHLOROQUINE; INDOLE DERIVATIVE; NITROGEN DERIVATIVE; OXYGEN; PYRAZOLE; PYRIMIDINE; QUININE; QUINOLINE;

EID: 84905168470     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.084     Document Type: Short Survey
Times cited : (50)

References (250)
  • 1
    • 0141741467 scopus 로고    scopus 로고
    • 6746 SERA peptide analogues immunogenicity and protective efficacy against malaria is associated with short α helix formation: Malaria protection associated with peptides α helix shortening
    • DOI 10.1016/S0196-9781(03)00187-6
    • M.P. Alba, L.M. Salazar, A. Puentes, M. Pinto, E. Torres, and M.E. Patarroyo 6746 SERA peptide analogues immunogenicity and protective efficacy against malaria is associated with short helix formation: malaria protection associated with peptides helix shortening Peptides 24 2003 999 1006 (Pubitemid 37130172)
    • (2003) Peptides , vol.24 , Issue.7 , pp. 999-1006
    • Alba, M.P.1    Salazar, L.M.2    Puentes, A.3    Pinto, M.4    Torres, E.5    Patarroyo, M.E.6
  • 2
    • 0037033989 scopus 로고    scopus 로고
    • Malaria in 2002
    • DOI 10.1038/415670a
    • B. Greenwood, and T. Mutabingwa Malaria in 2002 Nature 415 2002 670 672 (Pubitemid 34136399)
    • (2002) Nature , vol.415 , Issue.6872 , pp. 670-672
    • Greenwood, B.1    Mutabingwa, T.2
  • 3
    • 79952193925 scopus 로고    scopus 로고
    • (accessed 26.12.10.)
    • WHO World Malaria Report 2010 http://www.who.int/malaria/world-malaria- report-2010/en/index.html/ (accessed 26.12.10.)
    • (2010) World Malaria Report
  • 5
    • 15044338866 scopus 로고    scopus 로고
    • The global distribution of clinical episodes of Plasmodium falciparum malaria
    • DOI 10.1038/nature03342
    • R.W. Snow, C.A. Guerra, A.M. Noor, H.Y. Myint, and S.I. Hay The global distribution of clinical episodes of Plasmodium falciparum malaria Nature 434 2005 214 217 (Pubitemid 40388051)
    • (2005) Nature , vol.434 , Issue.7030 , pp. 214-217
    • Snow, R.W.1    Guerra, C.A.2    Noor, A.M.3    Myint, H.Y.4    Hay, S.I.5
  • 6
    • 0037033984 scopus 로고    scopus 로고
    • The economic and social burden of malaria
    • DOI 10.1038/415680a
    • J. Sachs, and P. Malaney The economic and social burden of malaria Nature 415 2002 680 685 (Pubitemid 34136401)
    • (2002) Nature , vol.415 , Issue.6872 , pp. 680-685
    • Sachs, J.1    Malaney, P.2
  • 8
    • 77950361904 scopus 로고    scopus 로고
    • Malaria in pregnancy and the newborn
    • S.J. Rogerson Malaria in pregnancy and the newborn Adv. Exp. Med. Biol. 659 2010 139 152
    • (2010) Adv. Exp. Med. Biol. , vol.659 , pp. 139-152
    • Rogerson, S.J.1
  • 9
    • 77954971154 scopus 로고    scopus 로고
    • Malaria and pregnancy: A global health perspective
    • J. Schantz-Dunn, and N.M. Nour Malaria and pregnancy: a global health perspective Rev. Obstet. Gynecol. 2 2009 186 192
    • (2009) Rev. Obstet. Gynecol. , vol.2 , pp. 186-192
    • Schantz-Dunn, J.1    Nour, N.M.2
  • 10
    • 11844299303 scopus 로고    scopus 로고
    • World Health Organization Geneva
    • Weekly Epidemiol Rec. vol. 71 1996 World Health Organization Geneva 25 32
    • (1996) Weekly Epidemiol Rec. , vol.71 , pp. 25-32
  • 11
    • 0031578369 scopus 로고    scopus 로고
    • Malaria Situation In 1994 W World Health Organization Geneva
    • World Malaria Situation in 1994 Weekly Epidemiol Rec. vol. 72 1997 World Health Organization Geneva 285 292
    • (1997) Weekly Epidemiol Rec. , vol.72 , pp. 285-292
  • 12
    • 0028778267 scopus 로고
    • Malaria Situation In 1992 W World Health Organization Geneva
    • World Malaria Situation in 1992 Weekly Epidemiol Rec. vol. 69 1994 World Health Organization Geneva 309 314
    • (1994) Weekly Epidemiol Rec. , vol.69 , pp. 309-314
  • 13
    • 0006881966 scopus 로고    scopus 로고
    • Malaria
    • R.L. Guerrant, D.H. Walker, P.F. Weller, Churchill Livingstone Philadelphia, PA, USA
    • D.J. Krogstad Malaria R.L. Guerrant, D.H. Walker, P.F. Weller, Tropical Infectious Diseases - Principles, Pathogens, & Practice vol. 1 1999 Churchill Livingstone Philadelphia, PA, USA 736 766
    • (1999) Tropical Infectious Diseases - Principles, Pathogens, & Practice , vol.1 , pp. 736-766
    • Krogstad, D.J.1
  • 14
    • 85053988039 scopus 로고    scopus 로고
    • The anopheles vector
    • H. Gilles, D.A. Warrell, Arnold London, UK
    • M. Service, and H. Townson The anopheles vector H. Gilles, D.A. Warrell, Essential Malariology 2002 Arnold London, UK 59 84
    • (2002) Essential Malariology , pp. 59-84
    • Service, M.1    Townson, H.2
  • 15
    • 33646108112 scopus 로고    scopus 로고
    • Dynamic regulation of single- and mixed-species malaria infection: Insights to specific and non-specific mechanisms of control
    • D. Gurarie, P.A. Zimmerman, and C.H. King Dynamic regulation of single- and mixed-species malaria infection: insights to specific and non-specific mechanisms of control J. Theor. Biol. 240 2006 185 199
    • (2006) J. Theor. Biol. , vol.240 , pp. 185-199
    • Gurarie, D.1    Zimmerman, P.A.2    King, C.H.3
  • 16
    • 1942423286 scopus 로고    scopus 로고
    • Mixed-species malaria infections in humans
    • DOI 10.1016/j.pt.2004.03.006, PII S1471492204000790
    • M. Mayxay, S. Pukrittayakamee, P.N. Newton, and N.J. White Mixed-species malaria infections in humans Trends Parasitol. 20 2004 233 240 (Pubitemid 38510320)
    • (2004) Trends in Parasitology , vol.20 , Issue.5 , pp. 233-240
    • Mayxay, M.1    Pukrittayakamee, S.2    Newton, P.N.3    White, N.J.4
  • 17
    • 6044244577 scopus 로고    scopus 로고
    • Why do we need to know more about mixed Plasmodium species infections in humans?
    • DOI 10.1016/j.pt.2004.07.004, PII S1471492204001795
    • P.A. Zimmerman, R.K. Mehlotra, L.J. Kasehagen, and J.W. Kazura Why do we need to know more about mixed Plasmodium species infections in humans? Trends Parasitol. 20 2004 440 447 (Pubitemid 39485679)
    • (2004) Trends in Parasitology , vol.20 , Issue.9 , pp. 440-447
    • Zimmerman, P.A.1    Mehlotra, R.K.2    Kasehagen, L.J.3    Kazura, J.W.4
  • 18
    • 35649027303 scopus 로고    scopus 로고
    • Neglect of Plasmodium vivax malaria
    • DOI 10.1016/j.pt.2007.08.011, PII S1471492207002425
    • J.K. Baird Neglect of Plasmodium vivax malaria Trends Parasitol. 23 2007 533 539 (Pubitemid 350026468)
    • (2007) Trends in Parasitology , vol.23 , Issue.11 , pp. 533-539
    • Baird, J.K.1
  • 21
    • 0034112744 scopus 로고    scopus 로고
    • Insecticide resistance in insect vectors of human disease
    • DOI 10.1146/annurev.ento.45.1.371
    • J. Hemingway, and H. Ranson Insecticide resistance in insect vectors of human disease Annu. Rev. Entomol. 45 2000 371 391 (Pubitemid 30187866)
    • (2000) Annual Review of Entomology , vol.45 , pp. 371-391
    • Hemingway, J.1    Ranson, H.2
  • 22
    • 33846256606 scopus 로고    scopus 로고
    • A review of human vaccine research and development: Malaria
    • DOI 10.1016/j.vaccine.2006.09.074, PII S0264410X06010760
    • M.P. Girard, Z.H. Reed, M. Friede, and M.P. Kieny A review of human vaccine research and development: malaria Vaccine 25 2007 1567 1580 (Pubitemid 46108198)
    • (2007) Vaccine , vol.25 , Issue.9 , pp. 1567-1580
    • Girard, M.P.1    Reed, Z.H.2    Friede, M.3    Kieny, M.P.4
  • 25
    • 0025614331 scopus 로고
    • Vector borne diseases
    • S. Sharma Vector borne diseases Prog. Drug. Res. 35 1990 365 485
    • (1990) Prog. Drug. Res. , vol.35 , pp. 365-485
    • Sharma, S.1
  • 27
    • 0034746828 scopus 로고    scopus 로고
    • Presents trend and future strategy in chemotherapy of malaria+
    • P.M.S. Chauhan, and S.K. Srivastava Present trends and future strategy in chemotherapy of malaria Curr. Med. Chem. 8 2001 1535 1542 (Pubitemid 33076801)
    • (2001) Current Medicinal Chemistry , vol.8 , Issue.13 , pp. 1535-1542
    • Chauhan, P.M.S.1    Srivastava, S.K.2
  • 28
    • 0035207181 scopus 로고    scopus 로고
    • Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action
    • C.W. Jefford Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action Curr. Med. Chem. 8 2001 1803 1826 (Pubitemid 33134072)
    • (2001) Current Medicinal Chemistry , vol.8 , Issue.15 , pp. 1803-1826
    • Jefford, C.W.1
  • 29
    • 0019718749 scopus 로고
    • The present status of malaria chemotherapy: Mefloquine, a novel antimalarial
    • DOI 10.1002/med.2610010304
    • T.R. Sweeney The present status of malaria chemotherapy: mefloquine, a novel antimalarial Med. Res. Rev. 1 1981 281 301 (Pubitemid 12039204)
    • (1981) Medicinal Research Reviews , vol.1 , Issue.3 , pp. 281-301
    • Sweeney, T.R.1
  • 30
    • 0026585915 scopus 로고
    • Quinoline-containing antimalarials-mode of action, drug resistance and its reversal
    • H. Ginsburg, and M. Krugliak Quinoline-containing antimalarials-mode of action, drug resistance and its reversal Biochem. Pharmacol. 43 1992 63 70
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 63-70
    • Ginsburg, H.1    Krugliak, M.2
  • 31
    • 0031080653 scopus 로고    scopus 로고
    • Quinoline antimalarials: Mechanisms of action and resistance
    • DOI 10.1016/S0020-7519(96)00152-X, PII S002075199600152X
    • M. Foley, and L. Tilley Quinoline antimalarials: mechanisms of action and resistance Int. J. Parasitol. 27 1997 231 240 (Pubitemid 27139713)
    • (1997) International Journal for Parasitology , vol.27 , Issue.2 , pp. 231-240
    • Foley, M.1    Tilley, L.2
  • 32
    • 0031847073 scopus 로고    scopus 로고
    • Quinoline antimalarials: Mechanisms of action and resistance and prospects for new agents
    • DOI 10.1016/S0163-7258(98)00012-6, PII S0163725898000126
    • M. Foley, and L. Tilley Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents Pharmacol. Ther. 79 1998 55 87 (Pubitemid 28318262)
    • (1998) Pharmacology and Therapeutics , vol.79 , Issue.1 , pp. 55-87
    • Foley, M.1    Tilley, L.2
  • 33
    • 0031965067 scopus 로고    scopus 로고
    • 4-Aminoquinolines - Past, present, and future: A chemical perspective
    • DOI 10.1016/S0163-7258(97)00084-3, PII S0163725897000843
    • P.M.O. Neill, P.G. Bray, S.R. Hawley, S.A. Ward, and B.K. Park 4-Aminoquinolines-past, present, and future: a chemical perspective Pharmacol. Ther. 77 1998 29 58 (Pubitemid 28059939)
    • (1998) Pharmacology and Therapeutics , vol.77 , Issue.1 , pp. 29-58
    • O'Neill, P.M.1    Bray, P.G.2    Hawley, S.R.3    Ward, S.A.4    Kevin Park, B.5
  • 34
    • 1142297431 scopus 로고    scopus 로고
    • Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs
    • DOI 10.1016/j.lfs.2003.10.003
    • C.D. Fitch Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs Life Sci. 74 2004 1957 1972 (Pubitemid 38210349)
    • (2004) Life Sciences , vol.74 , Issue.16 , pp. 1957-1972
    • Fitch, C.D.1
  • 35
    • 0344837694 scopus 로고    scopus 로고
    • Can primaquine therapy for vivax malaria be improved?
    • DOI 10.1016/S1471-4922(03)00005-9
    • J.K. Baird, and K.H. Reickmann Can primaquine therapy for vivax malaria be improved? Trends Parasitol. 19 2003 115 120 (Pubitemid 36338074)
    • (2003) Trends in Parasitology , vol.19 , Issue.3 , pp. 115-120
    • Baird, J.K.1    Rieckmann, K.H.2
  • 36
    • 0346848721 scopus 로고    scopus 로고
    • Primaquine for prevention of malaria in travelers
    • DOI 10.1086/379714
    • J.K. Baird, D.J. Fryauff, and S.L. Hoffman Primaquine for prevention of malaria in travelers Clin. Infect. Dis. 37 2003 1659 1667 (Pubitemid 37549954)
    • (2003) Clinical Infectious Diseases , vol.37 , Issue.12 , pp. 1659-1667
    • Baird, J.K.1    Fryauff, D.J.2    Hoffman, S.L.3
  • 37
    • 33745109939 scopus 로고    scopus 로고
    • Novel approaches to antimalarial drug discovery
    • C. Biot, and K. Chibale Novel approaches to antimalarial drug discovery Infect. Disord. Drug Targets 6 2006 173 204 (Pubitemid 43881023)
    • (2006) Infectious Disorders - Drug Targets , vol.6 , Issue.2 , pp. 173-204
    • Biot, C.1    Chibale, K.2
  • 38
    • 0013572735 scopus 로고
    • Synthesis of amino acid derivatives of 8-[(4-amino-1-methylbutyl)amino]- 6-4-substituted quinolines as potential antimalarial agents
    • R. Jain, S. Jain, R.C. Gupta, N. Anand, G.P. Dutta, and S.K. Puri Synthesis of amino acid derivatives of 8-[(4-amino-1-methylbutyl)amino]-6-4- substituted quinolines as potential antimalarial agents Indian J. Chem. 33B 1994 251 254
    • (1994) Indian J. Chem. , vol.33 B , pp. 251-254
    • Jain, R.1    Jain, S.2    Gupta, R.C.3    Anand, N.4    Dutta, G.P.5    Puri, S.K.6
  • 39
    • 0022378836 scopus 로고
    • 4-Substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents
    • DOI 10.1021/jm00149a004
    • F.I. Carroll, B. Berrang, and C.P. Linn 4-Substituted 5-[m-(trifluoromethyl)phenoxy] primaquine analogs as potential antimalarial agent J. Med. Chem. 28 1985 1564 1567 (Pubitemid 16204817)
    • (1985) Journal of Medicinal Chemistry , vol.28 , Issue.11 , pp. 1564-1567
    • Carroll, F.I.1    Berrang, B.2    Linn, C.P.3
  • 40
    • 9144273190 scopus 로고    scopus 로고
    • Discovery of a Bulky 2-tert-Butyl Group Containing Primaquine Analogue That Exhibits Potent Blood-Schizontocidal Antimalarial Activities and Complete Elimination of Methemoglobin Toxicity
    • DOI 10.1021/jm0304562
    • M. Jain, S. Vangapandu, S. Sachdeva, S. Singh, P.P. Singh, G.B. Jena, K. Tikoo, P. Ramarao, C.L. Kaul, and R. Jain Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity J. Med. Chem. 47 2004 285 287 (Pubitemid 38057872)
    • (2004) Journal of Medicinal Chemistry , vol.47 , Issue.2 , pp. 285-287
    • Jain, M.1    Vangapandu, S.2    Sachdeva, S.3    Singh, S.4    Singh, P.P.5    Jena, G.B.6    Tikoo, K.7    Ramarao, P.8    Kaul, C.L.9    Jain, R.10
  • 41
    • 20444506015 scopus 로고    scopus 로고
    • Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues
    • DOI 10.1016/j.bmc.2005.04.034, PII S0968089605003342
    • M. Jain, S.I. Khan, B.L. Tekwani, M.R. Jacob, S. Singh, P.P. Singh, and R. Jain Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues Bioorg. Med. Chem. 13 2005 4458 4466 (Pubitemid 40813233)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.14 , pp. 4458-4466
    • Jain, M.1    Khan, S.I.2    Tekwani, B.L.3    Jacob, M.R.4    Singh, S.5    Singh, P.P.6    Jain, R.7
  • 43
    • 0141504172 scopus 로고    scopus 로고
    • 8-Quinolinamines and their pro prodrug conjugates as potent blood-schizontocidal antimalarial agents
    • DOI 10.1016/j.bmc.2003.07.003
    • S. Vangapandu, S. Sachdeva, M. Jain, S. Singh, P.P. Singh, C.L. Kaul, and R. Jain 8-Quinolinamines and their pro prodrug conjugates as potent blood-schizontocidal antimalarial agents Bioorg. Med. Chem. 11 2003 4557 4568 (Pubitemid 37194260)
    • (2003) Bioorganic and Medicinal Chemistry , vol.11 , Issue.21 , pp. 4557-4568
    • Vangapandu, S.1    Sachdeva, S.2    Jain, M.3    Singh, S.4    Singh, P.P.5    Kaul, C.L.6    Jain, R.7
  • 44
    • 84962343524 scopus 로고    scopus 로고
    • A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4- ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists
    • DOI 10.1016/j.ejmech.2004.09.009, PII S022352340400193X
    • I. Sestili, A. Borioni, C. Mustazza, A. Rodomonte, L. Turchetto, M. Sbraccia, D. Riitano, and M.R.D. Giudice A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists Eur. J. Med. Chem. 39 2004 1047 1057 (Pubitemid 39574935)
    • (2004) European Journal of Medicinal Chemistry , vol.39 , Issue.12 , pp. 1047-1057
    • Sestili, I.1    Borioni, A.2    Mustazza, C.3    Rodomonte, A.4    Turchetto, L.5    Sbraccia, M.6    Riitano, D.7    Del Giudice, M.R.8
  • 47
    • 9644290865 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of 5-substituted amino-2,4-diamino-8- chloropyrimido-[4,5-b]quinolines as novel antimalarials
    • DOI 10.1016/j.bmcl.2004.10.037, PII S0960894X04012661
    • A. Joshi, S.S. Narkhede, and C.L. Viswanathan Design, synthesis and evaluation of 5-substituted amino-2,4-diamino-8-chloropyrimido-[4,5-b]quinolines as novel antimalarials Bioorg. Med. Chem. Lett. 15 2005 73 76 (Pubitemid 39575785)
    • (2005) Bioorganic and Medicinal Chemistry Letters , vol.15 , Issue.1 , pp. 73-76
    • Joshi, A.A.1    Narkhede, S.S.2    Viswanathan, C.L.3
  • 48
    • 58549088118 scopus 로고    scopus 로고
    • Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials
    • M. Misra, S.K. Pandey, V.P. Pandey, J. Pandey, R. Tripathi, and R.P. Tripathi Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials Bioorg. Med. Chem. 17 2009 625 633
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 625-633
    • Misra, M.1    Pandey, S.K.2    Pandey, V.P.3    Pandey, J.4    Tripathi, R.5    Tripathi, R.P.6
  • 50
    • 0018240067 scopus 로고
    • Synthesis of new pyrazolones as potent anti-inflammatory agents
    • A.I. Eid, M.A. Kira, and H.H. Fahmy Synthesis of new pyrazolones as potent anti-inflammatory agents J. Pharm. Belg 33 1978 303 311 (Pubitemid 9099912)
    • (1978) Journal de Pharmacie de Belgique , vol.33 , Issue.5 , pp. 303-311
    • Eid, A.I.1    Kira, M.A.2    Fahmy, H.H.3
  • 51
    • 0030744163 scopus 로고    scopus 로고
    • ω-Dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflammatory activity
    • G. Menozzi, L. Mosti, P. Fossa, F. Mattioli, and M. Ghia ω-Dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4- yl)methanols with analgesic and anti-inflammatory activity J. Heterocycl. Chem. 34 1997 963 968
    • (1997) J. Heterocycl. Chem. , vol.34 , pp. 963-968
    • Menozzi, G.1    Mosti, L.2    Fossa, P.3    Mattioli, F.4    Ghia, M.5
  • 52
    • 38849119065 scopus 로고    scopus 로고
    • Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents
    • DOI 10.1016/j.bmcl.2007.12.043, PII S0960894X07015028
    • M. Amir, H. Kumar, and S.A. Khan Synthesis and pharmacological evaluation of pyrazolines derivatives as new anti-inflammatory and analgesic agents Bioorg. Med. Chem. Lett. 18 2008 918 922 (Pubitemid 351193005)
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , Issue.3 , pp. 918-922
    • Amir, M.1    Kumar, H.2    Khan, S.A.3
  • 54
    • 0032995193 scopus 로고    scopus 로고
    • Synthesis and biological screening of new 1,3-diphenylpyrazoles with different heterocyclic moieties at position-4
    • T.I. El-Emary, and E.A. Bakhite Synthesis and biological screening of new 1,3-diphenylpyrazoles with different heterocyclic moieties at position-4 Pharmazie 54 1999 106 110
    • (1999) Pharmazie , vol.54 , pp. 106-110
    • El-Emary, T.I.1    Bakhite, E.A.2
  • 56
    • 84856320198 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of some pyrazole derivatives as anti-malarial agents
    • A.A. Bekhit, A. Hymete, H. Asfaw, and Ael-D. Bekhit Synthesis and biological evaluation of some pyrazole derivatives as anti-malarial agents Arch. Pharm. 345 2012 147 154
    • (2012) Arch. Pharm. , vol.345 , pp. 147-154
    • Bekhit, A.A.1    Hymete, A.2    Asfaw, H.3    Bekhit, A.-D.4
  • 58
    • 0025805362 scopus 로고
    • Trihaloacetylated enol ethers - General synthetic procedure and heterocyclic ring closure reactions with hydroxylamine
    • A. Colla, M.A.P. Martins, G. Clar, S. Krimmer, and P. Fischer Trihaloacetylated enol ethers - general synthetic procedure and heterocyclic ring closure reactions with hydroxylamine Synthesis 6 1991 483 486
    • (1991) Synthesis , vol.6 , pp. 483-486
    • Colla, A.1    Martins, M.A.P.2    Clar, G.3    Krimmer, S.4    Fischer, P.5
  • 59
    • 0000653201 scopus 로고    scopus 로고
    • Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles
    • H.G. Bonacorso, M.A.P. Martins, S.R.T. Bittencourt, R. Lourega, N. Zanatta, and A.F.C. Flores Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles J. Fluor. Chem. 99 1999 177 182
    • (1999) J. Fluor. Chem. , vol.99 , pp. 177-182
    • Bonacorso, H.G.1    Martins, M.A.P.2    Bittencourt, S.R.T.3    Lourega, R.4    Zanatta, N.5    Flores, A.F.C.6
  • 61
    • 0002633787 scopus 로고
    • Preparation and reaction of α-keto-ketene mercaptals
    • I. Shahak, and Y. Sasson Preparation and reaction of α-keto-ketene mercaptals Tetrahedron Lett. 14 1973 4207 4210
    • (1973) Tetrahedron Lett. , vol.14 , pp. 4207-4210
    • Shahak, I.1    Sasson, Y.2
  • 62
    • 84986446398 scopus 로고
    • A novel one step synthesis of 5(3)-methylthio-, alkoxy, amino- and hydroxypyrazoles using α-ketoketene-S,S-diacetals
    • S.M.S. Chauhan, and H. Junjappa A novel one step synthesis of 5(3)-methylthio-, alkoxy, amino- and hydroxypyrazoles using α-ketoketene- S,S-diacetals Synthesis 12 1975 798 801
    • (1975) Synthesis , vol.12 , pp. 798-801
    • Chauhan, S.M.S.1    Junjappa, H.2
  • 63
    • 25844500311 scopus 로고    scopus 로고
    • Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents
    • DOI 10.1016/j.bmcl.2005.08.023, PII S0960894X05010462
    • S.B. Katiyar, K. Srivastava, S.K. Puri, and P.M.S. Chauhan Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents Bioorg. Med. Chem. Lett. 15 2005 4957 4960 (Pubitemid 41400164)
    • (2005) Bioorganic and Medicinal Chemistry Letters , vol.15 , Issue.22 , pp. 4957-4960
    • Katiyar, S.B.1    Srivastava, K.2    Puri, S.K.3    Chauhan, P.M.S.4
  • 64
    • 40949164269 scopus 로고    scopus 로고
    • Synthesis and exploration of novel curcumin analogues as anti-malarial agents
    • DOI 10.1016/j.bmc.2007.12.054, PII S0968089607011248
    • S. Mishra, K. Karmodiya, N. Surolia, and A. Surolia Synthesis and exploration of novel curcumin analogues as anti-malarial agents Bioorg. Med. Chem. 16 2008 2894 2902 (Pubitemid 351418213)
    • (2008) Bioorganic and Medicinal Chemistry , vol.16 , Issue.6 , pp. 2894-2902
    • Mishra, S.1    Karmodiya, K.2    Surolia, N.3    Surolia, A.4
  • 66
    • 38149109936 scopus 로고    scopus 로고
    • Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions
    • N.E. Leadbeater, and J.R. Schmink Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions Nat. Protoc. 3 2008 1 7
    • (2008) Nat. Protoc. , vol.3 , pp. 1-7
    • Leadbeater, N.E.1    Schmink, J.R.2
  • 67
    • 77955424412 scopus 로고    scopus 로고
    • Synthesis of novel α-pyranochalcones and pyrazoline derivatives as Plasmodium falciparum growth inhibitors
    • G. Wanare, R. Aher, N. Kawathekar, R. Ranjan, N.K. Kaushik, and D. Sahal Synthesis of novel α-pyranochalcones and pyrazoline derivatives as Plasmodium falciparum growth inhibitors Bioorg. Med. Chem. Lett. 20 2010 4675 4678
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4675-4678
    • Wanare, G.1    Aher, R.2    Kawathekar, N.3    Ranjan, R.4    Kaushik, N.K.5    Sahal, D.6
  • 70
    • 56949083948 scopus 로고    scopus 로고
    • Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway
    • B.N. Acharya, D. Saraswat, and M.P. Kaushik Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway Eur. J. Med. Chem. 43 2008 2840 2852
    • (2008) Eur. J. Med. Chem. , vol.43 , pp. 2840-2852
    • Acharya, B.N.1    Saraswat, D.2    Kaushik, M.P.3
  • 72
    • 0242580787 scopus 로고    scopus 로고
    • Identification, Characterization, and Inhibition of Plasmodium falciparum β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ)
    • DOI 10.1074/jbc.M304283200
    • S.K. Sharma, M. Kapoor, T.N. Ramya, S. Kumar, G. Kumar, R. Modak, S. Sharma, N. Surolia, and A. Surolia Identification, characterization and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) J. Biol. Chem. 278 2003 45661 45671 (Pubitemid 37432708)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.46 , pp. 45661-45671
    • Sharma, S.K.1    Kapoor, M.2    Ramya, T.N.C.3    Kumar, S.4    Kumar, G.5    Modak, R.6    Sharma, S.7    Surolia, N.8    Surolia, A.9
  • 73
    • 31144454663 scopus 로고    scopus 로고
    • Synthesis and evaluation of substituted pyrazoles: Potential antimalarials targeting the enoyl-ACP reductase of Plasmodium Falciparum
    • DOI 10.1080/00397910500334561, PII GM63JV10081034W8
    • S. Kumar, G. Kumar, M. Kapoor, A. Surolia, and N. Surolia Synthesis and evaluation of substituted pyrazoles: potential antimalarials targeting the enoyl ACP reductase of Plasmodium falciparum Syn. Commun. 36 2006 215 226 (Pubitemid 43127925)
    • (2006) Synthetic Communications , vol.36 , Issue.2 , pp. 215-226
    • Kumar, S.1    Kumar, G.2    Kapoor, M.3    Surolia, A.4    Surolia, N.5
  • 74
    • 0042591222 scopus 로고    scopus 로고
    • Polyhalogenobenzimidazoles: Synthesis and their inhibitory activity against casein kinases
    • DOI 10.1016/S0968-0896(03)00403-6
    • M. Andrzejewska, M.A. Pagano, F. Meggio, A.M. Brunati, and Z. Kazimierczuk Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases Bioorg. Med. Chem. 11 2003 3997 4002 (Pubitemid 36970127)
    • (2003) Bioorganic and Medicinal Chemistry , vol.11 , Issue.18 , pp. 3997-4002
    • Andrzejewska, M.1    Pagano, M.A.2    Meggio, F.3    Brunati, A.M.4    Kazimierczuk, Z.5
  • 80
    • 79952453594 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents
    • J. Camacho, A. Barazarte, N. Gamboa, J. Rodrigues, R. Rojas, A. Vaisberg, R. Gilman, and J. Charris Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents Bioorg. Med. Chem. 19 2011 2023 2029
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 2023-2029
    • Camacho, J.1    Barazarte, A.2    Gamboa, N.3    Rodrigues, J.4    Rojas, R.5    Vaisberg, A.6    Gilman, R.7    Charris, J.8
  • 81
    • 34247895611 scopus 로고    scopus 로고
    • 2-Cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization
    • DOI 10.1016/j.bmcl.2007.03.070, PII S0960894X07003733
    • N. Zhang, S. Ayral-Kaloustian, T. Nguyen, R. Hernandezb, and C. Beyerb 2-Cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization Bioorg. Med. Chem. Lett. 17 2007 3003 3005 (Pubitemid 46702647)
    • (2007) Bioorganic and Medicinal Chemistry Letters , vol.17 , Issue.11 , pp. 3003-3005
    • Zhang, N.1    Ayral-Kaloustian, S.2    Nguyen, T.3    Hernandez, R.4    Beyer, C.5
  • 82
    • 34447623404 scopus 로고    scopus 로고
    • Collisionally-induced dissociation of substituted pyrimidine antiviral agents: Mechanisms of ion formation using gas phase hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry
    • DOI 10.1016/j.jasms.2007.05.001, PII S1044030507004175
    • A.M. Kamel, and B. Munson Collisionally-induced dissociation of substituted pyrimidine antiviral agents: mechanisms of ion formation using gas phase hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry J. Am. Soc. Mass Spectrom. 18 2007 1477 1492 (Pubitemid 47088999)
    • (2007) Journal of the American Society for Mass Spectrometry , vol.18 , Issue.8 , pp. 1477-1492
    • Kamel, A.M.1    Munson, B.2
  • 83
    • 33846424286 scopus 로고    scopus 로고
    • Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition
    • DOI 10.1021/jm060717i
    • N. Zhang, S. Ayral-Kaloustian, T. Nguyen, J. Afragola, R. Hernandez, J. Lucas, J. Gibbons, and C. Beyer Synthesis and SAR of [1,2,4]triazolo[1,5-a] pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition J. Med. Chem. 50 2007 319 327 (Pubitemid 46147711)
    • (2007) Journal of Medicinal Chemistry , vol.50 , Issue.2 , pp. 319-327
    • Zhang, N.1    Ayral-Kaloustian, S.2    Nguyen, T.3    Afragola, J.4    Hernandez, R.5    Lucas, J.6    Gibbons, J.7    Beyer, C.8
  • 84
    • 34047132283 scopus 로고    scopus 로고
    • One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities
    • DOI 10.1016/j.bmc.2007.03.028, PII S0968089607002180
    • S.M. Sondhi, S. Jain, M. Dinodia, R. Shuklab, and R. Raghubir One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities Bioorg. Med. Chem. 15 2007 3334 3344 (Pubitemid 46529272)
    • (2007) Bioorganic and Medicinal Chemistry , vol.15 , Issue.10 , pp. 3334-3344
    • Sondhi, S.M.1    Jain, S.2    Dinodia, M.3    Shukla, R.4    Raghubir, R.5
  • 85
    • 0035866588 scopus 로고    scopus 로고
    • Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c] pyrimidine derivatives on leukocyte functions and experimental inflammation
    • DOI 10.1021/jm000997g
    • P. Molina, E. Aller, A. Lorenzo, P. Lopez-Cremades, I. Rioja, A. Ubeda, M.C. Terencio, and M.J. Alcaraz Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c]pyrimidine derivatives on leukocyte functions and experimental inflammation J. Med. Chem. 44 2001 1011 1014 (Pubitemid 32861625)
    • (2001) Journal of Medicinal Chemistry , vol.44 , Issue.6 , pp. 1011-1014
    • Molina, P.1    Aller, E.2    Lorenzo, A.3    Lopez-Cremades, P.4    Rioja, I.5    Ubeda, A.6    Terencio, Ma.C.7    Alcaraz, Ma.J.8
  • 86
    • 0036753668 scopus 로고    scopus 로고
    • Progress in 5H[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity
    • DOI 10.1016/S0014-827X(02)01269-7, PII S0014827X02012697
    • O. Bruno, C. Brullo, S. Schenone, A. Ranise, E. Bondavalli, E. Barocelli, M. Tognolini, E. Magnanini, and V. Bollabeni Progress in 5H[1]benzopyrano[4,3- d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity Farmaco 57 2002 753 758 (Pubitemid 35287010)
    • (2002) Farmaco , vol.57 , Issue.9 , pp. 753-758
    • Bruno, O.1    Brullo, C.2    Schenone, S.3    Ranise, A.4    Bondavalli, F.5    Barocelli, E.6    Tognolini, M.7    Magnanini, F.8    Ballabeni, V.9
  • 87
    • 23444431982 scopus 로고    scopus 로고
    • Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates
    • DOI 10.1021/jm058213s
    • A. Gangjee, Y. Zeng, J.J. McGuire, and R.L. Kisliuk Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates J. Med. Chem. 48 2005 5329 5336 (Pubitemid 41113918)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.16 , pp. 5329-5336
    • Gangjee, A.1    Zeng, Y.2    McGuire, J.J.3    Kisliuk, R.L.4
  • 88
    • 1942520381 scopus 로고    scopus 로고
    • Synthesis and antimicrobial evaluation of naphtho[2,1-b]pyrano[2,3-d] pyrimidine and pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives
    • F.A. Eid, A.F.A. El-Wahab, G.A.M. El-Hag Ali, and M.M. Khafagy Synthesis and antimicrobial evaluation of naphtho[2,1-b]pyrano[2,3-d]pyrimidine and pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives Acta Pharm. 54 2004 13 26 (Pubitemid 38524311)
    • (2004) Acta Pharmaceutica , vol.54 , Issue.1 , pp. 13-26
    • Eid, F.A.1    Abd El-Wahab, A.H.F.2    El-Hag Ali, G.A.M.3    Khafagy, M.M.4
  • 89
    • 80052236805 scopus 로고    scopus 로고
    • Efficient synthesis of fused pyrimidine derivatives with biological activity via aza-wittig reaction
    • R. Qingyun, T. Xiaosong, and H. Hongwu Efficient synthesis of fused pyrimidine derivatives with biological activity via aza-wittig reaction Curr. Org. Synth. 8 2011 752 763
    • (2011) Curr. Org. Synth. , vol.8 , pp. 752-763
    • Qingyun, R.1    Xiaosong, T.2    Hongwu, H.3
  • 92
    • 19944399749 scopus 로고    scopus 로고
    • Antimalarial activity and synthesis of new trisubstituted pyrimidines
    • DOI 10.1016/j.bmcl.2005.04.014, PII S0960894X05004762
    • A. Agarwal, K. Srivastava, S.K. Puri, and P.M.S. Chauhan Antimalarial activity and synthesis of new trisubstituted pyrimidines Bioorg. Med. Chem. Lett. 15 2005 3130 3132 (Pubitemid 40755209)
    • (2005) Bioorganic and Medicinal Chemistry Letters , vol.15 , Issue.12 , pp. 3130-3132
    • Agarwal, A.1    Srivastava, K.2    Puri, S.K.3    Chauhan, P.M.S.4
  • 93
    • 84863812396 scopus 로고    scopus 로고
    • Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity
    • S. Manohar, U.C. Rajesh, S.I. Khan, B.L. Tekwani, and D.S. Rawat Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity ACS Med. Chem. Lett. 3 2012 555 559
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 555-559
    • Manohar, S.1    Rajesh, U.C.2    Khan, S.I.3    Tekwani, B.L.4    Rawat, D.S.5
  • 95
    • 33947452727 scopus 로고
    • Pyridine analogs of chalcone and their polymerization reactions
    • C.S. Marvel, L.E. Coleman, and G.P. Scott Pyridine analogs of chalcone and their polymerization reactions J. Org. Chem. 20 1955 1785 1792
    • (1955) J. Org. Chem. , vol.20 , pp. 1785-1792
    • Marvel, C.S.1    Coleman, L.E.2    Scott, G.P.3
  • 96
    • 25844455259 scopus 로고    scopus 로고
    • Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents
    • DOI 10.1016/j.bmc.2005.06.052, PII S0968089605005882
    • A. Agarwal, K. Srivastava, S.K. Puri, and P.M.S. Chauhan Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents Bioorg. Med. Chem. 13 2005 6226 6232 (Pubitemid 41400146)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.22 , pp. 6226-6232
    • Agarwal, A.1    Srivastava, K.2    Puri, S.K.3    Chauhan, P.M.S.4
  • 99
    • 37049162292 scopus 로고
    • Experiments on the synthesis of purine nucleosides. Part XXVI. 9-D-Glucopyranosidoisoguanine
    • K.J.M. Andrews, N. Anand, A.R. Todd, and A. Topham Experiments on the synthesis of purine nucleosides. Part XXVI. 9-D-Glucopyranosidoisoguanine J. Chem. Soc. 1949 1949 2490 2497
    • (1949) J. Chem. Soc. , vol.1949 , pp. 2490-2497
    • Andrews, K.J.M.1    Anand, N.2    Todd, A.R.3    Topham, A.4
  • 100
    • 19844379839 scopus 로고    scopus 로고
    • Synthesis of substituted indole derivatives as a new class of antimalarial agents
    • DOI 10.1016/j.bmcl.2005.04.011, PII S0960894X05004737
    • A. Agarwal, K. Srivastava, S.K. Puri, and P.M.S. Chauhan Synthesis of substituted indole derivatives as a new class of antimalarial agents Bioorg. Med. Chem. Lett. 15 2005 3133 3136 (Pubitemid 40762587)
    • (2005) Bioorganic and Medicinal Chemistry Letters , vol.15 , Issue.12 , pp. 3133-3136
    • Agarwal, A.1    Srivastava, K.2    Puri, S.K.3    Chauhan, P.M.S.4
  • 101
    • 0021271785 scopus 로고
    • The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro
    • W.M. Watkins, D.G. Sixsmith, and J.D. Chulay The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro Ann. Trop. Med. Parasitol. 78 1984 273 278 (Pubitemid 14075531)
    • (1984) Annals of Tropical Medicine and Parasitology , vol.78 , Issue.3 , pp. 273-278
    • Watkins, W.M.1    Sixsmith, D.G.2
  • 102
    • 0033027433 scopus 로고    scopus 로고
    • The antimalarial triazine WR99210 and the prodrug PS-15: Folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug
    • S.M. Kinyanjui, E.K. Mberu, P.A. Winstanley, D.P. Jacobus, and W.M. Watkins The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug Am. J. Trop. Med. Hyg. 60 1999 943 947 (Pubitemid 29296219)
    • (1999) American Journal of Tropical Medicine and Hygiene , vol.60 , Issue.6 , pp. 943-947
    • Kinyanjui, S.M.1    Mberu, E.K.2    Winstanley, P.A.3    Jacobus, D.P.4    Watkins, W.M.5
  • 104
    • 33947461891 scopus 로고
    • Chemical and biological studies on 1,2-dihydro-s-triazines. II. Three-component synthesis
    • E.J. Modest Chemical and biological studies on 1,2-dihydro-s-triazines. II. Three-component synthesis J. Org. Chem. 21 1956 1 13
    • (1956) J. Org. Chem. , vol.21 , pp. 1-13
    • Modest, E.J.1
  • 105
    • 0002837389 scopus 로고
    • Chemical and biological studies on 1,2-Dihydro-s-triazines. III. Two-component synthesis
    • E.J. Modest, and P. Levine Chemical and biological studies on 1,2-Dihydro-s-triazines. III. Two-component synthesis J. Org. Chem. 21 1956 14 20
    • (1956) J. Org. Chem. , vol.21 , pp. 14-20
    • Modest, E.J.1    Levine, P.2
  • 107
    • 8644264841 scopus 로고
    • Synthesis of 3,4,5-triamino-4H-1,2,4-triazole (guanazine) and its 4-arylideneamino derivatives
    • H. Emilsson Synthesis of 3,4,5-triamino-4H-1,2,4-triazole (guanazine) and its 4-arylideneamino derivatives J. Heterocycl. Chem. 26 1989 1077 1081
    • (1989) J. Heterocycl. Chem. , vol.26 , pp. 1077-1081
    • Emilsson, H.1
  • 108
    • 84987264507 scopus 로고
    • 1,2,4-triazines. III. A convenient synthesis of 1,2,4-triazines and their covalent hydration
    • W.W. Paudler, and T.K. Chen 1,2,4-triazines. III. A convenient synthesis of 1,2,4-triazines and their covalent hydration J. Heterocycl. Chem. 7 1970 767 771
    • (1970) J. Heterocycl. Chem. , vol.7 , pp. 767-771
    • Paudler, W.W.1    Chen, T.K.2
  • 109
    • 0000838956 scopus 로고
    • 1-Aryl-3,3-dialkyltriazenes as tumor inhibitors
    • C.S. Rondestvedt, and S.J. Davis 1-Aryl-3,3-dialkyltriazenes as tumor inhibitors J. Org. Chem. 22 1957 200 203
    • (1957) J. Org. Chem. , vol.22 , pp. 200-203
    • Rondestvedt, C.S.1    Davis, S.J.2
  • 110
    • 0000434251 scopus 로고
    • NMR study of hindered rotation in 1-aryl-3,3-dimethyltriazenes
    • M.H. Akhtar, R.S. McDaniel, M. Feser, and A.C. Oehlschlager NMR study of hindered rotation in 1-aryl-3,3-dimethyltriazenes Tetrahedron 24 1968 3899 3906
    • (1968) Tetrahedron , vol.24 , pp. 3899-3906
    • Akhtar, M.H.1    McDaniel, R.S.2    Feser, M.3    Oehlschlager, A.C.4
  • 112
    • 79959522795 scopus 로고    scopus 로고
    • An efficient synthesis for a new class antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
    • Y.K. Zhang, J.J. Plattner, E.E. Easom, D. Waterson, M. Ge, Z. Li, L. Li, and Y. Jian An efficient synthesis for a new class antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole Tetrahedron Lett. 52 2011 3909 3911
    • (2011) Tetrahedron Lett. , vol.52 , pp. 3909-3911
    • Zhang, Y.K.1    Plattner, J.J.2    Easom, E.E.3    Waterson, D.4    Ge, M.5    Li, Z.6    Li, L.7    Jian, Y.8
  • 113
    • 0842283436 scopus 로고    scopus 로고
    • First synthesis of antimalarial Machaeriols A and B
    • DOI 10.1016/j.tetlet.2003.12.107
    • A.G. Chittiboyina, C.R. Reddy, E.B. Watkins, and M.A. Avery First synthesis of antimalarial machaeriols A and B. Tetrahedron Lett. 45 2004 1689 1691 (Pubitemid 38169301)
    • (2004) Tetrahedron Letters , vol.45 , Issue.8 , pp. 1689-1691
    • Chittiboyina, A.G.1    Reddy, Ch.R.2    Watkins, E.B.3    Avery, M.A.4
  • 114
    • 33745584335 scopus 로고    scopus 로고
    • Design, synthesis and in vitro antimalarial activity of spiroperoxides
    • DOI 10.1016/j.tet.2006.05.065, PII S0040402006008581
    • H.X. Jin, Q. Zhang, H.S. Kim, Y. Wataya, H.H. Liu, and Y.K. Wu Design, synthesis and in vitro antimalarial activity of spiroperoxides Tetrahedron 62 2006 7699 7711 (Pubitemid 43994040)
    • (2006) Tetrahedron , vol.62 , Issue.33 , pp. 7699-7711
    • Jin, H.-X.1    Zhang, Q.2    Kim, H.-S.3    Wataya, Y.4    Liu, H.-H.5    Wu, Y.6
  • 115
    • 67650555692 scopus 로고    scopus 로고
    • Synthesis and in vitro antimalarial activity of spiro-analogues of peroxyplakoric acids
    • Y. Li, Q. Zhang, S. Wittlin, H.X. Jin, and Y.K. Wu Synthesis and in vitro antimalarial activity of spiro-analogues of peroxyplakoric acids Tetrahedron 65 2009 6972 6985
    • (2009) Tetrahedron , vol.65 , pp. 6972-6985
    • Li, Y.1    Zhang, Q.2    Wittlin, S.3    Jin, H.X.4    Wu, Y.K.5
  • 116
    • 34548238742 scopus 로고    scopus 로고
    • Further explorations on bridged 1,2,4-trioxanes
    • DOI 10.1016/j.tet.2007.07.090, PII S0040402007013397
    • Q. Zhang, and Y.K. Wu Further explorations on bridged 1,2,4-trioxanes Tetrahedron 63 2007 10189 10201 (Pubitemid 47320728)
    • (2007) Tetrahedron , vol.63 , Issue.41 , pp. 10189-10201
    • Zhang, Q.1    Wu, Y.2
  • 117
    • 33750605426 scopus 로고    scopus 로고
    • A facile access to bridged 1,2,4-trioxanes
    • DOI 10.1016/j.tet.2006.09.061, PII S0040402006015286
    • Q. Zhang, H.X. Jin, and Y.K. Wu A facile access to bridged 1,2,4-trioxanes Tetrahedron 62 2006 11627 11634 (Pubitemid 44691877)
    • (2006) Tetrahedron , vol.62 , Issue.50 , pp. 11627-11634
    • Zhang, Q.1    Jin, H.-X.2    Wu, Y.3
  • 119
    • 10344262032 scopus 로고    scopus 로고
    • Recent advances in therapeutic chalcones
    • DOI 10.1517/13543776.14.12.1669
    • L. Ni, C.Q. Meng, and J.A. Sikorski Recent advances in therapeutic chalcones Expert Opin. Ther. Patents 14 2004 1669 1691 (Pubitemid 39625100)
    • (2004) Expert Opinion on Therapeutic Patents , vol.14 , Issue.12 , pp. 1669-1691
    • Ni, L.1    Meng, C.Q.2    Sikorski, J.A.3
  • 124
    • 34548565604 scopus 로고    scopus 로고
    • Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety
    • DOI 10.1016/j.bmcl.2007.08.021, PII S0960894X07009699
    • V. Tomar, G. Bhattacharjee, Kamaluddin, and A. Kumar Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety Bioorg. Med. Chem. Lett. 17 2007 5321 5324 (Pubitemid 47391290)
    • (2007) Bioorganic and Medicinal Chemistry Letters , vol.17 , Issue.19 , pp. 5321-5324
    • Tomar, V.1    Bhattacharjee, G.2    Kamaluddin3    Kumar, A.4
  • 127
    • 32644446976 scopus 로고    scopus 로고
    • Efficient one-pot, two-step synthesis of (E)-cinnmaldehydes by dehydrogenation-oxidation of arylpropanes using DDQ under ultrasonic irradiation
    • DOI 10.1016/j.tet.2005.12.028, PII S004040200502209X
    • B.P. Joshi, A. Sharma, and A.K. Sinha Efficient one-pot, two-step synthesis of (E)-cinnmaldehydes by dehydrogenation-oxidation of arylpropanes using DDQ under ultrasonic irradiation Tetrahedron 62 2006 2590 2593 (Pubitemid 43243595)
    • (2006) Tetrahedron , vol.62 , Issue.11 , pp. 2590-2593
    • Joshi, B.P.1    Sharma, A.2    Sinha, A.K.3
  • 128
    • 77957832893 scopus 로고    scopus 로고
    • Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: Synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone
    • R. Kumar, D. Mohanakrishnan, A. Sharma, N.K. Kaushik, K. Kalia, A.K. Sinha, and D. Sahal Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone Eur. J. Med. Chem. 45 2010 5292 5301
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 5292-5301
    • Kumar, R.1    Mohanakrishnan, D.2    Sharma, A.3    Kaushik, N.K.4    Kalia, K.5    Sinha, A.K.6    Sahal, D.7
  • 130
    • 73549124302 scopus 로고    scopus 로고
    • Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity
    • V. Tomar, G. Bhattacharjee, Kamaluddin, S. Rajakumar, K. Srivastava, and S.K. Puri Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity Eur. J. Med. Chem. 45 2010 745 751
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 745-751
    • Tomar, V.1    Bhattacharjee, G.2    Kamaluddin3    Rajakumar, S.4    Srivastava, K.5    Puri, S.K.6
  • 131
  • 135
    • 0035818913 scopus 로고    scopus 로고
    • Antimalarial alkoxylated and hydroxylated chalones: Structure-activity relationship analysis
    • DOI 10.1021/jm0101747
    • M. Liu, P. Wilairat, and M.L. Go Antimalarial alkoxylated and hydroxylated chalones:structure-activity relationship analysis J. Med. Chem. 44 2001 4443 4452 (Pubitemid 33131668)
    • (2001) Journal of Medicinal Chemistry , vol.44 , Issue.25 , pp. 4443-4452
    • Liu, M.1    Wilairat, P.2    Go, M.-L.3
  • 138
    • 0031913851 scopus 로고    scopus 로고
    • Synthesis and anti-inflammatory effect of chalcones and related compounds
    • H.K. Hsieh, T.H. Lee, J.P. Wang, J.J. Wang, and C.N. Lin Synthesis and anti-inflammatory effect of chalcones and related compounds Pharm. Res. 15 1998 39 46
    • (1998) Pharm. Res. , vol.15 , pp. 39-46
    • Hsieh, H.K.1    Lee, T.H.2    Wang, J.P.3    Wang, J.J.4    Lin, C.N.5
  • 139
    • 0032547898 scopus 로고    scopus 로고
    • Antileishmaniai chalcones: Statistical design, synthesis, and three- dimensional quantitative structure-activity relationship analysis
    • DOI 10.1021/jm980410m
    • S.F. Nielsen, S.B. Christensen, G. Cruciani, A. Kharazmi, and T. Liljefors Antileishmanial chalcones:statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis J. Med. Chem. 41 1998 4819 4832 (Pubitemid 28530457)
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.24 , pp. 4819-4832
    • Nielsen, S.F.1    Christensen, S.B.2    Cruciani, G.3    Kharazmi, A.4    Liljefors, T.5
  • 141
    • 52049090608 scopus 로고    scopus 로고
    • The molecular cloning of artemisinic aldehyde delta 11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua
    • Y. Zhang, K.H. Teoh, D.W. Reed, L. Maes, A. Goossens, D.J.H. Olson, A.R.S. Ross, and P.S. Covello The molecular cloning of artemisinic aldehyde delta 11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua J. Biol. Chem. 283 2008 21501 21508
    • (2008) J. Biol. Chem. , vol.283 , pp. 21501-21508
    • Zhang, Y.1    Teoh, K.H.2    Reed, D.W.3    Maes, L.4    Goossens, A.5    Olson, D.J.H.6    Ross, A.R.S.7    Covello, P.S.8
  • 142
    • 84857029523 scopus 로고    scopus 로고
    • Continuous-flow synthesis of the anti-malaria drug artemisinin
    • F. Levesque, and P.H. Seeberger Continuous-flow synthesis of the anti-malaria drug artemisinin Angew. Chem. Int. Ed. 51 2012 1706 1709
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 1706-1709
    • Levesque, F.1    Seeberger, P.H.2
  • 143
    • 80054728059 scopus 로고    scopus 로고
    • Highly efficient continuous flow reactions using singlet oxygen as a "green" reagent
    • F. Levesque, and P.H. Seeberger Highly efficient continuous flow reactions using singlet oxygen as a "Green" reagent Org. Lett. 13 2011 5008 5011
    • (2011) Org. Lett. , vol.13 , pp. 5008-5011
    • Levesque, F.1    Seeberger, P.H.2
  • 146
    • 0037435053 scopus 로고    scopus 로고
    • Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy
    • DOI 10.1021/jm020461q
    • G.H. Posner, I.-H. Paik, St Sur, A.J. McRiner, K. Borstnik, S. Xie, and T.A. Shapiro Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy J. Med. Chem. 46 2003 1060 1065 (Pubitemid 36423152)
    • (2003) Journal of Medicinal Chemistry , vol.46 , Issue.6 , pp. 1060-1065
    • Posner, G.H.1    Paik, I.-H.2    Sur, S.3    McRiner, A.J.4    Borstnik, K.5    Xie, S.6    Shapiro, T.A.7
  • 147
    • 64349121305 scopus 로고    scopus 로고
    • Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells
    • A.S. Rosenthal, X. Chen, J.O. Liu, D.C. West, P.J. Hergenrother, T.A. Shapiro, and G.H. Posner Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells J. Med. Chem. 52 2009 1198 1203
    • (2009) J. Med. Chem. , vol.52 , pp. 1198-1203
    • Rosenthal, A.S.1    Chen, X.2    Liu, J.O.3    West, D.C.4    Hergenrother, P.J.5    Shapiro, T.A.6    Posner, G.H.7
  • 148
    • 39049132961 scopus 로고    scopus 로고
    • Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice
    • DOI 10.1016/j.bmcl.2007.12.074, PII S0960894X08000036
    • C. Singh, S. Chaudhary, and S.K. Puri Orally active esters of dihydroartemisinin: synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice Bioorg. Med. Chem. Lett. 18 2008 1436 1441 (Pubitemid 351233030)
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , Issue.4 , pp. 1436-1441
    • Singh, C.1    Chaudhary, S.2    Puri, S.K.3
  • 149
    • 0010417126 scopus 로고
    • Study on analogs of artemisinin II. The synthesis of some carboxylic esters and carbonates of dihydroarteannuin by using 4-(N,N-dimethylamino) pyridine as an active acylation catalyst
    • Y. Li, P.L. Yu, Y.X. Chen, and R.Y. Ji Study on analogs of artemisinin II. The synthesis of some carboxylic esters and carbonates of dihydroarteannuin by using 4-(N,N-dimethylamino)pyridine as an active acylation catalyst Acta Chim. Sin. 40 1982 557 561
    • (1982) Acta Chim. Sin. , vol.40 , pp. 557-561
    • Li, Y.1    Yu, P.L.2    Chen, Y.X.3    Ji, R.Y.4
  • 152
    • 79951545567 scopus 로고    scopus 로고
    • Synthesis and antimalarial activity of novel N-{2-[2-(2-aminoethoxy) ethoxy] ethyl}-7-chloroquinolin-4-amine and its derivatives
    • P. Tanwar, G.C. Yadav, U.K. Jaitley, N. Kaushik, and D. Sahal Synthesis and antimalarial activity of novel N-{2-[2-(2-aminoethoxy) ethoxy] ethyl}-7-chloroquinolin-4-amine and its derivatives Indian. J. Chem. 50B 2011 233 241
    • (2011) Indian. J. Chem. , vol.50 B , pp. 233-241
    • Tanwar, P.1    Yadav, G.C.2    Jaitley, U.K.3    Kaushik, N.4    Sahal, D.5
  • 153
    • 0016701866 scopus 로고
    • Antimalarials. 7.2,8-Bis(trifluoromethyl)-4-quinolinemethanols
    • P. Blumbergs, M.S. Ao, M.P. LaMontagne, and A. Markovac Antimalarials. 7.2,8-Bis(trifluoromethyl)-4-quinolinemethanols J. Med. Chem. 18 1975 1122 1126
    • (1975) J. Med. Chem. , vol.18 , pp. 1122-1126
    • Blumbergs, P.1    Ao, M.S.2    Lamontagne, M.P.3    Markovac, A.4
  • 154
    • 0037024173 scopus 로고    scopus 로고
    • 3: A mild and general catalyst for stille reactions of aryl chlorides and aryl bromides
    • DOI 10.1021/ja020012f
    • 3:a mild and general catalyst for Stille reactions of aryl chlorides and aryl bromides J. Am. Chem. Soc. 124 2002 6343 6348 (Pubitemid 34579386)
    • (2002) Journal of the American Chemical Society , vol.124 , Issue.22 , pp. 6343-6348
    • Littke, A.F.1    Schwarz, L.2    Fu, G.C.3
  • 156
    • 19544383409 scopus 로고    scopus 로고
    • M-CPBA/KOH: An efficient reagent for nucleophilic epoxidation of gem-deactivated olefins
    • DOI 10.1021/jo050131o
    • J.L.G. Ruano, C. Fajardo, A. Fraile, and M.R. Martin m-CPBA/KOH:an efficient reagent for nucleophilic epoxidation of gem-deactivated olefins J. Org. Chem. 70 2005 4300 4306 (Pubitemid 40734140)
    • (2005) Journal of Organic Chemistry , vol.70 , Issue.11 , pp. 4300-4306
    • Garcia Ruano, J.L.1    Fajardo, C.2    Fraile, A.3    Martin, M.R.4
  • 158
    • 33645611539 scopus 로고
    • Potential antimalarials. XVIII. Some mono- and di-mannich bases of 3-[7-chloro(and trifluoromethyl)quinolin-4-ylamino]phenol
    • G.B. Barlin, S.J. Ireland, T.M.T. Nguyen, B. Kotecka, and K.H. Rieckmann Potential antimalarials. XVIII. Some mono- and di-mannich bases of 3-[7-chloro(and trifluoromethyl)quinolin-4-ylamino]phenol Aust. J. Chem. 46 1993 1685 1693
    • (1993) Aust. J. Chem. , vol.46 , pp. 1685-1693
    • Barlin, G.B.1    Ireland, S.J.2    Nguyen, T.M.T.3    Kotecka, B.4    Rieckmann, K.H.5
  • 160
    • 72049117615 scopus 로고    scopus 로고
    • Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline- triazine conjugates
    • S. Manohar, S.I. Khan, and D.S. Rawat Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates Bioorg. Med. Chem. Lett. 20 2010 322 325
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 322-325
    • Manohar, S.1    Khan, S.I.2    Rawat, D.S.3
  • 161
    • 34548555614 scopus 로고    scopus 로고
    • Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents
    • DOI 10.1016/j.bmcl.2007.07.049, PII S0960894X07008682
    • A. Mahajan, S. Yeh, M. Nell, C.J.C. Rensburg, and K. Chibale Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents Bioorg. Med. Chem. Lett. 17 2007 5683 5685 (Pubitemid 47391300)
    • (2007) Bioorganic and Medicinal Chemistry Letters , vol.17 , Issue.20 , pp. 5683-5685
    • Mahajan, A.1    Yeh, S.2    Nell, M.3    Van Rensburg, C.E.J.4    Chibale, K.5
  • 162
    • 33845340165 scopus 로고    scopus 로고
    • Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines
    • DOI 10.1016/j.bmc.2006.10.036, PII S0968089606008674
    • K. Kaur, S.R. Patel, P. Patil, M. Jain, S.I. Khan, M.R. Jacob, S. Ganesan, B.L. Tekwani, and R. Jain Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines Bioorg. Med. Chem. 15 2007 915 930 (Pubitemid 44880711)
    • (2007) Bioorganic and Medicinal Chemistry , vol.15 , Issue.2 , pp. 915-930
    • Kaur, K.1    Patel, S.R.2    Patil, P.3    Jain, M.4    Khan, S.I.5    Jacob, M.R.6    Ganesan, S.7    Tekwani, B.L.8    Jain, R.9
  • 163
    • 33744999595 scopus 로고    scopus 로고
    • Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties
    • DOI 10.1016/j.ejmech.2006.03.021, PII S0223523406001425
    • M. Sassatelli, E. Debiton, B. Aboab, M. Prudhomme, and P. Moreau Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties Eur. J. Med. Chem. 41 2006 709 716 (Pubitemid 43866307)
    • (2006) European Journal of Medicinal Chemistry , vol.41 , Issue.6 , pp. 709-716
    • Sassatelli, M.1    Debiton, E.2    Aboab, B.3    Prudhomme, M.4    Moreau, P.5
  • 166
    • 25844530159 scopus 로고    scopus 로고
    • Synthesis and evaluation of molluscicidal and larvicidal activities of some novel enaminones derived from 4-hydroxyquinolinones: Part IX
    • DOI 10.1016/j.bmc.2005.06.038, PII S0968089605005626
    • M. Abass, and B.B. Mostafa Synthesis and evaluation of molluscicidal and larvicidal activities of some novel enaminones derived from 4- hydroxyquinolinones: part IX Bioorg. Med. Chem. 13 2005 6133 6144 (Pubitemid 41400134)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.22 , pp. 6133-6144
    • Abass, M.1    Mostafa, B.B.2
  • 167
    • 0030569401 scopus 로고    scopus 로고
    • Apicidins: Novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum
    • DOI 10.1016/0040-4039(96)01844-8, PII S0040403996018448
    • S.B. Singh, D.L. Zink, J.D. Polishook, A.W. Dombrowski, S.J. Darkin-Rattray, D.M. Schmatz, and M.A. Goetz Apicidins: novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum Tetrahedron Lett. 37 1996 8077 8080 (Pubitemid 26366232)
    • (1996) Tetrahedron Letters , vol.37 , Issue.45 , pp. 8077-8080
    • Singh, S.B.1    Zink, D.L.2    Polishook, J.D.3    Dombrowski, A.W.4    Darkin-Rattray, S.J.5    Schmatz, D.M.6    Goetz, M.A.7
  • 170
    • 0034619150 scopus 로고    scopus 로고
    • Tryptophan-replacement and indole-modified apicidins: Synthesis of potent and selective antiprotozoal agents
    • S.L. Colletti, C. Li, M.H. Fisher, M.J. Wyvratt, and P.T. Meinke Tryptophan-replacement and indole-modified apicidins: synthesis of potent and selective antiprotozoal agents Tetrahedron Lett. 41 2000 7825 7829
    • (2000) Tetrahedron Lett. , vol.41 , pp. 7825-7829
    • Colletti, S.L.1    Li, C.2    Fisher, M.H.3    Wyvratt, M.J.4    Meinke, P.T.5
  • 171
    • 7044272523 scopus 로고    scopus 로고
    • Synthesis and biological studies of 1-amino β-carbolines
    • DOI 10.1016/j.bmcl.2004.09.036, PII S0960894X04011485
    • Y. Boursereau, and I. Coldham Synthesis and biological studies of 1-amino β-carbolines Bioorg. Med. Chem. Lett. 14 2004 5841 5844 (Pubitemid 39421528)
    • (2004) Bioorganic and Medicinal Chemistry Letters , vol.14 , Issue.23 , pp. 5841-5844
    • Boursereau, Y.1    Coldham, I.2
  • 173
    • 33646453477 scopus 로고    scopus 로고
    • New potential antimalarial agents: Therapeutic-Index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria
    • L.H. Xie, Li Q., A.J. Lin, K. Smith, J. Zhang, and D.S. Skillman New potential antimalarial agents: therapeutic-Index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria Antimicrob. Agents Chemother. 50 2006 1649 1655
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1649-1655
    • Xie, L.H.1    Li, Q.2    Lin, A.J.3    Smith, K.4    Zhang, J.5    Skillman, D.S.6
  • 175
    • 57649158959 scopus 로고    scopus 로고
    • Search for new pharmacophores for antimalarial activity. Part II: Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazoline
    • S. Madapa, Z. Tusi, A. Mishra, K. Srivastava, S.K. Pandey, R. Tripathi, S.K. Puri, and S. Batra Search for new pharmacophores for antimalarial activity. Part II: synthesis and antimalarial activity of new 6-ureido-4- anilinoquinazoline Bioorg. Med. Chem. 17 2009 222 234
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 222-234
    • Madapa, S.1    Tusi, Z.2    Mishra, A.3    Srivastava, K.4    Pandey, S.K.5    Tripathi, R.6    Puri, S.K.7    Batra, S.8
  • 177
    • 0342290724 scopus 로고
    • Antimalarial activity and metabolism of biguanides
    • C.C. Smith, J. Ihrig, and R. Menne Antimalarial activity and metabolism of biguanides Am. J. Trop. Med. Hyg. 10 1961 694 703
    • (1961) Am. J. Trop. Med. Hyg. , vol.10 , pp. 694-703
    • Smith, C.C.1    Ihrig, J.2    Menne, R.3
  • 179
    • 0032481004 scopus 로고    scopus 로고
    • Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines
    • DOI 10.1021/jm980146x
    • D. De, F.M. Krogstad, L.D. Byers, and D.J. Krogstad Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines J. Med. Chem. 41 1998 4918 4926 (Pubitemid 28555449)
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.25 , pp. 4918-4926
    • De, D.1    Krogstad, F.M.2    Byers, L.D.3    Krogstad, D.J.4
  • 180
    • 0026494944 scopus 로고
    • Regioselective tosylation of aldonolactones
    • L. Lundt, and R. Madsen Regioselective tosylation of aldonolactones Synthesis 11 1992 1129 1132
    • (1992) Synthesis , vol.11 , pp. 1129-1132
    • Lundt, L.1    Madsen, R.2
  • 181
    • 56249130079 scopus 로고    scopus 로고
    • Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents
    • A. Kumar, K. Srivastava, R.S. Kumar, S.K. Puri, and P.M.S. Chauhan Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents Bioorg. Med. Chem. Lett. 18 2008 6530 6533
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 6530-6533
    • Kumar, A.1    Srivastava, K.2    Kumar, R.S.3    Puri, S.K.4    Chauhan, P.M.S.5
  • 183
    • 77956412327 scopus 로고    scopus 로고
    • Improved 2,4-diarylthiazole-based antiprion agents: Switching the sense of the amide group at C5 leads to an increase in potency
    • M.J. Thompson, J.C. Louth, G.K. Greenwood, F.J. Sorrell, S.G. Knight, N.B.P. Adams, and B. Chen Improved 2,4-diarylthiazole-based antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency Chem. Med. Chem. 5 2010 1476 1488
    • (2010) Chem. Med. Chem. , vol.5 , pp. 1476-1488
    • Thompson, M.J.1    Louth, J.C.2    Greenwood, G.K.3    Sorrell, F.J.4    Knight, S.G.5    Adams, N.B.P.6    Chen, B.7
  • 184
    • 79957872486 scopus 로고    scopus 로고
    • 2,4-Diarylthiazole antiprion compounds as a novel structural class of antimalarial leads
    • M.J. Thompson, J.C. Louth, S.M. Little, B. Chen, and I. Coldham 2,4-Diarylthiazole antiprion compounds as a novel structural class of antimalarial leads Bioorg. Med. Chem. Lett. 21 2011 3644 3647
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3644-3647
    • Thompson, M.J.1    Louth, J.C.2    Little, S.M.3    Chen, B.4    Coldham, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.