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Volumn 18, Issue 3, 2008, Pages 918-922

Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents

Author keywords

Analgesic; Anti inflammatory; Lipid peroxidation; Pyrazoline; Ulcerogenic

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CHALCONE; FLURBIPROFEN; HYDRAZINE; PYRAZOLINE DERIVATIVE;

EID: 38849119065     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.043     Document Type: Article
Times cited : (271)

References (32)
  • 12
    • 38849184612 scopus 로고    scopus 로고
    • William D.A., and Lemke T.L. (Eds), Williams and Wilkins, Lippincott, Philadelphia
    • In: William D.A., and Lemke T.L. (Eds). Foye's Principle of Medicinal Chemistry. 5th ed. (2002), Williams and Wilkins, Lippincott, Philadelphia 751
    • (2002) Foye's Principle of Medicinal Chemistry. 5th ed. , pp. 751
  • 14
    • 38849119757 scopus 로고
    • Reynold J.E.F. (Ed), Pharmaceutical Press, London
    • In: Reynold J.E.F. (Ed). Martindale, The Extra Pharmacopia. 30th ed. (1993), Pharmaceutical Press, London 1
    • (1993) Martindale, The Extra Pharmacopia. 30th ed. , pp. 1
  • 21
    • 38849085235 scopus 로고    scopus 로고
    • note
    • General procedure for synthesis of 3-aryl-1-(4-biphenyl)propen-1-ones: To a solution of 4-acetyl biphenyl (0.01 mol) in methanol and 1,4-dioxane (50 ml, 1:1), a concentrated solution of potassium hydroxide (5 ml) was added drop wise with stirring. Aromatic aldehydes (0.01 mol) were added to the above solution and the reaction mixture was stirred at room temperature for 12-14 h. It was slowly poured over crushed ice with constant stirring and the solid separated out was filtered, washed with water and recrystalised with ethanol, yield: 54-70% depending on aldehydes.
  • 22
    • 38849182309 scopus 로고    scopus 로고
    • note
    • General procedure for synthesis of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines: Compounds 1a-h (0.001 mol), hydrazine hydrate (0.003 mol) and few drops of conc. hydrochloric acid were added to a mixture of DMF and ethanol (25 ml, 1:1). It was then heated in an oil bath at 90-100 °C for 4 h. The colour of the reaction mixture changed to yellowish green. The reaction mixture was allowed to cool at room temperature and was kept in refrigerator for 4-5 h. Fine crystals thus separated out were filtered, washed with cold ethanol, dried and recrystallised with ethanol, yield: 83-95% depending on substitution.
  • 23
    • 38849106873 scopus 로고    scopus 로고
    • note
    • General procedure for synthesis of 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines: To compounds 2a-h (0.001 mol) in pyridine (10 ml), benzoyl chloride (0.002 mol) was added. The reaction mixture was heated on water bath for 3 h and poured over crushed ice mixed with dil. hydrochloric acid. The solid separated out was filtered, washed with water, dried and recrystallised from ethanol, yield: 60-78% depending on substitution.
  • 24
    • 38849134189 scopus 로고    scopus 로고
    • note
    • AM = 6.2 Hz, 1H, CH pyrazoline).
  • 31
    • 0003977184 scopus 로고
    • Varley H. (Ed), CBS Publishers and Distributors, New Delhi
    • In: Varley H. (Ed). Practical Clinical Biochemistry. 1st ed. (1988), CBS Publishers and Distributors, New Delhi 236
    • (1988) Practical Clinical Biochemistry. 1st ed. , pp. 236


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.