Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives

Journal of Medicinal Chemistry

Volumn 48, Issue 10, 2005, Pages 3654-3658

  Domínguez, José N ^a   León, Caritza ^a   Rodrigues, Juan ^a   De Domínguez, Neira Gamboa ^a   Gut, Jiri ^b   Rosenthal, Philip J ^b  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3' N (N' PHENYLURENYL)PHENYL] 3 (3,4,5 TRIMETHOXYPHENYL) 2 PROPEN 1 ONE; ANTIMALARIAL AGENT; BETA HEMATIN; CHALCONE DERIVATIVE; CYSTEINE PROTEASE FALCIPAIN 2; CYSTEINE PROTEINASE; GLOBIN; HEMATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; HYDROLYSIS; IC 50; IN VITRO STUDY; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHALCONES; CYSTEINE ENDOPEPTIDASES; GLOBINS; HEME; HEMEPROTEINS; HYDROLYSIS; MALARIA; MICE; PHENYLUREA COMPOUNDS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; POLYMERS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18644361984     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm058208o     Document Type: Article

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