Synthesis and biological evaluation of some pyrazole derivatives as anti-malarial agents

Archiv der Pharmazie

Volumn 345, Issue 2, 2012, Pages 147-154

  Bekhit, Adnan A ^a,b   Hymete, Ariaya ^b   Asfaw, Henok ^b   Bekhit, Alaa El Din A ^c  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Acute toxicity; Anti malarial activity; Docking; P. berghei; P. falciparum; Pyrazoles

Indexed keywords

1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOLE 4 CARBOXALDEHYDE; 1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 [[1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOL 4 YL]METHYLEN] 2 (2 FLUOROPHENYL)HYDRAZINE; 1 [[1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 2 (3 FLUOROPHENYL)HYDRAZINE; 1 [[1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 2 (4 FLUOROPHENYL)HYDRAZINE; 2 (2 FLUOROPHENYL) 1 [[3 PHENYL 1 (4 METHYLPHENYL) 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINE; 2 (2,4 DINITROPHENYL) 1 [[1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOL 4YL]METHYLENE]HYDRAZINE; 2 (2,4 DINITROPHENYL) 1 [[3 PHENYL 1 (4 METHYLPHENYL) 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINE; 2 (3 FLUOROPHENYL) 1 [[3 PHENYL 1 (4 METHYLPHENYL) 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINE; 2 (4 FLUOROPHENYL) 1 [[3 PHENYL 1 (4 METHYLPHENYL) 1H PYRAZOL 4 YL]METHYLENE]HYDRAZINE; 3 PHENYL 1 (4 METHYLPHENYL) 1H PYRAZOLE 4 CARBOXYLIC ACID; 3 PHENYL 1 (4 TOLYL) 1H PYRAZOLE 4 CARBOXALDEHYDE; ANTIMALARIAL AGENT; CHLOROQUINE; N' [1 (4 CHLOROPHENYL) 3 PHENYL 1H PYRAZOL 4 YL)METHYLENE]ISONICOTINOHYDRAZIDE; N' [3 PHENYL 1 (4 METHYLPHENYL) 1H PYRAZOL 4 YL)METHYLEN]ISONICOTINOHYDRAZIDE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG SAFETY; DRUG SYNTHESIS; EVALUATION; IC 50; MALARIA; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALS; ANTIMALARIALS; MALE; MICE; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856320198     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100078     Document Type: Article

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