Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5321-5324

  Tomar, V ^a   Bhattacharjee, G ^a   Kamaluddin, ^a   Ashok Kumar, ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b LLRM MEDICAL COLLEGE   (India)

Author keywords

Antibacterial; Antifungal; Chalcones; Claisen Schmidt reaction

Indexed keywords

2,5 DICHLOROTHIOPHENE; CHALCONE; CIPROFLOXACIN; PIPERAZINE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; EVALUATION; MICROANALYSIS; NONHUMAN; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; BENZALDEHYDES; CANDIDA; CANDIDA ALBICANS; CHALCONES; CIPROFLOXACIN; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

CANDIDA ALBICANS; ESCHERICHIA COLI; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 34548565604     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.021     Document Type: Article

References (24)

1. Okeke I.N., Laxmaninarayan R., Bhutta Z.A., Duse A.G., Jenkins P., O'Brien T.F., Pablos-Mendez A., and Klugman K.P. Lancet Infect. Dis. 5 (2005) 481
2. Mukhopadhyay A., and Peterson R.T. Curr. Opin. Chem. Biol. 10 (2006) 327
3. Selvakumar N., Srinivas D., Khera M.K., Kumar M.S., Mamidi N.V.S.R., Sarnaik H., Chandrasekar C., Rao B.S., Raheem M.A., Das J., Iqbal J., and Rajagopalan R. J. Med. Chem. 45 (2002) 3953
4. Nielsen S.F., Christensen S.B., Cruciani G., Kharazmi A., and Liljefors T. J. Med. Chem. 41 (1998) 4819
5. Li R., Kenyon G.L., Cohen F.E., Chen X., Gong B., Dominguez J.N., Davidson E., Kurzban G., Miller R.E., Nazum E.O., Rosenthal P.J., and McKerrow J.H. J. Med. Chem. 38 (1995) 5031
6. Liu M., Wilairat P., and Go M.L. J. Med. Chem. 44 (2001) 4443
7. Lopez S.N., Castelli M.V., Zacchino S.A., Dominguez J.N., Lobo G., Jaime C.C., Cortes J.C.G., Ribas J.C., Devia C., Ana M.R., and Ricardo D.E. Bioorg. Med. Chem. 9 (2001) 1999
8. Won S.J., Liu C.T., Tsao L.T., Weng J.R., Ko H.H., Wang J.P., and Lin C.N. Eur. J. Med. Chem. 40 (2005) 103
9. Hsieh H.K., Tsao L.T., Wang J.P., and Lin C.N. J. Pharm. Pharmcol. 52 (2000) 163
10. Lin, C. N.; Wang, J. P. U.S. Patent Appl. Publ., 2004, 13p.
11. Chen M., Christensen S.B., Theander T.G., and Kharazmi A. Antimicrob. Agents Chemother. 38 (1994) 1339
12. Kayser O., and Kiderlen A.F. Phytother. Res. 15 (2001) 148
13. Lunardi F.G.M., Rodrigues A.T., Correa R., Eger-Mangrich I., Stendel M., Grisard E.C., Assevery J., Calixto J.B., and Santos A.R.S. Antimicrob. Agents Chemother. 47 (2003) 1449
14. Hermoso A., Jimenez I.A., Mamani Z.A., Bazzocchi I.L., Pineiro J.E., Ravelo A.G., and Valladares B. Bioorg. Med. Chem. Lett. 11 (2003) 3975
15. Rojas J., Dominguez J.N., Charris J.E., Lobo G., Paya M., and Ferrandiz M.L. Eur. J. Med. Chem. 37 (2002) 699
16. Batt D.G., Goodman R., Jones D.G., Kerr J.S., Mantegna L.R., McAllister C., Newton R.C., Nurnberg S., Welch P.K., and Covington M.B. J. Med. Chem. 36 (1993) 1434
17. Ducki S., Forrest R., Hadfield J.A., Kendall A., Lawrence N.J., McGown A.T., and Rennison D. Bioorg. Med. Chem. Lett. 8 (1998) 1051
18. Saitoh T., and Shibata S. Tetrahedron Lett. 16 (1975) 4461
19. Okada K., Tamura Y., Yamamoto M., Inoue Y., Takagaki R., Takahashi K., Demizu S., Kajiyama K., Hiraga Y., and Kinoshita T. Chem. Pharm. Bull. 37 (1989) 2528
20. Bowden K., Dal Pozzo A., and Duah C.K. J. Chem. Res. Synop. (1990) 377
21. Choudhary P., Kumar R., and Verma K. Bioorg. Med. Chem. 14 (2006) 1819
22. Upadhayaya R.S., Sinha N., Jain S., Kishore N., Chandra R., and Arora S.K. Bioorg. Med. Chem. 12 (2004) 2225
23. Blatt, A. H., Org. Synth., New York, 1950; Vol. 2, pp 522-523.
24. Chuickshank R., Dugid J.P., Marmon D.P., and Swain R.H.A. Med. Microbiol. (1975) 2