Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4027-4031

  Deng, Xianming ^a,b   Nagle, Advait ^c   Wu, Tao ^c   Sakata, Tomoyo ^c   Henson, Kerstin ^c   Chen, Zhong ^c   Kuhen, Kelli ^c   Plouffe, David ^c   Winzeler, Elizabeth ^c   Adrian, Francisco ^c   Tuntland, Tove ^c   Chang, Jonathan ^c   Simerson, Susan ^c   Howard, Steven ^c   Ek, Jared ^c   Isbell, John ^c   Tully, David C ^c   Chatterjee, Arnab K ^c   Gray, Nathanael S ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

1H Imidazol 2 yl pyrimidine 4,6 diamines; Antimalarial

Indexed keywords

1H IMIDAZOL 2 YL PYRIMIDINE 4,6 DIAMINE DERIVATIVE; ANTIMALARIAL AGENT; DIAMINE DERIVATIVE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ANIMALS; ANTIMALARIALS; DRUG DISCOVERY; PLASMODIUM FALCIPARUM; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 77953873716     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.095     Document Type: Article

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