Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles

European Journal of Medicinal Chemistry

Volumn 37, Issue 12, 2002, Pages 973-978

  Andrzejewska, Mariola ^a   Yépez Mulia, Lilián ^d   Cedillo Rivera, Roberto ^f   Tapia, Amparo ^d   Vilpo, Leena ^b   Vilpo, Juhani ^b,c   Kazimierczuk, Zygmunt ^a,e  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c JORVI HOSPITAL   (Finland)

^d HOSPITAL DE PEDIATRÍA   (Mexico)

^e MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^f UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

Author keywords

2 Pentafluoroethylbenzimidazoles; 2 Trifluoromethylbenzimidazoles; Anticancer activity; Antiprotozoal activity

Indexed keywords

4,5,6 TRIFLUORO 2 TRIFLUOROMETHYLBENZIMIDAZOLE; 4,5,6,7 TETRABROMO 2 PENTAFLUOROETHYLBENZIMIDAZOLE; 4,6 DIBROMO 2 DIMETHYLAMINOETHYLTHIOBENZIMIDAZOLE; 4,6 DIBROMO 2 THIOBENZIMIDAZOLE; 5,6 DICHLORO 2 PENTAFLUOROETHYLBENZIMIDAZOLE; 5,6 DIMETHYL 2 PENTAFLUOROETHYLBENZIMIDAZOLE; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; GIARDIA LAMBLIA; HUMAN; HUMAN CELL; NONHUMAN; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRICHOMONAS VAGINALIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENTAMOEBA HISTOLYTICA; GIARDIA LAMBLIA; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP; TRICHOMONAS VAGINALIS;

EID: 0036952881     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01421-6     Document Type: Article

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