Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 16, 1998, Pages 2067-2070

  Wustrow, David J ^a   Capiris, Thomas ^a   Rubin, Ronald ^a   Knobelsdorf, James A ^a   Akunne, Hyacinth ^a   Duff Davis, M ^a   MacKenzie, Robert ^a   Pugsley, Thomas A ^a   Zoski, Kim T ^a   Heffner, Thomas G ^a   Wise, Lawrence D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CORTICOTROPIN RELEASE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CORTICOTROPIN-RELEASING HORMONE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032544170     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00372-2     Document Type: Article

References (14)

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14. 11. During the course of these investigations similar compounds appeared in the patent literature: Chen, C.; Webb, T. R.; McCarthy, J. R.; Moran, T. J.; Wilcoxen, K. M.; PCT Int. Appl. WO 97/29109; Arvanitis, A.J.; Charvat, R.J. PCT Int. Appl. WO 98/03510