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38849184612
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38849085235
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note
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General procedure for synthesis of 3-aryl-1-(4-biphenyl)propen-1-ones: To a solution of 4-acetyl biphenyl (0.01 mol) in methanol and 1,4-dioxane (50 ml, 1:1), a concentrated solution of potassium hydroxide (5 ml) was added drop wise with stirring. Aromatic aldehydes (0.01 mol) were added to the above solution and the reaction mixture was stirred at room temperature for 12-14 h. It was slowly poured over crushed ice with constant stirring and the solid separated out was filtered, washed with water and recrystalised with ethanol, yield: 54-70% depending on aldehydes.
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38849182309
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note
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General procedure for synthesis of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines: Compounds 1a-h (0.001 mol), hydrazine hydrate (0.003 mol) and few drops of conc. hydrochloric acid were added to a mixture of DMF and ethanol (25 ml, 1:1). It was then heated in an oil bath at 90-100 °C for 4 h. The colour of the reaction mixture changed to yellowish green. The reaction mixture was allowed to cool at room temperature and was kept in refrigerator for 4-5 h. Fine crystals thus separated out were filtered, washed with cold ethanol, dried and recrystallised with ethanol, yield: 83-95% depending on substitution.
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38849106873
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note
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General procedure for synthesis of 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines: To compounds 2a-h (0.001 mol) in pyridine (10 ml), benzoyl chloride (0.002 mol) was added. The reaction mixture was heated on water bath for 3 h and poured over crushed ice mixed with dil. hydrochloric acid. The solid separated out was filtered, washed with water, dried and recrystallised from ethanol, yield: 60-78% depending on substitution.
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24
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38849134189
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note
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AM = 6.2 Hz, 1H, CH pyrazoline).
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27
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0018667262
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Cioli V., Putzolu S., Rossi V., Barcellona S.P., and Corradino C. Toxicol. Appl. Pharmacol. 50 (1979) 283
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Putzolu, S.2
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Corradino, C.5
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0003977184
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Varley H. (Ed), CBS Publishers and Distributors, New Delhi
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In: Varley H. (Ed). Practical Clinical Biochemistry. 1st ed. (1988), CBS Publishers and Distributors, New Delhi 236
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